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semustine and Thrombocytopenia

semustine has been researched along with Thrombocytopenia in 17 studies

Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.

Thrombocytopenia: A subnormal level of BLOOD PLATELETS.

Research Excerpts

ExcerptRelevanceReference
"Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU)."7.66Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Schutt, AJ, 1982)
"Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)."5.26[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982)
"After en bloc resection of gastric adenocarcinoma, 180 patients were randomized to 2 years of 5-fluorouracil (5-FU) + semustine (MeCCNU) chemotherapy or to observation only."5.05Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275). ( Brunner, KW; Douglass, HO; Engstrom, PF; Lavin, PT, 1985)
"Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU)."3.66Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Schutt, AJ, 1982)
"Sixty-six patients with advanced colorectal cancer were treated with 5-fluorouracil, Mitomycin C, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea."1.27The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer. ( Chapman, J; Chinn, B; Demitrish, MM; Enochs, K; Garland, M; Groshko, G; Pederson, B; Rocchio, R; Vaughn, CB; Ward, D, 1986)
"Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)."1.26[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982)
" Further evaluation of vindesine will require dosage modification."1.26Sequential phase II studies of chemotherapy for colorectal cancer with 5-fluorouracil and vindesine with or without methyl-1,3 cis(2 chloroethyl)-1-nitrosourea. ( Bedikian, AY; Bennetts, RW; Bodey, GP; Karlin, DA; Stroehlein, JR; Valdivieso, M, 1982)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199017 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Togni, P1
Sessa, C1
Varini, M1
Cavalli, F1
Windschitl, H1
Scott, M1
Schutt, A1
McCormack, G1
Everson, L1
Cullinan, S1
Gerstner, J1
Krook, J1
Laurie, J1
Shreck, R1
Koller, CA1
Schwalm, D1
Liepman, M1
Natale, RB1
Wheeler, RH1
McCracken, JD1
Ray, P1
Heilbrun, LK1
Vaitkevicius, VK1
Saiki, JH1
Rivkin, SE1
Rossof, AH1
Moore, TN1
Engstrom, PF2
MacIntyre, JM1
Douglass, HO3
Muggia, F1
Mittelman, A2
Creagan, ET1
Ahmann, DL1
Schutt, AJ1
Green, SJ1
Stroehlein, JR1
Bedikian, AY1
Karlin, DA1
Valdivieso, M1
Bennetts, RW1
Bodey, GP1
Costanza, ME1
Nathanson, L1
Schoenfeld, D1
Wolter, J1
Colsky, J1
Regelson, W1
Cunningham, T1
Sedransk, N1
Diggs, CH1
Wiernik, PH2
Smyth, AC1
Maurice, P1
Glidewell, O1
Jacquillat, C1
Silver, RT1
Carey, R1
Pas, AT1
Cornell, CJ1
Burningham, RA1
Nissen, NI1
Holland, JF1
Chang, P1
Levine, MA1
Walker, MD1
Cedermark, BJ1
Kaufman, JH1
Posey, LE1
Morgan, LR1
O'Donnell, MR1
Ruckdeschel, JC1
Baxter, D1
McKneally, MF1
Caradonna, R1
Horton, J1
Vaughn, CB1
Chapman, J1
Garland, M1
Pederson, B1
Demitrish, MM1
Chinn, B1
Ward, D1
Enochs, K1
Groshko, G1
Rocchio, R1
Lavin, PT1
Brunner, KW1

Trials

11 trials available for semustine and Thrombocytopenia

ArticleYear
Randomized phase II studies in advanced colorectal carcinoma: a North Central Cancer Treatment Group study.
    Cancer treatment reports, 1983, Volume: 67, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Drug Evalu

1983
5-Fluorouracil, methyl-CCNU, and radiotherapy with or without testolactone for localized adenocarcinoma of the exocrine pancreas: a Southwest Oncology Group Study.
    Cancer, 1980, Oct-01, Volume: 46, Issue:7

    Topics: Adenocarcinoma; Aged; Agranulocytosis; Anorexia; Antineoplastic Agents; Clinical Trials as Topic; Do

1980
Controlled trial of adjuvant chemotherapy following curative resection for gastric cancer. The Gastrointestinal Tumor Study Group.
    Cancer, 1982, Mar-15, Volume: 49, Issue:6

    Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Humans; L

1982
Combination chemotherapy of advanced colorectal cancer utilizing 5-fluorouracil, semustine, dacarbazine, vincristine, and hydroxyurea: a phase III trial by the Eastern Cooperative Oncology Group (EST: 4275).
    Cancer, 1982, Apr-15, Volume: 49, Issue:8

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; Drug Administration

1982
Results with methyl-CCNU and DTIC in metastatic melanoma.
    Cancer, 1977, Volume: 40, Issue:3

    Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dacarbazine; Drug

1977
Comparison of methyl-CCNU and CCNU in patients with advanced forms of Hodgkin's disease, lymphosarcoma nad reticulum cell sarcoma.
    Cancer, 1978, Volume: 41, Issue:5

    Topics: Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leukopenia; Lomustine; Lymphoma, Non-Hodg

1978
A phase II study of intravenously- administered methyl CCNU in the treatment of advanced sarcomas.
    Cancer, 1976, Volume: 37, Issue:2

    Topics: Clinical Trials as Topic; Drug Evaluation; Giant Cell Tumors; Humans; Infusions, Parenteral; Leiomyo

1976
Combination with 5-fluorouracil, methyl-CCNU and beta-2-deoxythioguanosine in advanced colo-rectal adenocarcinoma.
    Clinical oncology, 1977, Volume: 3, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Deoxyribonucleosides; Drug Therapy, Combination; Fem

1977
Methyl-CCNU versus methyl-CCNU and 5-fluorouracil in carcinoma of the large bowel.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Arylsulfatases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluo

1977
Intensive induction chemotherapy for small cell anaplastic carcinoma of the lung.
    Cancer treatment reports, 1985, Volume: 69, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Clinical Trials as Topi

1985
Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275).
    Cancer, 1985, May-01, Volume: 55, Issue:9

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Fema

1985

Other Studies

6 other studies available for semustine and Thrombocytopenia

ArticleYear
[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma].
    Schweizerische medizinische Wochenschrift, 1982, Jun-26, Volume: 112, Issue:26

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Leu

1982
Phase I evaluation of semustine in a weekly schedule.
    Cancer treatment reports, 1983, Volume: 67, Issue:6

    Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Leukocyte Count; Leukopenia; Neoplasms; N

1983
Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma.
    Cancer treatment reports, 1982, Volume: 66, Issue:6

    Topics: Aged; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leukocyte Count; Leukopenia; Male;

1982
Sequential phase II studies of chemotherapy for colorectal cancer with 5-fluorouracil and vindesine with or without methyl-1,3 cis(2 chloroethyl)-1-nitrosourea.
    American journal of clinical oncology, 1982, Volume: 5, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; F

1982
Iv methyl-CCNU and ftorafur with or without methanol-extracted residue of BCG for metastatic adenocarcinoma of the colon.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Adenocarcinoma; BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Leuko

1977
The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer.
    American journal of clinical oncology, 1986, Volume: 9, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Flu

1986