semustine has been researched along with Rhabdomyosarcoma in 2 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Rhabdomyosarcoma: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, P | 1 |
| Levine, MA | 1 |
| Wiernik, PH | 1 |
| Walker, MD | 1 |
| Brent, TP | 1 |
| Houghton, PJ | 1 |
| Houghton, JA | 1 |
1 trial available for semustine and Rhabdomyosarcoma
| Article | Year |
|---|---|
A phase II study of intravenously- administered methyl CCNU in the treatment of advanced sarcomas.
Topics: Clinical Trials as Topic; Drug Evaluation; Giant Cell Tumors; Humans; Infusions, Parenteral; Leiomyo | 1976 |
1 other study available for semustine and Rhabdomyosarcoma
| Article | Year |
|---|---|
O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.
Topics: Animals; Drug Resistance; Female; Humans; Methyltransferases; Mice; Mice, Inbred CBA; Neoplasm Trans | 1985 |