semustine has been researched along with Remission, Spontaneous in 18 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Remission, Spontaneous: A spontaneous diminution or abatement of a disease over time, without formal treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of vincristine, methyl-CCNU, and methotrexate with or without MER-BCG achieved a 2% complete response (CR) and a 11% partial response (PR) with a median duration of 25-29 weeks in 124 evaluable patients with advanced adenocarcinoma of the colon and rectum." | 5.04 | Chemotherapy versus chemoimmunotherapy in advanced adenocarcinoma of the colon and rectum: a prospective randomized study. ( Barnes, P; Cooper, R; Howard, V; Muss, HB; Rhyne, L; Richards, F; Spurr, CL; Stuart, JJ; White, DR, 1979) |
| " Hematologic toxicity, however, was significantly different, with earlier time to the most severe blood count depressions, more frequent occurrence of severe depression, and a larger percentage of patients requiring dosage reduction on the 6-week regimen." | 2.65 | A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments. ( DeWys, WD; Khandekar, JD; Kosova, LA; Perlia, CP; Slayton, RE; Taylor, SG; Wolter, J, 1979) |
| "Fifty-two untreated patients with colorectal cancer were randomized to receive 5-fluorouracil (5-FU) alternating either with methotrexate (MTX) or Baker's Antifol (BAF) with or without the immunostimulant, levamisole (Program I)." | 2.64 | Sequential chemoimmunotherapy of colorectal cancer: evaluation of methotrexate, Baker's Antifol and levamisole. ( Bedikian, AY; Bodey, GP; Burgess, MA; Mavligit, GM; Rodriguez, V; Valdivieso, M, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Livingston, RB | 1 |
| Falkson, G | 2 |
| Moertel, CG | 2 |
| Lavin, P | 1 |
| Pretorius, FJ | 1 |
| Carbone, PP | 1 |
| Avellanosa, AM | 1 |
| West, CR | 1 |
| Tsukada, Y | 1 |
| Higby, DJ | 1 |
| Bakshi, S | 1 |
| Reese, PA | 1 |
| Jennings, E | 1 |
| Hrushesky, WJ | 1 |
| Murphy, GP | 1 |
| Costanza, ME | 1 |
| Nathanson, L | 1 |
| Schoenfeld, D | 1 |
| Wolter, J | 2 |
| Colsky, J | 1 |
| Regelson, W | 1 |
| Cunningham, T | 1 |
| Sedransk, N | 1 |
| Abdallah, AM | 1 |
| Soukop, M | 1 |
| Bell, G | 1 |
| Calman, KC | 1 |
| Maurice, P | 1 |
| Glidewell, O | 1 |
| Jacquillat, C | 1 |
| Silver, RT | 1 |
| Carey, R | 1 |
| Pas, AT | 1 |
| Cornell, CJ | 1 |
| Burningham, RA | 1 |
| Nissen, NI | 1 |
| Holland, JF | 1 |
| Buroker, T | 2 |
| Kim, PN | 2 |
| Groppe, C | 2 |
| McCracken, J | 2 |
| O'Bryan, R | 2 |
| Panettiere, F | 2 |
| Coltman, C | 1 |
| Bottomley, R | 2 |
| Wilson, H | 1 |
| Bonnet, J | 2 |
| Thigpen, T | 2 |
| Vaitkevicius, VK | 3 |
| Hoogstraten, B | 2 |
| Heilbrun, L | 2 |
| Kokoschka, EM | 1 |
| Luger, T | 1 |
| Micksche, M | 1 |
| Bedikian, AY | 1 |
| Valdivieso, M | 1 |
| Mavligit, GM | 1 |
| Burgess, MA | 1 |
| Rodriguez, V | 1 |
| Bodey, GP | 1 |
| Kemeny, N | 1 |
| Yagoda, A | 1 |
| Braun, D | 1 |
| Golbey, R | 1 |
| Richards, F | 1 |
| Muss, HB | 1 |
| Cooper, R | 1 |
| White, DR | 1 |
| Stuart, JJ | 1 |
| Howard, V | 1 |
| Barnes, P | 1 |
| Rhyne, L | 1 |
| Spurr, CL | 1 |
| Taylor, SG | 1 |
| DeWys, WD | 1 |
| Perlia, CP | 1 |
| Slayton, RE | 1 |
| Kosova, LA | 1 |
| Khandekar, JD | 1 |
| Costanzi, J | 1 |
| King, GW | 1 |
| Whitecar, J | 1 |
| Haas, C | 1 |
| Baker, LH | 1 |
| Talley, RW | 1 |
| Matter, R | 1 |
| Lehane, DE | 1 |
| Ruffner, BW | 1 |
| Jones, SE | 1 |
| Morrison, FS | 1 |
| Stephens, RL | 1 |
| Gehan, EA | 1 |
| Falkson, HC | 1 |
| Cedermark, BJ | 1 |
| Kaufman, JH | 1 |
| Douglass, HO | 1 |
| Mittelman, A | 1 |
1 review available for semustine and Remission, Spontaneous
| Article | Year |
|---|---|
Current status of the therapy of advanced renal carcinoma.
Topics: Adenocarcinoma; Androgens; Animals; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans | 1977 |
15 trials available for semustine and Remission, Spontaneous
| Article | Year |
|---|---|
Combination chemotherapy of bronchogenic carcinoma. I. Non-oat cell.
Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Bronchogenic; Clinical Trials as Topic; Cyclophosphamid | 1977 |
Chemotherapy studies in primary liver cancer: a prospective randomized clinical trial.
Topics: Adenoma, Bile Duct; Antineoplastic Agents; Bone Marrow; Carcinoma, Hepatocellular; Clinical Trials a | 1978 |
Results with methyl-CCNU and DTIC in metastatic melanoma.
Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dacarbazine; Drug | 1977 |
A controlled study of 5-fluorouracil versus 5-fluorouracil and methyl-CCNU in advanced gastrointestinal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorourac | 1977 |
Comparison of methyl-CCNU and CCNU in patients with advanced forms of Hodgkin's disease, lymphosarcoma nad reticulum cell sarcoma.
Topics: Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leukopenia; Lomustine; Lymphoma, Non-Hodg | 1978 |
5FU infusion with mitomycin-C versus 5 FU infusion with methyl-CCNU in the treatment of advanced colon cancer: a Southwest Oncology Group Study.
Topics: Adenocarcinoma; Bone Marrow; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Huma | 1978 |
[Immuno-chemotherapy in patients with disseminated metastasizing stage III melanoma. Randomized study with methyl-CCNU versus C. parvum plus methyl-CCNU].
Topics: Bacterial Vaccines; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; Nitrosourea Compo | 1978 |
Sequential chemoimmunotherapy of colorectal cancer: evaluation of methotrexate, Baker's Antifol and levamisole.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Colonic Neopl | 1978 |
A randomized study of two different schedules of methyl CCNU, 5-FU and vincristine for metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Digestive System; D | 1979 |
Chemotherapy versus chemoimmunotherapy in advanced adenocarcinoma of the colon and rectum: a prospective randomized study.
Topics: Adenocarcinoma; Antineoplastic Agents; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Dru | 1979 |
A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Bone Marrow; Clinical Trials as Topic; Drug Administration | 1979 |
5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer: a Southwest Oncology Group Study.
Topics: Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Drug Therapy, Combination; Female; Flu | 1979 |
Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU. A Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; | 1976 |
Fluorouracil, methyl-CCNU and vincristine in cancer of the colon.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Neopla | 1976 |
Combination with 5-fluorouracil, methyl-CCNU and beta-2-deoxythioguanosine in advanced colo-rectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Deoxyribonucleosides; Drug Therapy, Combination; Fem | 1977 |
2 other studies available for semustine and Remission, Spontaneous
| Article | Year |
|---|---|
Chemotherapy of nonirradiated malignant gliomas. Phase II: study of the combination of methyl-CCNU, vincristine, and procarbazine.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Brain Neoplasms; Drug Evaluation; Drug Therapy, Com | 1979 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |