semustine has been researched along with Recrudescence in 7 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The razoxane-treated patients experienced no significant toxicity apart from a readily reversible mild leukopenia in 52% while gastrointestinal symptoms necessitated stopping the drug in only four patients." | 2.65 | A controlled prospective trial of adjuvant razoxane in resectable colorectal cancer. ( Cassell, PC; Ellis, H; Evans, MG; Gilbert, JM; Hellmann, K; Stoodley, BJ; Wastell, C, 1981) |
| "Fifty-two patients with advanced colorectal cancer were treated with a combination of 5-Fluorouracil (FU) plus methyl-1,3-cis (2-chlorethyl)-1-nitrosourea (MeCCNU)." | 1.26 | Lack of effectiveness of combined 5- fluorouracil and methyl-CCNU therapy in advanced colorectal cancer. ( Frei, E; Lokich, JJ; Mayer, RJ; Skarin, AT, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Higgins, GA | 1 |
| Amadeo, JH | 1 |
| McElhinney, J | 1 |
| McCaughan, JJ | 1 |
| Keehn, RJ | 1 |
| Wilson, RE | 1 |
| Gilbert, JM | 1 |
| Cassell, PC | 1 |
| Ellis, H | 1 |
| Wastell, C | 1 |
| Hellmann, K | 1 |
| Evans, MG | 1 |
| Stoodley, BJ | 1 |
| Livingston, RB | 1 |
| Einhorn, LH | 1 |
| Burgess, MA | 1 |
| Gottlieb, JA | 2 |
| Lokich, JJ | 1 |
| Skarin, AT | 1 |
| Mayer, RJ | 1 |
| Frei, E | 1 |
| Day, TG | 1 |
| Wharton, JT | 1 |
| Rutledge, FN | 1 |
| Seitz, JF | 1 |
1 review available for semustine and Recrudescence
| Article | Year |
|---|---|
[Adjuvant chemotherapy in colonic cancer].
Topics: Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Levamisole; Postoper | 1990 |
3 trials available for semustine and Recrudescence
| Article | Year |
|---|---|
Efficacy of prolonged intermittent therapy with combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. A Veterans Administration Surgical Oncology Group report.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topi | 1984 |
Adjuvant therapy for colo-rectal cancer.
Topics: Adjuvants, Immunologic; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality | 1983 |
A controlled prospective trial of adjuvant razoxane in resectable colorectal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Fluorouracil; Humans; Piperazines; Razoxane; Rectal Neo | 1981 |
3 other studies available for semustine and Recrudescence
| Article | Year |
|---|---|
Sequential combination chemotherapy for advanced, recurrent, squamous carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Doxorubic | 1976 |
Lack of effectiveness of combined 5- fluorouracil and methyl-CCNU therapy in advanced colorectal cancer.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans | 1977 |
Chemotherapy for squamous carcinoma of the cervix: doxorubicin--methyl CCNU.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Doxorubicin; Drug Therapy, Combination; Female; Humans; Middl | 1978 |