semustine has been researched along with Pancreatic Neoplasms in 11 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-two patients with inoperable adenocarcinoma of the pancreas were treated with 5-fluorouracil (5-FU), mitomycin C (Mito-C), and 1(-2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU)." | 9.06 | Activity of 5-fluorouracil, mitomycin C, and methyl CCNU in inoperable adenocarcinoma of pancreas. ( Chapman, J; Chinn, B; Groshko, G; Maniscalco, B; Piper, D; Reznik, S; Vaughn, C; Ward, D, 1989) |
| "Of the 31 patients with stomach cancer who were evaluable for response and had had no previous chemotherapy, 12 (39%) achieved complete or partial remission." | 5.26 | Phase I--II study of the combination of 5-FU, doxorubicin, mitomycin, and semustine (FAMMe) in the treatment of adenocarcinoma of the stomach, gastroesophageal junction, and pancreas. ( Bennetts, RW; Heifetz, LJ; Jones, RD; Karlin, DA; Mahal, PS; Stroehlein, JR, 1982) |
| "Twenty-two patients with inoperable adenocarcinoma of the pancreas were treated with 5-fluorouracil (5-FU), mitomycin C (Mito-C), and 1(-2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU)." | 5.06 | Activity of 5-fluorouracil, mitomycin C, and methyl CCNU in inoperable adenocarcinoma of pancreas. ( Chapman, J; Chinn, B; Groshko, G; Maniscalco, B; Piper, D; Reznik, S; Vaughn, C; Ward, D, 1989) |
| "For Dukes' C colon cancer, postoperative adjuvant chemotherapy with a combination of fluorouracil and levamisole is now recommended as standard therapy." | 2.39 | Adjuvant postoperative therapy of gastrointestinal malignancies. ( Ilson, DH; Kelsen, DP, 1994) |
| "Of the 31 patients with stomach cancer who were evaluable for response and had had no previous chemotherapy, 12 (39%) achieved complete or partial remission." | 1.26 | Phase I--II study of the combination of 5-FU, doxorubicin, mitomycin, and semustine (FAMMe) in the treatment of adenocarcinoma of the stomach, gastroesophageal junction, and pancreas. ( Bennetts, RW; Heifetz, LJ; Jones, RD; Karlin, DA; Mahal, PS; Stroehlein, JR, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Courtenay, VD | 1 |
| Mills, J | 1 |
| Steel, GG | 1 |
| Sordillo, PP | 1 |
| Magill, GB | 1 |
| Kemeny, N | 1 |
| McCracken, JD | 1 |
| Ray, P | 1 |
| Heilbrun, LK | 1 |
| Vaitkevicius, VK | 2 |
| Saiki, JH | 1 |
| Rivkin, SE | 1 |
| Rossof, AH | 1 |
| Moore, TN | 1 |
| Hazel, JJ | 1 |
| Thirlwell, MP | 1 |
| Huggins, M | 1 |
| Maksymiuk, A | 1 |
| MacFarlane, JK | 1 |
| Karlin, DA | 1 |
| Stroehlein, JR | 1 |
| Bennetts, RW | 1 |
| Jones, RD | 1 |
| Heifetz, LJ | 1 |
| Mahal, PS | 1 |
| Ilson, DH | 1 |
| Kelsen, DP | 1 |
| Buroker, T | 1 |
| Kim, PN | 1 |
| Groppe, C | 1 |
| McCracken, J | 1 |
| O'Bryan, R | 1 |
| Panettiere, F | 1 |
| Costanzi, J | 1 |
| Bottomley, R | 1 |
| King, GW | 1 |
| Bonnet, J | 1 |
| Thigpen, T | 1 |
| Whitecar, J | 1 |
| Haas, C | 1 |
| Hoogstraten, B | 1 |
| Heilbrun, L | 1 |
| Moertel, CG | 2 |
| Douglass, HO | 1 |
| Hanley, J | 1 |
| Carbone, PP | 1 |
| Vaughn, C | 1 |
| Chapman, J | 1 |
| Chinn, B | 1 |
| Ward, D | 1 |
| Groshko, G | 1 |
| Maniscalco, B | 1 |
| Reznik, S | 1 |
| Piper, D | 1 |
2 reviews available for semustine and Pancreatic Neoplasms
| Article | Year |
|---|---|
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
Adjuvant postoperative therapy of gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined | 1994 |
5 trials available for semustine and Pancreatic Neoplasms
| Article | Year |
|---|---|
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
5-Fluorouracil, methyl-CCNU, and radiotherapy with or without testolactone for localized adenocarcinoma of the exocrine pancreas: a Southwest Oncology Group Study.
Topics: Adenocarcinoma; Aged; Agranulocytosis; Anorexia; Antineoplastic Agents; Clinical Trials as Topic; Do | 1980 |
Multi-drug chemotherapy with and without radiation for carcinoma of the stomach and pancreas: a prospective randomized trial.
Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up | 1981 |
5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer: a Southwest Oncology Group Study.
Topics: Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Drug Therapy, Combination; Female; Flu | 1979 |
Activity of 5-fluorouracil, mitomycin C, and methyl CCNU in inoperable adenocarcinoma of pancreas.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkylating Agents; Antineoplastic Combined Chemother | 1989 |
5 other studies available for semustine and Pancreatic Neoplasms
| Article | Year |
|---|---|
The spectrum of chemosensitivity of two human pancreatic carcinoma xenografts.
Topics: Altretamine; Animals; Antineoplastic Agents; Cell Line; Cisplatin; Cyclophosphamide; Hindlimb; Human | 1982 |
Phase II trial of methyl-CCNU, vincristine, 5-fluorouracil, and streptozotocin (MOF-Strep) in patients with disseminated pancreatic carcinoma.
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female | 1982 |
Phase I--II study of the combination of 5-FU, doxorubicin, mitomycin, and semustine (FAMMe) in the treatment of adenocarcinoma of the stomach, gastroesophageal junction, and pancreas.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Administration Sch | 1982 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |
Phase II study of methyl-CCNU in the treatment of advanced pancreatic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Blood Platelet Disorders; Drug Evaluation; Female; Humans; Leuk | 1976 |