semustine has been researched along with Lung Neoplasms in 34 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The addition of a nitrosourea appears to be an improvement over cyclophosphamide used alone in oat cell carcinoma and over the two drug combination of cyclophosphamide and methotrexate in both adenocarcinoma of the lung and oat cell disease." | 5.04 | Nitrosourea combinations in lung cancer. ( Livingston, RB, 1976) |
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| " Further, both disease staging and drug dosage have been shown to influence cure rates of combined-modality treatment." | 2.35 | Concepts for treatment of micrometastases developed in murine systems. ( Schabel, FM, 1976) |
| " When the dose of methyl-CCNU was further increased to 40 mg kg-1 toxic death occurred, which was, however, significantly reduced by 'priming' with the low dose given." | 1.27 | Priming with low doses of methyl-CCNU reduce the toxicity of high doses of methyl-CCNU and melphalan, and increase the lifespan of mice implanted with Lewis lung carcinoma. ( Livnat, I; Perk, K; Zimber, A, 1988) |
| "Treatment with Semustine (Methyl-CCNU) resulted in a partial response lasting 15 months." | 1.26 | Response of metastatic cloacogenic carcinoma to treatment with semustine. ( Wampler, GL; Zimm, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (94.12) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montgomery, JA | 2 |
| McCaleb, GS | 2 |
| Johnston, TP | 2 |
| Mayo, JG | 1 |
| Laster, WR | 2 |
| Weltz, MD | 1 |
| Perry, DJ | 1 |
| Blom, J | 1 |
| Butler, WM | 1 |
| Brandman, JR | 1 |
| Ruckdeschel, JC | 2 |
| O'Donnell, MR | 2 |
| Horton, J | 2 |
| Berman, R | 1 |
| Steel, GG | 3 |
| Kemeny, N | 1 |
| Schmid, FA | 1 |
| Otter, GM | 1 |
| Perri, GC | 1 |
| Hutchison, DJ | 1 |
| Philips, FS | 1 |
| Rose, WC | 2 |
| Stephens, TC | 4 |
| Adams, K | 3 |
| Peacock, JH | 4 |
| Zimm, S | 1 |
| Wampler, GL | 1 |
| Eisenbrand, G | 1 |
| Habs, M | 1 |
| Inaba, M | 1 |
| Yoshida, N | 1 |
| Tsukagoshi, S | 2 |
| Livingston, RB | 3 |
| Einhorn, LH | 1 |
| Bodey, GP | 2 |
| Burgess, MA | 1 |
| Freireich, EJ | 1 |
| Gottlieb, JA | 1 |
| McMahon, LJ | 1 |
| Jones, SE | 1 |
| Durie, BG | 1 |
| Salmon, SE | 1 |
| Lagakos, SW | 1 |
| Gutierrez, AC | 1 |
| Wilson, HE | 1 |
| Selawry, OS | 1 |
| Enck, RE | 1 |
| Schabel, FM | 3 |
| Twentyman, PR | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 1 |
| Wolf, J | 1 |
| Greager, JA | 1 |
| Culberson, G | 1 |
| Manning, B | 1 |
| Das Cupta, TK | 1 |
| Carchman, RA | 1 |
| Harris, LS | 1 |
| Munson, AE | 1 |
| Ushio, Y | 1 |
| Arita, N | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Hasegawa, H | 1 |
| Bitoh, S | 1 |
| Oku, Y | 1 |
| Ikeda, H | 1 |
| Kanai, N | 1 |
| Kanoh, M | 1 |
| Baxter, D | 1 |
| McKneally, MF | 1 |
| Caradonna, R | 1 |
| Zimber, A | 1 |
| Perk, K | 1 |
| Livnat, I | 1 |
| McMillan, TJ | 1 |
| Wasserman, TH | 1 |
| Slavik, M | 1 |
| Carter, SK | 1 |
| Spreafico, F | 1 |
| Garattini, S | 1 |
6 reviews available for semustine and Lung Neoplasms
| Article | Year |
|---|---|
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
[Fundamental studies on the surgical adjuvant chemotherapy to support the clinical efficacies].
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast N | 1997 |
Concepts for treatment of micrometastases developed in murine systems.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Cricetinae; Cyclop | 1976 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, | 1976 |
Methyl-CCNU inclinical cancer therapy.
Topics: Animals; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous | 1974 |
Selective antimetastatic treatment--current status and future prospects.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Drug Evaluation, Preclinical; Humans; Immunothe | 1974 |
8 trials available for semustine and Lung Neoplasms
| Article | Year |
|---|---|
Methyl-CCNU, 5-fluorouracil, vincristine, and streptozocin (MOF-STREP) in metastatic colo-rectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topi | 1983 |
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
Therapy of advanced squamous carcinoma of the lung: cyclophosphamide vesus "COMB".
Topics: Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Co | 1977 |
Combination chemotherapy of bronchogenic carcinoma. I. Non-oat cell.
Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Bronchogenic; Clinical Trials as Topic; Cyclophosphamid | 1977 |
Nitrosourea combinations in lung cancer.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carmustine; Clinical Trials as Topi | 1976 |
Nitrosoureas as single agents in the treatment of pulmonary cancer.
Topics: Carmustine; Clinical Trials as Topic; Cyclophosphamide; Female; Humans; Lomustine; Lung Neoplasms; M | 1976 |
Chemotherapy of brain metastases from lung carcinoma: a controlled randomized study.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma; Carcinom | 1991 |
Intensive induction chemotherapy for small cell anaplastic carcinoma of the lung.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Clinical Trials as Topi | 1985 |
21 other studies available for semustine and Lung Neoplasms
| Article | Year |
|---|---|
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma.
Topics: Animals; Carcinoma; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimen | 1977 |
Phase II study of methyl-CCNU, vincristine, 5-fluorouracil, and streptozotocin in advanced colorectal cancer. By the Gastrointestinal Tumor Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorour | 1984 |
Small cell cancer of lung; rapid tumor necrosis leading to serious pulmonary infections after intensive chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Cyclophosphamide; Drug Therapy, Combination; Empyema; | 1981 |
Induced and inherent resistance to alkylating agents in human small-cell bronchial carcinoma xenografts.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Cyclophosphamide; Drug Res | 1984 |
Differential uptake of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea and doxorubicin by Lewis lung carcinoma and Ridgway osteogenic sarcoma.
Topics: Animals; Dose-Response Relationship, Drug; Doxorubicin; Female; Injections, Intraperitoneal; Lung Ne | 1983 |
cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino] cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Half-Life; Indicators and Reagents; Lo | 1984 |
Identification of a subpopulation of MeCCNU resistant cells in previously untreated Lewis lung tumours.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Lung Neoplasms; Mice; Mic | 1984 |
Response of metastatic cloacogenic carcinoma to treatment with semustine.
Topics: Anus Neoplasms; Carcinoma, Transitional Cell; Drug Administration Schedule; Female; Fluorouracil; Hu | 1981 |
Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carmustine; Lomustine; Lung Neoplasms; Male; Neoplasms, | 1980 |
Preferential action of liposome-entrapped 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on lung metastasis of Lewis lung carcinoma as compared with the free drug.
Topics: Animals; Liposomes; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Exp | 1981 |
COMB (cyclophosphamide, oncovin, methyl-CCNU, and bleomycin): a four-drug combination in solid tumors.
Topics: Bleomycin; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Evaluation; Drug | 1975 |
Combination chemotherapy with methyl-CCNU (NSC-95441), cyclophosphamide (NSC-26271), vincristine (NSC-67574), methotrexate (NSC-740), and bleomycin (NSC-125066) in advanced bronchogenic carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Bleomycin; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Ca | 1975 |
Mallory-Weiss lesion following cancer chemotherapy.
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Lung Neoplasms; Male; Mallory-Weiss Syndrome; Methy | 1977 |
Sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of the EMT6 tumor in vivo as determined by both tumor volume response and in vitro plating assay.
Topics: Animals; Carmustine; Cell Count; Cell Cycle; Cell Survival; Clone Cells; Lung Neoplasms; Male; Mamma | 1978 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Chemotherapy, BCG, and serum from tumor-bearing mice: comparative effects on growth and spread of mouse Lewis lung cancer.
Topics: Animals; BCG Vaccine; Cyclophosphamide; Disease Models, Animal; Hindlimb; Immunotherapy; L-Lactate D | 1975 |
The inhibition of DNA synthesis by cannabinoids.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; D | 1976 |
Priming with low doses of methyl-CCNU reduce the toxicity of high doses of methyl-CCNU and melphalan, and increase the lifespan of mice implanted with Lewis lung carcinoma.
Topics: Animals; Lung Neoplasms; Male; Melphalan; Mice; Mice, Inbred C57BL; Nitrosourea Compounds; Semustine | 1988 |
Development of MeCCNU-resistance in clonally derived lines of Lewis lung carcinoma.
Topics: Animals; Cell Line; Cell Survival; Clone Cells; Dose-Response Relationship, Drug; Drug Resistance; F | 1987 |
Temporal interactions in the Lewis lung tumour between cytotoxic drugs and acute or fractionated radiotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cisplatin; Cobalt Radioisoto | 1986 |
Emergence of nitrosourea resistant sublines of Lewis lung tumour following MeCCNU treatment in vivo.
Topics: Animals; Carmustine; Cell Line; Cell Survival; Cisplatin; Cyclophosphamide; Dose-Response Relationsh | 1986 |