semustine has been researched along with Liver Neoplasms in 20 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Despite moderately elevated transaminase levels (all cases) and bilirubin levels (three cases), plasma Adriamycin profiles in hepatoma patients were not elevated (terminal half-life of 30 hours) and were indistinguishable from that of non-hepatoma patients with normal liver functions." | 2.65 | Adriamycin and methyl-CCNU combination therapy in hepatocellular carcinoma: clinical and pharmacokinetic aspects. ( Bateman, JR; Chan, KK; Chlebowski, RT; Ryden, VM; Tong, MJ; Weiner, JM, 1981) |
| "In the treatment of metastatic liver cancer, arterial chemotherapy and transarterial embolization are the major modality." | 1.27 | [Current status of diagnosis and treatment of metastatic liver cancer]. ( Abe, M; Hirai, K; Kubo, Y; Majima, Y, 1987) |
| "Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU)." | 1.27 | Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine. ( Hahn, RG; Moertel, CG; O'Connell, MJ; Rubin, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (90.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Falkson, G | 3 |
| MacIntyre, JM | 2 |
| Moertel, CG | 6 |
| Johnson, LA | 1 |
| Scherman, RC | 1 |
| Frytak, S | 1 |
| Rubin, J | 3 |
| Davis, HL | 1 |
| Weltz, MD | 1 |
| Perry, DJ | 1 |
| Blom, J | 1 |
| Butler, WM | 1 |
| Chlebowski, RT | 1 |
| Chan, KK | 1 |
| Tong, MJ | 1 |
| Weiner, JM | 1 |
| Ryden, VM | 1 |
| Bateman, JR | 1 |
| Joishy, SK | 1 |
| Bennett, JM | 1 |
| Balasegaram, M | 1 |
| Moertel, C | 1 |
| Carbone, PP | 2 |
| Kemeny, N | 1 |
| Whitehouse, JM | 1 |
| Grandjouan, S | 1 |
| Fabri, MC | 1 |
| Barranco, SC | 1 |
| Haenelt, BR | 1 |
| Gee, EL | 1 |
| Lavin, P | 1 |
| Pretorius, FJ | 1 |
| Costanza, ME | 1 |
| Nathanson, L | 1 |
| Schoenfeld, D | 1 |
| Wolter, J | 1 |
| Colsky, J | 1 |
| Regelson, W | 1 |
| Cunningham, T | 1 |
| Sedransk, N | 1 |
| Bécouarn, Y | 1 |
| Brunet, R | 1 |
| Ravaud, A | 1 |
| Bussières, E | 1 |
| Lagarde, P | 1 |
| Kubo, Y | 1 |
| Abe, M | 1 |
| Majima, Y | 1 |
| Hirai, K | 1 |
| O'Connell, MJ | 2 |
| Hahn, RG | 1 |
| Taylor, I | 1 |
| Glimelius, B | 1 |
| Adson, MA | 1 |
| Schutt, AJ | 1 |
| Ilstrup, DM | 1 |
5 reviews available for semustine and Liver Neoplasms
| Article | Year |
|---|---|
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
[Adjuvant chemotherapy in colonic cancers].
Topics: Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Heparin; Humans; | 1994 |
[Systemic chemotherapy in metastatic colorectal adenocarcinomas].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasms; Fem | 1992 |
Adjuvant cytotoxic chemotherapy for colorectal cancer: the present position.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combine | 1988 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; | 1986 |
9 trials available for semustine and Liver Neoplasms
| Article | Year |
|---|---|
Primary liver cancer. An Eastern Cooperative Oncology Group Trial.
Topics: Adenoma, Bile Duct; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Body W | 1984 |
Chemotherapy of large bowel cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Floxuridine; Fluorouraci | 1982 |
Methyl-CCNU, 5-fluorouracil, vincristine, and streptozocin (MOF-STREP) in metastatic colo-rectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topi | 1983 |
Adriamycin and methyl-CCNU combination therapy in hepatocellular carcinoma: clinical and pharmacokinetic aspects.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combina | 1981 |
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
Chemotherapy studies in primary liver cancer: a prospective randomized clinical trial.
Topics: Adenoma, Bile Duct; Antineoplastic Agents; Bone Marrow; Carcinoma, Hepatocellular; Clinical Trials a | 1978 |
Results with methyl-CCNU and DTIC in metastatic melanoma.
Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dacarbazine; Drug | 1977 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; | 1986 |
Clinical trial of adjuvant chemotherapy after surgical resection of colorectal cancer metastatic to the liver.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neopl | 1985 |
8 other studies available for semustine and Liver Neoplasms
| Article | Year |
|---|---|
Metabolic studies of delta-9-tetrahydrocannabinol in cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dronabinol; Female; Fluorouracil; Gastr | 1984 |
Phase II study of methyl-CCNU, vincristine, 5-fluorouracil, and streptozotocin in advanced colorectal cancer. By the Gastrointestinal Tumor Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorour | 1984 |
Clinical and chemotherapeutic study of hepatocellular carcinoma in Malaysia: a comparison with African and American patients.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Fluorouracil; Follow-Up Studies; Humans; Liver Neopl | 1982 |
Colorectal cancer. Chemotherapy.
Topics: Adjuvants, Pharmaceutic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; | 1982 |
Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyta | 1978 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |
[Current status of diagnosis and treatment of metastatic liver cancer].
Topics: alpha-Fetoproteins; Angiography; Antigens, Neoplasm; Antigens, Tumor-Associated, Carbohydrate; Antin | 1987 |
Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin; | 1988 |