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semustine and Leukopenia

semustine has been researched along with Leukopenia in 19 studies

Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.

Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).

Research Excerpts

ExcerptRelevanceReference
"Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU)."7.66Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Schutt, AJ, 1982)
"Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)."5.26[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982)
"After en bloc resection of gastric adenocarcinoma, 180 patients were randomized to 2 years of 5-fluorouracil (5-FU) + semustine (MeCCNU) chemotherapy or to observation only."5.05Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275). ( Brunner, KW; Douglass, HO; Engstrom, PF; Lavin, PT, 1985)
"Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU)."3.66Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Schutt, AJ, 1982)
"Sixty-six patients with advanced colorectal cancer were treated with 5-fluorouracil, Mitomycin C, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea."1.27The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer. ( Chapman, J; Chinn, B; Demitrish, MM; Enochs, K; Garland, M; Groshko, G; Pederson, B; Rocchio, R; Vaughn, CB; Ward, D, 1986)
"Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)."1.26[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199019 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crider, AM1
Lamey, R1
Floss, HG1
Cassady, JM1
Bradner, WJ1
Togni, P1
Sessa, C1
Varini, M1
Cavalli, F1
Windschitl, H1
Scott, M1
Schutt, A1
McCormack, G1
Everson, L1
Cullinan, S1
Gerstner, J1
Krook, J1
Laurie, J1
Shreck, R1
Koller, CA1
Schwalm, D1
Liepman, M1
Natale, RB1
Wheeler, RH1
Creagan, ET1
Ahmann, DL1
Schutt, AJ1
Green, SJ1
Rivkin, SE1
Gottlieb, JA1
Thigpen, T1
El Mawla, NG1
Saiki, J1
Dixon, DO1
Diggs, CH1
Wiernik, PH2
Smyth, AC1
Maurice, P1
Glidewell, O1
Jacquillat, C1
Silver, RT1
Carey, R1
Pas, AT1
Cornell, CJ1
Burningham, RA1
Nissen, NI1
Holland, JF1
Berd, D1
Wilson, EJ1
Bellet, RE1
Mastrangelo, MJ1
White, LA1
Perry, MC1
Kardinal, CG1
Kennedy, BJ1
Weiss, RB1
Carey, RW1
Gutin, PH1
Walker, MD2
Chang, P1
Levine, MA1
Cedermark, BJ1
Kaufman, JH1
Douglass, HO3
Mittelman, A1
Posey, LE1
Morgan, LR1
Moertel, CG1
Hanley, J1
Carbone, PP1
O'Donnell, MR1
Ruckdeschel, JC1
Baxter, D1
McKneally, MF1
Caradonna, R1
Horton, J1
Vaughn, CB1
Chapman, J1
Garland, M1
Pederson, B1
Demitrish, MM1
Chinn, B1
Ward, D1
Enochs, K1
Groshko, G1
Rocchio, R1
Engstrom, PF1
Lavin, PT1
Brunner, KW1

Trials

8 trials available for semustine and Leukopenia

ArticleYear
Randomized phase II studies in advanced colorectal carcinoma: a North Central Cancer Treatment Group study.
    Cancer treatment reports, 1983, Volume: 67, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Drug Evalu

1983
Controlled trial of adjuvant chemotherapy following curative resection for gastric cancer. The Gastrointestinal Tumor Study Group.
    Cancer, 1982, Mar-15, Volume: 49, Issue:6

    Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Humans; L

1982
Comparison of methyl-CCNU and CCNU in patients with advanced forms of Hodgkin's disease, lymphosarcoma nad reticulum cell sarcoma.
    Cancer, 1978, Volume: 41, Issue:5

    Topics: Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leukopenia; Lomustine; Lymphoma, Non-Hodg

1978
A phase II study of intravenously- administered methyl CCNU in the treatment of advanced sarcomas.
    Cancer, 1976, Volume: 37, Issue:2

    Topics: Clinical Trials as Topic; Drug Evaluation; Giant Cell Tumors; Humans; Infusions, Parenteral; Leiomyo

1976
Combination with 5-fluorouracil, methyl-CCNU and beta-2-deoxythioguanosine in advanced colo-rectal adenocarcinoma.
    Clinical oncology, 1977, Volume: 3, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Deoxyribonucleosides; Drug Therapy, Combination; Fem

1977
Methyl-CCNU versus methyl-CCNU and 5-fluorouracil in carcinoma of the large bowel.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Arylsulfatases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluo

1977
Intensive induction chemotherapy for small cell anaplastic carcinoma of the lung.
    Cancer treatment reports, 1985, Volume: 69, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Clinical Trials as Topi

1985
Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275).
    Cancer, 1985, May-01, Volume: 55, Issue:9

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Fema

1985

Other Studies

11 other studies available for semustine and Leukopenia

ArticleYear
Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:8

    Topics: Animals; Antineoplastic Agents; Leukemia, Experimental; Leukopenia; Mice; Neoplasms, Experimental; N

1980
[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma].
    Schweizerische medizinische Wochenschrift, 1982, Jun-26, Volume: 112, Issue:26

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Leu

1982
Phase I evaluation of semustine in a weekly schedule.
    Cancer treatment reports, 1983, Volume: 67, Issue:6

    Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Leukocyte Count; Leukopenia; Neoplasms; N

1983
Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma.
    Cancer treatment reports, 1982, Volume: 66, Issue:6

    Topics: Aged; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leukocyte Count; Leukopenia; Male;

1982
Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.
    Cancer, 1980, Aug-01, Volume: 46, Issue:3

    Topics: Age Factors; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Gastrointestinal Diseases; Huma

1980
Iv methyl-CCNU and ftorafur with or without methanol-extracted residue of BCG for metastatic adenocarcinoma of the colon.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Adenocarcinoma; BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Leuko

1977
Effect of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea adjuvant therapy on the immune response of patients with malignant melanoma.
    Cancer research, 1979, Volume: 39, Issue:11

    Topics: Adult; Aged; Antibody Formation; Antigens; Dinitrochlorobenzene; Escherichia coli; Female; Hemocyani

1979
Phase II study of 5-fluorouracil, methyl-CCNU, and daunorubicin in colorectal cancer: a Cancer and Leukemia Group B study.
    Cancer treatment reports, 1979, Volume: 63, Issue:2

    Topics: Adenocarcinoma; Colonic Neoplasms; Daunorubicin; Drug Evaluation; Drug Therapy, Combination; Female;

1979
Iv methyl-CCNU, VM-26, and cranial irradiation in therapy for malignant brain tumors.
    Cancer treatment reports, 1977, Volume: 61, Issue:9

    Topics: Brain Neoplasms; Humans; Injections, Intravenous; Leukopenia; Nitrosourea Compounds; Podophyllotoxin

1977
Phase II study of methyl-CCNU in the treatment of advanced pancreatic carcinoma.
    Cancer treatment reports, 1976, Volume: 60, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Anemia; Blood Platelet Disorders; Drug Evaluation; Female; Humans; Leuk

1976
The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer.
    American journal of clinical oncology, 1986, Volume: 9, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Flu

1986