semustine has been researched along with Leukopenia in 19 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU)." | 7.66 | Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Schutt, AJ, 1982) |
| "Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)." | 5.26 | [The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982) |
| "After en bloc resection of gastric adenocarcinoma, 180 patients were randomized to 2 years of 5-fluorouracil (5-FU) + semustine (MeCCNU) chemotherapy or to observation only." | 5.05 | Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275). ( Brunner, KW; Douglass, HO; Engstrom, PF; Lavin, PT, 1985) |
| "Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU)." | 3.66 | Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma. ( Ahmann, DL; Creagan, ET; Green, SJ; Schutt, AJ, 1982) |
| "Sixty-six patients with advanced colorectal cancer were treated with 5-fluorouracil, Mitomycin C, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea." | 1.27 | The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer. ( Chapman, J; Chinn, B; Demitrish, MM; Enochs, K; Garland, M; Groshko, G; Pederson, B; Rocchio, R; Vaughn, CB; Ward, D, 1986) |
| "Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)." | 1.26 | [The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crider, AM | 1 |
| Lamey, R | 1 |
| Floss, HG | 1 |
| Cassady, JM | 1 |
| Bradner, WJ | 1 |
| Togni, P | 1 |
| Sessa, C | 1 |
| Varini, M | 1 |
| Cavalli, F | 1 |
| Windschitl, H | 1 |
| Scott, M | 1 |
| Schutt, A | 1 |
| McCormack, G | 1 |
| Everson, L | 1 |
| Cullinan, S | 1 |
| Gerstner, J | 1 |
| Krook, J | 1 |
| Laurie, J | 1 |
| Shreck, R | 1 |
| Koller, CA | 1 |
| Schwalm, D | 1 |
| Liepman, M | 1 |
| Natale, RB | 1 |
| Wheeler, RH | 1 |
| Creagan, ET | 1 |
| Ahmann, DL | 1 |
| Schutt, AJ | 1 |
| Green, SJ | 1 |
| Rivkin, SE | 1 |
| Gottlieb, JA | 1 |
| Thigpen, T | 1 |
| El Mawla, NG | 1 |
| Saiki, J | 1 |
| Dixon, DO | 1 |
| Diggs, CH | 1 |
| Wiernik, PH | 2 |
| Smyth, AC | 1 |
| Maurice, P | 1 |
| Glidewell, O | 1 |
| Jacquillat, C | 1 |
| Silver, RT | 1 |
| Carey, R | 1 |
| Pas, AT | 1 |
| Cornell, CJ | 1 |
| Burningham, RA | 1 |
| Nissen, NI | 1 |
| Holland, JF | 1 |
| Berd, D | 1 |
| Wilson, EJ | 1 |
| Bellet, RE | 1 |
| Mastrangelo, MJ | 1 |
| White, LA | 1 |
| Perry, MC | 1 |
| Kardinal, CG | 1 |
| Kennedy, BJ | 1 |
| Weiss, RB | 1 |
| Carey, RW | 1 |
| Gutin, PH | 1 |
| Walker, MD | 2 |
| Chang, P | 1 |
| Levine, MA | 1 |
| Cedermark, BJ | 1 |
| Kaufman, JH | 1 |
| Douglass, HO | 3 |
| Mittelman, A | 1 |
| Posey, LE | 1 |
| Morgan, LR | 1 |
| Moertel, CG | 1 |
| Hanley, J | 1 |
| Carbone, PP | 1 |
| O'Donnell, MR | 1 |
| Ruckdeschel, JC | 1 |
| Baxter, D | 1 |
| McKneally, MF | 1 |
| Caradonna, R | 1 |
| Horton, J | 1 |
| Vaughn, CB | 1 |
| Chapman, J | 1 |
| Garland, M | 1 |
| Pederson, B | 1 |
| Demitrish, MM | 1 |
| Chinn, B | 1 |
| Ward, D | 1 |
| Enochs, K | 1 |
| Groshko, G | 1 |
| Rocchio, R | 1 |
| Engstrom, PF | 1 |
| Lavin, PT | 1 |
| Brunner, KW | 1 |
8 trials available for semustine and Leukopenia
| Article | Year |
|---|---|
Randomized phase II studies in advanced colorectal carcinoma: a North Central Cancer Treatment Group study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Drug Evalu | 1983 |
Controlled trial of adjuvant chemotherapy following curative resection for gastric cancer. The Gastrointestinal Tumor Study Group.
Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Humans; L | 1982 |
Comparison of methyl-CCNU and CCNU in patients with advanced forms of Hodgkin's disease, lymphosarcoma nad reticulum cell sarcoma.
Topics: Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leukopenia; Lomustine; Lymphoma, Non-Hodg | 1978 |
A phase II study of intravenously- administered methyl CCNU in the treatment of advanced sarcomas.
Topics: Clinical Trials as Topic; Drug Evaluation; Giant Cell Tumors; Humans; Infusions, Parenteral; Leiomyo | 1976 |
Combination with 5-fluorouracil, methyl-CCNU and beta-2-deoxythioguanosine in advanced colo-rectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Deoxyribonucleosides; Drug Therapy, Combination; Fem | 1977 |
Methyl-CCNU versus methyl-CCNU and 5-fluorouracil in carcinoma of the large bowel.
Topics: Arylsulfatases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluo | 1977 |
Intensive induction chemotherapy for small cell anaplastic carcinoma of the lung.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Clinical Trials as Topi | 1985 |
Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275).
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Fema | 1985 |
11 other studies available for semustine and Leukopenia
| Article | Year |
|---|---|
Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Leukemia, Experimental; Leukopenia; Mice; Neoplasms, Experimental; N | 1980 |
[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma].
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Leu | 1982 |
Phase I evaluation of semustine in a weekly schedule.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Leukocyte Count; Leukopenia; Neoplasms; N | 1983 |
Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma.
Topics: Aged; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leukocyte Count; Leukopenia; Male; | 1982 |
Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.
Topics: Age Factors; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Gastrointestinal Diseases; Huma | 1980 |
Iv methyl-CCNU and ftorafur with or without methanol-extracted residue of BCG for metastatic adenocarcinoma of the colon.
Topics: Adenocarcinoma; BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Leuko | 1977 |
Effect of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea adjuvant therapy on the immune response of patients with malignant melanoma.
Topics: Adult; Aged; Antibody Formation; Antigens; Dinitrochlorobenzene; Escherichia coli; Female; Hemocyani | 1979 |
Phase II study of 5-fluorouracil, methyl-CCNU, and daunorubicin in colorectal cancer: a Cancer and Leukemia Group B study.
Topics: Adenocarcinoma; Colonic Neoplasms; Daunorubicin; Drug Evaluation; Drug Therapy, Combination; Female; | 1979 |
Iv methyl-CCNU, VM-26, and cranial irradiation in therapy for malignant brain tumors.
Topics: Brain Neoplasms; Humans; Injections, Intravenous; Leukopenia; Nitrosourea Compounds; Podophyllotoxin | 1977 |
Phase II study of methyl-CCNU in the treatment of advanced pancreatic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Blood Platelet Disorders; Drug Evaluation; Female; Humans; Leuk | 1976 |
The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Flu | 1986 |