semustine has been researched along with Leukemia L 1210 in 18 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| " Immunotherapy with VCN-treated membranes was effective only when combined with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU)." | 1.26 | Immunotherapy of L1210 leukemia using neuraminidase-modified plasma membranes combined with chemotherapy. ( Brandt, AE; Jameson, AK; Pincus, JH, 1981) |
| "Studies have been conducted on liver microsomal enzymes of B6D2F(1) mice bearing a Day 4 L1210 ascites tumor after treatment with a single intraperitoneal injection of 5-fluorouracil (FUra) alone, and in combination with either cyclophosphamide (CP), methotrexate (MTX), or methyl-CCNU (MeCCNU)." | 1.26 | Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia. ( Klubes, P; Miller, HG; Trevithick, J, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crider, AM | 1 |
| Lu, CK | 1 |
| Floss, HG | 1 |
| Cassady, JM | 1 |
| Clemens, JA | 1 |
| Johnston, TP | 2 |
| McCaleb, GS | 2 |
| Clayton, SD | 1 |
| Frye, JL | 1 |
| Krauth, CA | 1 |
| Montgomery, JA | 3 |
| Mayo, JG | 1 |
| Laster, WR | 2 |
| Hansch, C | 1 |
| Leo, A | 1 |
| Schmidt, C | 1 |
| Jow, PY | 1 |
| Oguro, M | 1 |
| Yanagawa, T | 1 |
| Takenaga, K | 1 |
| Brandt, AE | 2 |
| Pincus, JH | 1 |
| Jameson, AK | 1 |
| Griswold, DP | 1 |
| Corbett, TH | 1 |
| Schabel, FM | 3 |
| Klubes, P | 1 |
| Trevithick, J | 1 |
| Miller, HG | 1 |
| Papermaster, BW | 1 |
| Kaltenbach, ML | 1 |
| Rose, WC | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 1 |
| Bekesi, JG | 1 |
| Roboz, JP | 1 |
| Zimmerman, E | 1 |
| Holland, JF | 1 |
| Carchman, RA | 1 |
| Harris, LS | 1 |
| Munson, AE | 1 |
| Young, RC | 1 |
| Goldberg, D | 1 |
| Grotzinger, KR | 1 |
| Schmid, FA | 2 |
| Otter, GM | 2 |
| Hirano, I | 1 |
| Chen, CF | 1 |
| Spreafico, F | 1 |
| Garattini, S | 1 |
2 reviews available for semustine and Leukemia L 1210
| Article | Year |
|---|---|
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, | 1976 |
Selective antimetastatic treatment--current status and future prospects.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Drug Evaluation, Preclinical; Humans; Immunothe | 1974 |
16 other studies available for semustine and Leukemia L 1210
| Article | Year |
|---|---|
Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Ergolines; Leukemia L1210; Mice; Nitrosourea Compounds; Prolactin; R | 1979 |
Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Isomerism; Leukemia L1210; Mice; Mice | 1977 |
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma.
Topics: Animals; Carcinoma; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimen | 1977 |
Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Mice; Models, Theoretical; Nitrosourea Compounds; So | 1980 |
[Antitumor activity of a new nitrosourea, MCNU, on a cellular morphological basis evaluated by a new in vitro antitumor sensitivity assay].
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Re | 1984 |
Correspondence re: J. H. Pincus, A. K. Jameson, and A. E. Brandt. Immunotherapy of L1210 leukemia using neuraminidase-modified plasma membranes combined with chemotherapy. Cancer Res., 41: 3082-3086, 1981.
Topics: Animals; Carmustine; Cell Membrane; Immunotherapy; Leukemia L1210; Mice; Neuraminidase; Semustine | 1982 |
Immunotherapy of L1210 leukemia using neuraminidase-modified plasma membranes combined with chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Membrane; Female; Immunotherapy; Leukemia L1210; Mice; Neuramin | 1981 |
Clonogenicity and growth of experimental tumors in relation to developing resistance and therapeutic failure.
Topics: Animals; Clone Cells; Cyclophosphamide; Drug Resistance; Humans; Leukemia L1210; Melanoma; Mice; Neo | 1981 |
Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia.
Topics: Animals; Cyclophosphamide; Drug Interactions; Fluorouracil; Leukemia L1210; Liver; Male; Methotrexat | 1980 |
Lymphokine preparations: a new approach to cancer immunotherapy.
Topics: Animals; Guinea Pigs; Humans; Immunity, Cellular; Immunotherapy; Leukemia L1210; Lymphokines; Lympho | 1978 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Treatment of spontaneous leukemia in AKR mice with chemotherapy, immunotherapy, or interferon.
Topics: AKR murine leukemia virus; Animals; Antibodies, Viral; Antigens, Neoplasm; Antineoplastic Agents; Dr | 1976 |
The inhibition of DNA synthesis by cannabinoids.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; D | 1976 |
Alterations in 3H-thymidine incorporation into DNA induced by methyl CCNU (1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea) in normal and tumorous tissues in vivo.
Topics: Animals; Bone Marrow; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Intesti | 1976 |
L1210 leukemia hybrids isolated after fusion of alkylating agent-resistant sublines.
Topics: Alkylating Agents; Animals; Cell Fusion; Cell Line; Cell Separation; Chromosomes; Cyclophosphamide; | 1988 |
Drug sensitivity of methylnitrosourea- and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea-resistant L1210 lines.
Topics: Alkylating Agents; Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Survival; Drug Administ | 1986 |