semustine has been researched along with Kidney Failure, Chronic in 2 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nephrotoxicity of semustine (methyl-CCNU) has been studied in 45 adult patients with surgically resected Stage I or II malignant melanoma who received this drug as adjuvant chemotherapy." | 9.05 | Nephrotoxicity of semustine (methyl-CCNU) in patients with malignant melanoma receiving adjuvant chemotherapy. ( Fisher, RI; Jensen-Akula, M; Mandard, JC; Micetich, KC, 1981) |
| "The nephrotoxicity of semustine (methyl-CCNU) has been studied in 45 adult patients with surgically resected Stage I or II malignant melanoma who received this drug as adjuvant chemotherapy." | 5.05 | Nephrotoxicity of semustine (methyl-CCNU) in patients with malignant melanoma receiving adjuvant chemotherapy. ( Fisher, RI; Jensen-Akula, M; Mandard, JC; Micetich, KC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Micetich, KC | 1 |
| Jensen-Akula, M | 1 |
| Mandard, JC | 1 |
| Fisher, RI | 1 |
| Harmon, WE | 1 |
| Cohen, HJ | 1 |
| Schneeberger, EE | 1 |
| Grupe, WE | 1 |
1 trial available for semustine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Nephrotoxicity of semustine (methyl-CCNU) in patients with malignant melanoma receiving adjuvant chemotherapy.
Topics: Adolescent; Adult; Aged; Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Humans; Kidney; | 1981 |
1 other study available for semustine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Chronic renal failure in children treated with methyl CCNU.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Humans; Kidney; Kidney Failure, Chronic; Nitro | 1979 |