semustine has been researched along with Hematologic Diseases in 5 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Hematologic Diseases: Disorders of the blood and blood forming tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On closer examination, the agents that appear to be responsible for these especially adverse effects are methotrexate and methyl-CCNU." | 2.65 | Clinical trials and drug toxicity in the elderly. The experience of the Eastern Cooperative Oncology Group. ( Begg, CB; Carbone, PP, 1983) |
| "Patients with advanced colorectal cancer and no prior chemotherapy were randomized to six treatment regimens: A) fluorouracil (FU) alone; B) FU + hydroxyurea (HU); C) semustine (SE) + dacarbazine (DA); D) FU + HU alternating with SE + DA; E) SE + razoxane (RA); F) mitomycin (MI) + DA." | 2.65 | Chemotherapy of advanced colorectal carcinoma: fluorouracil alone vs. two drug combinations using fluorouracil, hydroxyurea, semustine, dacarbazine, razoxane, and mitomycin. A phase III trial by the Eastern Cooperative Oncology Group (EST: 1278). ( Engstrom, PF; Klaassen, DJ; MacIntyre, JM; Mittelman, A, 1984) |
| "Twenty-two patients had squamous carcinoma and 1 had adenosquamous carcinoma." | 1.27 | Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix. ( Allegra, JC; Carlson, JA; Day, TG; Greenberg, RA; Masterson, BJ; Woodcock, TM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Higgins, GA | 2 |
| Donaldson, RC | 1 |
| Rogers, LS | 1 |
| Juler, GL | 1 |
| Keehn, RJ | 2 |
| Begg, CB | 1 |
| Carbone, PP | 1 |
| Amadeo, JH | 1 |
| McElhinney, J | 1 |
| McCaughan, JJ | 1 |
| Engstrom, PF | 1 |
| MacIntyre, JM | 1 |
| Mittelman, A | 1 |
| Klaassen, DJ | 1 |
| Carlson, JA | 1 |
| Day, TG | 1 |
| Allegra, JC | 1 |
| Woodcock, TM | 1 |
| Greenberg, RA | 1 |
| Masterson, BJ | 1 |
4 trials available for semustine and Hematologic Diseases
1 other study available for semustine and Hematologic Diseases
| Article | Year |
|---|---|
Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Do | 1984 |