semustine has been researched along with Experimental Neoplasms in 41 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| "Single doses of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea caused transient suppression of [3H]thymidine incorporation into DNA in bone marrow and gastrointestinal mucosa and more prolonged inhibition of such incorporation in B16 melanoma." | 3.65 | Inhibition and recovery of DNA synthesis in host tissues and sensitive and resistant B16 melanoma after 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea, a predictor of therapeutic efficacy. ( Brereton, HD; Bryant, TL; Young, RC, 1975) |
| " Further, both disease staging and drug dosage have been shown to influence cure rates of combined-modality treatment." | 2.35 | Concepts for treatment of micrometastases developed in murine systems. ( Schabel, FM, 1976) |
| "A dose-response relation for the cytotoxic activity of chloroethylnitrosourea cancer chemotherapeutic agents in cell culture has been developed." | 1.26 | Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture. ( Deen, DF; Weinkam, RJ, 1982) |
| " The results imply that dosage scheduling in the treatment of murine melanomas must be individualized." | 1.26 | Effect of scheduling of combinations of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on the Harding-Passey and Cloudman S91 mouse melanomas. ( Hill, GJ; Hill, HZ, 1982) |
| "Seven human brain tumors were transplanted into the brains (6/7 takes) and subcutaneous tissues (7/7 takes) of athymic nude mice." | 1.26 | Human brain tumor transplantation into nude mice. ( Basler, GA; Chernik, NL; Posner, JB; Shapiro, WR, 1979) |
| " These results showed that the maximum tolerated dosage of the agents administered intrarectally suppressed the development of new tumors after start of the treatment and also the growth of tumors which were detected by endoscopy before the treatment." | 1.26 | Cancer chemotherapy model using autochthonous large bowel cancer in rats. ( Kono, K; Narisawa, T; Takahashi, T; Yamaguchi, T, 1978) |
| " However, with certain dosage schedules such as every 2 hr for 5 injections daily on 2 consecutive days, i." | 1.26 | Chemotherapy of an experimental glioma with nitrosoureas. ( Day, A; Liberman, L; Ng, R; Tator, CH, 1977) |
| " The three drugs show similar threshold-type dose-response survival curves on asynchronous cells treated for 1 hr." | 1.26 | A comparison of the lethal effects of three nitrosourea derivatives on cultured human lymphoma cells. ( Drewinko, B; Gottlieb, JA; Loo, TL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montgomery, JA | 1 |
| McCaleb, GS | 1 |
| Johnston, TP | 1 |
| Mayo, JG | 1 |
| Laster, WR | 3 |
| Crider, AM | 1 |
| Lamey, R | 1 |
| Floss, HG | 1 |
| Cassady, JM | 1 |
| Bradner, WJ | 1 |
| Komiyama, K | 1 |
| Edanami, K | 1 |
| Kuroda, T | 1 |
| Umezawa, I | 1 |
| Weinkam, RJ | 1 |
| Deen, DF | 1 |
| Hill, HZ | 2 |
| Hill, GJ | 2 |
| Cowen, DM | 1 |
| Siegerstetter, J | 1 |
| Janik, AC | 1 |
| Double, JA | 1 |
| Osieka, R | 3 |
| Glatte, P | 1 |
| Haedecke, U | 1 |
| Schmidt, CG | 1 |
| Williams, PD | 1 |
| Kantor, P | 1 |
| Murphy, GP | 2 |
| Eisenbrand, G | 1 |
| Habs, M | 1 |
| Inaba, M | 1 |
| Yoshida, N | 1 |
| Tsukagoshi, S | 1 |
| Griswold, DP | 3 |
| Corbett, TH | 2 |
| Schabel, FM | 7 |
| Clement, JJ | 1 |
| Gorman, MS | 1 |
| Wodinsky, I | 2 |
| Catane, R | 1 |
| Johnson, RK | 1 |
| Barranco, SC | 1 |
| Haenelt, BR | 1 |
| Gee, EL | 1 |
| Mabel, JA | 1 |
| Merker, PC | 1 |
| Sturgeon, ML | 1 |
| Geran, RI | 1 |
| Bono, VH | 1 |
| Shapiro, WR | 2 |
| Basler, GA | 1 |
| Chernik, NL | 1 |
| Posner, JB | 2 |
| Hrushesky, WJ | 1 |
| Miller, CL | 1 |
| Pfaller, M | 1 |
| Weiss, K | 1 |
| Galin, M | 1 |
| Hasegawa, H | 1 |
| Wolpert, MK | 1 |
| Venditti, JM | 1 |
| Rose, WC | 2 |
| Veras, GH | 1 |
| Bateman, AE | 1 |
| Fu, KK | 1 |
| Towse, GD | 1 |
| Schrecker, AW | 1 |
| Schultz, RM | 1 |
| Chirigos, MA | 1 |
| Erickson, LC | 1 |
| Kohn, KW | 2 |
| Thomas, CB | 1 |
| Narisawa, T | 1 |
| Kono, K | 1 |
| Yamaguchi, T | 1 |
| Takahashi, T | 2 |
| Walker, MD | 2 |
| Papermaster, BW | 1 |
| Kaltenbach, ML | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 2 |
| Tator, CH | 1 |
| Day, A | 1 |
| Ng, R | 1 |
| Liberman, L | 1 |
| Hilton, J | 1 |
| Brereton, HD | 1 |
| Bryant, TL | 1 |
| Young, RC | 1 |
| Pezzotta, S | 1 |
| Agradi, E | 1 |
| Paoletti, P | 1 |
| Greager, JA | 1 |
| Culberson, G | 1 |
| Manning, B | 1 |
| Das Cupta, TK | 1 |
| Carchman, RA | 1 |
| Harris, LS | 1 |
| Munson, AE | 1 |
| Drewinko, B | 1 |
| Loo, TL | 1 |
| Gottlieb, JA | 1 |
| Spreafico, F | 1 |
| Garattini, S | 1 |
6 reviews available for semustine and Experimental Neoplasms
| Article | Year |
|---|---|
Concepts for treatment of micrometastases developed in murine systems.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Cricetinae; Cyclop | 1976 |
Review of mechanism of action studies of the nitrosoureas.
Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Cell Survival | 1976 |
Current status of the therapy of advanced renal carcinoma.
Topics: Adenocarcinoma; Androgens; Animals; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans | 1977 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, | 1976 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
Selective antimetastatic treatment--current status and future prospects.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Drug Evaluation, Preclinical; Humans; Immunothe | 1974 |
1 trial available for semustine and Experimental Neoplasms
| Article | Year |
|---|---|
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
35 other studies available for semustine and Experimental Neoplasms
| Article | Year |
|---|---|
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma.
Topics: Animals; Carcinoma; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimen | 1977 |
Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Leukemia, Experimental; Leukopenia; Mice; Neoplasms, Experimental; N | 1980 |
Antitumor effect of 3-[3-(2-chloroethyl)-3-nitrosoureido]-3-deoxy-D-glucopyranose on murine tumors.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia, Experimental; Leukocyte Cou | 1981 |
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture.
Topics: Animals; Biotransformation; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Respon | 1982 |
Effect of scheduling of combinations of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on the Harding-Passey and Cloudman S91 mouse melanomas.
Topics: Animals; Cell Line; Dacarbazine; Drug Administration Schedule; Drug Therapy, Combination; Female; Me | 1982 |
The assessment of response of murine transplantable colon tumors to combination chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carmustine; Cell Line; Colonic Neoplasms; Dimethylhy | 1982 |
[Enhancement of MeCCNU potency (chemosensitization) by misonidazole in a human melanoma xenograft system].
Topics: Animals; Cell Line; Drug Interactions; Female; Humans; Melanoma; Mice; Mice, Nude; Misonidazole; Neo | 1982 |
Evaluation of vincristine, CCNU and methyl-CCNU at high level doses in an experimental murine renal adenocarcinoma model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Kidney Neoplasms; Lomustine; Male; Mice; Neoplasm Tr | 1981 |
Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carmustine; Lomustine; Lung Neoplasms; Male; Neoplasms, | 1980 |
Preferential action of liposome-entrapped 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on lung metastasis of Lewis lung carcinoma as compared with the free drug.
Topics: Animals; Liposomes; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Exp | 1981 |
Clonogenicity and growth of experimental tumors in relation to developing resistance and therapeutic failure.
Topics: Animals; Clone Cells; Cyclophosphamide; Drug Resistance; Humans; Leukemia L1210; Melanoma; Mice; Neo | 1981 |
Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.
Topics: Alkylating Agents; Animals; Aziridines; Benzoquinones; Cyclohexenes; Cyclophosphamide; Drug Therapy, | 1980 |
Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyta | 1978 |
Combination chemotherapy against B16 melanoma: bleomycin/vinblastine, bleomycin/cis-diamminedichloroplatinum, 5-fluorouracil/BCNU and 5-fluorouracil/methyl-CCNU.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cisplatin; Dose-Response Relationship, Drug; | 1978 |
Human brain tumor transplantation into nude mice.
Topics: Animals; Brain Neoplasms; Carmustine; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Transplantati | 1979 |
Effects of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, and L-phenylalanine mustard on B16, Cloudman S91, and Harding-Passey mouse melanomas.
Topics: Animals; Cell Count; Dacarbazine; Female; Melanoma; Melphalan; Mice; Mice, Inbred Strains; Neoplasm | 1979 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
Design and evaluation of combination chemotherapy trials in experimental animal tumor systems.
Topics: Animals; Antineoplastic Agents; Carmustine; Cisplatin; Colonic Neoplasms; Drug Evaluation, Preclinic | 1979 |
Evaluation of whole-body hyperthermia as an adjunct to chemotherapy in murine tumors.
Topics: Animals; Antineoplastic Agents; Body Temperature; Cyclophosphamide; Dactinomycin; Doxorubicin; Femal | 1979 |
The combination of methyl-CCNU and irradiation: cell survival studies on a human tumor xenograft.
Topics: Adenocarcinoma; Animals; Cell Survival; Dose-Response Relationship, Radiation; Humans; Mice; Mice, I | 1979 |
Effect of macrophage activation by immunoadjuvants on serum levels of lysosomal hydrolases in mice.
Topics: Acetylglucosaminidase; Adjuvants, Immunologic; Animals; Glucuronidase; Hydrolases; Lysosomes; Macrop | 1979 |
Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea-induced DNA damage in two human colon tumor cell lines.
Topics: Animals; Cell Line; Colonic Neoplasms; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Mice; Mic | 1978 |
DNA cross-linking by in vivo treatment with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of sensitive and resistant human colon carcinoma xenograms in nude mice.
Topics: Alkalies; Animals; Colonic Neoplasms; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Female; | 1978 |
Cancer chemotherapy model using autochthonous large bowel cancer in rats.
Topics: Administration, Topical; Animals; Drug Evaluation, Preclinical; Female; Fluorouracil; Intestinal Neo | 1978 |
The contemporary role of chemotherapy in the treatment of malignant brain tumor.
Topics: Adrenal Cortex Hormones; Animals; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Dru | 1978 |
Lymphokine preparations: a new approach to cancer immunotherapy.
Topics: Animals; Guinea Pigs; Humans; Immunity, Cellular; Immunotherapy; Leukemia L1210; Lymphokines; Lympho | 1978 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Chemotherapy of an experimental glioma with nitrosoureas.
Topics: Animals; Brain Neoplasms; Drug Administration Schedule; Ependymoma; Female; Glioma; Injections; Inje | 1977 |
Nitrosourea pharmacodynamics in relation to the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Glioma; Humans; Lomustine; Mice; Molecula | 1976 |
Inhibition and recovery of DNA synthesis in host tissues and sensitive and resistant B16 melanoma after 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea, a predictor of therapeutic efficacy.
Topics: Animals; Bone Marrow; Cell Division; Depression, Chemical; DNA; DNA, Neoplasm; Gastric Mucosa; Intes | 1975 |
The effect of BCNU, CCNU and MeCCNU in the prevention of the development of tumors of the nervous system.
Topics: Animals; Brain Neoplasms; Carmustine; Ethylnitrosourea; Neoplasms, Experimental; Nitrosourea Compoun | 1975 |
Chemotherapy, BCG, and serum from tumor-bearing mice: comparative effects on growth and spread of mouse Lewis lung cancer.
Topics: Animals; BCG Vaccine; Cyclophosphamide; Disease Models, Animal; Hindlimb; Immunotherapy; L-Lactate D | 1975 |
The inhibition of DNA synthesis by cannabinoids.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; D | 1976 |
A comparison of the lethal effects of three nitrosourea derivatives on cultured human lymphoma cells.
Topics: Amphotericin B; Carmustine; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, D | 1976 |
Growth support of small B16 melanoma implants with nitrosourea-sterilized fractions of the same tumor.
Topics: Animals; Carmustine; Cell Line; Cells, Cultured; Melanoma; Mice; Neoplasm Transplantation; Neoplasms | 1976 |