semustine has been researched along with Colonic Neoplasms in 118 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients with advanced colorectal carcinoma were treated with combination chemotherapy consisting of actinomycin D, vincristine, methyl-CCNU, and methotrexate." | 7.67 | Treatment of advanced colorectal carcinoma with actinomycin D, vincristine, methyl-CCNU, and methotrexate. ( Cooper, MR; Craig, JB; Jackson, DV; Muss, HB; Richards, FR; Spurr, CL; Stuart, JJ; White, DR, 1987) |
| "Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)." | 5.26 | [The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982) |
| "In a randomized, multicenter study, 168 evaluable patients with colorectal adenocarcinoma at B2, C1 or C2 stages of the Dukes, Astler and Coller classification, were treated after radical surgery with BCG and 5-fluorouracil alone (regimen A) or in combination with hydroxyurea, methyl-CCNU and mitomycin C (regimen B)." | 5.05 | Preliminary research on the evaluation of some prognostic factors in a randomized study of adjuvant immunochemotherapy in colorectal adenocarcinoma. ( De Vecchis, L; Lagomarsino Caprino, MC; Mazzei, T; Periti, P; Popoli, P, 1984) |
| "In a randomized multi-institutional trial of the Eastern Cooperative Oncology Group, 316 patients with advanced measurable colorectal adenocarcinoma were treated with a weekly schedule of 5-fluorouracil given orally and intravenously with oral-5-fluorouracil in combination with cyclophosphamide or 6-thioguanine, or with oral Methyl CCNU administered once every eight weeks." | 5.04 | Chemotherapy of advanced measurable colon and rectal carcinoma with oral 5-fluorouracil, alone or in combination with cyclophosphamide or 6-thioguanine, with intravenous 5-fluorouracil or beta-2'-deoxythioguanosine or with oral 3(4-methyl-cyclohexyl)-1(2- ( Carbone, P; Conroy, JF; Douglass, HO; Lavin, PT; Woll, J, 1978) |
| "The combination of vincristine, methyl-CCNU, and methotrexate with or without MER-BCG achieved a 2% complete response (CR) and a 11% partial response (PR) with a median duration of 25-29 weeks in 124 evaluable patients with advanced adenocarcinoma of the colon and rectum." | 5.04 | Chemotherapy versus chemoimmunotherapy in advanced adenocarcinoma of the colon and rectum: a prospective randomized study. ( Barnes, P; Cooper, R; Howard, V; Muss, HB; Rhyne, L; Richards, F; Spurr, CL; Stuart, JJ; White, DR, 1979) |
| "Patients with Dukes' B colon cancer benefit from adjuvant chemotherapy and should be presented with this treatment option." | 3.79 | Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04) ( Atkins, JN; Bear, HD; Jones, J; Mamounas, E; Rockette, H; Song, K; Wieand, S; Wolmark, N, 1999) |
| "Twenty patients with advanced colorectal carcinoma were treated with combination chemotherapy consisting of actinomycin D, vincristine, methyl-CCNU, and methotrexate." | 3.67 | Treatment of advanced colorectal carcinoma with actinomycin D, vincristine, methyl-CCNU, and methotrexate. ( Cooper, MR; Craig, JB; Jackson, DV; Muss, HB; Richards, FR; Spurr, CL; Stuart, JJ; White, DR, 1987) |
| "Consecutive studies were undertaken in advanced colorectal adenocarcinoma, comparing two different schedules of the combination methyl-CCNU, 6-thioguanine, and 5-fluorouracil in 89 patients." | 3.66 | Methyl-CCNU, 6-thioguanine, and 5-fluorouracil in advanced colorectal cancer. ( Aroney, RS; Bell, DR; Chan, WK; Dalley, DN; Levi, JA, 1981) |
| "Patients with advanced colorectal cancer and no prior chemotherapy were randomized to six treatment regimens: A) fluorouracil (FU) alone; B) FU + hydroxyurea (HU); C) semustine (SE) + dacarbazine (DA); D) FU + HU alternating with SE + DA; E) SE + razoxane (RA); F) mitomycin (MI) + DA." | 2.65 | Chemotherapy of advanced colorectal carcinoma: fluorouracil alone vs. two drug combinations using fluorouracil, hydroxyurea, semustine, dacarbazine, razoxane, and mitomycin. A phase III trial by the Eastern Cooperative Oncology Group (EST: 1278). ( Engstrom, PF; Klaassen, DJ; MacIntyre, JM; Mittelman, A, 1984) |
| "The razoxane-treated patients experienced no significant toxicity apart from a readily reversible mild leukopenia in 52% while gastrointestinal symptoms necessitated stopping the drug in only four patients." | 2.65 | A controlled prospective trial of adjuvant razoxane in resectable colorectal cancer. ( Cassell, PC; Ellis, H; Evans, MG; Gilbert, JM; Hellmann, K; Stoodley, BJ; Wastell, C, 1981) |
| "Combinations of active agents in gastric cancer hold promise as effective surgical adjuvant therapy." | 2.65 | Adjuvant chemotherapy in colon and gastric cancer. ( Haller, DG; Kisner, DL; Macdonald, JS, 1982) |
| "Fifty-two untreated patients with colorectal cancer were randomized to receive 5-fluorouracil (5-FU) alternating either with methotrexate (MTX) or Baker's Antifol (BAF) with or without the immunostimulant, levamisole (Program I)." | 2.64 | Sequential chemoimmunotherapy of colorectal cancer: evaluation of methotrexate, Baker's Antifol and levamisole. ( Bedikian, AY; Bodey, GP; Burgess, MA; Mavligit, GM; Rodriguez, V; Valdivieso, M, 1978) |
| " Preoperative radiotherapy with a dosage of 35-45 Gy can lead to downstaging of rectal cancer." | 2.39 | [Developments up to now and current status of adjuvant chemo- and radiotherapy in colonic and rectal carcinoma]. ( Eble, MJ; Kraus, TW; Raeth, U, 1994) |
| "For Dukes' C colon cancer, postoperative adjuvant chemotherapy with a combination of fluorouracil and levamisole is now recommended as standard therapy." | 2.39 | Adjuvant postoperative therapy of gastrointestinal malignancies. ( Ilson, DH; Kelsen, DP, 1994) |
| " Further, both disease staging and drug dosage have been shown to influence cure rates of combined-modality treatment." | 2.35 | Concepts for treatment of micrometastases developed in murine systems. ( Schabel, FM, 1976) |
| "Sixty-six patients with advanced colorectal cancer were treated with 5-fluorouracil, Mitomycin C, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea." | 1.27 | The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer. ( Chapman, J; Chinn, B; Demitrish, MM; Enochs, K; Garland, M; Groshko, G; Pederson, B; Rocchio, R; Vaughn, CB; Ward, D, 1986) |
| "Cancer is one of the most serious illnesses of the elderly." | 1.27 | Management of cancer in the elderly. Implications of the aging process. ( Neilan, BA, 1985) |
| "Thirty-six patients with advanced colorectal cancer whose disease progressed during treatment with 5-fluorouracil (5-FU) chemotherapy were treated with methyl-CCNU and methotrexate." | 1.27 | Methyl-CCNU and methotrexate therapy in patients with advanced colorectal cancer after failure of 5-fluorouracil chemotherapy. ( Bazos, MJ; Evans, WK; Myers, R; Shepherd, FA; Zorzitto, ML, 1986) |
| "Sixteen patients with advanced colo-rectal cancer were treated with the combination methyl-CCNU, vincristin, 5-fluorouracil and streptozotocin (MOF-Strepto)." | 1.26 | [The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma]. ( Cavalli, F; Sessa, C; Togni, P; Varini, M, 1982) |
| " Further evaluation of vindesine will require dosage modification." | 1.26 | Sequential phase II studies of chemotherapy for colorectal cancer with 5-fluorouracil and vindesine with or without methyl-1,3 cis(2 chloroethyl)-1-nitrosourea. ( Bedikian, AY; Bennetts, RW; Bodey, GP; Karlin, DA; Stroehlein, JR; Valdivieso, M, 1982) |
| "Fifty-two patients with advanced colorectal cancer were treated with a combination of 5-Fluorouracil (FU) plus methyl-1,3-cis (2-chlorethyl)-1-nitrosourea (MeCCNU)." | 1.26 | Lack of effectiveness of combined 5- fluorouracil and methyl-CCNU therapy in advanced colorectal cancer. ( Frei, E; Lokich, JJ; Mayer, RJ; Skarin, AT, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 103 (87.29) | 18.7374 |
| 1990's | 11 (9.32) | 18.2507 |
| 2000's | 3 (2.54) | 29.6817 |
| 2010's | 1 (0.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McElhinney, RS | 1 |
| McCormick, JE | 1 |
| Bibby, MC | 2 |
| Double, JA | 3 |
| Radacic, M | 1 |
| Dumont, P | 1 |
| Zhang, SZ | 1 |
| Grem, J | 1 |
| Smith, RE | 1 |
| Colangelo, L | 2 |
| Wieand, HS | 1 |
| Begovic, M | 1 |
| Wolmark, N | 4 |
| Higgins, GA | 5 |
| Donaldson, RC | 2 |
| Rogers, LS | 2 |
| Juler, GL | 1 |
| Keehn, RJ | 2 |
| Queisser, W | 1 |
| Heim, ME | 1 |
| Togni, P | 1 |
| Sessa, C | 1 |
| Varini, M | 1 |
| Cavalli, F | 1 |
| Kemeny, N | 5 |
| Yagoda, A | 3 |
| Braun, D | 3 |
| Weltz, MD | 1 |
| Perry, DJ | 1 |
| Blom, J | 1 |
| Butler, WM | 1 |
| Amadeo, JH | 1 |
| McElhinney, J | 1 |
| McCaughan, JJ | 1 |
| Wilson, RE | 1 |
| Fritze, D | 1 |
| Hine, KR | 1 |
| Dykes, PW | 1 |
| Engstrom, PF | 4 |
| MacIntyre, JM | 4 |
| Mittelman, A | 7 |
| Klaassen, DJ | 2 |
| Lagomarsino Caprino, MC | 1 |
| Mazzei, T | 1 |
| De Vecchis, L | 1 |
| Popoli, P | 1 |
| Periti, P | 1 |
| Roth, A | 1 |
| Kolarić, K | 1 |
| Wheeler, GP | 1 |
| Bowdon, BJ | 1 |
| Torbert, JW | 1 |
| Webster, J | 1 |
| Alexander, JA | 1 |
| Windschitl, H | 1 |
| Scott, M | 3 |
| Schutt, A | 1 |
| McCormack, G | 1 |
| Everson, L | 1 |
| Cullinan, S | 1 |
| Gerstner, J | 1 |
| Krook, J | 1 |
| Laurie, J | 1 |
| Shreck, R | 1 |
| Mechl, Z | 1 |
| Ahmann, FR | 1 |
| Douglass, HO | 7 |
| Muggia, F | 2 |
| Moayeri, H | 2 |
| DiBenedetto, J | 2 |
| Gilbert, JM | 1 |
| Cassell, PC | 1 |
| Ellis, H | 1 |
| Wastell, C | 1 |
| Hellmann, K | 2 |
| Evans, MG | 1 |
| Stoodley, BJ | 1 |
| Humphrey, EW | 1 |
| Shields, TW | 1 |
| Macdonald, JS | 4 |
| Haller, DG | 1 |
| Kisner, DL | 1 |
| Cowen, DM | 1 |
| Siegerstetter, J | 1 |
| Janik, AC | 1 |
| Stroehlein, JR | 1 |
| Bedikian, AY | 2 |
| Karlin, DA | 1 |
| Valdivieso, M | 2 |
| Bennetts, RW | 1 |
| Bodey, GP | 2 |
| Breeden, JH | 1 |
| Vollmer, JT | 1 |
| Twomey, PL | 1 |
| Whitehouse, JM | 1 |
| Duncan, W | 1 |
| Sutton, JE | 1 |
| Roos, IA | 1 |
| Hillcoat, BL | 2 |
| Windschitl, HE | 1 |
| Krook, JE | 2 |
| Everson, LK | 2 |
| Cullinan, SA | 2 |
| Aroney, RS | 1 |
| Dalley, DN | 1 |
| Chan, WK | 1 |
| Bell, DR | 1 |
| Levi, JA | 1 |
| Golbey, R | 2 |
| Bianucci, P | 1 |
| Pastorino, G | 1 |
| Shetty, MR | 1 |
| Tarquini, A | 1 |
| Mascia, V | 1 |
| Massidda, B | 1 |
| Chessa, PP | 1 |
| Pellegrini, A | 1 |
| Epenetos, AA | 1 |
| Amos, C | 1 |
| Collis, C | 1 |
| Slevin, M | 1 |
| Rohatiner, A | 1 |
| Baille-Johnson, H | 1 |
| Pitts, J | 1 |
| Wrigley, PF | 1 |
| Kraus, TW | 1 |
| Eble, MJ | 1 |
| Raeth, U | 1 |
| Ilson, DH | 1 |
| Kelsen, DP | 1 |
| Mezger, J | 1 |
| Grandjouan, S | 1 |
| Fabri, MC | 1 |
| Tsukagoshi, S | 1 |
| Kodaira, S | 1 |
| Mamounas, E | 1 |
| Wieand, S | 2 |
| Bear, HD | 1 |
| Atkins, JN | 1 |
| Song, K | 1 |
| Jones, J | 2 |
| Rockette, H | 2 |
| Kubanek, B | 1 |
| Woolley, PV | 2 |
| Schein, PS | 3 |
| Schabel, FM | 3 |
| Karrer, K | 1 |
| Denck, H | 1 |
| Pridun, N | 1 |
| Diggs, CH | 1 |
| Wiernik, PH | 1 |
| Smyth, AC | 1 |
| Berman, R | 1 |
| Giles, GR | 2 |
| Malhotra, A | 1 |
| Bird, GG | 1 |
| Gajjar, PD | 1 |
| Bunch, GA | 1 |
| Hall, R | 1 |
| Buroker, T | 2 |
| Wojtaszak, B | 1 |
| Dindogru, A | 1 |
| DeMattia, M | 1 |
| Baker, L | 1 |
| Groth, C | 1 |
| Vaitkevicius, VK | 3 |
| Kim, PN | 1 |
| Groppe, C | 1 |
| McCracken, J | 1 |
| O'Bryan, R | 1 |
| Panettiere, F | 1 |
| Coltman, C | 1 |
| Bottomley, R | 1 |
| Wilson, H | 1 |
| Bonnet, J | 2 |
| Thigpen, T | 1 |
| Hoogstraten, B | 1 |
| Heilbrun, L | 1 |
| Mavligit, GM | 1 |
| Burgess, MA | 1 |
| Rodriguez, V | 1 |
| Lavin, PT | 3 |
| Woll, J | 1 |
| Conroy, JF | 1 |
| Carbone, P | 1 |
| Richards, F | 2 |
| Muss, HB | 3 |
| Cooper, R | 1 |
| White, DR | 3 |
| Stuart, JJ | 3 |
| Howard, V | 1 |
| Barnes, P | 1 |
| Rhyne, L | 1 |
| Spurr, CL | 3 |
| Weiss, RB | 2 |
| DeVita, VT | 1 |
| Belt, RJ | 1 |
| Stephens, R | 1 |
| Zeitoun, P | 1 |
| Salas, H | 1 |
| White, LA | 1 |
| Perry, MC | 1 |
| Kardinal, CG | 1 |
| Kennedy, BJ | 1 |
| Carey, RW | 2 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| Wolpert, MK | 1 |
| Venditti, JM | 1 |
| Brutti, A | 1 |
| Liberati, AM | 1 |
| Biscottini, B | 1 |
| Fatati, G | 1 |
| Sini, S | 1 |
| Barzi, AM | 1 |
| Grignani, F | 1 |
| Bhide, S | 1 |
| Habs, M | 1 |
| Reinbold, H | 1 |
| Schmähl, D | 1 |
| Evans, JT | 2 |
| Carbone, PP | 1 |
| Joss, RA | 1 |
| Goldberg, RS | 1 |
| Yates, JW | 1 |
| Lokich, JJ | 1 |
| Skarin, AT | 1 |
| Mayer, RJ | 1 |
| Frei, E | 1 |
| Erickson, LC | 1 |
| Osieka, R | 3 |
| Kohn, KW | 2 |
| Thomas, CB | 1 |
| Fischetti, MR | 1 |
| Weitzman, SA | 1 |
| Kaufman, S | 1 |
| Kelley, RM | 1 |
| Sohier, WD | 1 |
| Greco, FA | 1 |
| Richardson, RL | 1 |
| Shulman, SF | 1 |
| Oldham, RK | 1 |
| Kane, RC | 1 |
| Cashdollar, MR | 1 |
| Bernath, AM | 1 |
| McCulloch, PB | 1 |
| Figueredo, AT | 1 |
| Ehsan, MH | 1 |
| Rosenfeld, JM | 1 |
| Lawton, JO | 1 |
| Kisner, D | 1 |
| Moertel, CG | 6 |
| Falkson, G | 1 |
| Falkson, HC | 1 |
| Carter, SK | 3 |
| Cedermark, BJ | 1 |
| Kaufman, JH | 1 |
| Posey, LE | 1 |
| Morgan, LR | 1 |
| Kisner, DF | 1 |
| Smythe, T | 1 |
| Smith, L | 1 |
| Ducreux, M | 1 |
| Seitz, JF | 1 |
| Glatte, P | 1 |
| Niederle, N | 1 |
| Schmidt, CG | 1 |
| Schutt, AJ | 3 |
| Buroker, TR | 1 |
| Fleming, TR | 1 |
| Mailliard, JA | 1 |
| Marschke, RF | 1 |
| Laurie, JA | 1 |
| Ottery, FD | 1 |
| Scupham, RK | 1 |
| Weese, JL | 1 |
| Reichman, B | 1 |
| Geller, N | 1 |
| Hollander, P | 1 |
| Glimelius, B | 1 |
| Vaughn, CB | 1 |
| Chapman, J | 1 |
| Garland, M | 1 |
| Pederson, B | 1 |
| Demitrish, MM | 1 |
| Chinn, B | 1 |
| Ward, D | 1 |
| Enochs, K | 1 |
| Groshko, G | 1 |
| Rocchio, R | 1 |
| Fisher, B | 1 |
| Redmond, C | 1 |
| Wickerham, DL | 1 |
| Fisher, ER | 1 |
| Glass, A | 1 |
| Lerner, H | 1 |
| Lawrence, W | 1 |
| Panettiere, FJ | 1 |
| Goodman, PJ | 1 |
| Costanzi, JJ | 1 |
| Cruz, AB | 1 |
| McCracken, JD | 1 |
| Brownlee, RW | 1 |
| Laufman, L | 1 |
| Stephens, RL | 1 |
| Thomas, PR | 1 |
| Stablein, DM | 1 |
| Steinberg, SM | 1 |
| Barkin, JS | 1 |
| Nauta, RJ | 1 |
| O'Connell, MJ | 2 |
| Rubin, J | 2 |
| Hahn, RG | 1 |
| Gilbert, J | 1 |
| Case, LD | 1 |
| Jackson, DV | 2 |
| Cooper, MR | 2 |
| Zekan, P | 1 |
| Cruz, J | 1 |
| Sertoli, MR | 1 |
| Guarneri, D | 1 |
| Rubagotti, A | 1 |
| Porcile, G | 1 |
| Nobile, MT | 1 |
| Rosso, R | 1 |
| Craig, JB | 1 |
| Richards, FR | 1 |
| Neilan, BA | 1 |
| Caruso, U | 1 |
| Elli, M | 1 |
| Cravotto, E | 1 |
| Tisone, G | 1 |
| Lombardo, PA | 1 |
| Silvaroli, M | 1 |
| Ficorella, C | 1 |
| Cortesi, E | 1 |
| Casciani, CU | 1 |
| Adson, MA | 1 |
| Ilstrup, DM | 1 |
| Platinskiĭ, LV | 1 |
| Sokolova, VD | 1 |
| Ozhiganov, EL | 1 |
| Zorzitto, ML | 1 |
| Myers, R | 1 |
| Bazos, MJ | 1 |
| Shepherd, FA | 1 |
| Evans, WK | 1 |
| Wasserman, TH | 1 |
| Slavik, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Clinical Trial to Evaluate Postoperative Immunotherapy and Postoperative Systemic Chemotherapy in the Management of Resectable Colon Cancer[NCT00427570] | Phase 3 | 0 participants | Interventional | 1977-09-30 | Completed | ||
| A Clinical Trial to Assess the Relative Efficacy of 5-FU + Leucovorin, 5-FU + Levamisole, and 5-FU + Leucovorin + Levamisole in Patients With Dukes' B and C Carcinoma of the Colon[NCT00425152] | Phase 3 | 2,151 participants (Actual) | Interventional | 1989-07-31 | Completed | ||
| A Clinical Trial to Evaluate the Postoperative Portal Vein Infusion of 5-Fluorouracil and Heparin in Patients With Resectable Adenocarcinoma of the Colon[NCT00427310] | Phase 3 | 1,158 participants (Actual) | Interventional | 1984-03-31 | Completed | ||
| A Clinical Trial Comparing Oral Uracil/Ftorafur (UFT) Plus Leucovorin (LV) With 5-Fluorouracil (5-FU) Plus LV in the Treatment of Patients With Stages II And III Carcinoma of the Colon[NCT00378716] | Phase 3 | 1,608 participants (Actual) | Interventional | 1997-02-28 | Completed | ||
| Phase I Trial of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine[NCT00359606] | Phase 1 | 58 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| Phase 0 Trial of [F-18]-5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine[NCT01479348] | Early Phase 1 | 5 participants (Actual) | Interventional | 2011-11-01 | Terminated (stopped due to Slow, insufficient accrual.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the number of participants with serious and non-serious adverse events assessed by the Common Terminology Criteria for Adverse Events (CTCAE v4.0). A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life-threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. (NCT01479348)
Timeframe: Date treatment consent signed to date off study, approximately 20 months and 12 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| 1/Intravenous (IV) Tetrahydrouridine (THU) | 2 |
[F-18]-5-fluoro-2'-deoxycytidine (FdCyd) was administered intravenously with administration of tetrahydrouridine (THU) and the frequency and severity of adverse events was observed. A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life-threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. Grade 0 is normal, Grade 1 is mild, Grade 2 is moderate, Grade 3 is severe or medically significant but not immediately life-threatening, Grade 4 is life-threatening consequences, and Grade 5 is death related to adverse event. (NCT01479348)
Timeframe: Within 5 days after interventions
| Intervention | adverse events (Number) | |||||
|---|---|---|---|---|---|---|
| Day 1 Adverse Events | Day 2, Grade 2 Hypoalbuminemia | Day 2, Grade 3 Anemia | Day 3 Adverse Events | Day 4 Adverse Events | Day 5 Adverse Events | |
| 1/Intravenous (IV) Tetrahydrouridine (THU) | 0 | 1 | 1 | 0 | 0 | 0 |
Radiation dosimetry was determined based on the first patients. This involved making region of interest measurements on the scan for each major organ and measuring the uptake. Using standard dosimetry software this is converted into mSv/MBq, a standard measure of dosimetry. The software is known as Organ Level INternal Dose Assessment/EXponential Modeling (OLINDA) and is commonly used to generate this kind of data. (NCT01479348)
Timeframe: 1 year
| Intervention | mSv/MBq (Mean) | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adrenals | Brain | Breasts | Gallbladder wall | Lower large intestine wall | Small intestine | Stomach wall | Upper large intestine wall | Heart wall | Kidneys | Liver | Lungs | Muscle | Ovaries | Pancreas | Red marrow | Osteogenic cells | Skin | Spleen | Testes | Thymus | Thyroid | Urinary bladder wall | Uterus | |
| 1/Intravenous (IV) Tetrahydrouridine (THU) | 1.83 | 8.17 | 1.03 | 4.05 | 2.52 | 2.13 | 1.90 | 2.04 | 1.10 | 5.26 | 6.02 | 1.82 | 1.16 | 1.57 | 1.63 | 1.14 | 1.71 | 8.65 | 1.69 | 1.03 | 1.12 | 8.23 | 7.96 | 1.63 |
Participants were scanned by positron emission tomography (PET) and lesions were measured at 4 time points after injection. (NCT01479348)
Timeframe: 9 minutes, 32 minutes, 56 minutes and 2 hours after injection
| Intervention | TBR ratio (Number) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pt 1 L. Parotid adenosquam. cell ca at 9 min | Pt 1 L. Parotid adenosquam. cell ca at 32 min | Pt 1 L. Parotid adenosquam. cell ca at 56 min | Pt 1 L. Parotid adenosquam. cell ca at 2 hrs | Pt 2 R. Parapharyngeal Spindle Cell Ca at 9 min | Pt 2 R. Parapharyngeal Spindle Cell Ca at 32 min | Pt 2 R. Parapharyngeal Spindle Cell Ca at 56 min | Pt 2 R. Parapharyngeal Spindle Cell Ca at 2 hrs | Pt 3 Non-small Cell Lung Ca at 9 min | Pt 3 Non-small Cell Lung Ca at 32 min | Pt 3 Non-small Cell Lung Ca at 56 min | Pt 3 Non-small Cell Lung Ca at 2 hrs | Pt 4 Non-small Cell Lung Ca at 9 min | Pt 4 Non-small Cell Lung Ca at 32 min | Pt 4 Non-small Cell Lung Ca at 56 min | Pt 4 Non-small Cell Lung Ca at 2 hrs | Pt 5 Hepatocellular Ca at 9 min | Pt 5 Hepatocellular Ca at 32 min | Pt 5 Hepatocellular Ca at 56 min | Pt 5 Hepatocellular Ca at 2 hrs | |
| 1/Intravenous (IV) Tetrahydrouridine (THU) | 1.4 | 1.5 | 1.5 | 1.6 | 1.9 | 1.7 | 1.7 | 1.6 | 1.4 | 1.4 | 1.5 | 1.7 | 2.4 | 2.1 | 1.6 | 2.0 | NA | NA | NA | NA |
19 reviews available for semustine and Colonic Neoplasms
| Article | Year |
|---|---|
[Advances in research on capecitabine as adjuvant treatment for colon cancer after radical resection].
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cape | 2010 |
Chemotherapy in alimentary tract malignomas.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Cytarabine; Doxor | 1981 |
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
[Developments up to now and current status of adjuvant chemo- and radiotherapy in colonic and rectal carcinoma].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colon | 1994 |
Adjuvant postoperative therapy of gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined | 1994 |
[Adjuvant therapy in colorectal carcinomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluoroura | 1994 |
[Adjuvant chemotherapy in colonic cancers].
Topics: Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Heparin; Humans; | 1994 |
[Fundamental studies on the surgical adjuvant chemotherapy to support the clinical efficacies].
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast N | 1997 |
[The current status of postoperative adjuvant chemotherapy for colorectal cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colect | 1997 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Chemotherapy of colorectal carcinoma.
Topics: Administration, Oral; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Drug Administration Sche | 1976 |
Concepts for treatment of micrometastases developed in murine systems.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Cricetinae; Cyclop | 1976 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, | 1976 |
Current protocol approaches in large bowel cancer.
Topics: Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; Drug Th | 1976 |
Accomplishments in surgical adjuvant therapy for large bowel cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Drug T | 1992 |
[Adjuvant chemotherapy in colonic cancer].
Topics: Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Levamisole; Postoper | 1990 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; | 1986 |
[Chemotherapy of cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms | 1985 |
Methyl-CCNU inclinical cancer therapy.
Topics: Animals; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous | 1974 |
51 trials available for semustine and Colonic Neoplasms
| Article | Year |
|---|---|
Randomized trial of adjuvant therapy in colon carcinoma: 10-year results of NSABP protocol C-01.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; | 2004 |
Chemotherapy after palliative resection of colorectal cancer. Yorkshire Gastrointestinal Tumour Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Th | 1984 |
Efficacy of MER immunotherapy when added to a regimen of 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. A Veterans Administration Surgical Oncology Group report.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Clinical Trials as Topic; | 1984 |
Metastatic colorectal carcinoma. A prospective randomized trial of Methyl-CCNU, 5-Fluorouracil (5-FU) and vincristine (MOF) versus MOF plus streptozotocin (MOF-Strep).
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials | 1983 |
Methyl-CCNU, 5-fluorouracil, vincristine, and streptozocin (MOF-STREP) in metastatic colo-rectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topi | 1983 |
Current status of adjuvant therapy in the treatment of large bowel cancer.
Topics: Antineoplastic Agents; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Fluorouracil; Human | 1983 |
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
Efficacy of prolonged intermittent therapy with combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. A Veterans Administration Surgical Oncology Group report.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topi | 1984 |
Adjuvant therapy for colo-rectal cancer.
Topics: Adjuvants, Immunologic; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality | 1983 |
Adjuvant therapy of colon cancer--results of a prospectively randomized trial.
Topics: BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Drug Therapy, C | 1984 |
[Adjuvant therapy in colonic cancer].
Topics: Clinical Trials as Topic; Colonic Neoplasms; Fluorouracil; Humans; Immunotherapy; Leukemia; Prospect | 1984 |
Prospective randomised trial of early cytotoxic therapy for recurrent colorectal carcinoma detected by serum CEA.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Clinical Trials as Topic; | 1984 |
Chemotherapy of advanced colorectal carcinoma: fluorouracil alone vs. two drug combinations using fluorouracil, hydroxyurea, semustine, dacarbazine, razoxane, and mitomycin. A phase III trial by the Eastern Cooperative Oncology Group (EST: 1278).
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Ne | 1984 |
Preliminary research on the evaluation of some prognostic factors in a randomized study of adjuvant immunochemotherapy in colorectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Colonic Ne | 1984 |
Randomized phase II studies in advanced colorectal carcinoma: a North Central Cancer Treatment Group study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Drug Evalu | 1983 |
Methyl-CCNU and ftorafur in treatment of rectosigmoidal tumors and ftorafur capsules in treatment of colorectal tumors.
Topics: Capsules; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Huma | 1981 |
Adjuvant chemotherapy of colorectal carcinoma.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Fluorouracil; Humans; Rectal Neo | 1982 |
Combination chemotherapy containing semustine (MeCCNU) in patients with advanced colorectal cancer previously treated with 5-fluorouracil (5-Fu).
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; | 1983 |
A controlled prospective trial of adjuvant razoxane in resectable colorectal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Fluorouracil; Humans; Piperazines; Razoxane; Rectal Neo | 1981 |
Adjuvant therapy for large bowel cancer: update of Veterans Administration Surgical Oncology Group Trials.
Topics: BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; H | 1981 |
Adjuvant chemotherapy in colon and gastric cancer.
Topics: BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; F | 1982 |
Combination chemotherapy of advanced colorectal cancer utilizing 5-fluorouracil, semustine, dacarbazine, vincristine, and hydroxyurea: a phase III trial by the Eastern Cooperative Oncology Group (EST: 4275).
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; Drug Administration | 1982 |
[Adjuvant therapy in colorectal carcinomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluoroura | 1994 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
Topics: Adenocarcinoma; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; C | 1999 |
[Initial experiences with a nation-wide Austrian study of adjuvant chemo- and immunotherapy of colorectal cancer following radical surgery].
Topics: Antineoplastic Agents; Austria; Colectomy; Colonic Neoplasms; Drug Therapy, Combination; Fluorouraci | 1979 |
Randomized trial of melphalan plus 5-fluorouracil (5-FU) versus methyl-CCNU plus 5-FU in patients with advanced colorectal cancer.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; H | 1978 |
Phase II trial of ftorafur with mitomycin C versus ftorafur with methyl-CCNU in untreated colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Drug Ther | 1978 |
5FU infusion with mitomycin-C versus 5 FU infusion with methyl-CCNU in the treatment of advanced colon cancer: a Southwest Oncology Group Study.
Topics: Adenocarcinoma; Bone Marrow; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Huma | 1978 |
Sequential chemoimmunotherapy of colorectal cancer: evaluation of methotrexate, Baker's Antifol and levamisole.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Colonic Neopl | 1978 |
Chemotherapy of advanced measurable colon and rectal carcinoma with oral 5-fluorouracil, alone or in combination with cyclophosphamide or 6-thioguanine, with intravenous 5-fluorouracil or beta-2'-deoxythioguanosine or with oral 3(4-methyl-cyclohexyl)-1(2-
Topics: Adenocarcinoma; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Colonic Neoplasms; Cyc | 1978 |
A randomized study of two different schedules of methyl CCNU, 5-FU and vincristine for metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Digestive System; D | 1979 |
Chemotherapy versus chemoimmunotherapy in advanced adenocarcinoma of the colon and rectum: a prospective randomized study.
Topics: Adenocarcinoma; Antineoplastic Agents; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Dru | 1979 |
The dilemma regarding postoperative chemotherapy in primary carcinoma of the colon.
Topics: Antineoplastic Agents; BCG Vaccine; Breast Neoplasms; Carcinoma; Clinical Trials as Topic; Colonic N | 1979 |
Phase II evaluation of diglycoaldehyde, VP-16-213, and the combination of methyl-CCNU and beta-2'-deoxythioguanosine in previously treated patients with colorectal cancer: an Eastern Cooperative Oncology Group study (EST-1275).
Topics: Aldehydes; Colonic Neoplasms; Deoxyguanosine; Drug Evaluation; Drug Therapy, Combination; Etoposide; | 1979 |
Chemotherapy of large intestinal carcinoma. Current results and future prospects.
Topics: Administration, Oral; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Colonic Neoplasms | 1975 |
Nitrosoureas: useful agents for the treatment of advanced gastrointestinal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combin | 1976 |
Fluorouracil, methyl-CCNU and vincristine in cancer of the colon.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Neopla | 1976 |
Current protocol approaches in large bowel cancer.
Topics: Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; Drug Th | 1976 |
Combination with 5-fluorouracil, methyl-CCNU and beta-2-deoxythioguanosine in advanced colo-rectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Deoxyribonucleosides; Drug Therapy, Combination; Fem | 1977 |
Methyl-CCNU versus methyl-CCNU and 5-fluorouracil in carcinoma of the large bowel.
Topics: Arylsulfatases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluo | 1977 |
Chemotherapy of large bowel carcinoma--fluorouracil (FU) + hydroxyurea (HU) vs. methyl-CCNU, oncovin, fluorouracil, and streptozotocin (MOF-Strep). An Eastern Cooperative Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorour | 1985 |
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluat | 1985 |
Implementation of the group sequential methodology in a randomized trial in metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neopl | 1988 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; | 1986 |
Postoperative adjuvant chemotherapy or BCG for colon cancer: results from NSABP protocol C-01.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Clinical Trials as Topic; Colonic | 1988 |
Adjuvant therapy in large bowel adenocarcinoma: long-term results of a Southwest Oncology Group Study.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine | 1988 |
The effects of liver directed radiotherapy and chemotherapy on liver function tests and hematological parameters in patients with surgically resected colon cancer: findings from the Gastrointestinal Tumor Study Group.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bone Marrow; Carcinoma; Clinical Trials as Topic; | 1987 |
A randomized clinical trial of combination chemotherapy in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neopl | 1987 |
Combination chemotherapy (5-fluorouracil, methyl-CCNU, mitomycin C) versus 5-fluorouracil alone for advanced previously untreated colorectal carcinoma. A phase III study of the Piedmont Oncology Association.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; C | 1986 |
Adjuvant immunochemotherapy in colorectal cancer Dukes C.
Topics: Adjuvants, Immunologic; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fema | 1987 |
Clinical trial of adjuvant chemotherapy after surgical resection of colorectal cancer metastatic to the liver.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neopl | 1985 |
53 other studies available for semustine and Colonic Neoplasms
| Article | Year |
|---|---|
Nucleoside analogs. 14. The synthesis of antitumor activity in mice of molecular combinations of 5-fluorouracil and N-(2-Chloroethyl)-N-nitrosourea moieties separated by a three-carbon chain.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Ethylnitrosourea; Fluorouracil; Mammary Neoplasms | 1996 |
Adjuvant therapy for colon cancer: a historical perspective.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-F | 2004 |
[The combination methyl-CCNU, vincristine, 5-fluorouracil and streptozotocin in the treatment of advanced colo-rectal adenocarcinoma].
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Leu | 1982 |
Phase II study of methyl-CCNU, vincristine, 5-fluorouracil, and streptozotocin in advanced colorectal cancer. By the Gastrointestinal Tumor Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorour | 1984 |
Adjuvant therapy for carcinoma of the colon and rectum.
Topics: Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Humans; L | 1984 |
[A clinical study (phase II) of a combination of 5-fluorouracil, vincristine and methyl CCNU in patients with advanced carcinoma of the large intestine].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; | 1983 |
Characterisation and chemosensitivity of a well-differentiated murine transplantable adenocarcinoma of the colon.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Busulfan; Colonic Neoplasms; Cyclophosphamide; Dose- | 1983 |
Biological and biochemical effects of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea on two transplantable murine colon tumors.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; DNA Replication; Kinetics; Mice; Mice, Inbred | 1983 |
Metastatic colorectal cancer. Combination chemotherapy in patients previously treated with 5-fluorouracil.
Topics: Adult; Aged; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middl | 1980 |
The assessment of response of murine transplantable colon tumors to combination chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carmustine; Cell Line; Colonic Neoplasms; Dimethylhy | 1982 |
Sequential phase II studies of chemotherapy for colorectal cancer with 5-fluorouracil and vindesine with or without methyl-1,3 cis(2 chloroethyl)-1-nitrosourea.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; F | 1982 |
Toxicity of very high dose nitrosourea administration.
Topics: Adenocarcinoma; Bone Marrow; Colonic Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Nitr | 1982 |
Colorectal cancer. Chemotherapy.
Topics: Adjuvants, Pharmaceutic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; | 1982 |
Colorectal cancer. Prospects in management.
Topics: Adjuvants, Immunologic; Adjuvants, Pharmaceutic; Colonic Neoplasms; Fluorouracil; Humans; Postoperat | 1982 |
Combined actions of 5-fluorouracil and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on human colonic carcinoma cells in vitro.
Topics: Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Thera | 1982 |
Combination chemotherapy in patients with advanced colorectal carcinoma previously treated with 5-FU.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Nitrosourea Compou | 1982 |
Methyl-CCNU, 6-thioguanine, and 5-fluorouracil in advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1981 |
Therapy for metastatic colorectal carcinoma with a combination of methyl-CCNU, 5-fluorouracil vincristine and streptozotocin (MOF-Strep).
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorourac | 1980 |
[Immunochemotherapeutic treatment of gastrointestinal neoplasms].
Topics: Adjuvants, Immunologic; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Prognos | 1981 |
Methyl CCNU therapy linked leukemia.
Topics: Adult; Bone Marrow; Colonic Neoplasms; Female; Humans; Leukemia; Nitrosourea Compounds; Semustine | 1981 |
[Current aspects of precautional therapy of colorectal neoplasms].
Topics: Antineoplastic Agents; BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Immunotherapy; Postoper | 1980 |
Comparison of two combination chemotherapy regimens in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorourac | 1980 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, A | 2001 |
[Incurable colon cancer. 2. Limits and possibilities of palliative drug- and radiotherapy].
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Palliativ | 1979 |
Iv methyl-CCNU and ftorafur with or without methanol-extracted residue of BCG for metastatic adenocarcinoma of the colon.
Topics: Adenocarcinoma; BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Leuko | 1977 |
Phase I-II study of ftorafur and methyl-CCNU in advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Bone Marrow; Colonic Neoplasms; Digestive System; Drug Evaluation; Drug | 1979 |
[Nonsurgical treatments of colonic cancers: chemotherapy, immunotherapy, radiotherapy].
Topics: Adenocarcinoma; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Human | 1979 |
Phase II study of 5-fluorouracil, methyl-CCNU, and daunorubicin in colorectal cancer: a Cancer and Leukemia Group B study.
Topics: Adenocarcinoma; Colonic Neoplasms; Daunorubicin; Drug Evaluation; Drug Therapy, Combination; Female; | 1979 |
Design and evaluation of combination chemotherapy trials in experimental animal tumor systems.
Topics: Animals; Antineoplastic Agents; Carmustine; Cisplatin; Colonic Neoplasms; Drug Evaluation, Preclinic | 1979 |
Combination chemotherapy with 5-fluorouracil and methyl-CCNU for the treatment of advanced gastrointestinal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Blood Cells; Colonic Neoplasms; Drug Administration Schedule; Dr | 1979 |
Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on Yoshida sarcoma ascites cells implanted into the colon wall of rats.
Topics: Animals; Body Weight; Carmustine; Colonic Neoplasms; Cyclophosphamide; Male; Nitrosourea Compounds; | 1979 |
Combination chemotherapy of colorectal cancer with 5-fluorouracil, methyl-1,3-cis(2-chloroethyl)-1-nitrosourea, and vincristine.
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Fluoro | 1979 |
Lack of effectiveness of combined 5- fluorouracil and methyl-CCNU therapy in advanced colorectal cancer.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans | 1977 |
Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea-induced DNA damage in two human colon tumor cell lines.
Topics: Animals; Cell Line; Colonic Neoplasms; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Mice; Mic | 1978 |
DNA cross-linking by in vivo treatment with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of sensitive and resistant human colon carcinoma xenograms in nude mice.
Topics: Alkalies; Animals; Colonic Neoplasms; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Female; | 1978 |
Treatment of advanced colorectal cancer with a combination of 5-fluorouracil and methyl-CCNU.
Topics: Adenocarcinoma; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Nitrosourea Comp | 1978 |
Phase II study of melphalan in colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Male; | 1978 |
Combination of constant-infusion 5-fluorouracil, methyl-CCNU, mitomycin C, and vincristine in advanced colorectal carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; H | 1978 |
Treatment of advanced colorectal cancer with methyl-CCNU plus 5-day 5-fluorouracil infusion.
Topics: Adult; Aged; Bone Marrow Diseases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Therapy, Combin | 1978 |
Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
Topics: Adenocarcinoma; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Pare | 1978 |
Chemotherapy for known residual disease after resection of gastric and colorectal cancer.
Topics: Carcinoembryonic Antigen; Carmustine; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; H | 1978 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |
5-Fluorouracil (5-FU), methyl-CCNU, and vincristine in the treatment of advanced colorectal cancer: phase II study utilizing weekly 5-FU.
Topics: Adult; Aged; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combina | 1976 |
Editorial: Large-bowel cancer-The current status of treatment.
Topics: Adjuvants, Immunologic; BCG Vaccine; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combi | 1976 |
Editorial: Large-bowel cancer-The current status of treatment.
Topics: Adjuvants, Immunologic; BCG Vaccine; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combi | 1976 |
Editorial: Large-bowel cancer-The current status of treatment.
Topics: Adjuvants, Immunologic; BCG Vaccine; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combi | 1976 |
Editorial: Large-bowel cancer-The current status of treatment.
Topics: Adjuvants, Immunologic; BCG Vaccine; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combi | 1976 |
[Adjuvant treatment of resected colon cancers using a 5-fluorouracil-levamisole combination].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Fluoro | 1991 |
Response of human colon carcinoma xenografts to recombinant human tumor necrosis factor (TNF).
Topics: Animals; Colonic Neoplasms; Cytarabine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasm Trans | 1989 |
Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement.
Topics: Adult; Cholecystectomy; Cholecystitis; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; | 1986 |
The efficacy of 5-fluorouracil, mitomycin C, and methyl CCNU in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Flu | 1986 |
MOF as control arm for NSABP adjuvant chemotherapy trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Fluoro | 1988 |
Treatment of advanced colorectal carcinoma with actinomycin D, vincristine, methyl-CCNU, and methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Dactinomycin; Female; | 1987 |
Management of cancer in the elderly. Implications of the aging process.
Topics: Aged; Aging; Colonic Neoplasms; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acu | 1985 |
Colorectal cancer (Duke's group B2, C1, C2): adjuvant chemotherapy and toxicity.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chemical and Drug Induced | 1985 |
Methyl-CCNU and methotrexate therapy in patients with advanced colorectal cancer after failure of 5-fluorouracil chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil | 1986 |