Compounds > semustine
Page last updated: 2024-11-04

semustine and Cholera Infantum

semustine has been researched along with Cholera Infantum in 5 studies

Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.

Research Excerpts

ExcerptRelevanceReference
"Two hundred forty-one patients with unresectable gastric adenocarcinoma were entered, between December 1978 and March 1981, into a prospectively randomized comparison of three chemotherapy regimens to identify therapeutic activity and determine patient tolerability: (1) 5-fluorouracil plus Adriamycin (FA); (2) FA plus methyl-CCNU (FAMe); and (3) FA plus mitomycin C (FAMi)."5.05Randomized study of combination chemotherapy in unresectable gastric cancer. The Gastrointestinal Tumor Study Group. ( , 1984)
"Patients with advanced colorectal cancer and no prior chemotherapy were randomized to six treatment regimens: A) fluorouracil (FU) alone; B) FU + hydroxyurea (HU); C) semustine (SE) + dacarbazine (DA); D) FU + HU alternating with SE + DA; E) SE + razoxane (RA); F) mitomycin (MI) + DA."2.65Chemotherapy of advanced colorectal carcinoma: fluorouracil alone vs. two drug combinations using fluorouracil, hydroxyurea, semustine, dacarbazine, razoxane, and mitomycin. A phase III trial by the Eastern Cooperative Oncology Group (EST: 1278). ( Engstrom, PF; Klaassen, DJ; MacIntyre, JM; Mittelman, A, 1984)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Higgins, GA2
Donaldson, RC1
Rogers, LS1
Juler, GL1
Keehn, RJ2
Amadeo, JH1
McElhinney, J1
McCaughan, JJ1
Engstrom, PF1
MacIntyre, JM1
Mittelman, A1
Klaassen, DJ1
Rivkin, SE1
Gottlieb, JA1
Thigpen, T1
El Mawla, NG1
Saiki, J1
Dixon, DO1

Trials

4 trials available for semustine and Cholera Infantum

ArticleYear
Efficacy of MER immunotherapy when added to a regimen of 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. A Veterans Administration Surgical Oncology Group report.
    Cancer, 1984, Jul-15, Volume: 54, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Clinical Trials as Topic;

1984
Efficacy of prolonged intermittent therapy with combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. A Veterans Administration Surgical Oncology Group report.
    Cancer, 1984, Jan-01, Volume: 53, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topi

1984
Chemotherapy of advanced colorectal carcinoma: fluorouracil alone vs. two drug combinations using fluorouracil, hydroxyurea, semustine, dacarbazine, razoxane, and mitomycin. A phase III trial by the Eastern Cooperative Oncology Group (EST: 1278).
    American journal of clinical oncology, 1984, Volume: 7, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Ne

1984
Randomized study of combination chemotherapy in unresectable gastric cancer. The Gastrointestinal Tumor Study Group.
    Cancer, 1984, Jan-01, Volume: 53, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Doxorubici

1984

Other Studies

1 other study available for semustine and Cholera Infantum

ArticleYear
Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.
    Cancer, 1980, Aug-01, Volume: 46, Issue:3

    Topics: Age Factors; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Gastrointestinal Diseases; Huma

1980