semustine has been researched along with Carcinoma, Hepatocellular in 7 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Despite moderately elevated transaminase levels (all cases) and bilirubin levels (three cases), plasma Adriamycin profiles in hepatoma patients were not elevated (terminal half-life of 30 hours) and were indistinguishable from that of non-hepatoma patients with normal liver functions." | 2.65 | Adriamycin and methyl-CCNU combination therapy in hepatocellular carcinoma: clinical and pharmacokinetic aspects. ( Bateman, JR; Chan, KK; Chlebowski, RT; Ryden, VM; Tong, MJ; Weiner, JM, 1981) |
| "Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU)." | 1.27 | Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine. ( Hahn, RG; Moertel, CG; O'Connell, MJ; Rubin, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Falkson, G | 3 |
| MacIntyre, JM | 2 |
| Moertel, CG | 3 |
| Johnson, LA | 1 |
| Scherman, RC | 1 |
| Chlebowski, RT | 1 |
| Chan, KK | 1 |
| Tong, MJ | 1 |
| Weiner, JM | 1 |
| Ryden, VM | 1 |
| Bateman, JR | 1 |
| Joishy, SK | 1 |
| Bennett, JM | 1 |
| Balasegaram, M | 1 |
| Moertel, C | 1 |
| Carbone, PP | 2 |
| Barranco, SC | 1 |
| Haenelt, BR | 1 |
| Gee, EL | 1 |
| Lavin, P | 1 |
| Pretorius, FJ | 1 |
| O'Connell, MJ | 1 |
| Hahn, RG | 1 |
| Rubin, J | 1 |
| Glimelius, B | 1 |
1 review available for semustine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; | 1986 |
4 trials available for semustine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Primary liver cancer. An Eastern Cooperative Oncology Group Trial.
Topics: Adenoma, Bile Duct; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Body W | 1984 |
Adriamycin and methyl-CCNU combination therapy in hepatocellular carcinoma: clinical and pharmacokinetic aspects.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combina | 1981 |
Chemotherapy studies in primary liver cancer: a prospective randomized clinical trial.
Topics: Adenoma, Bile Duct; Antineoplastic Agents; Bone Marrow; Carcinoma, Hepatocellular; Clinical Trials a | 1978 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; | 1986 |
3 other studies available for semustine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Clinical and chemotherapeutic study of hepatocellular carcinoma in Malaysia: a comparison with African and American patients.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Fluorouracil; Follow-Up Studies; Humans; Liver Neopl | 1982 |
Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyta | 1978 |
Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin; | 1988 |