semustine has been researched along with Cancer of Stomach in 40 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of the 31 patients with stomach cancer who were evaluable for response and had had no previous chemotherapy, 12 (39%) achieved complete or partial remission." | 5.26 | Phase I--II study of the combination of 5-FU, doxorubicin, mitomycin, and semustine (FAMMe) in the treatment of adenocarcinoma of the stomach, gastroesophageal junction, and pancreas. ( Bennetts, RW; Heifetz, LJ; Jones, RD; Karlin, DA; Mahal, PS; Stroehlein, JR, 1982) |
| "This prospective evaluation of 5-fluorouracil (5-FU) and methyl-CCNU administered in combination to patients with surgery for histologically proved gastric adenocarcinoma is based upon 312 patients randomized between August 1974 and May 1980." | 5.05 | Efficacy of prolonged intermittent therapy with combined 5-FU and methyl-CCNU following resection for gastric carcinoma. A Veterans Administration Surgical Oncology, Group report. ( Amadeo, JH; Higgins, GA; Humphrey, EW; Keehn, RJ; Smith, DE, 1983) |
| "Two hundred forty-one patients with unresectable gastric adenocarcinoma were entered, between December 1978 and March 1981, into a prospectively randomized comparison of three chemotherapy regimens to identify therapeutic activity and determine patient tolerability: (1) 5-fluorouracil plus Adriamycin (FA); (2) FA plus methyl-CCNU (FAMe); and (3) FA plus mitomycin C (FAMi)." | 5.05 | Randomized study of combination chemotherapy in unresectable gastric cancer. The Gastrointestinal Tumor Study Group. ( , 1984) |
| "In a prospectively randomized trial, patients with advanced locally recurrent or metastatic gastric adenocarcinoma were randomized to receive 5-fluorouracil (5-FU) and methyl-CCNU; 5-FU, Adriamycin (Adria Laboratories, Columbus, Ohio), and methyl-CCNU; 5-FU, Adriamycin, and mitomycin C; or Adriamycin and mitomycin C alone." | 5.05 | An Eastern Cooperative Oncology Group evaluation of combinations of methyl-CCNU, mitomycin C, Adriamycin, and 5-fluorouracil in advanced measurable gastric cancer (EST 2277). ( Douglass, HO; Goudsmit, A; Klaassen, DJ; Lavin, PT; Paul, AR, 1984) |
| "After en bloc resection of gastric adenocarcinoma, 180 patients were randomized to 2 years of 5-fluorouracil (5-FU) + semustine (MeCCNU) chemotherapy or to observation only." | 5.05 | Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275). ( Brunner, KW; Douglass, HO; Engstrom, PF; Lavin, PT, 1985) |
| "Eighteen previously untreated patients with advanced nonresectable adenocarcinoma of the stomach were treated with a four-drug regimen consisting of 5-fluorouracil, methyl-CCNU, adriamycin, and mitomycin C." | 5.04 | 5-fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer. ( Bunn, PA; Cohen, MH; Eddy, JL; Ihde, DC; Minna, JD; Nugent, JL, 1978) |
| "Twenty-five patients with locally advanced but resectable adenocarcinoma of the stomach were given concomitant postoperative radiotherapy to the tumor bed and chemotherapy with 5-Fluorouracil (5-FU)." | 3.67 | Combined 5-fluorouracil (5-FU) and radiation therapy following resection of locally advanced gastric carcinoma. ( Gez, E; Sulkes, A; Weshler, Z; Yablonsky-Peretz, T, 1986) |
| "One hundred and three cases of advanced gastric cancer were randomly allocated into Group A (Me-CCNU, 5-Fu and ADM) and Group B (ACNU, 5-Fu and ADM)." | 2.68 | [ACNU and methyl-CCNU in combination chemotherapy for advanced gastric cancer: a randomized comparative study. Shanghai ACNU Collaborative Study Group]. ( Li, D; Xiao, S; Zhang, D, 1996) |
| "Gastric cancer is the most chemotherapy-responsive adenocarcinoma of the major gastrointestinal sites." | 2.65 | Current management of advanced and locally unresectable gastric carcinoma. ( Ahlgren, JD; Schein, PS; Smith, FP; Woolley, PV, 1982) |
| "Combinations of active agents in gastric cancer hold promise as effective surgical adjuvant therapy." | 2.65 | Adjuvant chemotherapy in colon and gastric cancer. ( Haller, DG; Kisner, DL; Macdonald, JS, 1982) |
| "For Dukes' C colon cancer, postoperative adjuvant chemotherapy with a combination of fluorouracil and levamisole is now recommended as standard therapy." | 2.39 | Adjuvant postoperative therapy of gastrointestinal malignancies. ( Ilson, DH; Kelsen, DP, 1994) |
| "A clone of human gastric cancer cells (AGS-6) and the parental line (AGS-P) from which it was isolated were used in cell survival studies to determine whether pretreatment for 24, 48 or 72h with alpha-difluoromethylornithine (DFMO, 5mM) would increase the cell's sensitivity to 5-Fluorouracil (5FU), Adriamycin (Adria), 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU), or Bleomycin (Bleo)." | 1.28 | Schedule dependent potentiation of antitumor drug effects by alpha-difluoromethylornithine in human gastric carcinoma cells in vitro. ( Barranco, SC; Ford, PJ; Ho, BY; Koester, SK; Reumont, KJ; Townsend, CM, 1990) |
| "Of the 31 patients with stomach cancer who were evaluable for response and had had no previous chemotherapy, 12 (39%) achieved complete or partial remission." | 1.26 | Phase I--II study of the combination of 5-FU, doxorubicin, mitomycin, and semustine (FAMMe) in the treatment of adenocarcinoma of the stomach, gastroesophageal junction, and pancreas. ( Bennetts, RW; Heifetz, LJ; Jones, RD; Karlin, DA; Mahal, PS; Stroehlein, JR, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (75.00) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 2 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, Y | 1 |
| Takiguchi, S | 1 |
| Mori, T | 1 |
| Yasuda, T | 1 |
| Yano, M | 1 |
| Monden, M | 1 |
| Queisser, W | 1 |
| Heim, ME | 1 |
| Kemeny, N | 1 |
| Higgins, GA | 1 |
| Amadeo, JH | 1 |
| Smith, DE | 1 |
| Humphrey, EW | 1 |
| Keehn, RJ | 1 |
| Eichler, G | 1 |
| Habs, M | 2 |
| Schmähl, D | 1 |
| Douglass, HO | 4 |
| Lavin, PT | 3 |
| Goudsmit, A | 1 |
| Klaassen, DJ | 1 |
| Paul, AR | 1 |
| Schein, PS | 1 |
| Smith, FP | 1 |
| Woolley, PV | 1 |
| Ahlgren, JD | 1 |
| Gropp, C | 1 |
| Havemann, K | 1 |
| Hazel, JJ | 1 |
| Thirlwell, MP | 1 |
| Huggins, M | 1 |
| Maksymiuk, A | 1 |
| MacFarlane, JK | 1 |
| Macdonald, JS | 1 |
| Haller, DG | 1 |
| Kisner, DL | 1 |
| Karlin, DA | 1 |
| Stroehlein, JR | 1 |
| Bennetts, RW | 1 |
| Jones, RD | 1 |
| Heifetz, LJ | 1 |
| Mahal, PS | 1 |
| Bianucci, P | 1 |
| Pastorino, G | 1 |
| Eisenbrand, G | 1 |
| Ilson, DH | 1 |
| Kelsen, DP | 1 |
| Shparik, IaV | 1 |
| Xiao, S | 1 |
| Li, D | 1 |
| Zhang, D | 1 |
| Kitamura, M | 1 |
| Arai, K | 1 |
| Iwasaki, Y | 1 |
| Saka, M | 1 |
| Sasako, M | 1 |
| Katai, H | 1 |
| Sano, T | 1 |
| Kingston, RD | 1 |
| Ellis, DJ | 1 |
| Powell, J | 1 |
| Brookes, VS | 1 |
| Waterhouse, JA | 1 |
| Hurst, MD | 1 |
| Smith, JA | 1 |
| Bunn, PA | 1 |
| Nugent, JL | 1 |
| Ihde, DC | 1 |
| Cohen, MH | 1 |
| Eddy, JL | 1 |
| Minna, JD | 1 |
| Buroker, T | 1 |
| Kim, PN | 1 |
| Groppe, C | 1 |
| McCracken, J | 1 |
| O'Bryan, R | 1 |
| Panettiere, F | 1 |
| Costanzi, J | 1 |
| Bottomley, R | 1 |
| King, GW | 1 |
| Bonnet, J | 1 |
| Thigpen, T | 1 |
| Whitecar, J | 1 |
| Haas, C | 1 |
| Vaitkevicius, VK | 1 |
| Hoogstraten, B | 1 |
| Heilbrun, L | 1 |
| Bedikian, AY | 1 |
| Valdivieso, M | 1 |
| Khankhanian, N | 1 |
| Benjamin, RS | 1 |
| Bodey, GP | 1 |
| Brutti, A | 1 |
| Liberati, AM | 1 |
| Biscottini, B | 1 |
| Fatati, G | 1 |
| Sini, S | 1 |
| Barzi, AM | 1 |
| Grignani, F | 1 |
| Giles, GR | 1 |
| Lawton, JO | 1 |
| Moertel, CG | 3 |
| Mittelman, JA | 1 |
| Bakemeier, RF | 1 |
| Engstrom, P | 1 |
| Hanley, J | 1 |
| Barranco, SC | 2 |
| Townsend, CM | 2 |
| Ho, BY | 1 |
| Reumont, KJ | 1 |
| Koester, SK | 1 |
| Ford, PJ | 1 |
| Weintraub, B | 1 |
| MacLean, KK | 1 |
| Beasley, EG | 1 |
| Jenkins, VK | 1 |
| Clark, JL | 1 |
| Barcewicz, P | 1 |
| Nava, HR | 1 |
| Goodwin, PS | 1 |
| Takahashi, T | 1 |
| Kim, JP | 1 |
| Lacave, A | 1 |
| Wils, J | 1 |
| Bleiberg, H | 1 |
| Diaz-Rubio, E | 1 |
| Duez, N | 1 |
| Dalesio, O | 1 |
| Gez, E | 1 |
| Sulkes, A | 1 |
| Yablonsky-Peretz, T | 1 |
| Weshler, Z | 1 |
| Engstrom, PF | 1 |
| Brunner, KW | 1 |
7 reviews available for semustine and Cancer of Stomach
| Article | Year |
|---|---|
Chemotherapy in alimentary tract malignomas.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Cytarabine; Doxor | 1981 |
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
Adjuvant postoperative therapy of gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined | 1994 |
[Adjuvant chemotherapy of gastric cancer].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Ant | 1995 |
[Evaluation of clinical trials on adjuvant chemotherapy for curatively resected gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials a | 1997 |
[Current status and problem of adjuvant chemotherapy for curatively resected gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; | 2000 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
21 trials available for semustine and Cancer of Stomach
| Article | Year |
|---|---|
A comparison of combination chemotherapy and combined modality therapy for locally advanced gastric carcinoma. Gastrointestinal Tumor Study Group.
Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up | 1982 |
The systemic chemotherapy of hepatic metastases.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Dacarbazine; D | 1983 |
Efficacy of prolonged intermittent therapy with combined 5-FU and methyl-CCNU following resection for gastric carcinoma. A Veterans Administration Surgical Oncology, Group report.
Topics: Adenocarcinoma; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Fluorouracil; Gastrectomy | 1983 |
Randomized study of combination chemotherapy in unresectable gastric cancer. The Gastrointestinal Tumor Study Group.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Doxorubici | 1984 |
An Eastern Cooperative Oncology Group evaluation of combinations of methyl-CCNU, mitomycin C, Adriamycin, and 5-fluorouracil in advanced measurable gastric cancer (EST 2277).
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fl | 1984 |
Current management of advanced and locally unresectable gastric carcinoma.
Topics: Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; | 1982 |
Multi-drug chemotherapy with and without radiation for carcinoma of the stomach and pancreas: a prospective randomized trial.
Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up | 1981 |
Adjuvant chemotherapy in colon and gastric cancer.
Topics: BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; F | 1982 |
Controlled trial of adjuvant chemotherapy following curative resection for gastric cancer. The Gastrointestinal Tumor Study Group.
Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Humans; L | 1982 |
[ACNU and methyl-CCNU in combination chemotherapy for advanced gastric cancer: a randomized comparative study. Shanghai ACNU Collaborative Study Group].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chin | 1996 |
The West Midlands gastric carcinoma chemotherapy trial: planning and results.
Topics: Adenocarcinoma; Aged; Carcinoma; Clinical Trials as Topic; Disability Evaluation; Evaluation Studies | 1978 |
5-fluorouracil, methyl-CCNU, adriamycin, and mitomycin C in the treatment of advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Doxorubicin; Drug Eval | 1978 |
5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer: a Southwest Oncology Group Study.
Topics: Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Drug Therapy, Combination; Female; Flu | 1979 |
Nitrosoureas: useful agents for the treatment of advanced gastrointestinal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combin | 1976 |
Sequential and combination chemotherapy of advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedul | 1976 |
The concept of locally advanced gastric cancer. Effect of treatment on outcome. The Gastrointestinal Tumor Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Female; Fluo | 1990 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
Adjuvant treatments following curative resection for gastric cancer. The Italian Gastrointestinal Tumor Study Group.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality T | 1988 |
Immunochemosurgery as a new approach to reasonable treatment of advanced cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Clinical Trials | 1988 |
An EORTC Gastrointestinal Group phase III evaluation of combinations of methyl-CCNU, 5-fluorouracil, and adriamycin in advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topi | 1987 |
Postoperative adjuvant 5-fluorouracil plus methyl-CCNU therapy for gastric cancer patients. Eastern Cooperative Oncology Group study (EST 3275).
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Fema | 1985 |
14 other studies available for semustine and Cancer of Stomach
| Article | Year |
|---|---|
[The introduction of preoperative staging laparoscopy and molecular diagnosis of peritoneal lavages for the treatment of advanced gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Humans; Infusions, Pare | 2002 |
Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combina
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Disease Models, Animal; Dox | 1983 |
[Chemotherapy of stomach cancer].
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Cisplatin; Doxorubicin; Drug Administration Sched | 1982 |
Phase I--II study of the combination of 5-FU, doxorubicin, mitomycin, and semustine (FAMMe) in the treatment of adenocarcinoma of the stomach, gastroesophageal junction, and pancreas.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Administration Sch | 1982 |
[Immunochemotherapeutic treatment of gastrointestinal neoplasms].
Topics: Adjuvants, Immunologic; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Prognos | 1981 |
Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carmustine; Lomustine; Lung Neoplasms; Male; Neoplasms, | 1980 |
Chemotherapy for sarcoma of the stomach.
Topics: Adult; Aged; Asparaginase; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Drug Therapy, C | 1979 |
Combination chemotherapy with 5-fluorouracil and methyl-CCNU for the treatment of advanced gastrointestinal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Blood Cells; Colonic Neoplasms; Drug Administration Schedule; Dr | 1979 |
Chemotherapy for known residual disease after resection of gastric and colorectal cancer.
Topics: Carcinoembryonic Antigen; Carmustine; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; H | 1978 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |
Schedule dependent potentiation of antitumor drug effects by alpha-difluoromethylornithine in human gastric carcinoma cells in vitro.
Topics: Adenocarcinoma; Antineoplastic Agents; Bleomycin; Cell Cycle; Cell Survival; Doxorubicin; Drug Admin | 1990 |
Relationship between glutathione levels and drug or radiation sensitivities in human gastric cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Chlorambucil; Cyclophosphamide; Doxor | 1991 |
Adjuvant 5-FU and MeCCNU improves survival following curative gastrectomy for adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemot | 1990 |
Combined 5-fluorouracil (5-FU) and radiation therapy following resection of locally advanced gastric carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle A | 1986 |