semustine has been researched along with Cancer of Gastrointestinal Tract in 22 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hematologic toxicity, however, was significantly different, with earlier time to the most severe blood count depressions, more frequent occurrence of severe depression, and a larger percentage of patients requiring dosage reduction on the 6-week regimen." | 2.65 | A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments. ( DeWys, WD; Khandekar, JD; Kosova, LA; Perlia, CP; Slayton, RE; Taylor, SG; Wolter, J, 1979) |
| " With the dosage and schedule we used, and in our patient population of largely elderly adults, THC therapy resulted in an overall more unpleasant treatment experience than that noted with prochlorperazine or placebo." | 2.65 | Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo. ( Creagan, ET; Frytak, S; Moertel, CG; O'Connell, MJ; O'Fallon, JR; Rubin, J; Schutt, AJ; Schwartau, NW, 1979) |
| "For Dukes' C colon cancer, postoperative adjuvant chemotherapy with a combination of fluorouracil and levamisole is now recommended as standard therapy." | 2.39 | Adjuvant postoperative therapy of gastrointestinal malignancies. ( Ilson, DH; Kelsen, DP, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (95.45) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frytak, S | 2 |
| Moertel, CG | 5 |
| Rubin, J | 2 |
| Boice, JD | 2 |
| Greene, MH | 2 |
| Killen, JY | 2 |
| Ellenberg, SS | 2 |
| Keehn, RJ | 2 |
| McFadden, E | 2 |
| Chen, TT | 2 |
| Fraumeni, JF | 2 |
| Vaughn, CB | 1 |
| Brady, P | 1 |
| Chinn, BJ | 1 |
| Daversa, GC | 1 |
| Parzuchowski, JS | 1 |
| Bianucci, P | 1 |
| Pastorino, G | 1 |
| Ilson, DH | 1 |
| Kelsen, DP | 1 |
| Athlin, L | 1 |
| Domellöf, L | 1 |
| Björkstén, B | 1 |
| Abdallah, AM | 1 |
| Soukop, M | 1 |
| Bell, G | 1 |
| Calman, KC | 1 |
| Taylor, SG | 1 |
| DeWys, WD | 1 |
| Perlia, CP | 1 |
| Wolter, J | 1 |
| Slayton, RE | 1 |
| Kosova, LA | 1 |
| Khandekar, JD | 1 |
| Brutti, A | 1 |
| Liberati, AM | 1 |
| Biscottini, B | 1 |
| Fatati, G | 1 |
| Sini, S | 1 |
| Barzi, AM | 1 |
| Grignani, F | 1 |
| O'Fallon, JR | 1 |
| Creagan, ET | 1 |
| O'Connell, MJ | 1 |
| Schutt, AJ | 2 |
| Schwartau, NW | 1 |
| Hillcoat, BL | 1 |
| McCulloch, PB | 1 |
| Figueredo, AT | 1 |
| Ehsan, MH | 1 |
| Rosenfeld, JM | 1 |
| Fleischer, I | 1 |
| Wainstein, R | 1 |
| Jovtis, S | 1 |
| Colombato, LO | 1 |
| Giles, GR | 1 |
| Lawton, JO | 1 |
| Paul, AR | 1 |
| Catalano, RB | 1 |
| Engstrom, PF | 1 |
| Baker, LH | 2 |
| Talley, RW | 1 |
| Matter, R | 1 |
| Lehane, DE | 1 |
| Ruffner, BW | 1 |
| Jones, SE | 1 |
| Morrison, FS | 1 |
| Stephens, RL | 1 |
| Gehan, EA | 1 |
| Vaitkevicius, VK | 2 |
| Douglass, HO | 1 |
| Lavin, PT | 1 |
| Reitemeier, RJ | 1 |
| Hahn, RG | 1 |
| Carter, SK | 1 |
| Wasserman, TH | 1 |
| Gehan, E | 1 |
| Stablein, D | 1 |
1 review available for semustine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Adjuvant postoperative therapy of gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined | 1994 |
8 trials available for semustine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Leukemia and preleukemia after adjuvant treatment of gastrointestinal cancer with semustine (methyl-CCNU).
Topics: Acute Disease; Aged; Clinical Trials as Topic; Combined Modality Therapy; Female; Gastrointestinal N | 1983 |
Combination chemotherapy in advanced gastrointestinal malignancy.
Topics: Adenocarcinoma; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Drug Therapy, Combinat | 1980 |
A controlled study of 5-fluorouracil versus 5-fluorouracil and methyl-CCNU in advanced gastrointestinal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorourac | 1977 |
A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Bone Marrow; Clinical Trials as Topic; Drug Administration | 1979 |
Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.
Topics: Adult; Aged; Antiemetics; Double-Blind Method; Dronabinol; Drug Evaluation; Fluorouracil; Gastrointe | 1979 |
Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU. A Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; | 1976 |
Nitrosoureas: useful agents for the treatment of advanced gastrointestinal cancer.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combin | 1976 |
Randomized prospective trial comparing 5-fluorouracil (NSC-19893) to 5-fluorouracil and methyl-CCNU (NSC-95441) in advanced gastrointestinal cancer.
Topics: Adenocarcinoma; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms | 1976 |
13 other studies available for semustine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Metabolic studies of delta-9-tetrahydrocannabinol in cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dronabinol; Female; Fluorouracil; Gastr | 1984 |
Acute leukemia after adjuvant therapy of gastrointestinal cancer with semustine (methyl-CCNU)
Topics: Acute Disease; Gastrointestinal Neoplasms; Humans; Leukemia; Nitrosourea Compounds; Semustine | 1984 |
[Immunochemotherapeutic treatment of gastrointestinal neoplasms].
Topics: Adjuvants, Immunologic; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Prognos | 1981 |
The effect of combination chemotherapy on neutrophil function in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Chemotaxis, Leukocyte; Drug Administration Schedule; Drug Therap | 1979 |
Combination chemotherapy with 5-fluorouracil and methyl-CCNU for the treatment of advanced gastrointestinal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Blood Cells; Colonic Neoplasms; Drug Administration Schedule; Dr | 1979 |
Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
Topics: Adenocarcinoma; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Pare | 1978 |
[Treatment of advanced digestive cancer with fluorouracil and methyl-CCNU].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Ma | 1978 |
Chemotherapy for known residual disease after resection of gastric and colorectal cancer.
Topics: Carcinoembryonic Antigen; Carmustine; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; H | 1978 |
Phase I trial of ICRF-159 in combination with 1.3 bis-(2-chloroethyl)-1-nitrosourea (MeCCNU).
Topics: Bone Marrow; Drug Evaluation; Drug Therapy, Combination; Gastrointestinal Neoplasms; Humans; Neoplas | 1978 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |
Therapy for gastrointestinal cancer with the nitrosoureas alone and in drug combination.
Topics: Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms; Humans; Lomustine; Nitrosourea | 1976 |
The nitrosoureas--thoughts for the future.
Topics: Antineoplastic Agents; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Ne | 1976 |
Leukemia after adjuvant chemotherapy with semustine (methyl-CCNU)--evidence of a dose-response effect.
Topics: Dose-Response Relationship, Drug; Gastrointestinal Neoplasms; Humans; Leukemia; Nitrosourea Compound | 1986 |