semustine has been researched along with Brain Neoplasms in 41 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the therapeutic efficacy of two regimens of postoperative radiotherapy with concurrent chemotherapy using temozolomide (TMZ) and teniposide (VM-26) plus semustine (Me-CCNU) in adult patients with grade III-IV cerebral gliomas." | 5.16 | [Comparison of two regimens of postoperative concurrent chemoradiotherapy in adult patients with grade III-IV cerebral gliomas]. ( Gu, K; Wang, J; Zhai, X; Zhang, J, 2012) |
| "Within three weeks of definitive surgical intervention, 467 patients with histologically proved malignant glioma were randomized to receive one of four treatment regimens: semustine (MeCCNU), radiotherapy, carmustine (BCNU) plus radiotherapy, or semustine plus radiotherapy." | 5.05 | Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. ( Alexander, E; Batzdorf, U; Brooks, WH; Byar, DP; Green, SB; Hunt, WE; MacCarty, CS; Mahaley, MS; Mealey, J; Owens, G; Ransohoff, J; Robertson, JT; Shapiro, WR; Smith, KR; Strike, TA; Walker, MD; Wilson, CB, 1980) |
| "Patients with anaplastic astrocytoma had a median survival of 27 months as compared to 8 months for patients with glioblastoma." | 2.65 | Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. ( Chang, CH; Horton, J; Kramer, S; Nelson, JS; Perez-Tamayo, R; Salazer, O; Schoenfeld, D; Tsukada, Y; Weinstein, A, 1983) |
| "Four who had nonirradiated anaplastic astrocytomas all responded and survived for 38+ to 48." | 1.27 | Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and systemic chemotherapy for malignant gliomas: a follow-up study. ( Avellanosa, AM; Barua, NR; Hong, CI; Patel, A; West, CR, 1983) |
| "A dose-response relation for the cytotoxic activity of chloroethylnitrosourea cancer chemotherapeutic agents in cell culture has been developed." | 1.26 | Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture. ( Deen, DF; Weinkam, RJ, 1982) |
| "Seven human brain tumors were transplanted into the brains (6/7 takes) and subcutaneous tissues (7/7 takes) of athymic nude mice." | 1.26 | Human brain tumor transplantation into nude mice. ( Basler, GA; Chernik, NL; Posner, JB; Shapiro, WR, 1979) |
| "Metastatic medulloblastoma is a rare clinical phenomenon." | 1.26 | Chemotherapeutic response in metastatic medulloblastoma: report of two cases and a review of the literature. ( Kovacs, SG; Nathanson, L, 1978) |
| " However, with certain dosage schedules such as every 2 hr for 5 injections daily on 2 consecutive days, i." | 1.26 | Chemotherapy of an experimental glioma with nitrosoureas. ( Day, A; Liberman, L; Ng, R; Tator, CH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (82.93) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 1 (2.44) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Liu, Y | 1 |
| He, H | 1 |
| Chen, X | 1 |
| Chen, J | 1 |
| Lu, YC | 1 |
| Zhai, X | 1 |
| Wang, J | 1 |
| Zhang, J | 1 |
| Gu, K | 1 |
| Kobiakov, GL | 1 |
| Kyuma, Y | 1 |
| Nakajima, F | 1 |
| Shinonaga, M | 1 |
| Yamashita, T | 1 |
| Kuwabara, T | 1 |
| Osieka, R | 1 |
| Glatte, P | 1 |
| Pannenbäcker, R | 1 |
| Schmidt, CG | 1 |
| West, CR | 2 |
| Avellanosa, AM | 2 |
| Barua, NR | 1 |
| Patel, A | 1 |
| Hong, CI | 1 |
| Chang, CH | 1 |
| Horton, J | 1 |
| Schoenfeld, D | 2 |
| Salazer, O | 1 |
| Perez-Tamayo, R | 1 |
| Kramer, S | 1 |
| Weinstein, A | 1 |
| Nelson, JS | 1 |
| Tsukada, Y | 2 |
| Oredsson, SM | 1 |
| Pegg, AE | 2 |
| Alhonen-Hongisto, L | 1 |
| Deen, DF | 2 |
| Marton, LJ | 1 |
| Namer, IJ | 1 |
| Pamir, MN | 1 |
| Benli, K | 1 |
| Erbengi, A | 1 |
| Shapiro, WR | 4 |
| Cohen, RJ | 1 |
| Walker, MD | 8 |
| Green, SB | 1 |
| Byar, DP | 1 |
| Alexander, E | 1 |
| Batzdorf, U | 1 |
| Brooks, WH | 1 |
| Hunt, WE | 1 |
| MacCarty, CS | 1 |
| Mahaley, MS | 1 |
| Mealey, J | 1 |
| Owens, G | 1 |
| Ransohoff, J | 1 |
| Robertson, JT | 1 |
| Smith, KR | 1 |
| Wilson, CB | 3 |
| Strike, TA | 1 |
| Weinkam, RJ | 1 |
| Schacht, RG | 1 |
| Feiner, HD | 1 |
| Gallo, GR | 1 |
| Lieberman, A | 1 |
| Baldwin, DS | 1 |
| Basler, GA | 1 |
| Chernik, NL | 1 |
| Posner, JB | 2 |
| Monfardini, S | 1 |
| Brambilla, C | 1 |
| Solero, CL | 1 |
| Vaghi, A | 1 |
| Valagussa, P | 1 |
| Morello, G | 1 |
| Bonadonna, G | 1 |
| Higby, DJ | 1 |
| Bakshi, S | 1 |
| Reese, PA | 1 |
| Jennings, E | 1 |
| Costanza, ME | 1 |
| Nathanson, L | 2 |
| Wolter, J | 1 |
| Colsky, J | 1 |
| Regelson, W | 1 |
| Cunningham, T | 1 |
| Sedransk, N | 1 |
| Harmon, WE | 1 |
| Cohen, HJ | 1 |
| Schneeberger, EE | 1 |
| Grupe, WE | 1 |
| Hasegawa, H | 2 |
| Gutin, PH | 1 |
| Kovacs, SG | 1 |
| Lee, W | 1 |
| Moore, RP | 1 |
| Wampler, GL | 1 |
| Gehan, EA | 1 |
| Levin, VA | 2 |
| Tator, CH | 1 |
| Day, A | 1 |
| Ng, R | 1 |
| Liberman, L | 1 |
| Crist, WM | 1 |
| Ragab, AH | 1 |
| Vietti, TJ | 1 |
| Ducos, R | 1 |
| Chu, JY | 1 |
| Hilton, J | 1 |
| Brisman, R | 1 |
| Housepian, EM | 1 |
| Chang, C | 1 |
| Duffy, P | 1 |
| Balis, E | 1 |
| Pezzotta, S | 1 |
| Agradi, E | 1 |
| Paoletti, P | 1 |
| Massin, F | 1 |
| Coudert, B | 1 |
| Foucher, P | 1 |
| Lombard, JN | 1 |
| Reybet-Degat, O | 1 |
| Jeannin, L | 1 |
| Camus, P | 1 |
| Boaziz, C | 1 |
| Breau, JL | 1 |
| Morere, JF | 1 |
| Israël, L | 1 |
| Ushio, Y | 1 |
| Arita, N | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Bitoh, S | 1 |
| Oku, Y | 1 |
| Ikeda, H | 1 |
| Kanai, N | 1 |
| Kanoh, M | 1 |
| Dolan, ME | 1 |
| Stine, L | 1 |
| Mitchell, RB | 1 |
| Moschel, RC | 1 |
| Evans, CG | 1 |
| Bodell, WJ | 1 |
| Tokuda, K | 1 |
| Doane-Setzer, P | 1 |
| Smith, MT | 1 |
| Wasserman, TH | 1 |
| Slavik, M | 1 |
| Carter, SK | 1 |
7 reviews available for semustine and Brain Neoplasms
| Article | Year |
|---|---|
[Clinical significance of mustoforan in management of malignant glioma].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Blood-Brain Barr | 2007 |
Treatment of neuroectodermal brain tumors.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; | 1982 |
Treatment of brain tumors.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Cell Divis | 1977 |
Chemotherapy: the agents in current use.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; Drug Therapy, Combination; Glioma; | 1975 |
[Nitrosourea-induced lung diseases].
Topics: Adult; Brain Neoplasms; Carmustine; Child; Drug Therapy, Combination; Female; Humans; Iatrogenic Dis | 1992 |
[Brain metastases of malignant melanomas].
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Dacarbazine; Humans; Interl | 1991 |
Methyl-CCNU inclinical cancer therapy.
Topics: Animals; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous | 1974 |
11 trials available for semustine and Brain Neoplasms
| Article | Year |
|---|---|
[Comparison of two regimens of postoperative concurrent chemoradiotherapy in adult patients with grade III-IV cerebral gliomas].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherap | 2012 |
Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study.
Topics: Adult; Age Factors; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials | 1983 |
Treatment of neuroectodermal brain tumors.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; | 1982 |
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.
Topics: Aged; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Administration Schedule; Glioma; H | 1980 |
Chemotherapy: adjuvant to surgery and radiation therapy.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Fluorouracil; Glioma; | 1975 |
Brain Tumor Study Group: a survey of current activities.
Topics: Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Evaluation; Glioma; Humans; National Ins | 1977 |
Treatment of brain tumors.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Cell Divis | 1977 |
Results with methyl-CCNU and DTIC in metastatic melanoma.
Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dacarbazine; Drug | 1977 |
Clinical studies in malignant gliomas and their treatment with the nitrosoureas.
Topics: Brain Neoplasms; Clinical Trials as Topic; Evaluation Studies as Topic; Glioma; Humans; Nitrosourea | 1976 |
Adjuvant nitrosourea therapy for glioblastoma.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Child; Child, Preschool; Drug Evaluation; Fema | 1976 |
Chemotherapy of brain metastases from lung carcinoma: a controlled randomized study.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma; Carcinom | 1991 |
25 other studies available for semustine and Brain Neoplasms
| Article | Year |
|---|---|
Candidate genes influencing sensitivity and resistance of human glioblastoma to Semustine.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Computational Biology; Dat | 2011 |
[Maintenance immunochemotherapy for gliomas (author's transl)].
Topics: Antineoplastic Agents; Brain Neoplasms; Doxorubicin; Drug Therapy, Combination; Glioma; Humans; Pici | 1981 |
Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system.
Topics: Animals; Bone Marrow; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Female; Humans; | 1983 |
Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and systemic chemotherapy for malignant gliomas: a follow-up study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin | 1983 |
Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line; Cell Survival; | 1984 |
[Intracranial ependymomas. Study of 81 cases and comparison with the literature].
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Ependymoma; | 1984 |
Leukemia after therapy with methyl CCNU.
Topics: Brain Neoplasms; Female; Frontal Lobe; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myelo | 1980 |
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture.
Topics: Animals; Biotransformation; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Respon | 1982 |
Nephrotoxicity of nitrosoureas.
Topics: Adolescent; Adult; Aged; Biopsy; Blood Urea Nitrogen; Brain Neoplasms; Carmustine; Child; Creatinine | 1981 |
Human brain tumor transplantation into nude mice.
Topics: Animals; Brain Neoplasms; Carmustine; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Transplantati | 1979 |
Adjuvant chemotherapy with nitrosourea compounds following surgery plus radiotherapy in glioblastoma multiforme.
Topics: Brain Neoplasms; Carmustine; Glioblastoma; Humans; Lomustine; Nitrosourea Compounds; Semustine | 1978 |
Chemotherapy of nonirradiated malignant gliomas. Phase II: study of the combination of methyl-CCNU, vincristine, and procarbazine.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Brain Neoplasms; Drug Evaluation; Drug Therapy, Com | 1979 |
Chronic renal failure in children treated with methyl CCNU.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Humans; Kidney; Kidney Failure, Chronic; Nitro | 1979 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
Iv methyl-CCNU, VM-26, and cranial irradiation in therapy for malignant brain tumors.
Topics: Brain Neoplasms; Humans; Injections, Intravenous; Leukopenia; Nitrosourea Compounds; Podophyllotoxin | 1977 |
Chemotherapeutic response in metastatic medulloblastoma: report of two cases and a review of the literature.
Topics: Adolescent; Adult; Bone Neoplasms; Brain Neoplasms; Cyclophosphamide; Dactinomycin; Drug Therapy, Co | 1978 |
Interstitial pulmonary fibrosis as a complication of prolonged methyl-CCNU therapy.
Topics: Brain Neoplasms; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Pu | 1978 |
The contemporary role of chemotherapy in the treatment of malignant brain tumor.
Topics: Adrenal Cortex Hormones; Animals; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Dru | 1978 |
Chemotherapy of an experimental glioma with nitrosoureas.
Topics: Animals; Brain Neoplasms; Drug Administration Schedule; Ependymoma; Female; Glioma; Injections; Inje | 1977 |
Chemotherapy of childhood medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Child; Cyclophosphamide; Dexamethasone; D | 1976 |
Nitrosourea pharmacodynamics in relation to the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Glioma; Humans; Lomustine; Mice; Molecula | 1976 |
Nitrosourea chemotherapy for primary malignant gliomas.
Topics: Brain Neoplasms; Carmustine; Drug Therapy, Combination; Fluorouracil; Glioma; Humans; Lomustine; Neo | 1976 |
The effect of BCNU, CCNU and MeCCNU in the prevention of the development of tumors of the nervous system.
Topics: Animals; Brain Neoplasms; Carmustine; Ethylnitrosourea; Neoplasms, Experimental; Nitrosourea Compoun | 1975 |
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Topics: Animals; Brain Neoplasms; Cricetinae; Dose-Response Relationship, Drug; Female; Glioma; Guanine; Hum | 1990 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatograp | 1987 |