semustine has been researched along with Benign Neoplasms in 18 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On closer examination, the agents that appear to be responsible for these especially adverse effects are methotrexate and methyl-CCNU." | 2.65 | Clinical trials and drug toxicity in the elderly. The experience of the Eastern Cooperative Oncology Group. ( Begg, CB; Carbone, PP, 1983) |
| " Hematologic toxicity, however, was significantly different, with earlier time to the most severe blood count depressions, more frequent occurrence of severe depression, and a larger percentage of patients requiring dosage reduction on the 6-week regimen." | 2.65 | A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments. ( DeWys, WD; Khandekar, JD; Kosova, LA; Perlia, CP; Slayton, RE; Taylor, SG; Wolter, J, 1979) |
| " In order to enhance clinical effects of the nitrosoureas, further investigation of the design in therapeutic schedules on the basis of their pharmacokinetic characteristics will be needed." | 2.36 | [Cancer chemotherapy with special reference to pharmacokinetics of nitrosoureas]. ( Wakui, A, 1982) |
| "Cancer is one of the most serious illnesses of the elderly." | 1.27 | Management of cancer in the elderly. Implications of the aging process. ( Neilan, BA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (94.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Wakui, A | 1 |
| Begg, CB | 1 |
| Carbone, PP | 1 |
| Calabresi, P | 1 |
| Robak, T | 1 |
| Koller, CA | 1 |
| Schwalm, D | 1 |
| Liepman, M | 1 |
| Natale, RB | 1 |
| Wheeler, RH | 1 |
| Griswold, DP | 1 |
| Corbett, TH | 1 |
| Schabel, FM | 1 |
| Livingston, RB | 1 |
| Einhorn, LH | 1 |
| Bodey, GP | 1 |
| Burgess, MA | 1 |
| Freireich, EJ | 1 |
| Gottlieb, JA | 1 |
| Athlin, L | 2 |
| Domellöf, L | 2 |
| Björkstén, B | 1 |
| Lehane, DE | 1 |
| Lane, M | 1 |
| Tranum, B | 1 |
| Costanzi, J | 1 |
| Padilla, F | 1 |
| Taylor, SG | 1 |
| DeWys, WD | 1 |
| Perlia, CP | 1 |
| Wolter, J | 1 |
| Slayton, RE | 1 |
| Kosova, LA | 1 |
| Khandekar, JD | 1 |
| Haas, CD | 1 |
| Stephens, RL | 1 |
| Leite, CJ | 1 |
| Goodwin, JW | 1 |
| Hoogstraten, B | 1 |
| Berghem, L | 1 |
| Paul, AR | 1 |
| Catalano, RB | 1 |
| Engstrom, PF | 1 |
| Slavik, M | 2 |
| Takahashi, T | 1 |
| Neilan, BA | 1 |
| Wasserman, TH | 1 |
| Carter, SK | 1 |
4 reviews available for semustine and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
[Cancer chemotherapy with special reference to pharmacokinetics of nitrosoureas].
Topics: Carmustine; Humans; Kinetics; Lomustine; Neoplasms; Nimustine; Nitrosourea Compounds; Semustine; Sol | 1982 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
Methyl-CCNU inclinical cancer therapy.
Topics: Animals; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous | 1974 |
5 trials available for semustine and Benign Neoplasms
| Article | Year |
|---|---|
Clinical trials and drug toxicity in the elderly. The experience of the Eastern Cooperative Oncology Group.
Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cycloph | 1983 |
[Use of nitrosourea compounds in cancer chemotherapy].
Topics: Carmustine; Clinical Trials as Topic; Humans; Lomustine; Neoplasms; Nitrosourea Compounds; Semustine | 1982 |
Phase I trial of combination methotrexate and methyl-CCNU in patients with advanced neoplastic diseases.
Topics: Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Methotrexate; Neoplasm | 1977 |
A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Bone Marrow; Clinical Trials as Topic; Drug Administration | 1979 |
Emulsion and activated carbon in cancer chemotherapy.
Topics: Administration, Oral; Adult; Aged; Animals; Bleomycin; Breast Neoplasms; Carbon; Clinical Trials as | 1986 |
10 other studies available for semustine and Benign Neoplasms
| Article | Year |
|---|---|
Leukemia after cytotoxic chemotherapy--a pyrrhic victory?
Topics: Acute Disease; Antineoplastic Agents; Humans; Leukemia; Neoplasms; Preleukemia; Semustine | 1983 |
Phase I evaluation of semustine in a weekly schedule.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Leukocyte Count; Leukopenia; Neoplasms; N | 1983 |
Clonogenicity and growth of experimental tumors in relation to developing resistance and therapeutic failure.
Topics: Animals; Clone Cells; Cyclophosphamide; Drug Resistance; Humans; Leukemia L1210; Melanoma; Mice; Neo | 1981 |
COMB (cyclophosphamide, oncovin, methyl-CCNU, and bleomycin): a four-drug combination in solid tumors.
Topics: Bleomycin; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Evaluation; Drug | 1975 |
The effect of combination chemotherapy on neutrophil function in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Chemotaxis, Leukocyte; Drug Administration Schedule; Drug Therap | 1979 |
Unexpected pain syndrome during a phase I study of lv methyl-CCNU.
Topics: Humans; Infusions, Parenteral; Neoplasms; Nitrosourea Compounds; Pain; Semustine; Syndrome | 1977 |
The effect of combination chemotherapy on the reticuloendothelial system in man.
Topics: Aged; Antineoplastic Agents; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lomustine; Mac | 1978 |
Phase I trial of ICRF-159 in combination with 1.3 bis-(2-chloroethyl)-1-nitrosourea (MeCCNU).
Topics: Bone Marrow; Drug Evaluation; Drug Therapy, Combination; Gastrointestinal Neoplasms; Humans; Neoplas | 1978 |
Clinical studies with nitrosoureas in various solid tumors.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Carmustine; Female; Genital Neoplasms, F | 1976 |
Management of cancer in the elderly. Implications of the aging process.
Topics: Aged; Aging; Colonic Neoplasms; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acu | 1985 |