semustine has been researched along with Benign Neoplasms, Brain in 41 studies
Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
semustine : An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the therapeutic efficacy of two regimens of postoperative radiotherapy with concurrent chemotherapy using temozolomide (TMZ) and teniposide (VM-26) plus semustine (Me-CCNU) in adult patients with grade III-IV cerebral gliomas." | 5.16 | [Comparison of two regimens of postoperative concurrent chemoradiotherapy in adult patients with grade III-IV cerebral gliomas]. ( Gu, K; Wang, J; Zhai, X; Zhang, J, 2012) |
| "Within three weeks of definitive surgical intervention, 467 patients with histologically proved malignant glioma were randomized to receive one of four treatment regimens: semustine (MeCCNU), radiotherapy, carmustine (BCNU) plus radiotherapy, or semustine plus radiotherapy." | 5.05 | Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. ( Alexander, E; Batzdorf, U; Brooks, WH; Byar, DP; Green, SB; Hunt, WE; MacCarty, CS; Mahaley, MS; Mealey, J; Owens, G; Ransohoff, J; Robertson, JT; Shapiro, WR; Smith, KR; Strike, TA; Walker, MD; Wilson, CB, 1980) |
| "Patients with anaplastic astrocytoma had a median survival of 27 months as compared to 8 months for patients with glioblastoma." | 2.65 | Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. ( Chang, CH; Horton, J; Kramer, S; Nelson, JS; Perez-Tamayo, R; Salazer, O; Schoenfeld, D; Tsukada, Y; Weinstein, A, 1983) |
| "Four who had nonirradiated anaplastic astrocytomas all responded and survived for 38+ to 48." | 1.27 | Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and systemic chemotherapy for malignant gliomas: a follow-up study. ( Avellanosa, AM; Barua, NR; Hong, CI; Patel, A; West, CR, 1983) |
| "A dose-response relation for the cytotoxic activity of chloroethylnitrosourea cancer chemotherapeutic agents in cell culture has been developed." | 1.26 | Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture. ( Deen, DF; Weinkam, RJ, 1982) |
| "Seven human brain tumors were transplanted into the brains (6/7 takes) and subcutaneous tissues (7/7 takes) of athymic nude mice." | 1.26 | Human brain tumor transplantation into nude mice. ( Basler, GA; Chernik, NL; Posner, JB; Shapiro, WR, 1979) |
| "Metastatic medulloblastoma is a rare clinical phenomenon." | 1.26 | Chemotherapeutic response in metastatic medulloblastoma: report of two cases and a review of the literature. ( Kovacs, SG; Nathanson, L, 1978) |
| " However, with certain dosage schedules such as every 2 hr for 5 injections daily on 2 consecutive days, i." | 1.26 | Chemotherapy of an experimental glioma with nitrosoureas. ( Day, A; Liberman, L; Ng, R; Tator, CH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (82.93) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 1 (2.44) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Liu, Y | 1 |
| He, H | 1 |
| Chen, X | 1 |
| Chen, J | 1 |
| Lu, YC | 1 |
| Zhai, X | 1 |
| Wang, J | 1 |
| Zhang, J | 1 |
| Gu, K | 1 |
| Kobiakov, GL | 1 |
| Kyuma, Y | 1 |
| Nakajima, F | 1 |
| Shinonaga, M | 1 |
| Yamashita, T | 1 |
| Kuwabara, T | 1 |
| Osieka, R | 1 |
| Glatte, P | 1 |
| Pannenbäcker, R | 1 |
| Schmidt, CG | 1 |
| West, CR | 2 |
| Avellanosa, AM | 2 |
| Barua, NR | 1 |
| Patel, A | 1 |
| Hong, CI | 1 |
| Chang, CH | 1 |
| Horton, J | 1 |
| Schoenfeld, D | 2 |
| Salazer, O | 1 |
| Perez-Tamayo, R | 1 |
| Kramer, S | 1 |
| Weinstein, A | 1 |
| Nelson, JS | 1 |
| Tsukada, Y | 2 |
| Oredsson, SM | 1 |
| Pegg, AE | 2 |
| Alhonen-Hongisto, L | 1 |
| Deen, DF | 2 |
| Marton, LJ | 1 |
| Namer, IJ | 1 |
| Pamir, MN | 1 |
| Benli, K | 1 |
| Erbengi, A | 1 |
| Shapiro, WR | 4 |
| Cohen, RJ | 1 |
| Walker, MD | 8 |
| Green, SB | 1 |
| Byar, DP | 1 |
| Alexander, E | 1 |
| Batzdorf, U | 1 |
| Brooks, WH | 1 |
| Hunt, WE | 1 |
| MacCarty, CS | 1 |
| Mahaley, MS | 1 |
| Mealey, J | 1 |
| Owens, G | 1 |
| Ransohoff, J | 1 |
| Robertson, JT | 1 |
| Smith, KR | 1 |
| Wilson, CB | 3 |
| Strike, TA | 1 |
| Weinkam, RJ | 1 |
| Schacht, RG | 1 |
| Feiner, HD | 1 |
| Gallo, GR | 1 |
| Lieberman, A | 1 |
| Baldwin, DS | 1 |
| Basler, GA | 1 |
| Chernik, NL | 1 |
| Posner, JB | 2 |
| Monfardini, S | 1 |
| Brambilla, C | 1 |
| Solero, CL | 1 |
| Vaghi, A | 1 |
| Valagussa, P | 1 |
| Morello, G | 1 |
| Bonadonna, G | 1 |
| Higby, DJ | 1 |
| Bakshi, S | 1 |
| Reese, PA | 1 |
| Jennings, E | 1 |
| Costanza, ME | 1 |
| Nathanson, L | 2 |
| Wolter, J | 1 |
| Colsky, J | 1 |
| Regelson, W | 1 |
| Cunningham, T | 1 |
| Sedransk, N | 1 |
| Harmon, WE | 1 |
| Cohen, HJ | 1 |
| Schneeberger, EE | 1 |
| Grupe, WE | 1 |
| Hasegawa, H | 2 |
| Gutin, PH | 1 |
| Kovacs, SG | 1 |
| Lee, W | 1 |
| Moore, RP | 1 |
| Wampler, GL | 1 |
| Gehan, EA | 1 |
| Levin, VA | 2 |
| Tator, CH | 1 |
| Day, A | 1 |
| Ng, R | 1 |
| Liberman, L | 1 |
| Crist, WM | 1 |
| Ragab, AH | 1 |
| Vietti, TJ | 1 |
| Ducos, R | 1 |
| Chu, JY | 1 |
| Hilton, J | 1 |
| Brisman, R | 1 |
| Housepian, EM | 1 |
| Chang, C | 1 |
| Duffy, P | 1 |
| Balis, E | 1 |
| Pezzotta, S | 1 |
| Agradi, E | 1 |
| Paoletti, P | 1 |
| Massin, F | 1 |
| Coudert, B | 1 |
| Foucher, P | 1 |
| Lombard, JN | 1 |
| Reybet-Degat, O | 1 |
| Jeannin, L | 1 |
| Camus, P | 1 |
| Boaziz, C | 1 |
| Breau, JL | 1 |
| Morere, JF | 1 |
| Israël, L | 1 |
| Ushio, Y | 1 |
| Arita, N | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Bitoh, S | 1 |
| Oku, Y | 1 |
| Ikeda, H | 1 |
| Kanai, N | 1 |
| Kanoh, M | 1 |
| Dolan, ME | 1 |
| Stine, L | 1 |
| Mitchell, RB | 1 |
| Moschel, RC | 1 |
| Evans, CG | 1 |
| Bodell, WJ | 1 |
| Tokuda, K | 1 |
| Doane-Setzer, P | 1 |
| Smith, MT | 1 |
| Wasserman, TH | 1 |
| Slavik, M | 1 |
| Carter, SK | 1 |
7 reviews available for semustine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
[Clinical significance of mustoforan in management of malignant glioma].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Blood-Brain Barr | 2007 |
Treatment of neuroectodermal brain tumors.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; | 1982 |
Treatment of brain tumors.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Cell Divis | 1977 |
Chemotherapy: the agents in current use.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; Drug Therapy, Combination; Glioma; | 1975 |
[Nitrosourea-induced lung diseases].
Topics: Adult; Brain Neoplasms; Carmustine; Child; Drug Therapy, Combination; Female; Humans; Iatrogenic Dis | 1992 |
[Brain metastases of malignant melanomas].
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Dacarbazine; Humans; Interl | 1991 |
Methyl-CCNU inclinical cancer therapy.
Topics: Animals; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous | 1974 |
11 trials available for semustine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
[Comparison of two regimens of postoperative concurrent chemoradiotherapy in adult patients with grade III-IV cerebral gliomas].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherap | 2012 |
Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study.
Topics: Adult; Age Factors; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials | 1983 |
Treatment of neuroectodermal brain tumors.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; | 1982 |
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.
Topics: Aged; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Administration Schedule; Glioma; H | 1980 |
Chemotherapy: adjuvant to surgery and radiation therapy.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Fluorouracil; Glioma; | 1975 |
Brain Tumor Study Group: a survey of current activities.
Topics: Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Evaluation; Glioma; Humans; National Ins | 1977 |
Treatment of brain tumors.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Cell Divis | 1977 |
Results with methyl-CCNU and DTIC in metastatic melanoma.
Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dacarbazine; Drug | 1977 |
Clinical studies in malignant gliomas and their treatment with the nitrosoureas.
Topics: Brain Neoplasms; Clinical Trials as Topic; Evaluation Studies as Topic; Glioma; Humans; Nitrosourea | 1976 |
Adjuvant nitrosourea therapy for glioblastoma.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Child; Child, Preschool; Drug Evaluation; Fema | 1976 |
Chemotherapy of brain metastases from lung carcinoma: a controlled randomized study.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma; Carcinom | 1991 |
25 other studies available for semustine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Candidate genes influencing sensitivity and resistance of human glioblastoma to Semustine.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Computational Biology; Dat | 2011 |
[Maintenance immunochemotherapy for gliomas (author's transl)].
Topics: Antineoplastic Agents; Brain Neoplasms; Doxorubicin; Drug Therapy, Combination; Glioma; Humans; Pici | 1981 |
Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system.
Topics: Animals; Bone Marrow; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Female; Humans; | 1983 |
Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and systemic chemotherapy for malignant gliomas: a follow-up study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin | 1983 |
Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line; Cell Survival; | 1984 |
[Intracranial ependymomas. Study of 81 cases and comparison with the literature].
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Ependymoma; | 1984 |
Leukemia after therapy with methyl CCNU.
Topics: Brain Neoplasms; Female; Frontal Lobe; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myelo | 1980 |
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture.
Topics: Animals; Biotransformation; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Respon | 1982 |
Nephrotoxicity of nitrosoureas.
Topics: Adolescent; Adult; Aged; Biopsy; Blood Urea Nitrogen; Brain Neoplasms; Carmustine; Child; Creatinine | 1981 |
Human brain tumor transplantation into nude mice.
Topics: Animals; Brain Neoplasms; Carmustine; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Transplantati | 1979 |
Adjuvant chemotherapy with nitrosourea compounds following surgery plus radiotherapy in glioblastoma multiforme.
Topics: Brain Neoplasms; Carmustine; Glioblastoma; Humans; Lomustine; Nitrosourea Compounds; Semustine | 1978 |
Chemotherapy of nonirradiated malignant gliomas. Phase II: study of the combination of methyl-CCNU, vincristine, and procarbazine.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Brain Neoplasms; Drug Evaluation; Drug Therapy, Com | 1979 |
Chronic renal failure in children treated with methyl CCNU.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Humans; Kidney; Kidney Failure, Chronic; Nitro | 1979 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
Iv methyl-CCNU, VM-26, and cranial irradiation in therapy for malignant brain tumors.
Topics: Brain Neoplasms; Humans; Injections, Intravenous; Leukopenia; Nitrosourea Compounds; Podophyllotoxin | 1977 |
Chemotherapeutic response in metastatic medulloblastoma: report of two cases and a review of the literature.
Topics: Adolescent; Adult; Bone Neoplasms; Brain Neoplasms; Cyclophosphamide; Dactinomycin; Drug Therapy, Co | 1978 |
Interstitial pulmonary fibrosis as a complication of prolonged methyl-CCNU therapy.
Topics: Brain Neoplasms; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Pu | 1978 |
The contemporary role of chemotherapy in the treatment of malignant brain tumor.
Topics: Adrenal Cortex Hormones; Animals; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Dru | 1978 |
Chemotherapy of an experimental glioma with nitrosoureas.
Topics: Animals; Brain Neoplasms; Drug Administration Schedule; Ependymoma; Female; Glioma; Injections; Inje | 1977 |
Chemotherapy of childhood medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Child; Cyclophosphamide; Dexamethasone; D | 1976 |
Nitrosourea pharmacodynamics in relation to the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Glioma; Humans; Lomustine; Mice; Molecula | 1976 |
Nitrosourea chemotherapy for primary malignant gliomas.
Topics: Brain Neoplasms; Carmustine; Drug Therapy, Combination; Fluorouracil; Glioma; Humans; Lomustine; Neo | 1976 |
The effect of BCNU, CCNU and MeCCNU in the prevention of the development of tumors of the nervous system.
Topics: Animals; Brain Neoplasms; Carmustine; Ethylnitrosourea; Neoplasms, Experimental; Nitrosourea Compoun | 1975 |
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Topics: Animals; Brain Neoplasms; Cricetinae; Dose-Response Relationship, Drug; Female; Glioma; Guanine; Hum | 1990 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatograp | 1987 |