selinexor and Thymus-Neoplasms

Exportin 1 (XPO1) mediates nuclear export of many cellular factors known to play critical roles in malignant processes, and selinexor (KPT-330) is the first XPO1-selective inhibitor of nuclear export compound in advanced clinical development phase for cancer treatment. We demonstrated here that inhibition of XPO1 drives nuclear accumulation of important cargo tumor suppressor proteins, including transcription factor FOXO3a and p53 in thymic epithelial tumor (TET) cells, and induces p53-dependent and -independent antitumor activity

Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Exportin 1 Protein; Female; Humans; Hydrazines; Karyopherins; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasms, Glandular and Epithelial; Random Allocation; Receptors, Cytoplasmic and Nuclear; Thymus Neoplasms; Triazoles; Xenograft Model Antitumor Assays