selinexor has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for selinexor and Breast-Neoplasms
Article | Year |
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Selinexor improves the anti-cancer effect of tucidinostat on TP53 wild-type breast cancer.
Histone deacetylase (HDAC) is closely related to the initiation and development of breast cancer (BC). Its inhibitor (HDACi) has been used to treat BC, while the efficacy of clinical trials was not reached expectations. HDACi combined with other drugs may be an effective strategy. This study explored the effect of HDACi tucidinostat combined with selinexor, an exportin 1 (XPO1) inhibitor, on ER Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hydrazines; Mice; Mice, Nude; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2022 |