Page last updated: 2024-10-20

selenic acid and Alzheimer Disease

selenic acid has been researched along with Alzheimer Disease in 12 studies

Selenic Acid: A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jin, N3
Zhu, H1
Liang, X1
Huang, W1
Xie, Q1
Xiao, P1
Ni, J4
Liu, Q6
Iqbal, J2
Zhang, K2
Zhao, Y2
Shen, L3
Van der Jeugd, A1
Parra-Damas, A1
Baeta-Corral, R1
Soto-Faguás, CM1
Ahmed, T1
LaFerla, FM1
Giménez-Llort, L1
D'Hooge, R1
Saura, CA1
Cardoso, BR1
Roberts, BR1
Malpas, CB2
Vivash, L2
Genc, S2
Saling, MM2
Desmond, P2
Steward, C2
Hicks, RJ2
Callahan, J2
Brodtmann, A2
Collins, S2
Macfarlane, S2
Corcoran, NM3
Hovens, CM4
Velakoulis, D2
O'Brien, TJ3
Hare, DJ1
Bush, AI1
Chen, P2
Wang, LX1
Sui, XJ1
Li, SM1
Wang, Y2
Ni, JZ2
Wang, L1
Li, S1
Shultz, SR1
Wright, DK1
Zheng, P1
Stuchbery, R1
Liu, SJ1
Sashindranath, M1
Medcalf, RL1
Johnston, LA1
Jones, NC1
Zheng, L1
Zhu, HZ1
Wang, BT1
Zhao, QH1
Du, XB1
Zheng, Y1
Jiang, L1
Zhang, Y1
Martin, D1
Hutter-Paier, B1
Windisch, M1
Nguyen, T1
Nheu, L1
Sundstrom, LE1
Costello, AJ1
van Eersel, J1
Ke, YD1
Liu, X1
Delerue, F1
Kril, JJ1
Götz, J1
Ittner, LM1

Trials

2 trials available for selenic acid and Alzheimer Disease

ArticleYear
Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2019, Volume: 16, Issue:1

    Topics: Aged; Alzheimer Disease; Antioxidants; Central Nervous System; Dietary Supplements; Double-Blind Met

2019
A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2016, 07-22, Volume: 54, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition; Diffusion

2016

Other Studies

10 other studies available for selenic acid and Alzheimer Disease

ArticleYear
Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease.
    Experimental neurology, 2017, Volume: 297

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; beta Catenin; Disease Models, A

2017
Effect of Sodium Selenate on Hippocampal Proteome of 3×Tg-AD Mice-Exploring the Antioxidant Dogma of Selenium against Alzheimer's Disease.
    ACS chemical neuroscience, 2018, 07-18, Volume: 9, Issue:7

    Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Gene Expression Regulation; Hippoc

2018
Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice.
    Scientific reports, 2018, 04-24, Volume: 8, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Dietary Su

2018
Selenium positively affects the proteome of 3 × Tg-AD mice cortex by altering the expression of various key proteins: unveiling the mechanistic role of selenium in AD prevention.
    Journal of neuroscience research, 2018, Volume: 96, Issue:11

    Topics: Alzheimer Disease; Animals; Antioxidants; Cerebral Cortex; Disease Models, Animal; Gene Ontology; Ma

2018
Comparative Serum Proteomic Analysis of the Effects of Sodium Selenate on a Mouse Model of Alzheimer's Disease.
    Biological trace element research, 2019, Volume: 192, Issue:2

    Topics: alpha 1-Antitrypsin; Alzheimer Disease; Animals; Disease Models, Animal; Glycoproteins; Haptoglobins

2019
Phosphoproteomic profiling of selenate-treated Alzheimer's disease model cells.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line; Cell Survival; Computational Biol

2014
Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.
    Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 5

    Topics: Alzheimer Disease; Animals; Brain Injuries; Disease Models, Animal; Humans; Male; Phosphorylation; R

2015
Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease.
    Scientific reports, 2016, 12-23, Volume: 6

    Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Glutathione Peroxidase; Ion

2016
Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2010, Volume: 17, Issue:8

    Topics: Alzheimer Disease; Analysis of Variance; Animals; Blotting, Western; Cell Line, Tumor; Cells, Cultur

2010
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-03, Volume: 107, Issue:31

    Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Disease Models, Animal; Memory; Mice; Mice, Transgenic

2010