selegiline has been researched along with MPTP Neurotoxicity Syndrome in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (73.33) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaslin, J; Khrustalyov, D; Panula, P; Reenilä, I; Sallinen, V; Sundvik, M; Torkko, V | 1 |
| Choudhury, ME; Kubo, M; Matsuda, S; Moritoyo, T; Nagai, M; Nishikawa, N; Nomoto, M; Yabe, H | 1 |
| Brekke, L; Ebadi, M; Sangchot, P; Sharma, S; Shavali, S | 1 |
| Antkiewicz-Michaluk, L; Herman, ZS; Obuchowicz, E; Romańska, I | 1 |
| Baranowski, TC; Blavo, DO; Cato, C; Doan, TN; McKinley, ET; Rubinstein, AL | 1 |
| Bae, BI; Cascio, MB; Dawson, TM; Dawson, VL; Hara, MR; Hester, LD; Sawa, A; Snyder, SH; Thomas, B | 1 |
| Ishikawa, M; Kitagawa, H; Koga, K; Kurihara, N; Mitsumoto, Y; Mori, A; Nakai, M; Ohashi, S | 1 |
| Chapman, H; Crook, B; Hows, ME; Medhurst, AD; Quinn, LP; Upton, N; Vidgeon-Hart, M; Virley, DJ | 1 |
| Corsini, GU; Fascetti, F; Fornai, F; Maggio, R; Vaglini, F | 1 |
| Chiueh, CC; Krishna, G; Mohanakumar, KP; Murphy, DL; Obata, T; Sternberger, LM; Wu, RM | 1 |
| Chia, LG; Kuo, JS; Lee, EH; Yang, YL | 1 |
| Agata, M; Matsumoto, J; Sasada, N; Takahashi, T; Toyofuku, H | 1 |
| Adeyemo, OM; Markey, CJ; Markey, SP; Pollard, HB; Youdim, MB | 1 |
| Andrews, AM; Murphy, DL | 1 |
| Griffiths, H; Lai, M; Lunec, J; Pall, H; Williams, A | 1 |
| Hattori, T; Sugimoto, T; Takada, M | 1 |
| Ali, SF; Freyaldenhoven, TE; Hart, RW | 1 |
| Arányi, P; Gaál, J; Kardos, V; Király, I; Kollár, E; Patthy, M; Sziráki, I; Tömösközi, Z | 1 |
| Cavalletti, M; Corsini, GU; Fascetti, F; Fornai, F; Tedeschi, D; Vaglini, F | 1 |
| Koller, WC | 1 |
| Ebert, MH; Lynn, JC; Schmidt, DE; Whetsell, WO | 1 |
| Langston, JW; Tetrud, JW | 1 |
| Lieberman, A | 1 |
| Kofman, OS | 1 |
| Pai, KS; Ravindranath, V | 1 |
| Chen, S | 1 |
| Bellomo, G; Di Monte, D; Smith, MT; Wu, EY | 1 |
| Fuller, RW; Hemrick-Luecke, SK | 1 |
| Deutch, AY; Deutsch, AY; Elsworth, JD; Goldstein, M; Roth, RH | 1 |
| Hess, A | 1 |
4 review(s) available for selegiline and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia.
Topics: Animals; Antioxidants; Basal Ganglia; Corpus Striatum; Dopamine; Free Radical Scavengers; Free Radicals; Humans; Hydroxyl Radical; Melanins; MPTP Poisoning; Nerve Degeneration; Parkinson Disease; Rats; Salicylates; Selegiline; Substantia Nigra | 1994 |
Neuroprotective therapy for Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Humans; Infections; Mitochondria; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1997 |
Protective and preventive therapeutic strategies: monoamine oxidase inhibitors.
Topics: Humans; Monoamine Oxidase Inhibitors; MPTP Poisoning; Parkinson Disease; Parkinson Disease, Secondary; Selegiline; Substantia Nigra | 1992 |
Deprenyl: protective vs. symptomatic effect.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Humans; MPTP Poisoning; Parkinson Disease; Selegiline | 1991 |
26 other study(ies) available for selegiline and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
MPTP and MPP+ target specific aminergic cell populations in larval zebrafish.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Biogenic Monoamines; Catecholamines; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Image Processing, Computer-Assisted; Immunohistochemistry; Larva; Locomotion; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Norepinephrine; Selegiline; Swimming; Zebrafish | 2009 |
Zonisamide attenuates MPTP neurotoxicity in marmosets.
Topics: Animals; Antiparkinson Agents; Callithrix; Corpus Striatum; Dopamine; Female; Humans; Isoxazoles; Male; MPTP Poisoning; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
The multiple actions of selegiline.
Topics: Animals; Antiparkinson Agents; Cells, Cultured; Dopamine; Female; Glutamic Acid; Mesencephalon; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Selegiline | 2002 |
Increased striatal neuropeptide Y immunoreactivity and its modulation by deprenyl, clonidine and L-dopa in MPTP-treated mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Dopamine; Homovanillic Acid; Immunohistochemistry; Levodopa; Male; Mice; MPTP Poisoning; Neuropeptide Y; Neuroprotective Agents; Selegiline; Serotonin | 2003 |
Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Targeting; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; MPTP Poisoning; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nomifensine; Oligodeoxyribonucleotides, Antisense; Selegiline; Species Specificity; Swimming; Tyrosine 3-Monooxygenase; Zebrafish | 2005 |
Neuroprotection by pharmacologic blockade of the GAPDH death cascade.
Topics: Animals; Antiparkinson Agents; Apoptosis; Cell Line; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; In Vitro Techniques; Male; Mice; MPTP Poisoning; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide; Nuclear Proteins; Oxepins; Parkinson Disease; Selegiline; Ubiquitin-Protein Ligases | 2006 |
H MRS identifies lactate rise in the striatum of MPTP-treated C57BL/6 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Piperazines; Protons; Selegiline; Time Factors | 2006 |
The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B.
Topics: Animals; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Hypoglycemic Agents; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Nerve Degeneration; Neuroglia; Pioglitazone; Postural Balance; PPAR gamma; Psychomotor Performance; Selegiline; Serotonin; Substantia Nigra; Thiazolidinediones | 2008 |
(+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Ditiocarb; Dizocilpine Maleate; Dopamine; Drug Synergism; Haplorhini; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Piperazines; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
Interactions among deprenyl, clorgyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on catecholamines in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Catecholamines; Clorgyline; Dopamine; Dopamine Agents; Drug Interactions; Hippocampus; Male; Mice; Mice, Inbred BALB C; MPTP Poisoning; Neostriatum; Norepinephrine; Selegiline; Serotonin | 1994 |
A study of the biological pharmacology of IFO, a new selective and reversible monoamine oxidase-B inhibitor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Monoamines; Brain; Dopamine; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neostriatum; Nervous System Diseases; Oxadiazoles; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Selegiline | 1994 |
L-deprenyl confers specific protection against MPTP-induced Parkinson's disease-like movement disorder in the goldfish.
Topics: Animals; Brain; Clorgyline; Disease Models, Animal; Dopamine; Goldfish; Monoamine Oxidase; Motor Activity; MPTP Poisoning; Norepinephrine; Parkinson Disease, Secondary; Selegiline | 1993 |
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors | 1993 |
An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxides; MPTP Poisoning; Neurons; Pargyline; Rats; Reactive Oxygen Species; Selegiline; Superoxide Dismutase; Tumor Cells, Cultured | 1993 |
MPTP neurotoxicity to cerebellar Purkinje cells in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benztropine; Dose-Response Relationship, Drug; Male; Mazindol; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Neurotoxins; Pargyline; Purkinje Cells; Selegiline | 1993 |
MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice.
Topics: 1-Methyl-4-phenylpyridinium; Aging; Analysis of Variance; Animals; Body Temperature Regulation; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Selegiline; Species Specificity | 1995 |
Novel sites of action for deprenyl in MPTP-parkinsonism: metabolite-mediated protection against striatal neurotoxicity and suppression of MPTP-induced increase of dopamine turnover in C57BL mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease; Parkinson Disease, Secondary; Selegiline; Time Factors | 1995 |
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Ditiocarb; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nicotine; Piperazines; Selegiline; Serotonin | 1996 |
Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Dogs; Dopamine; Dopamine Agents; Homovanillic Acid; MPTP Poisoning; Neurons; Neuroprotective Agents; Organ Culture Techniques; Selegiline; Substantia Nigra | 1997 |
Emerging perspectives in Parkinson's disease.
Topics: Animals; Humans; Levodopa; MPTP Poisoning; Neurology; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1992 |
Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; MPTP Poisoning; NADPH-Ferrihemoprotein Reductase; Pargyline; Phenobarbital; Piperazines; Piperonyl Butoxide; Proadifen; Selegiline | 1991 |
[Study of an MPTP-induced parkinsonian animal model in the rhesus monkey and the mechanism of the action of MPTP].
Topics: Animals; Disease Models, Animal; Macaca mulatta; Male; MPTP Poisoning; MSH Release-Inhibiting Hormone; Parkinson Disease, Secondary; Selegiline | 1990 |
Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Survival; Fluorescent Dyes; Fructose; In Vitro Techniques; Intracellular Membranes; Liver; Male; Membrane Potentials; Mitochondria, Liver; MPTP Poisoning; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Selegiline | 1990 |
Tissue concentrations of MPTP and MPP+ after administration of lethal and sublethal doses of MPTP to mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Oral; Animals; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Male; Mice; Monoamine Oxidase; MPTP Poisoning; Selegiline; Tissue Distribution | 1990 |
3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation.
Topics: Animals; Cerebellum; Corpus Striatum; Dopamine; Extrapyramidal Tracts; Male; Molecular Structure; MPTP Poisoning; Nerve Degeneration; Pyridines; Rats; Rats, Inbred Strains; Selegiline | 1990 |
The effects of monoamine oxidase inhibition and dopamine uptake blockade on MPTP-induced increase of 2-[3H]deoxyglucose uptake in specific mesencephalic catecholaminergic nuclei.
Topics: Animals; Clorgyline; Deoxy Sugars; Deoxyglucose; Dopamine; Indoles; Mazindol; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Selegiline; Substantia Nigra; Tegmentum Mesencephali | 1990 |