selegiline has been researched along with Idiopathic Parkinson Disease in 737 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 144 (19.54) | 18.7374 |
1990's | 344 (46.68) | 18.2507 |
2000's | 139 (18.86) | 29.6817 |
2010's | 88 (11.94) | 24.3611 |
2020's | 22 (2.99) | 2.80 |
Authors | Studies |
---|---|
Bolognesi, ML; Cavalli, A; Melchiorre, C; Minarini, A; Recanatini, M; Rosini, M; Tumiatti, V | 1 |
Abe, K; Horiguchi, Y; Kitabatake, M; Mohri, K; Nagai, J; Ogawa, K; Taguchi, K; Tsuchiya, Y; Yokoyama, T | 1 |
Matos, MJ; Orallo, F; Picciau, C; Santana, L; Uriarte, E; Viña, D | 1 |
Camins, A; Camps, P; Duque, MD; Kelly, JM; López-Querol, M; Prathalingam, SR; Sureda, FX; Torres, E; Valverde, E; Vázquez, S | 1 |
Alcaro, S; Bolasco, A; Cardia, MC; Distinto, S; Gaspari, M; Kirchmair, J; Maccioni, E; Markt, P; Meleddu, R; Ortuso, F; Sanna, ML; Secci, D; Wolber, G; Yáñez, M | 1 |
Legoabe, LJ; Petzer, A; Petzer, JP | 1 |
Choo, H; Choo, IH; Jo, S; Keum, G; Kim, J; Kim, T; Lee, CJ; Lee, J; Lim, EJ; Min, SJ; Moon, B; Nam, G; Park, HR; Park, KD; Yeom, M | 1 |
Almos, T; Edmondson, DE; Massari, ME; Rojas, RJ; Scott, R | 1 |
Amar, M; Ferrié, L; Figadère, B; Harfouche, A; Le Douaron, G; Michel, PP; Raisman-Vozari, R; Séon-Méniel, B; Sepulveda-Diaz, JE | 1 |
Petzer, A; Petzer, JP; Terre'Blanche, G; Van der Walt, MM | 1 |
Aktumsek, A; Alcaro, S; Bagetta, D; Carradori, S; De Monte, C; De Vita, D; Guglielmi, P; Ortuso, F; Petzer, A; Petzer, JP; Secci, D; Zengin, G | 1 |
Bahn, YS; Choi, JW; Han, G; Jang, BK; Kim, HJ; Kim, S; Lee, YR; Lee, YS; Pae, AN; Park, JH; Park, KD; Shin, SJ; Yeon, SK | 1 |
Legoabe, LJ; Petzer, A; Petzer, JP; Qhobosheane, MA | 1 |
Bao, XQ; Gao, F; Li, L; Tao, D; Wang, L; Wang, Y; Yang, BB; Zhang, D | 1 |
Legoabe, LJ; Meiring, L; Petzer, A; Petzer, JP | 1 |
Danış, Ö; Elzien Alamin Ali, H; Odabaş, Z; Ozalp, L | 1 |
Agnieszka, W; Małgorzata, K; Paweł, P | 1 |
Hall, J; Johnson, L; Mason, D; O'Bryant, SE; Petersen, M; Zhang, F | 1 |
Chen, SD; Jenner, P; Tan, YY | 1 |
Chew, ZX; Chye, SM; Koh, RY; Lim, CL; Ling, APK; Ng, KY | 1 |
Jost, WH | 1 |
Chen, J; Cheng, X; Han, Y; Jin, H; Li, J; Liu, C; Luo, W; Mao, C; Meng, M; Miao, H; Xiong, K; Zhang, J; Zhu, X | 1 |
Chen, J; Chen, Y; Yu, H; Zhao, J; Zheng, Y; Zhu, J | 1 |
Chou, SC; Tai, CH; Tseng, SH | 1 |
Alborghetti, M; Bianchini, E; Galli, S; Pontieri, FE; Rinaldi, D; Sforza, M | 1 |
Iguchi, Y; Kitagawa, T; Komatsu, T; Maku, T; Mimori, M; Mitsumura, H; Murakami, H; Okumura, M; Omoto, S; Ozawa, M; Sakai, K; Sato, T; Shiraishi, T; Takatsu, H; Umehara, T | 1 |
Bovenzi, R; Candelise, N; Ferri, A; Grillo, P; Mercuri, NB; Schirinzi, T; Simonetta, C; Valle, C; Zenuni, H | 1 |
Cai, G; Cai, H; Cui, Y; Feng, T; Lin, F; Su, D; Yan, R | 1 |
Fay-Karmon, T; Gutman-Sharabi, N; Halperin, R; Khashab, R; Landau, R; Leibowitz, A; Shabtai, Z; Sharabi, Y | 1 |
Asano, H; Hatabu, A; Ikeda, K; Takagi, T; Tian, YS; Ueda, M | 1 |
Riederer, P; Szökő, É; Tábi, T; Vécsei, L; Youdim, MB | 1 |
Maruyama, W; Naoi, M; Shamoto-Nagai, M | 1 |
Parambi, DGT | 1 |
Binde, CD; Gåsemyr, JI; Klemp, M; Natvig, B; Tvete, IF | 1 |
Bianchi, ML; Carimati, F; Gallazzi, M; Mauri, M; Princiotta Cariddi, L; Rebecchi, V; Riboldazzi, G; Versino, M | 1 |
Ji, F; Jiang, R; Su, Z; Xue, R; Zhou, Y; Zhu, X; Zhuo, C | 1 |
Canesi, M; Cereda, E; Cilia, R; Mariani, CB; Pezzoli, G; Tesei, S; Zecchinelli, AL | 1 |
Magyar, K; Riederer, P; Szökő, É; Tábi, T; Vécsei, L | 1 |
Mishra, KP; Niranjan, R; Thakur, AK | 1 |
Auinger, P; Christine, CW; Green, R; Joslin, A; Yelpaala, Y | 1 |
Müller, T; Riederer, P | 1 |
Rukmangathen, R; Yalavarthi, PR; Yallamalli, IM | 1 |
Ali, J; Baboota, S; Dang, S; Kumar, S; Nigam, K | 1 |
Binde, CD; Gåsemyr, J; Klemp, M; Natvig, B; Tvete, IF | 1 |
Alborghetti, M; Nicoletti, F | 1 |
Bajaj, A; Gaud, R; Sridhar, V; Wairkar, S | 1 |
Deshmukh, R; Kumar, A; Mishra, N; Sharma, R; Sharma, S | 1 |
Asano, AGC; Asano, NMJ; de Souza, PRE; Dos Santos, EUD; Duarte, EBC; Maia, MMD; Miranda, LMR | 1 |
Chen, XB; Jiang, DQ; Jiang, LL; Li, MX; Zhou, XW | 1 |
Sheehan, J; Thorpe, M; Wilson, L | 1 |
Magyar, K; Szökő, E; Tábi, T; Vécsei, L | 1 |
Agúndez, JA; Alonso-Navarro, H; García-Martín, E; Jiménez-Jiménez, FJ | 1 |
Auinger, P; Cain, KC; Ginghina, C; Kang, UJ; Liu, C; Mattison, HA; McDermott, MP; Shi, M; Stewart, T; Zhang, J | 1 |
Inaba-Hasegawa, K; Maruyama, W; Naoi, M | 1 |
Miklya, I | 4 |
Bai, Y; Cai, D; Zhao, Q | 1 |
Almeida, KJ; Campos Sousa, RN; de Oliveira Filho, MC; Guimarães Silva, JS; Lopes Nery, PC | 1 |
Luo, S | 1 |
Alamri, Y; Anderson, TJ; Dalrymple-Alford, JC; Espiner, EA; Prickett, TC | 1 |
Augustine, EF; Auinger, P; Constantinescu, R; Elm, J; Khadim, L; Kieburtz, K; Sharma, S | 1 |
Hayashi, R; Kohsaka, M; Oeda, T; Sawada, H; Sudoh, S; Sugiyama, H; Tomita, S; Umemura, A; Yamamoto, K | 1 |
Godse, RD; Nair, HA; Wasnik, MN | 1 |
Auinger, P; Cain, KC; Cholerton, B; Ginghina, C; Liu, C; Shi, M; Stewart, T; Zhang, J | 1 |
Alken, RG; Feltmann, K; Konradsson-Geuken, Å; Malmlöf, T; Schilström, B; Schneider, F; Svensson, TH | 1 |
Luo, S; Wang, J | 1 |
Göltl, P; Hafenscher, F; Miklya, I; Pencz, N | 1 |
Marconi, S; Zwingers, T | 1 |
Ellmén, J; Kieburtz, K; Kuoppamäki, M; Vahteristo, M | 1 |
Müller, T | 1 |
Friede, M; Jost, WH; Schnitker, J | 1 |
Becker, S; Eisbach, SE; Fernández, CO; Fonseca-Ornelas, L; Giller, K; Outeiro, TF; Paulat, M; Zweckstetter, M | 1 |
Auinger, P; Cain, KC; Cholerton, B; Ginghina, C; Liu, C; Shi, M; Zhang, J | 1 |
Hasegawa, T | 1 |
Doyu, M; Ibi, T; Niwa, J; Taguchi, S | 1 |
Cheng, X; Li, S; Liu, B; Lv, C; Ma, Y; Mao, W; Sun, J; Zhang, J | 1 |
Buda, S; Degli Esposti, L; Nobili, F; Piccinni, C; Sangiorgi, D | 1 |
Chen, G; Luo, S | 1 |
Asgharnejad, M; Bauer, L; Boroojerdi, B; Giladi, N; Grieger, F | 1 |
Hattori, N; Mori, H; Yoritaka, A | 1 |
Belvisi, D; Berardelli, A; Bologna, M; Colella, D; Fabbrini, G; Fasano, A; Leodori, G; Paparella, G; Stirpe, P | 1 |
Ali, J; Baboota, S; Kumar, S | 1 |
Cheng, X; Li, S; Liu, B; Liu, Y; Lv, C; Ma, Y; Mao, W; Sun, J; Zhang, J | 1 |
Grünblatt, E; Müller, T; Riederer, P | 1 |
Ben-Shlomo, Y; Evans, A; Head, J; Katzenschlager, R; Lees, AJ; Schrag, A | 1 |
Chetsawang, B; Ebadi, M; Govitrapong, P; Kooncumchoo, P | 1 |
Aoki, Y; Endo, S; Fujino, Y; Fujita, Y; Inoue, Y; Niitsu, H; Onodera, M; Takahashi, K; Takei, M | 1 |
Jost, WH; Klasser, M; Reichmann, H | 1 |
Aasly, JO; Beiske, AG; Bekkelund, SI; Dietrichs, E; Larsen, JP; Tysnes, OB; Vilming, ST | 1 |
Löhle, M; Storch, A | 1 |
Klivényi, P; Rákóczi, K; Vécsei, L | 1 |
Pirtosek, Z | 1 |
Lewitt, PA | 7 |
Amit, T; Drigues, N; Sagi, Y; Weinreb, O; Youdim, MB | 1 |
Dayoub, EJ; Dorsey, ER; George, B; Holloway, RG; Saubermann, LA; Thompson, JP | 1 |
Castrén, E; Gyárfás, T; Knuuttila, J; Lindholm, P; Rantamäki, T | 1 |
Caslake, R; Counsell, C; Ives, N; Macleod, A; Stowe, R | 1 |
Anderson, SW; Auinger, P; Chou, KL; Como, PG; Growdon, JC; Litvan, I; Marder, KS; McDermott, MP; Uc, EY | 1 |
Eberly, SW; Fahn, S; Hyson, C; Lang, AE; Marras, C; Oakes, D; Schwid, SR; Shoulson, I | 1 |
Büttner, T; Csoti, I; Kassubek, J; Reichmann, H; Riederer, P; Schulz, JB; Wüllner, U | 1 |
Adar, L; Goren, T; Sasson, N; Weiss, YM | 1 |
Schneemilch, C | 1 |
Amit, T; Bar-Am, O; Weinreb, O; Youdim, MB | 1 |
Bosco, D; Bosco, F; Consoli, A; Plastino, M; Rotondo, A | 1 |
Williams, R | 1 |
Bornholdt, J; Clausen, RP; Felding, J; Kristensen, JL | 1 |
Imamura, K; Nagatsu, T; Okayasu, N | 2 |
Landau, WM | 3 |
Davidson, A; Hunter, C; Isaacson, SH; Ondo, WG; Silver, DE; Stewart, RM; Tetrud, JW | 1 |
Au, WL; Li, SC; Luo, N; Seah, SH; Tan, LC; Wee, HL; Zhao, YJ | 1 |
Knudsen Gerber, DS | 1 |
Chairangsaris, P; Chinvarun, Y; Nidhinandana, S; Orrawanhanothai, P; Sithinamsuwan, P; Suphakasem, S; Suwantamee, J; Thithum, K; Udommongkol, C; Wongmek, W | 1 |
Keller, D | 1 |
Auinger, P; LeWitt, P; Lu, M; Schultz, L | 1 |
Ascherio, A; Auinger, P; Chen, H; Eberly, S; Huang, X; Mailman, R; Oakes, D; Schwarzschild, M | 1 |
Magyar, K | 1 |
Holford, NH; Nutt, JG; Vu, TC | 2 |
Borges, F; Cadoni, E; Ferino, G; Laguna, R; Matos, MJ; Santana, L; Uriarte, E; Viña, D | 1 |
Chen, R; Chuang, R; Hamani, C; Hodaie, M; Lim, SY; Lozano, AM; Mazzella, F; Moro, E; Neagu, B; Saha, U; Steeves, T; Tsang, EW | 1 |
Munhoz, RP; Teive, HA; Zavala, JA | 1 |
Keränen, T; Kuusisto, H; Luukkaala, T; Mattila, T | 1 |
Dimpfel, W; Hoffmann, JA; Müller, T; Oehlwein, C | 1 |
Djaldetti, R; Melamed, E; Ziv, I | 1 |
Fann, JR | 1 |
Fahn, S; Kieburtz, K; Lang, A; Langston, JW; LeWitt, P; Oakes, D; Olanow, CW; Penney, JB; Rudolph, A; Shoulson, I; Tanner, C | 1 |
Efimenko, VN; Evtushenko, SK; Kazarian, NE; Lutskiĭ, IS | 1 |
Brekke, L; Ebadi, M; Sangchot, P; Sharma, S; Shavali, S | 1 |
Gille, G; Müller, T; Przuntek, H; Reichmann, H; Riederer, P; Riess, O; Schwartz, A; Schwarz, J; Vogt, T | 1 |
Kondo, T; Mizuno, Y; Okuma, Y; Takubo, H; Yokochi, F | 1 |
Bhattacharya, KF; Kaufmann, H; Nouri, S; Olanow, CW; Yahr, MD | 1 |
Vécsei, L | 1 |
Agid, Y; Olanow, CW; Schapira, AH | 1 |
Knoll, B; Knoll, J; Miklya, I | 1 |
Iida, Y; Saji, H | 1 |
Chalmers-Redman, R; Tatton, N; Tatton, W | 1 |
Ahlner, J; Dizdar, N; Kronstrand, R; Larson, G | 1 |
Foley, P; Gerlach, M; Riederer, P | 1 |
Rascol, O | 1 |
Hauser, RA; Hubble, JP; Truong, DD | 1 |
Double, K; Gerlach, M; Reichmann, H; Riederer, P | 1 |
Okamoto, K; Tanaka, M | 1 |
de la Llave, Y; Garcia de Yébenes, J; Garcia-Borreguero, D; Larrosa, O; Schwarz, C | 1 |
Kelsberg, G; Rich, J; Schreck, J; Ward, R | 1 |
Boyce, M; Clarke, A; Corn, TH; Johnson, ES; Johnston, A; MacMahon, DG; Mallard, N; Warrington, S | 1 |
Lachenmayer, L; Riederer, P | 1 |
Endo, T; Hamaue, N; Hirafuji, M; Hiroshige, T; Machida, M; Minami, M; Ogata, A; Parvez, SH; Saito, H; Tashiro, K; Terado, M | 1 |
Bertoni, JM; Hauser, RA; Molho, E; Sethi, KD; Waters, CH | 1 |
Hirata, A; Kaida, K; Kamakura, K; Kanzaki, M; Masaki, T; Mochizuki, H; Motoyoshi, K; Nakamura, R | 1 |
Clarke, CE | 1 |
Castro, A; Dapena, MD; Linazasoro, G; Van Blercom, N | 1 |
Nielsen, KK; Stimpel, H; Werdelin, LM; Winge, K | 1 |
Kang, SY; Lee, MH; Lee, SK; Sohn, YH | 1 |
Jenner, P | 1 |
Koller, WC; Tetrud, JW | 1 |
Riederer, PF; Youdim, MB | 1 |
Clarke, C; Moore, AP | 3 |
Bellik, L; Marco, JI; Romera, M; Sanz, E; Unzeta, M | 1 |
Lang, AE; Marras, C; McDermott, MP; Naglie, G; Rochon, PA; Rudolph, A; Tanner, CM | 1 |
Klein, C; Rabey, JM; Stryjer, R; Treves, TA | 1 |
Kurlan, R | 1 |
Goetz, CG; Poewe, W; Rascol, O; Sampaio, C | 1 |
Waters, C | 1 |
Gaszner, P; Miklya, I | 1 |
Argyriou, AA; Papapetropoulos, S | 1 |
Chen, JJ; Swope, DM | 1 |
Counsell, CE; Ives, N; Macleod, AD; Stowe, R | 1 |
Shults, CW | 2 |
Bate, G; Kirkpatrick, P; Schapira, A | 1 |
Bhat, V; Weiner, WJ | 1 |
Adler, CH; Thorpy, MJ | 1 |
Lew, MF | 1 |
Burgut, FT; Henchcliffe, C; Schumacher, HC | 1 |
Ludolph, A; Odin, P; Oehlwein, C; Polzer, U; Renner, R; Schüler, P; Shing, M; Storch, A; Werner, G | 1 |
Bakhle, YS; Youdim, MB | 1 |
Bae, BI; Cascio, MB; Dawson, TM; Dawson, VL; Hara, MR; Hester, LD; Sawa, A; Snyder, SH; Thomas, B | 1 |
Hägglund, J; Heinonen, E; Kaugesaar, T; Mäki-Ikola, O; Pålhagen, S; Palm, R | 1 |
Chan, PL; Holford, NH; Kieburtz, K; Nutt, JG; Shoulson, I | 1 |
Jain, S; Lo, SE | 1 |
Das, SK; Gangopadhya, PK; Ray, J; Roy, T | 1 |
Brodsky, MA; Koudelka, C; Swarztrauber, K | 1 |
Olanow, CW | 9 |
Chang, YL; Fernandez, HH; Munson, SK; Okun, MS; Shapiro, MA | 1 |
Ikeda, N; Inoue, N; Itoh, S; Kudo, K; Nishida, K | 1 |
Herkes, GK; McKay, D; Meagher, LJ; Needham, M | 1 |
Youdim, MB | 3 |
Haapaniemi, HT; Korpelainen, TJ; Myllylä, VV; Pursiainen, V; Sotaniemi, AK | 1 |
Bertoni, J; Kricorian, G; Leehey, M; Lew, MF; Pahwa, R | 1 |
Annanmaki, T; Murros, K; Muuronen, A | 1 |
Dell'Antone, P; Drago, D; IbnLkayat, M; Zatta, P | 1 |
Chen, JJ; Fernandez, HH | 2 |
Hermanowicz, N | 1 |
Poston, KL; Waters, C | 1 |
Akao, Y; Maruyama, W; Naoi, M; Shamoto-Nagai, M; Yamaoka, Y; Yi, H | 1 |
Chen, JJ; Dashtipour, K; Swope, DM | 1 |
Lang, AE; Marras, C; McDermott, MP; Naglie, G; Rochon, PA; Tanner, CM | 1 |
Preskorn, SH | 1 |
Klivényi, P; Vécsei, L | 1 |
Weiner, M | 1 |
Lang, AE | 1 |
Jellinger, K; Riederer, P | 1 |
Colucci d'Amato, C; Cristillo, A; Puccini, A; Vizioli, R | 1 |
Calne, DB; Ebert, MH; Eisler, T; Kopin, IJ; Krebs, H; Lake, CR; Murphy, DL; Nelson, R; Teräväinen, H; Weise, V; Whetzel, N | 1 |
Cohen, G | 1 |
Birkmayer, W; Danielczyk, W; Jellinger, K; Koppel, H; Reynolds, GP; Riederer, P; Seemann, D; Ulm, G | 1 |
Birkmayer, W; Knoll, J; Riederer, P; Youdim, MB | 1 |
Hardie, R; Lees, AJ; Sandler, M; Stern, GM | 1 |
Gallai, M; Tariska, I | 1 |
Birkmayer, W; Riederer, P | 1 |
Bihari, K; Csanda, E; Köves, A; Mogyorós, I; Takáts, A; Tárczy, M | 1 |
Rabey, MJ; Streifler, M | 1 |
Csanda, E; Katona, G; Köves, A; Mogyorós, I; Takáts, A; Tárczy, M | 1 |
Goodgold, A; Gopinathan, G; Hiesiger, E; Lieberman, AN; Nelson, J; Neophytides, A; Walker, R | 1 |
Shreeve, C | 1 |
Birkmayer, W | 4 |
Rinne, UK | 7 |
Hardie, RJ; Lees, AJ; Sandler, M; Stern, GM | 1 |
Csanda, E; Tárczy, M | 3 |
Gerstenbrand, F; Poewe, W; Ransmayr, G | 2 |
Hajba, A; Presthus, J | 1 |
Portin, R; Rinne, UK | 1 |
Sandler, M | 2 |
Knoll, J | 14 |
Ekstedt, J; Johansson, F; Oreland, L | 1 |
Bergmann, KJ; Mendoza, MR; Moros, D; Yahr, MD | 1 |
Quinn, NP | 2 |
Da Prada, M; Haefely, WE; Keller, HH; Kettler, R; Pieri, L | 1 |
Zaleska, B | 1 |
Reiderer, P; Reynolds, GP | 1 |
Agnoli, A; Baldassarre, M; D'Urso, R; Del Roscio, S; Falaschi, P; Frajese, G; Mearelli, S; Rocco, A; Ruggieri, S | 1 |
Jenner, P; Marsden, CD; Parkes, JD; Schachter, M; Testa, B | 1 |
Lavie, P; Wajsbort, J; Youdim, MB | 1 |
Longstreth, WT | 1 |
Calne, DB; Chuang, LW; Eisler, T; Karoum, F; Klein, DF; Liebowitz, MR; Quitkin, FM; Wyatt, RJ | 1 |
Elsworth, JD; Lees, AJ; Sandler, M; Stern, GM; Ward, C | 1 |
Birkmayer, W; Riederer, P; Youdim, MB | 1 |
Ghika, J | 1 |
Bushenbark, K; Esterlitz, J; Gauger, L; Hauser, RA; Hubble, J; Koller, W; Lilienfeld, D; Malapira, T; Olanow, CW | 1 |
Eadie, MJ | 1 |
Brooks, DJ; Morrish, PK; Sawle, GV | 1 |
Ludin, HP | 1 |
Gerlach, M; Riederer, P; Youdim, MB | 2 |
Bankiewicz, KS; Finberg, JP; Goldstein, DS; Kopin, IJ; Wang, J | 1 |
Burns, RS; Davis, TL; Roznoski, M | 2 |
Garcia-Monco, JC; Gomez Beldarrain, M; Padierna, A | 1 |
Janjua, R; Roos, RA; van Kempen, GM | 1 |
Sweeney, PJ | 2 |
Danysz, W; Quack, G; Rogoz, Z; Skuza, G | 1 |
Herrscher, M; Messer-Kremer, M; Sagez, JF; Schlienger, JL | 1 |
Carter, J; Fahn, S; Gauthier, S; Goetz, CG; Golbe, LI; Jankovic, J; Koller, W; Lang, AE; McDermott, MP; Olanow, CW | 1 |
Hastie, IR; Mukherjee, D | 1 |
Heinonen, EH; Kilkku, OI; Myllylä, VV; Sotaniemi, KA; Vuorinen, JA | 1 |
Brannan, T; Yahr, MD | 1 |
Berry, MD; Juorio, AV; Paterson, IA | 1 |
Chiueh, CC; Mohanakumar, KP; Murphy, DL; Wu, RM | 1 |
Chiueh, CC; Krishna, G; Mohanakumar, KP; Murphy, DL; Obata, T; Sternberger, LM; Wu, RM | 1 |
Bhatia, M; Jain, S; Maheshwari, MC | 1 |
Alexoff, D; Fowler, JS; Logan, J; MacGregor, RR; Pappas, N; Schyler, D; Shea, C; Volkow, ND; Wang, GJ; Wolf, AP | 1 |
Haas, RH; Hill, LR; Nakano, K; Nasirian, F; Pay, M; Shults, CW; Ward, DM | 1 |
Holdup, D; Liptrot, J; Phillipson, O | 1 |
Bennett, KM; Castiello, U | 1 |
Beizer, JL | 1 |
Quinn, N | 3 |
Lefebvre, H; Moore, N; Noblet, C; Wolf, LM | 1 |
Kopin, IJ | 1 |
Brady, J; Carter, J; Como, P; Growdon, J; Huber, S; Kanigan, B; Kieburtz, K; Landow, E; McDermott, M; Rudolph, A | 1 |
Eberli, F; Greminger, P; Schmid, PA; Speich, R; Suter, T | 1 |
Yoshida, M | 1 |
Finberg, JP; Youdim, MB | 2 |
Lange, KW; Riederer, P; Youdim, MB | 2 |
Goldstein, B; Schneider, LS; Tariot, PN | 1 |
Tipton, KF | 1 |
Imai, T; Nakamura, Y; Ogawa, N; Tachibana, H; Takahashi, M; Yorifuji, S; Yuasa, R | 1 |
Waters, CH | 3 |
Kondo, T; Mizuno, Y; Takubo, H; Yokochi, F | 2 |
Standaert, DG; Stern, MB | 1 |
Chamontin, B; Llau, ME; Montastruc, JL; Rascol, A; Rascol, O; Senard, JM; Tran, MA | 1 |
Finali, G; Piccinin, GL; Piccirilli, M | 1 |
Ward, CD | 1 |
Bransome, ED; Hendry, LB; Rowland, MJ | 1 |
Calne, DB; Uitti, RJ; Vingerhoets, FJ | 1 |
Dichgans, J; Klockgether, T | 1 |
Ahlskog, JE | 3 |
Iacono, RP; Toyama, SC | 1 |
Oakes, D | 2 |
Bulgaru, D; Büttner, T; Klotz, P; Kuhn, W; Przuntek, H; Steinberg, R; Voss, L | 1 |
Clow, A; Glover, V; Sandler, M | 1 |
Stern, G | 3 |
Rinne, JO | 2 |
Heinonen, EH; Myllylä, VV; Sotaniemi, KA; Vuorinen, JA | 3 |
Riederer, P; Youdim, MB | 2 |
Allain, H; Neukirch, HC; Pollak, P | 1 |
Fénelon, G | 1 |
Fahn, S; García de Yébenes, J; Mena, MA; Pardo, B | 1 |
McFarland, HR | 1 |
Boulton, AA; Juorio, AV; Li, XM; Paterson, IA | 1 |
Singer, TP; Tipton, KF | 1 |
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Bravi, D; Chase, TN; Davis, TL; Mouradian, MM; Roberts, JW | 1 |
Achiron, A; Djaldetti, R; Dressler, R; Melamed, E; Ziv, I | 1 |
Hubble, JP; Koller, WC; Waters, C | 1 |
Davis, PH; Zweig, RM | 1 |
Koivikko, L; Portin, R; Revonsuo, A; Rinne, JO; Rinne, UK | 1 |
Drummond, SS; Krueger, KM; Metzer, WS; Shea, BR | 1 |
Kofman, OS | 2 |
Lieberman, A | 5 |
Silverstein, PM | 1 |
Cummings, JL | 1 |
Blitzer, A; Bressman, SB; Brin, MF; Fahn, S; Hunt, A; Stewart, C; Winfield, L | 1 |
Ahlskog, JE; Kokmen, E; Low, PA; Nickander, KK; Petersen, RC; Tyce, GM; Uitti, RJ | 1 |
Calne, DB | 2 |
Lees, AJ | 3 |
Szirmai, I; Tárczy, M | 1 |
Arányi, P; Gaál, J; Kardos, V; Király, I; Kollár, E; Patthy, M; Sziráki, I; Tömösközi, Z | 1 |
Heinonen, E; Kilkku, O; Mäki-Ikola, O | 1 |
Anderson, KE; Girdwood, AC; Wilson, JA | 1 |
Godbold, JH; Koller, W; Olanow, CW | 1 |
Jenner, P; Silva, MT; Watts, PM | 1 |
Bland, R; MacMahon, DG | 1 |
Boulton, AA; Lai, CT; Yu, PH | 1 |
Gerlach, M; Riederer, P; Vogt, H | 1 |
Jellinger, KA | 1 |
Checkoway, H; Franklin, GM; Kushleika, J; Moon, JD; Smith-Weller, T; Swanson, PD; Woods, JS | 1 |
Ebadi, M; Hao, R; Pfeiffer, RF | 1 |
Fahn, S | 1 |
Ahlskog, JE; Low, PA; Nickander, KK; O'Brien, JF; Tyce, GM; Uitti, RJ | 1 |
Brownlee, HJ; Stacy, M | 1 |
Calzetti, S; Cassio, A; Negrotti, A | 1 |
Iacano, RP; Mohamed, AS; Schoonenberg, T | 1 |
Newton, W | 1 |
Bergus, G | 1 |
Hayes, HD | 1 |
Dalrymple-Alford, JC; Donaldson, IM; Jamieson, CF | 1 |
Kishore, A; Snow, BJ | 1 |
Falip, R; López-Arlandis, J; Manzanares, R; Martín, R; Matías-Guiu, J; Provencio, R; Ruiz, C | 1 |
Bowes, SG; Charlett, A; Dickins, J; Dobbs, RJ; Dobbs, SM; Faulkner, G; Hunt, WB; Kirollos, C; Nicholson, PW; O'Neill, CJ; Purkiss, AG; Weller, C | 1 |
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Dierks, T; Grosse, H; Kuhn, W; Müller, T; Rommelspacher, H | 1 |
Dubois, B; Montastruc, JL | 1 |
Bloem, BR; Klaassen, AA; van Hilten, JJ | 1 |
Fazzini, E; Fowler, JS; Volkow, ND | 1 |
Korczyn, AD; Nisipeanu, P | 1 |
Fedorova, NV; Glozman, ZhM; Saltykova, NM | 1 |
Mahmood, I; Marinac, JS; Mason, WD; Willsie, S | 1 |
Dostert, P; La Croix, R; Strolin Benedetti, M | 1 |
Schneider, E | 1 |
Hely, MA; Morris, JG | 1 |
Charlett, A; Dobbs, RJ; Dobbs, SM | 1 |
Montastruc, JL; Rascol, O; Senard, JM | 1 |
Temlett, JA | 1 |
Koller, WC | 3 |
Heinonen, EH; Mäki-Ikola, O; Myllylä, VV; Rinne, UK; Sotaniemi, K | 1 |
Desser, H; Gerlach, M; Riederer, P; Youdim, MB | 1 |
Lengyel, J; Magyar, K; Szende, B; Tekes, K | 1 |
Chalmers-Redman, RM; Ju, WY; Tatton, NA; Tatton, WG; Wadia, JS | 1 |
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Fahn, S; Godbold, J; Langston, JW; Olanow, CW | 1 |
Heinonen, E; Mäki-Ikola, O | 1 |
Araya, F; Castillo, JL; Miranda, CM; Sáez, D | 1 |
Head, J; Lees, AJ; Shlomo, YB | 1 |
Ajax, T; Dobson, J; Rodnitzky, R | 1 |
Myllylä, VV; Sotaniemi, K; Suominen, K; Tolonen, U; Turkka, J | 1 |
Boas, J; Larsen, JP | 1 |
Cui, L; LeWitt, P; Oakes, D | 1 |
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Hakulinen, P; Heinonen, EH; Mäki-Ikola, O; Myllylä, VV; Sotaniemi, KA | 1 |
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Dostert, P; Hashizume, Y; Kasamatsu, T; Kohda, K; Maruyama, W; Naoi, M; Takahashi, T | 1 |
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Hantler, CB; Noorily, SH; Sako, EY | 1 |
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Jiménez-Jiménez, FJ; Molina, JA | 1 |
Boonkongchuen, P; Churchyard, A; Lees, AJ; Mathias, CJ | 1 |
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Hauser, RA; Zesiewicz, TA | 2 |
McCallum, RW; Sarosiek, I; Shifflett, J; Soykan, I; Wooten, GF | 1 |
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Hagell, P; Odin, P; Vinge, E | 1 |
Brooks, DJ; Brunt, ER; Korczyn, AD; Poewe, WH; Rascol, O; Stocchi, F | 1 |
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Furst, P; Kragten, E; Lalande, I; Muller, D; Roggo, S; Schindler, P; van Oostrum, J; Waldmeier, P; Zimmermann, K | 1 |
Maloteaux, JM | 1 |
Imke, S | 1 |
Charlett, A; Dobbs, RJ; Dobbs, SM; Peterson, DW; Purkiss, AG; Weller, C; Wright, DJ | 1 |
Ciccone, CD | 1 |
Breteler, MM | 1 |
Abrams, KR | 1 |
Arenas, J; Benito-León, J; Cisneros, E; de Bustos, F; Gasalla, T; Jiménez-Jiménez, FJ; Molina, JA; Navarro, JA; Ortí-Pareja, M; Tallón-Barranco, A | 1 |
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De Weerdt, W; Dom, R; Lesaffre, E; Nieuwboer, A | 1 |
Ben-Shlomo, Y; Churchyard, A; Head, J; Hurwitz, B; Lees, AJ; Ockelford, J; Overstall, P | 1 |
Mytilineou, C; Olanow, CW; Tatton, W | 1 |
Brannan, T; Martínez-Tica, J; Prikhojan, A; Yahr, MD | 1 |
Ruggieri, S; Silver, DE | 1 |
Fahn, S; Kuskowski, MA; Vatassery, GT | 1 |
Heinonen, EH; Myllylä, V | 1 |
Armstrong, B; Hollowell, J; Nichols, T; Thorogood, M | 1 |
Dorflinger, EE; Hauser, RA; Molho, E; Pedder, S; Shale, H | 1 |
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Heinonen, E; Myllylä, V | 1 |
Hägglund, J; Heinonen, EH; Kaugesaar, T; Kontants, H; Mäki-Ikola, O; Pålhagen, S; Palm, R; Turunen, J | 1 |
Aguilar, MV; de Bustos, F; González-Muñoz, MJ; Jiménez-Jiménez, FJ; Martínez-Para, MC; Martínez-Salio, A; Mateos-Vega, CJ; Meseguer, I; Molina, JA; Ortí-Pareja, M; Zurdo, M | 1 |
Heinonen, EH; Kilkku, O; Lammintausta, R; Larsen, JP; Mäki-Ikola, O; Myllylä, VV; Olanow, CW; Pålhagen, S; Przuntek, H; Rinne, UK; Sotaniemi, KA | 1 |
Shoulson, I | 5 |
Counsell, C | 1 |
Retz, W; Riederer, P; Rösler, M; Thome, J | 1 |
Mahmood, I | 1 |
Aaltonen, H; Heinonen, E; Kilkku, O; Mäki-Ikola, O | 1 |
Meco, G; Raschetti, R; Spila-Alegiani, S; Vanacore, N | 1 |
Conrad, B; Dichgans, J; Kraus, PH; Krauseneck, P; Pergande, G; Przuntek, H; Rinne, U; Schimrigk, K; Schnitker, J; Vogel, HP | 1 |
Churchyard, A; Lees, AJ; Mathias, CJ | 1 |
Kurlan, R; Siderowf, A | 1 |
Hubble, JP | 1 |
Bryson, HM; Chrisp, P; Milne, RJ | 1 |
Chari, G; Gold, M; Hauser, RA; Zesiewicz, TA | 1 |
Castronuovo, J; Feigin, A; Innis, RB; Marek, KL; Seibyl, JP; Sheff, K; Zoghbi, S | 1 |
Ballering, LA; Jansen Steur, EN | 1 |
Ballesteros, J; Jaúregui, JV; Meana, JJ; Ruiz, J; Soto, J; Ulibarri, I | 1 |
Boas, J; Erdal, JE; Larsen, JP | 1 |
Barcenilla, B; Berbel, A; de Bustos, F; Fernández-Vivancos, E; Gómez-Escalonilla, C; Hernánz, A; Jiménez-Jiménez, FJ; Molina, JA; Villanueva, C; Zurdo, M | 1 |
Cole, WC; Kumar, B; Prasad, KN | 1 |
Stacy, M | 1 |
Bémeur, C; Lambert, J; Montgomery, J; Ste-Marie, L; Vachon, L | 1 |
Ghaemi, M; Rudolf, J; Schmülling, S | 1 |
Haberle, D; Magyar, K | 1 |
Maruyama, W; Naoi, M | 2 |
Ahuja, GK; Behari, M; Dixit, SN | 1 |
Dirr, A; Gerlach, M; Gerstner, A; Götz, ME; Harth, R; Janetzky, B; Kuhn, W; Riederer, P | 1 |
Busenbark, K; Hauser, RA; Hubble, JP; Koller, WC; Malapira, T; Olanow, CW | 1 |
Myllylä, V | 1 |
Damier, P | 1 |
Mauro, VF; Ohlinger, MJ; Rose, LM | 1 |
Maruyama, W; Naoi, M; Yagi, K; Youdim, M | 1 |
Klegeris, A; McGeer, PL | 1 |
Hillier, CE; Hinds, NP; Wiles, CM | 1 |
Akao, Y; Maruyama, W; Nakagawa, Y; Naoi, M; Takahashi, T | 1 |
Langston, JW; Tanner, CM | 1 |
Davey, PG; Donnan, PT; MacDonald, TM; Steinke, DT; Stubbings, C | 1 |
Haapaniemi, TH; Kallio, MA; Korpelainen, JT; Myllylä, VV; Sotaniemi, KA; Suominen, K; Tolonen, U | 1 |
Bradford, HF; Goggi, J; Jauniaux, E; Riaz, SS; Stern, GM; Theofilopoulos, S | 1 |
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Marsh, C; Preskorn, SH; Shad, MU | 1 |
Boulton, AA; Cools, AR; Kato, AC; Tatton, WG; Waldmeier, PC | 1 |
Arenas, J; Barcenilla, B; Berbel, A; Camacho, A; De Bustos, F; Gómez, P; Gómez-Escalonilla, C; Jiménez-Jiménez, FJ; Molina, JA; Vargas, C; Zurdo, M | 1 |
Bocsi, J; Bökönyi, G; Kéri, G; Magyar, K; Szende, B; Timár, F | 1 |
Giladi, N; Kandinov, B; Korczyn, AD; Orlov, Y; Paleacu, D; Shabtai, H; Simon, ES; Treves, TA | 1 |
Awaya, T; Chiba, K; Hayase, N; Kimura, K; Matsubara, K; Ogawa, S; Senda, T; Shimizu, K; Uezono, T | 1 |
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Haapaniemi, TH; Korpelainen, JT; Myllylä, VV; Sotaniemi, KA; Suominen, K; Tolonen, U | 1 |
Fahn, S; Giladi, N; Jankovic, J; McDermott, MP; Przedborski, S; Stern, M; Tanner, C | 1 |
Ball, J | 1 |
Ahlskog, JE; Van Gerpen, JA | 1 |
Ben-Shlomo, Y; Lees, A | 1 |
Amano, T; Fukuuchi, Y; Ito, D; Sato, H | 1 |
Miyoshi, K | 1 |
Hidestrand, M; Ingelman-Sundberg, M; Nyman, L; Oscarson, M; Pelkonen, O; Salonen, JS; Turpeinen, M | 1 |
Ben-Shlomo, Y; Head, J; Katzenschlager, R; Lees, AJ | 1 |
Horiuchi, E; Kanazawa, I; Murata, M | 1 |
Jankovic, J | 1 |
Ebadi, M; El Refaey, H; Sharma, S; Shavali, S | 1 |
Goetz, CG; Leurgans, S; Raman, R | 1 |
Bilbao Garay, J; Castilla Castellano, V; Dhimes Tejada, P; Mesa Plaza, N | 1 |
Lander, CM; Lees, A; Stern, G | 1 |
Antal, J; Antóny, M; Csanaky, A; Csanda, E | 1 |
Reynolds, GP; Riederer, P; Sandler, M | 1 |
Birkmayer, W; Jellinger, K; Riederer, P; Youdim, MB | 1 |
Yahr, MD | 2 |
Ashford, A; Glover, V; Sandler, M; Stern, GM | 1 |
Lees, AJ; Sandler, M; Stern, GM | 1 |
Rinne, UK; Siirtola, T; Sonninen, V | 1 |
Jellinger, K; Reynolds, GP; Riederer, P; Sandler, M; Seemann, D | 1 |
Berg, MJ; Collier, DS; Fincham, RW | 1 |
Siemers, E | 1 |
Nag, D | 1 |
Castoldi, AF; Checkoway, H; Costa, LG; Lund, BO; Swanson, PD; Woods, JS | 1 |
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Dimitsopulos, T; Kurlan, R | 1 |
Ahuja, GK; Behari, M; Prasad, K; Singh, K | 1 |
Dietrichs, E | 1 |
Calne, DB; Mak, E; Schulzer, M | 1 |
Levivier, M; Przedborski, S | 1 |
Ecseryné Puskás, M; Hermecz, I | 1 |
Kovács, A | 1 |
Martin, WR | 1 |
Horstink, MW; Kuiper, MA; Wolters, EC | 1 |
Baronti, F; Boldry, RC; Chase, TN; Davis, TL; Mouradian, MM | 1 |
Málly, J | 1 |
Grimes, D; Mohr, E; Vezina, P | 1 |
Langston, JW; Tetrud, JW | 3 |
Calne, D; Olanow, CW | 1 |
Madeja, UD | 1 |
Szelenyi, I; Wessel, K | 1 |
Anderson, JJ; Bravi, D; Chase, TN; Dagani, F; Davis, TL; Ferrari, R; Gillespie, M | 1 |
Bodkin, JA; Cohen, BM; Zornberg, GL | 1 |
Clough, CG | 1 |
Heinonen, EH; Lammintausta, R | 1 |
Marsden, CD | 1 |
Kuhn, W; Przuntek, H | 2 |
Robin, DW | 1 |
Horowski, R; Runge, I | 1 |
Hietanen, MH | 1 |
Chrisp, P; Mammen, GJ; Sorkin, EM | 1 |
Heinonen, EH; Ingvarsson, PE; Johnels, B; Matousek, M; Steg, G | 1 |
Oreland, L | 1 |
Fazzini, E; Lieberman, A | 1 |
Allain, H; Cougnard, J; Neukirch, HC | 1 |
Chacón, JN; Truscott, TG | 1 |
Elizan, TS; Moros, DA; Yahr, MD | 1 |
Fuller, MA; Tolbert, SR | 1 |
Grimes, JD | 1 |
Paljärvi, L; Rinne, JO; Rinne, UK; Röyttä, M; Rummukainen, J | 1 |
Jacobs, MB; Varon, J | 1 |
Cedarbaum, JM; Green-Parsons, A; Toy, LH | 1 |
Bruggi, P; Horowski, R; Martignoni, E; Nappi, G; Pacchetti, C; Rainer, E; Runge, I | 1 |
Asari, S; Goldstein, M; Nakashima, H; Nishimoto, A | 1 |
Hauser, RA; Olanow, CW | 1 |
Ogawa, N | 1 |
Boyson, SJ | 1 |
Dettner, O; Gerlach, M; Kuhn, W; Przuntek, H; Russ, H | 1 |
Nagatsu, T; Naoi, M | 1 |
Alimov, IIu; Ganiev, KhG; Nazhmidinova, MN | 1 |
Ahlskog, JE; Wilkinson, JM | 1 |
Bhatti, AR; Devlin, AJ; Ramsden, DB; Williams, AC | 1 |
Raub, W | 1 |
Calesnick, B | 1 |
George, CF; Robertson, DR | 1 |
Cedarbaum, JM; Clark, M; Harts, A; Kutt, H; Silvestri, M | 1 |
Baas, H; Fischer, PA | 2 |
Kalász, H; Kerecsen, L; Knoll, J; Pucsok, J | 1 |
Golbe, LI; Langston, JW; Shoulson, I | 1 |
Cotton, P | 1 |
Allen, WA | 1 |
deVries, J; Suchowersky, O | 1 |
Giron, LT; Koller, WC | 1 |
Langston, JW | 2 |
Bodian, CA; Elizan, TS; Mendoza, MR; Moros, DA; Pang, S; Yahr, MD | 3 |
Fornadi, F; Ulm, G | 2 |
Curry, SH; Eatough, VM; Frankel, JP; Kempster, PA; Lees, AJ; Rogers, D; Stern, GM | 1 |
Poungvarin, N; Viriyavejakul, A | 1 |
Kurth, MC; Langston, JW; Tetrud, JW | 1 |
Pearce, JM | 1 |
Susel, Z; Yarnitsky, D | 1 |
Heikkila, RE; Sieber, BA; Terleckyj, I | 1 |
Hodges, LC; Rapp, CG | 1 |
Kraus, P; Kuhn, W; Przuntek, H | 1 |
Calne, DB; Calne, S; Douglas, J; Postnikoff, D; Poulin, K; Ross, S; Tsui, JK; Woodward, W | 1 |
Lewin, R | 3 |
Golbe, LI | 2 |
Chung, E; Dvorozniak, MT; Lee, DH; Mendoza, M; van Woert, MH; Yahr, MD | 1 |
Nightingale, SL | 1 |
D'Anglejan-Chatillon, J | 1 |
Friedman, JH | 1 |
Eatough, VM; Frankel, JP; Kempster, PA; Lees, AJ; Nathanson, M; Stern, GM; Stibe, CM | 1 |
Heinonen, EH; Rinne, UK | 1 |
Heinonen, EH; Rinne, UK; Tuominen, J | 1 |
Parker, S; Teychenne, PF | 1 |
Aljanati, R; Buzo, R; Caamaño, JL; Chouza, C; De Medina, O; Fernandez, A; Romero, S; Scaramelli, A | 1 |
Eatough, V; Frankel, J; Lees, AJ; Stern, GM | 1 |
Boesen, F; Dupont, E; Heinonen, E; Mikkelsen, B; Mogensen, P; Rasmussen, C; Sivertsen, B | 1 |
Elizan, TS; Moros, D; Yahr, MD | 1 |
Heinonen, EH; Myllylä, VV; Sotaniemi, KA; Tuominen, J | 1 |
Anttila, M; Heinonen, EH; Kotila, M; Lamintausta, R; Myllylä, V; Rinne, UK; Salonen, JS; Savijärvi, M; Sotaniemi, K | 1 |
Goetz, CG; Klawans, HL; Rajput, AH; Tanner, CM; Thiessen, B; Uitti, RJ | 1 |
Birkmayer, G; Danielczyk, W; Kienzl, E; Konradi, C; Riederer, P; Schay, V; Sofic, E; Youdim, MB | 1 |
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Jenner, P; Marsden, CD | 1 |
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Cacudi, N; de Mari, M; Ferrari, E; Iliceto, G; Lamberti, P | 1 |
Caraceni, T; Giovannini, P; Piccolo, I; Scigliano, G | 1 |
Birkmayer, GD; Birkmayer, W | 1 |
Agnoli, A; Baronti, F; Denaro, A; Ruggieri, S; Stocchi, F | 1 |
Csanda, E; Takáts, A; Tárczy, M | 1 |
Caraceni, T; Giovannini, P; Grassi, MP; Martignoni, E; Nappi, G; Pacchetti, C; Piccolo, I | 1 |
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Dostert, P; Strolin Benedetti, M | 1 |
Aminoff, MJ | 1 |
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Caraceni, T; Giovannini, P; Grassi, MP; Piccolo, I; Scigliano, G; Soliveri, P | 1 |
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220 review(s) available for selegiline and Idiopathic Parkinson Disease
Article | Year |
---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium Channel Blockers; Chelating Agents; Cholinesterase Inhibitors; Humans; Huntington Disease; Ligands; Multiple Sclerosis; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurotransmitter Agents; Parkinson Disease; Plaque, Amyloid | 2008 |
How to Optimize the Effectiveness and Safety of Parkinson's Disease Therapy? - A Systematic Review of Drugs Interactions with Food and Dietary Supplements.
Topics: Antiparkinson Agents; Dietary Supplements; Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2022 |
Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future.
Topics: Dopamine Agents; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2022 |
A critical appraisal of MAO-B inhibitors in the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agents; Humans; Indans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2022 |
Monoamine-oxidase Type B Inhibitors and Cognitive Functions in Parkinson's Disease: Beyond the Primary Mechanism of Action.
Topics: Antiparkinson Agents; Cognition; Dopamine; Humans; Indans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Quality of Life; Selegiline | 2023 |
Comparative efficacy and safety of monoamine oxidase type B inhibitors plus channel blockers and monoamine oxidase type B inhibitors as adjuvant therapy to levodopa in the treatment of Parkinson's disease: a network meta-analysis of randomized controlled
Topics: Antiparkinson Agents; Bayes Theorem; Humans; Indans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Network Meta-Analysis; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Zonisamide | 2023 |
Selegiline: a molecule with innovative potential.
Topics: Animals; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2020 |
Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apoptosis; Homeostasis; Humans; Indans; Mitochondria; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2020 |
Treatment of Parkinson's Disease by MAO-B Inhibitors, New Therapies and Future Challenges - A Mini-Review.
Topics: Alanine; Benzylamines; Biomarkers; Clinical Trials as Topic; Functional Neuroimaging; Genetic Therapy; Humans; Indans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nanoparticles; Neuroprotective Agents; Parkinson Disease; Selegiline; Transplantation | 2020 |
Comparative effectiveness of dopamine agonists and monoamine oxidase type-B inhibitors for Parkinson's disease: a multiple treatment comparison meta-analysis.
Topics: Dopamine Agonists; Drug Therapy, Combination; Humans; Indans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Treatment Outcome | 2020 |
Comparison for Efficacy and Tolerability among Ten Drugs for Treatment of Parkinson's Disease: A Network Meta-Analysis.
Topics: Bromocriptine; Cluster Analysis; Dopamine Agonists; Drug Therapy, Combination; Humans; Indoles; Levodopa; Network Meta-Analysis; Parkinson Disease; Picolinic Acids; Pramipexole; Selegiline; Tetrahydronaphthalenes; Thiophenes | 2017 |
Pharmacological aspects of the neuroprotective effects of irreversible MAO-B inhibitors, selegiline and rasagiline, in Parkinson's disease.
Topics: Humans; Indans; Monoamine Oxidase Inhibitors; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Selegiline | 2018 |
Monoamine oxidase-B inhibitors in the treatment of Parkinson's disease: clinical-pharmacological aspects.
Topics: Humans; Indans; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Selegiline | 2018 |
A multiple treatment comparison meta-analysis of monoamine oxidase type B inhibitors for Parkinson's disease.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Treatment Outcome | 2018 |
Different Generations of Type-B Monoamine Oxidase Inhibitors in Parkinson's Disease: From Bench to Bedside.
Topics: Alanine; Antiparkinson Agents; Benzylamines; Dopamine Agents; Humans; Indans; Levodopa; Male; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2019 |
Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson's disease: a meta-analysis.
Topics: Activities of Daily Living; Combined Modality Therapy; Drug Therapy, Combination; Humans; Levodopa; Mental Status and Dementia Tests; Parkinson Disease; Selegiline; Treatment Outcome | 2020 |
Anti-Parkinson's disease drugs and pharmacogenetic considerations.
Topics: Aryl Hydrocarbon Hydroxylases; Benzothiazoles; Benztropine; Bromocriptine; Cabergoline; Catechols; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Ergolines; Genetic Markers; Humans; Indans; Indoles; Levodopa; Lisuride; Nitriles; Parkinson Disease; Pergolide; Pharmacogenetics; Pramipexole; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Selegiline | 2013 |
Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms.
Topics: Animals; Apoptosis; Gene Expression; Genes, bcl-2; Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2013 |
[The role of alpha-synuclein in Parkinson's disease].
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Endocytosis; Exocytosis; Humans; Lewy Bodies; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Prions; Protein Structure, Secondary; Selegiline | 2014 |
Comparative efficacy of selegiline versus rasagiline in the treatment of early Parkinson's disease.
Topics: Antiparkinson Agents; Humans; Indans; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Treatment Outcome | 2014 |
Pooled analysis of phase III with entacapone in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Catechols; Clinical Trials, Phase III as Topic; Dopamine Agonists; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nausea; Nitriles; Parkinson Disease; Randomized Controlled Trials as Topic; Retrospective Studies; Selegiline | 2014 |
Pharmacokinetic/pharmacodynamic evaluation of rasagiline mesylate for Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Catechols; Disease Progression; Humans; Indans; Monoamine Oxidase Inhibitors; Nitriles; Oxidative Stress; Parkinson Disease; Selegiline | 2014 |
The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015).
Topics: Aging; Alzheimer Disease; Animals; Brain; Catecholamines; Depressive Disorder, Major; Dopamine; History, 20th Century; Humans; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Rats; Selegiline | 2016 |
[Motor symptoms in Parkinson disease].
Topics: Age Factors; Antiparkinson Agents; Deep Brain Stimulation; Dopamine Agonists; Dyskinesias; Dystonia; Humans; Levodopa; Muscle Rigidity; Parkinson Disease; Selegiline; Treatment Outcome; Tremor | 2008 |
[Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings].
Topics: Animals; Creatine; Dopamine Agonists; Glatiramer Acetate; Humans; Indans; Kynurenic Acid; Micronutrients; Nerve Degeneration; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Peptides; Selegiline; Tocopherols; Ubiquinone | 2009 |
'Bad guys' among the antiparkinsonian drugs.
Topics: Antiparkinson Agents; Benzophenones; Cholinergic Antagonists; Cognition; Dopamine Agonists; Humans; Levodopa; Nitrophenols; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Survival Rate; Tolcapone; Treatment Outcome | 2009 |
MAO-B inhibitor know-how: back to the pharm.
Topics: Antiparkinson Agents; Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2009 |
Monoamine oxidase B inhibitors versus other dopaminergic agents in early Parkinson's disease.
Topics: Dopamine Agonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 2009 |
[On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease].
Topics: Amantadine; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methylaspartate; Parkinson Disease; Piperidines; Selegiline | 2010 |
Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity.
Topics: Animals; Antiparkinson Agents; Cells, Cultured; Disease Models, Animal; Humans; Indans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Protein Structure, Quaternary; Selegiline | 2010 |
[The feasibility of synthetic enhancer substances for preventive nanotherapy].
Topics: Alzheimer Disease; Animals; Brain Stem; Catecholamines; Depressive Disorder; Feasibility Studies; Humans; Liposomes; Nanomedicine; Neurons; Nootropic Agents; Parkinson Disease; Preventive Medicine; Selegiline; Serotonin; Ubiquitin-Protein Ligases | 2010 |
Selegiline and rasagiline: twins or distant cousins?
Topics: Humans; Inactivation, Metabolic; Indans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2011 |
The pharmacology of selegiline.
Topics: Animals; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline; Structure-Activity Relationship | 2011 |
Neurological effects of psychopharmacological agents.
Topics: Aged; Anti-Anxiety Agents; Antidepressive Agents; Antimanic Agents; Antiparkinson Agents; Antipsychotic Agents; Bundle-Branch Block; Delirium; Depressive Disorder; Humans; Lithium; Male; Nervous System Diseases; Parkinson Disease; Psychotropic Drugs; Selegiline | 2002 |
MAO-B inhibitors for the treatment of Parkinson's disease.
Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 2002 |
[Monoamine oxidase inhibitors: prospects for the use in clinical practice].
Topics: Alzheimer Disease; Animals; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Rats; Selegiline; Tourette Syndrome | 2002 |
Practical importance of neuroprotection in Parkinson's disease.
Topics: Amantadine; Antiparkinson Agents; Dopamine Agonists; Humans; Indoles; Neuroprotective Agents; Parkinson Disease; Selegiline | 2002 |
Recent advances in Parkinson's disease.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Dopamine; Dopamine Agents; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline | 2002 |
[Biomedical imaging in pharmacology with nuclear medical imaging methodologies: positron emission tomography (PET) and single photon emission computed tomography (SPECT)].
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Dyskinesia, Drug-Induced; Humans; Parkinson Disease; Selegiline; Synaptic Transmission; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 2003 |
Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Glyceraldehyde-3-Phosphate Dehydrogenases; HSP70 Heat-Shock Proteins; Humans; Monoamine Oxidase; Neurons; Neuroprotective Agents; Pargyline; Parkinson Disease; Propylamines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Selegiline; Superoxide Dismutase | 2003 |
The relevance of preclinical studies for the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Benzophenones; Drug Evaluation, Preclinical; Humans; Levodopa; Neuroprotective Agents; Nitrophenols; Parkinson Disease; Selegiline; Tolcapone | 2003 |
Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Disease Progression; Dopamine Agonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Receptors, Dopamine; Selegiline | 2003 |
Clinical inquiries. What is the best initial treatment of Parkinson's disease?
Topics: Antiparkinson Agents; Clinical Trials as Topic; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 2003 |
Selegiline's neuroprotective capacity revisited.
Topics: Antiparkinson Agents; Brain; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuroprotective Agents; Parkinson Disease; Recovery of Function; Selegiline | 2003 |
A "cure" for Parkinson's disease: can neuroprotection be proven with current trial designs?
Topics: Antiparkinson Agents; Brain; Cost-Benefit Analysis; Dopamine Agonists; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Quality of Life; Randomized Controlled Trials as Topic; Selegiline; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 2004 |
Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apoptosis; Clinical Trials as Topic; Drug Evaluation, Preclinical; Haplorhini; Humans; Inactivation, Metabolic; Indans; Mice; Mice, Transgenic; Models, Neurological; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Oxepins; Oxidative Stress; Pargyline; Parkinson Disease; Propylamines; Selegiline | 2004 |
A novel formulation of selegiline for the treatment of Parkinson's disease.
Topics: Absorption; Administration, Oral; Antiparkinson Agents; Biotransformation; Forecasting; Freeze Drying; Humans; Monoamine Oxidase Inhibitors; Mouth Mucosa; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Solubility; Tablets; Treatment Outcome | 2004 |
A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson's disease.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Basal Ganglia; Cheese; Child; Child, Preschool; Dopamine; Drug Design; Humans; Hypertension; Infant; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Neurotransmitter Agents; Parkinson Disease; Selegiline; Tyramine | 2004 |
Clinical trials of neuroprotection for Parkinson's disease.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Creatine; Dopamine Agonists; Double-Blind Method; Humans; Indans; Minocycline; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Nerve Tissue Proteins; Neuroprotective Agents; Oxepins; Parkinson Disease; Picolinic Acids; Randomized Controlled Trials as Topic; Riluzole; Selegiline; Ubiquinone | 2004 |
Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 2003 |
Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Drug Therapy, Combination; Globus Pallidus; Humans; Levodopa; Parkinson Disease; Selegiline; Thalamus | 2004 |
Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004.
Topics: Amantadine; Antiparkinson Agents; Apomorphine; Benzophenones; Benzothiazoles; Bromocriptine; Cabergoline; Catechol O-Methyltransferase Inhibitors; Deep Brain Stimulation; Dihydroergocryptine; Ergolines; Fetal Tissue Transplantation; Globus Pallidus; Humans; Indans; Indoles; Levodopa; Lisuride; Mesencephalon; Monoamine Oxidase Inhibitors; Neurosurgical Procedures; Nitrophenols; Parkinson Disease; Pergolide; Piribedil; Pramipexole; Selegiline; Thiazoles; Tolcapone | 2005 |
Other pharmacological treatments for motor complications and dyskinesias.
Topics: Amantadine; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Dopamine Agonists; Dyskinesia, Drug-Induced; Gait; Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Periodicity; Purinergic P1 Receptor Antagonists; Purines; Selegiline | 2005 |
Treatment possibilities of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antiparkinson Agents; Benzofurans; Clinical Trials as Topic; Evaluation Studies as Topic; Female; Genetic Predisposition to Disease; Humans; Mesencephalon; Neuroprotective Agents; Parkinson Disease; Reproducibility of Results; Research Design; Selegiline; United States | 2004 |
Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease.
Topics: Animals; Clinical Trials as Topic; Drug Interactions; Humans; Indans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2005 |
Monoamine oxidase B inhibitors for early Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Picolinic Acids; Randomized Controlled Trials as Topic; Selegiline | 2005 |
Parkinson's disease.
Topics: Deep Brain Stimulation; Deglutition Disorders; Dopamine Agonists; Drug Therapy, Combination; Globus Pallidus; Humans; Levodopa; Parkinson Disease; Selegiline; Thalamus | 2005 |
Parkinson's disease. Diagnosis and the initiation of therapy.
Topics: Antioxidants; Diagnosis, Differential; Dopamine Agonists; Humans; Hypokinesia; Indans; Levodopa; Muscle Rigidity; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Selegiline; Tremor | 2005 |
Parkinson's disease and sleep.
Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Cholinergic Antagonists; Dopamine Agonists; Fatigue; Humans; Parkinson Disease; REM Sleep Behavior Disorder; Restless Legs Syndrome; Risk Factors; Selegiline; Sleep Disorders, Circadian Rhythm | 2005 |
Selegiline orally disintegrating tablets for the treatment of Parkinson's disease.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Expert Testimony; Humans; Meta-Analysis as Topic; Monoamine Oxidase Inhibitors; Parkinson Disease; Pharmaceutical Preparations; Selegiline | 2005 |
Recent advances in Parkinson's disease therapy: use of monoamine oxidase inhibitors.
Topics: Antiparkinson Agents; Brain; Clinical Trials as Topic; Diet Therapy; Dopamine Agents; Drug Evaluation; Drug Interactions; Expert Testimony; Humans; Indans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2005 |
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness.
Topics: Animals; Cholinesterase Inhibitors; Dementia; Depressive Disorder; History, 20th Century; History, 21st Century; Humans; Indans; Iron; Iron Deficiencies; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2006 |
Patient page. Slowing down a "slow" movement disorder: selegiline's benefit in treating Parkinson disease.
Topics: Disease Progression; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 2006 |
The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30.
Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Humans; Hydroxyquinolines; Indans; Models, Biological; Neuroprotective Agents; Parkinson Disease; Selegiline | 2006 |
Community and long-term care management of Parkinson's disease in the elderly: focus on monoamine oxidase type B inhibitors.
Topics: Aged; Aging; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase Inhibitors; Dopamine Agonists; Homes for the Aged; Humans; Indans; Levodopa; Monoamine Oxidase Inhibitors; Nursing Homes; Parkinson Disease; Selegiline | 2007 |
Zydis selegiline in the management of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Humans; Neuroprotective Agents; Parkinson Disease; Selegiline; Technology, Pharmaceutical | 2007 |
Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Drug Interactions; Drug Therapy, Combination; Food-Drug Interactions; Humans; Indans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2007 |
Monoamine oxidase-B inhibition in the treatment of Parkinson's disease.
Topics: Alanine; Antiparkinson Agents; Benzylamines; Dopamine Agonists; Humans; Indans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2007 |
Update on antiparkinsonian agents.
Topics: Aged; Amantadine; Antiparkinson Agents; Blood-Brain Barrier; Bromocriptine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Gastrointestinal Diseases; Histamine H1 Antagonists; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Receptors, Dopamine; Selegiline; Vascular Resistance | 1982 |
[Biochemical bases of Parkinson disease].
Topics: Acetylcholine; Amantadine; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Dopa Decarboxylase; Dopamine; gamma-Aminobutyric Acid; Homovanillic Acid; Humans; Levodopa; Norepinephrine; Parkinson Disease; Receptors, Dopamine; Selegiline; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase | 1984 |
Anti-parkinsonian drugs today.
Topics: Amantadine; Amphetamines; Antiparkinson Agents; Brain Chemistry; Catechol O-Methyltransferase Inhibitors; Dopamine beta-Hydroxylase; Droxidopa; Humans; Kinetics; Levodopa; Mental Disorders; Parasympatholytics; Parkinson Disease; Selegiline | 1984 |
The pharmacology of Parkinson's disease: basic aspects and recent advances.
Topics: Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Bromocriptine; Carbidopa; Corpus Striatum; Dopamine; Ergolines; Humans; Kidney; Kinetics; Levodopa; Lisuride; Liver; Methyldopa; Norepinephrine; Parkinson Disease; Pergolide; Receptors, Dopamine; Selegiline; Serotonin; Stereotyped Behavior; Substantia Nigra; Tyramine | 1984 |
[Progress in the treatment of degenerative diseases of the nervous system. Selected problems].
Topics: Amyotrophic Lateral Sclerosis; Antiparkinson Agents; Humans; Huntington Disease; Lithium; Neostigmine; Parkinson Disease; Penicillamine; Phthalazines; Selegiline; Tetrabenazine; Tiapamil Hydrochloride | 1980 |
[Stage-adjusted treatment of idiopathic Parkinson syndrome].
Topics: Antiparkinson Agents; Bromocriptine; Carboxy-Lyases; Cholinergic Antagonists; Disability Evaluation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Levodopa; Neurologic Examination; Parkinson Disease; Selegiline | 1995 |
Neuroprotective therapeutic strategies. Comparison of experimental and clinical results.
Topics: Animals; Humans; Nervous System Diseases; Parkinson Disease; Selegiline; Vitamin E | 1995 |
Rationale for (-)deprenyl (selegiline) medication in Parkinson's disease and in prevention of age-related nigral changes.
Topics: Aging; Alzheimer Disease; Animals; Antiparkinson Agents; Drug Administration Schedule; Humans; Parkinson Disease; Selegiline; Substantia Nigra | 1995 |
Parkinson's disease: managing symptoms and preserving function.
Topics: Amantadine; Antiparkinson Agents; Cholinergic Antagonists; Delayed-Action Preparations; Drug Combinations; Fetal Tissue Transplantation; Humans; Levodopa; Parkinson Disease; Selegiline | 1995 |
[Changing drug therapy of Parkinson disease].
Topics: Antiparkinson Agents; Corpus Striatum; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline; Synaptic Transmission | 1993 |
Possible mechanisms of action of (-)deprenyl and other MAO-B inhibitors in some neurologic and psychiatric disorders.
Topics: Aging; Alzheimer Disease; Animals; Cognition Disorders; Depressive Disorder; Humans; Longevity; Mental Disorders; Monoamine Oxidase Inhibitors; Nervous System Diseases; Parkinson Disease; Schizophrenia; Selegiline | 1994 |
Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline).
Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Animals; Antioxidants; Corpus Striatum; Free Radicals; Humans; Hydroxyl Radical; Lipid Peroxidation; Monoamine Oxidase; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra | 1994 |
In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia.
Topics: Animals; Antioxidants; Basal Ganglia; Corpus Striatum; Dopamine; Free Radical Scavengers; Free Radicals; Humans; Hydroxyl Radical; Melanins; MPTP Poisoning; Nerve Degeneration; Parkinson Disease; Rats; Salicylates; Selegiline; Substantia Nigra | 1994 |
Clinical trials of neuroprotection in Parkinson's disease: long-term selegiline and alpha-tocopherol treatment.
Topics: Clinical Trials as Topic; Humans; Neuroprotective Agents; Parkinson Disease; Selegiline; Time Factors; Vitamin E | 1994 |
Treatment options in Parkinson's disease.
Topics: Cholinergic Antagonists; Dopamine Agonists; Female; Humans; Levodopa; Male; Parkinson Disease; Selegiline | 1995 |
Drug treatment of Parkinson's disease.
Topics: Age Factors; Aged; Amantadine; Antiparkinson Agents; Cholinergic Agents; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 1995 |
Is selegiline neuroprotective in Parkinson's disease?
Topics: Animals; Brain; Clinical Trials as Topic; Enzyme Induction; Glutamic Acid; Humans; Hydrogen Peroxide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Parkinson Disease; Selegiline; Superoxide Dismutase | 1994 |
Monoamine oxidase and catecholamine metabolism.
Topics: Animals; Catechol O-Methyltransferase; Catecholamines; Humans; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1994 |
[Parkinson's disease--current topics].
Topics: Adult; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 1994 |
Pharmacological actions of l-deprenyl (selegiline) and other selective monoamine oxidase B inhibitors.
Topics: Animals; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1994 |
Biochemical actions of l-deprenyl (selegiline).
Topics: Animals; Autonomic Nervous System; Enzyme Induction; Humans; Oxidation-Reduction; Parkinson Disease; Receptors, N-Methyl-D-Aspartate; Selegiline; Superoxide Dismutase | 1994 |
Therapy with l-deprenyl (selegiline) and relation to abuse liability.
Topics: Alzheimer Disease; Depressive Disorder; Drug Synergism; Humans; Parkinson Disease; Selegiline; Substance-Related Disorders | 1994 |
What is it that l-deprenyl (selegiline) might do?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Humans; Monoamine Oxidase Inhibitors; Nervous System; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1994 |
Update on the management of Parkinson's disease.
Topics: Depression; Diagnosis, Differential; Dopamine Agents; Hallucinations; Humans; Levodopa; Parkinson Disease; Selegiline | 1993 |
Strategies in the treatment of early Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Levodopa; Long-Term Care; Neurologic Examination; Parkinson Disease; Selegiline | 1993 |
Treatment of Parkinson's disease. From theory to practice.
Topics: Aged; Antiparkinson Agents; Carbidopa; Clinical Trials as Topic; Dopamine; Drug Combinations; Free Radicals; Humans; Levodopa; Oxygen; Parkinson Disease; Selegiline | 1994 |
Effects of dopaminergic drugs on superoxide dismutase: implications for senescence.
Topics: Aging; Animals; Corpus Striatum; Enzyme Induction; Free Radicals; Humans; Isatin; Life Expectancy; Nerve Degeneration; Parkinson Disease; Pergolide; Rats; Selegiline; Substantia Nigra; Superoxide Dismutase | 1993 |
The pharmacological basis of the beneficial effects of (-)deprenyl (selegiline) in Parkinson's and Alzheimer's diseases.
Topics: Aging; Alzheimer Disease; Animals; Avoidance Learning; Catalase; Corpus Striatum; Drug Therapy, Combination; Learning; Levodopa; Male; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra; Superoxide Dismutase | 1993 |
Die Pathoklise [Parkinson's disease].
Topics: Animals; Brain; Cells, Cultured; Disease Models, Animal; Fetus; Humans; Levodopa; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra | 1993 |
A rationale for monoamine oxidase inhibition as neuroprotective therapy for Parkinson's disease.
Topics: Free Radicals; Humans; Lipid Peroxidation; Monoamine Oxidase Inhibitors; Nerve Degeneration; Parkinson Disease; Reactive Oxygen Species; Selegiline; Substantia Nigra | 1993 |
Nigral degeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Haplorhini; Humans; Isoenzymes; Monoamine Oxidase; Nerve Degeneration; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Selegiline; Substantia Nigra | 1993 |
The relevance of glial monoamine oxidase-B and polyamines to the action of selegiline in Parkinson's disease.
Topics: Corpus Striatum; Dopamine; Humans; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Degeneration; Neuroglia; Parkinson Disease; Polyamines; Reactive Oxygen Species; Selegiline; Substantia Nigra | 1993 |
Neuroprotection by anti-oxidant strategies in Parkinson's disease.
Topics: Antioxidants; Corpus Striatum; Dopamine; Humans; Monoamine Oxidase; Parkinson Disease; Reactive Oxygen Species; Receptors, Dopamine; Selegiline; Substantia Nigra; Vitamin E | 1993 |
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aging; Animals; Biological Transport; Humans; Mitochondria; Nervous System; Oxidation-Reduction; Parkinson Disease; Selegiline; Species Specificity | 1993 |
MAO-B inhibitors in Parkinson's disease.
Topics: Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurologic Examination; Parkinson Disease; Receptors, Dopamine; Selegiline | 1993 |
Treatment of Parkinson's disease.
Topics: Alzheimer Disease; Antiparkinson Agents; Carbidopa; Drug Therapy, Combination; Humans; Levodopa; Neurons; Parkinson Disease; Receptors, Dopamine; Selegiline | 1993 |
A scientific rationale for protective therapy in Parkinson's disease.
Topics: Antiparkinson Agents; Calcium; Cell Death; Clinical Trials as Topic; Dopamine; Free Radicals; Homeostasis; Humans; Mitochondria; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Selegiline | 1993 |
Moderate Parkinson's disease. Strategies for maximizing treatment.
Topics: Antiparkinson Agents; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline | 1996 |
Lewy body diseases with dementia: pathophysiology and treatment.
Topics: Alzheimer Disease; Cerebral Cortex; Corpus Striatum; Humans; Lewy Bodies; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Substantia Nigra | 1995 |
Controversies in the therapy of Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Treatment options for early Parkinson's disease.
Topics: Algorithms; Amantadine; Antiparkinson Agents; Cholinergic Antagonists; Cognition Disorders; Dopamine Agonists; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline | 1996 |
Treatment of early Parkinson's disease: are complicated strategies justified?
Topics: Animals; Antiparkinson Agents; Bromocriptine; Carbidopa; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Pergolide; Selegiline | 1996 |
Drug management of Parkinson's disease.
Topics: Amantadine; Antiparkinson Agents; Bromocriptine; Humans; Levodopa; Parkinson Disease; Selegiline; Trihexyphenidyl | 1996 |
Controversies in the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Levodopa; Neurologic Examination; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Treatment Outcome | 1996 |
New directions in the drug treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Apomorphine; Bromocriptine; Dopamine Agonists; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline | 1996 |
(-)Deprenyl (selegiline) in Parkinson's disease: a pharmacologist's comment.
Topics: Antiparkinson Agents; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Selegiline monotherapy in the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Humans; Parkinson Disease; Selegiline | 1996 |
Role of selegiline in combination therapy of Parkinson's disease.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Selegiline: current perspectives on issues related to neuroprotection and mortality.
Topics: Humans; Neuroprotective Agents; Parkinson Disease; Selegiline; Survival Analysis | 1996 |
New horizons in molecular mechanisms underlying Parkinson's disease and in our understanding of the neuroprotective effects of selegiline.
Topics: Binding Sites; Clinical Trials as Topic; Corpus Striatum; Disease Progression; gamma-Aminobutyric Acid; Humans; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Neurotoxins; Nootropic Agents; Oxidative Stress; Parkinson Disease; Polyamines; Receptors, N-Methyl-D-Aspartate; Selegiline; Substantia Nigra | 1996 |
The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (-)-deprenyl research.
Topics: Age Factors; Animals; Apoptosis; Dopamine; Humans; Hypertension; Levodopa; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Neurotoxins; Norepinephrine; Parkinson Disease; PC12 Cells; Rats; Selegiline | 1996 |
(-)-Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Gene Expression Regulation; Humans; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Degeneration; Nerve Tissue Proteins; Neurites; Neuroglia; Neurons; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Parkinson Disease; Protein Synthesis Inhibitors; Rats; Selegiline | 1996 |
Deprenyl in the treatment of Parkinson's disease: clinical effects and speculations on mechanism of action.
Topics: 1-Methyl-4-phenylpyridinium; Antioxidants; Apoptosis; Clinical Trials as Topic; Dopamine; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Randomized Controlled Trials as Topic; Selegiline | 1996 |
Selegiline and mortality in Parkinson's disease.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 1996 |
Parkinson's disease: diagnosis, pathology, and treatment.
Topics: Antiparkinson Agents; Diagnosis, Differential; Dopamine Agonists; Female; Humans; Levodopa; Male; Parkinson Disease; Selegiline; Syndrome | 1997 |
Neuroprotective therapy for Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Humans; Infections; Mitochondria; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1997 |
Retrospective study of selegiline-antidepressant drug interactions and a review of the literature.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antiparkinson Agents; Bupropion; Comorbidity; Depression; Drug Interactions; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Selegiline | 1997 |
Attempts to obtain neuroprotection in Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Humans; Neuroprotective Agents; Parkinson Disease; Selegiline | 1997 |
Contemporary approaches to the pharmacotherapeutic management of Parkinson's disease: an overview.
Topics: Antiparkinson Agents; Dopamine Agonists; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline | 1997 |
[Neuroprotective and neurorestorative therapy in Parkinson's disease].
Topics: Antiparkinson Agents; Apoptosis; Brain Tissue Transplantation; Chelation Therapy; Corpus Striatum; Dopamine; Erythrocytes; Free Radicals; Gangliosides; Genetic Therapy; Glutathione Peroxidase; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neurons; Oxidative Stress; Parkinson Disease; Selegiline; Selenium; Vitamin E | 1997 |
Early idiopathic parkinsonism: initiation and optimization of treatment.
Topics: Amantadine; Cholinergic Antagonists; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 1994 |
Mid-stage parkinsonism with mild motor fluctuations.
Topics: Catechol O-Methyltransferase Inhibitors; Delayed-Action Preparations; Dopamine Agonists; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1994 |
Parkinson's disease: drug therapy.
Topics: Amantadine; Antiparkinson Agents; Apomorphine; Cholinergic Antagonists; Dopamine Agonists; Dyskinesia, Drug-Induced; Guidelines as Topic; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Treatment Outcome | 1997 |
Pregnancy in Parkinson's disease: a review of the literature and a case report.
Topics: Abnormalities, Drug-Induced; Adjuvants, Pharmaceutic; Adult; Amantadine; Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Dopamine Agents; Enzyme Inhibitors; Female; Humans; Levodopa; Mice; Parkinson Disease; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Rabbits; Rats; Selegiline | 1998 |
(-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain.
Topics: Animals; Antiparkinson Agents; Brain; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Receptors, Catecholamine; Selegiline | 1998 |
Free-radical toxicity and antioxidant medications in Parkinson's disease.
Topics: Antioxidants; Antiparkinson Agents; Clinical Trials as Topic; Free Radicals; Humans; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Selegiline | 1998 |
Neuroprotection by selegiline and other MAO inhibitors.
Topics: Animals; Antiparkinson Agents; Blood Pressure; Clinical Trials as Topic; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Posture; Prospective Studies; Selegiline | 1998 |
The neuroprotective and neuronal rescue effects of (-)-deprenyl.
Topics: Animals; Antiparkinson Agents; Benzylamines; Biotransformation; Brain; Humans; Melanoma; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Rats; Selegiline; Tissue Distribution; Tumor Cells, Cultured | 1998 |
Current status of selegiline as a neuroprotective agent in Parkinson's disease.
Topics: Antiparkinson Agents; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Parkinson Disease; Selegiline | 1998 |
Initiating therapy for Parkinson's disease.
Topics: Activities of Daily Living; Adult; Aged; Amantadine; Antiparkinson Agents; Carbidopa; Cholinergic Antagonists; Delayed-Action Preparations; Dopamine Agonists; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline | 1998 |
Safety of selegiline (deprenyl) in the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Drug Interactions; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1998 |
Effect of selegiline on mortality in patients with Parkinson's disease: a meta-analysis.
Topics: Aged; Antiparkinson Agents; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Proportional Hazards Models; Prospective Studies; Randomized Controlled Trials as Topic; Selegiline; Survival Rate | 1998 |
Neuroprotection for Parkinson's disease.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Dopamine Agents; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline; Vitamin E | 1998 |
DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism.
Topics: Antioxidants; Antiparkinson Agents; Clinical Trials as Topic; Disease Progression; Humans; Neuroprotective Agents; Parkinson Disease; Selegiline; Vitamin E | 1998 |
Effect of adding selegiline to levodopa in early, mild Parkinson's disease. Formal systematic review of data on patients in all relevant trials is required.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Drug Combinations; Follow-Up Studies; Humans; Levodopa; Parkinson Disease; Selegiline | 1998 |
Free radicals in Alzheimer's dementia: currently available therapeutic strategies.
Topics: Alzheimer Disease; Antioxidants; Drugs, Chinese Herbal; Free Radical Scavengers; Free Radicals; Humans; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Piperazines; Psychotropic Drugs; Selegiline; Thiophenes; Vitamins | 1998 |
Effect of adding selegiline to levodopa in early, mild Parkinson's disease. Evidence is insufficient to show that combined treatment increases mortality.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Drug Combinations; Humans; Levodopa; Parkinson Disease; Selegiline; Survival Analysis; Treatment Outcome | 1998 |
Management of early Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Disease Progression; Dopamine Agents; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline; Treatment Outcome | 1999 |
Monoamine oxidase and catechol-O-methyltransferase inhibitors.
Topics: Benzophenones; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Enzyme Inhibitors; Humans; Monoamine Oxidase Inhibitors; Nitriles; Nitrophenols; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Tolcapone | 1999 |
Novel drugs for Parkinson's disease.
Topics: Antiparkinson Agents; Biological Availability; Dopamine Agonists; Free Radical Scavengers; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Treatment Outcome | 1999 |
Selegiline: an appraisal of the basis of its pharmacoeconomic and quality-of-life benefits in Parkinson's disease.
Topics: Cost of Illness; Humans; Levodopa; Parkinson Disease; Quality of Life; Selegiline; Treatment Outcome | 1992 |
Current issues in depression in Parkinson's disease.
Topics: Aged; Antidepressive Agents; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Parkinson Disease; Psychomotor Performance; Selective Serotonin Reuptake Inhibitors; Selegiline | 1999 |
Multiple antioxidants in the prevention and treatment of Parkinson's disease.
Topics: Animals; Antioxidants; Antiparkinson Agents; Humans; Mutation; Oxidative Stress; Parkinson Disease; Selegiline; Vitamins | 1999 |
Neuroprotective and neuronal rescue effects of selegiline: review.
Topics: Animals; Apoptosis; Humans; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Parkinson Disease; Rats; Selegiline | 1999 |
[Drug therapy of Parkinson's disease].
Topics: Antiparkinson Agents; Cholinesterase Inhibitors; Dopamine Agents; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 1997 |
[What strategies are recommended for early stage disease? Other treatments].
Topics: Amantadine; Antioxidants; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Cholinergic Antagonists; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2000 |
(-)Deprenyl (Selegiline): past, present and future.
Topics: Aging; Alzheimer Disease; Animals; Brain Chemistry; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2000 |
[Parkinson's disease].
Topics: Antiparkinson Agents; Depression; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selective Serotonin Reuptake Inhibitors; Selegiline | 2001 |
Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.
Topics: Aging; Alzheimer Disease; Animals; Benzofurans; Brain; Catecholamines; Depression; Humans; Neuroprotective Agents; Parkinson Disease; Propylamines; Selegiline; Serotonin | 2001 |
Parkinson's disease therapy: treatment of early and late disease.
Topics: Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Dopamine Agonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Time Factors | 2001 |
Neuroprotective actions of selegiline.
Topics: Animals; Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Selegiline; Treatment Outcome | 2002 |
[Serotonin syndrome: report of a fatal case and review of the literature].
Topics: Aged; Antiparkinson Agents; Carbidopa; Depressive Disorder, Major; Drug Combinations; Drug Synergism; Fatal Outcome; Fluoxetine; Humans; Levodopa; Male; Parkinson Disease; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin Syndrome | 2002 |
Recent advances in research on Parkinsonism.
Topics: Acetylcholinesterase; Adult; Apomorphine; Benserazide; Brain; Bromocriptine; Carbidopa; Dopa Decarboxylase; Dopamine; Drug Therapy, Combination; gamma-Aminobutyric Acid; Humans; Levodopa; Norepinephrine; Parkinson Disease; Selegiline; Serotonin; Substance P; Tyrosine 3-Monooxygenase | 1978 |
Parkinsonism treatment: Part III--Update.
Topics: Antioxidants; Dopamine Agents; Female; Fetal Tissue Transplantation; Humans; Male; Middle Aged; Parasympatholytics; Parkinson Disease; Pergolide; Selegiline; Vitamin E | 1992 |
An integrated approach to patient management in Parkinson's disease.
Topics: Activities of Daily Living; Antiparkinson Agents; Carbidopa; Dopamine Agents; Drug Combinations; Humans; Levodopa; Parkinson Disease; Selegiline | 1992 |
Recent progress in the treatment of Parkinson's disease.
Topics: Amantadine; Dopamine Agents; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Selegiline | 1992 |
Early therapy for Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agents; Humans; Levodopa; Long-Term Care; Neurologic Examination; Parkinson Disease; Selegiline | 1992 |
[Drug therapy of Parkinson disease].
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Receptors, Dopamine; Selegiline | 1992 |
[Current therapeutic approach in Parkinson disease].
Topics: Antiparkinson Agents; Apomorphine; Bromocriptine; Fetal Tissue Transplantation; Humans; Levodopa; Mesencephalon; Parkinson Disease; Selegiline; Vitamin E | 1992 |
[A drug ahead of its time: the success story of selegiline].
Topics: Brain; Europe; Humans; Parkinson Disease; Selegiline; United States | 1992 |
["Widening horizons" in the clinical application of selegiline].
Topics: Alzheimer Disease; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1992 |
Neurotoxicity and neuroprotection in Parkinson's disease.
Topics: Antiparkinson Agents; Glutathione; Humans; Iron; Melanins; Mitochondria; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Selegiline; Substantia Nigra | 1992 |
Neuroprotective clinical strategies for Parkinson's disease.
Topics: Drug Therapy, Combination; Humans; Iron; Oxidation-Reduction; Parkinson Disease; Selegiline; Vitamin E | 1992 |
[Selegiline in Parkinson's disease; symptomatic or causal effect?].
Topics: Energy Metabolism; Free Radicals; Humans; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 1992 |
Deprenyl in Parkinson's disease: mechanisms, neuroprotective effect, indications and adverse effects.
Topics: Humans; Neurons; Parkinson Disease; Selegiline | 1992 |
Treatment strategies for extension of levodopa effect.
Topics: Catechol O-Methyltransferase Inhibitors; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Infusions, Parenteral; Levodopa; Parkinson Disease; Selegiline | 1992 |
Protective and preventive therapeutic strategies: monoamine oxidase inhibitors.
Topics: Humans; Monoamine Oxidase Inhibitors; MPTP Poisoning; Parkinson Disease; Parkinson Disease, Secondary; Selegiline; Substantia Nigra | 1992 |
Does selegiline monotherapy in Parkinson's disease act by symptomatic or protective mechanisms?
Topics: Double-Blind Method; Forecasting; Humans; Models, Neurological; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 1992 |
[The dopamine agonist, lisuride, in the therapy of Parkinson disease].
Topics: Drug Therapy, Combination; Humans; Levodopa; Lisuride; Parkinson Disease; Selegiline | 1992 |
Selegiline--an overview of its role in the treatment of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Humans; Monoamine Oxidase; Parkinson Disease; Selegiline | 1992 |
The pharmacological profile of (-)deprenyl (selegiline) and its relevance for humans: a personal view.
Topics: Alzheimer Disease; Animals; Brain; Humans; Parkinson Disease; Selegiline | 1992 |
(-)Deprenyl-medication: a strategy to modulate the age-related decline of the striatal dopaminergic system.
Topics: Aging; Alzheimer Disease; Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Parkinson Disease; Rats; Receptors, Dopamine; Selegiline; Substantia Nigra | 1992 |
Antioxidative therapeutic strategies for Parkinson's disease.
Topics: Antioxidants; Double-Blind Method; Free Radical Scavengers; Humans; Parkinson Disease; Selegiline; Vitamin E | 1992 |
Parkinson's disease: management.
Topics: Basal Ganglia; Confounding Factors, Epidemiologic; Dopamine Agents; Humans; Parkinson Disease; Selegiline | 1991 |
A review of the pharmacology of selegiline.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Humans; Isoenzymes; Levodopa; Monoamine Oxidase; Neurotransmitter Agents; Parkinson Disease; Selegiline; Survival Rate | 1991 |
Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Adrenal Glands; Adult; Antiparkinson Agents; Brain Chemistry; Child; Child, Preschool; Cytoplasmic Granules; Dyskinesia, Drug-Induced; Environmental Pollutants; Fetus; Humans; Levodopa; Middle Aged; Palliative Care; Parkinson Disease; Prevalence; Research; Selegiline; Substantia Nigra; Time Factors | 1990 |
Selegiline in the treatment of Parkinson's disease.
Topics: Humans; Parkinson Disease; Selegiline | 1991 |
Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease.
Topics: Adult; Aged; Animals; Drug Interactions; Humans; Middle Aged; Parkinson Disease; Selegiline | 1991 |
Monoamine oxidase, dopamine and Parkinson's disease.
Topics: Animals; Brain; Dopamine; Humans; Isoenzymes; Monoamine Oxidase; Neurologic Examination; Parkinson Disease; Selegiline | 1991 |
Nigral degeneration in Parkinson's disease in relation to clinical features.
Topics: Corpus Striatum; Humans; Levodopa; Nerve Degeneration; Neural Pathways; Neurologic Examination; Parkinson Disease; Selegiline; Substantia Nigra | 1991 |
Selegiline hydrochloride and cognition.
Topics: Aged; Alzheimer Disease; Attention; Dementia; Depressive Disorder; Humans; Mental Recall; Middle Aged; Neurologic Examination; Neuropsychological Tests; Parkinson Disease; Reaction Time; Selegiline | 1991 |
New strategies in the treatment of early Parkinson's disease.
Topics: Brain; Drug Therapy, Combination; Humans; Isoenzymes; Monoamine Oxidase; Neurologic Examination; Parkinson Disease; Selegiline | 1991 |
Selegiline: initial or adjunctive therapy of Parkinson's disease?
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Parkinson Disease; Selegiline | 1991 |
Deprenyl: protective vs. symptomatic effect.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Humans; MPTP Poisoning; Parkinson Disease; Selegiline | 1991 |
Deprenyl: the exciting possibility of protective effect.
Topics: Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1991 |
[New anti-parkinsonian drugs].
Topics: Antiparkinson Agents; Bromocriptine; Humans; Lisuride; Parkinson Disease; Pergolide; Picolinic Acids; Selegiline | 1991 |
Drug therapy for Parkinson's disease in the elderly.
Topics: Aged; Amantadine; Antiparkinson Agents; Carboxy-Lyases; Dopamine Antagonists; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Selegiline | 1990 |
The modern management of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Humans; Levodopa; Parkinson Disease; Selegiline | 1990 |
[Slowing the progression of Parkinson syndrome by early administration of deprenyl].
Topics: Animals; Drug Administration Schedule; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Selegiline | 1990 |
Selegiline and Parkinson's disease. Protective and symptomatic considerations.
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1990 |
Selegiline HC1: Selective MAO-type B inhibitor.
Topics: Drug Administration Schedule; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1990 |
Selegiline as neuroprotective therapy in Parkinson's disease: concepts and controversies.
Topics: Brain; Free Radicals; Humans; Models, Neurological; Monoamine Oxidase; Neurotoxins; Oxygen; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1990 |
Nigrostriatal dopaminergic activity, deprenyl treatment, and longevity.
Topics: Aged; Animals; Corpus Striatum; Humans; Longevity; Male; Neural Pathways; Parkinson Disease; Rats; Receptors, Dopamine; Selegiline; Substantia Nigra | 1990 |
[Protective therapy in Parkinson's disease].
Topics: Animals; Humans; Levodopa; Pargyline; Parkinson Disease; Selegiline | 1990 |
Parkinson's disease: new treatment strategies.
Topics: Adrenal Medulla; Animals; Brain Tissue Transplantation; Fetal Tissue Transplantation; Humans; Neurologic Examination; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1990 |
Parkinson's disease update.
Topics: Adrenal Medulla; Clinical Trials as Topic; Humans; Parkinson Disease; Selegiline; Vitamin E | 1989 |
Selegiline in the treatment of Parkinson's disease.
Topics: Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Selegiline for parkinsonism--an update.
Topics: Humans; Parkinson Disease; Selegiline | 1989 |
New perspectives in the treatment of Parkinson's disease.
Topics: Bromocriptine; Dopamine; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Receptors, Dopamine; Selegiline; Sincalide | 1986 |
The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine; Ergolines; Humans; Levodopa; Macaca mulatta; Neural Pathways; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Quinpirole; Rats; Saimiri; Selegiline; Species Specificity; Substantia Nigra | 1986 |
The role of MAO in MPTP toxicity--a review.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chemical Phenomena; Chemistry; Haplorhini; Hydrogen Peroxide; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroglia; Neurons; Oxidation-Reduction; Parkinson Disease; Pyridines; Rats; Selegiline; Species Specificity; Structure-Activity Relationship; Substrate Specificity | 1986 |
Pharmacological approaches to Parkinson's disease in the different phases of evolution.
Topics: Antidepressive Agents, Tricyclic; Antiparkinson Agents; Carboxy-Lyases; Drug Therapy, Combination; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Receptors, Dopamine; Selegiline | 1986 |
Pharmacology of MAO B inhibitors: mode of action of (-)deprenyl in Parkinson's disease.
Topics: Animals; Brain; Dopamine; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Serotonin; Tyramine | 1986 |
Overview of the present state of MAO inhibitors.
Topics: Animals; Benzamides; Humans; Hydrazines; Isoquinolines; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Parkinson Disease; Phenethylamines; Piperidines; Selegiline; Structure-Activity Relationship | 1987 |
'On-off' phenomenon: description, incidence and management.
Topics: Bromocriptine; Dose-Response Relationship, Drug; Humans; Levodopa; Monoamine Oxidase Inhibitors; Movement Disorders; Parkinson Disease; Selegiline | 1987 |
R-(-)-deprenyl and parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benserazide; Clorgyline; Dopamine; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1987 |
Prevention of progression of Parkinson's disease with antioxidative therapy.
Topics: Antioxidants; Humans; Parkinson Disease; Selegiline; Vitamin E | 1988 |
Controversies in the management of Parkinson's disease.
Topics: Bromocriptine; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1986 |
Deprenyl as symptomatic therapy in Parkinson's disease.
Topics: Antiparkinson Agents; Humans; Parkinson Disease; Phenethylamines; Selegiline | 1988 |
Deprenyl as prophylaxis against Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Parkinson Disease; Phenethylamines; Pyridines; Selegiline | 1988 |
The facilitation of dopaminergic activity in the aged brain by (-)deprenyl. A proposal for a strategy to improve the quality of life in senescence.
Topics: Aged; Aging; Animals; Brain; Depression; Dopamine; Geriatrics; Humans; Male; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Quality of Life; Rats; Selegiline; Sexual Behavior | 1985 |
Update on the treatment of Parkinson's disease.
Topics: Amantadine; Bromocriptine; Carbidopa; Drug Synergism; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Selegiline; Time Factors | 1985 |
154 trial(s) available for selegiline and Idiopathic Parkinson Disease
Article | Year |
---|---|
Analysis of a precision medicine approach to treating Parkinson's disease: Analysis of the DATATOP study.
Topics: alpha-Tocopherol; Antiparkinson Agents; Humans; Parkinson Disease; Precision Medicine; Proteomics; Selegiline | 2022 |
Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's Disease.
Topics: alpha-Tocopherol; Antioxidants; Antiparkinson Agents; Cognition Disorders; Double-Blind Method; Female; Follow-Up Studies; Homocysteine; Humans; Male; Mental Status Schedule; Middle Aged; Parkinson Disease; Predictive Value of Tests; Selegiline; Treatment Outcome; Vitamin B 12 | 2018 |
Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease.
Topics: Adult; Aged; Amyloid beta-Peptides; Antiparkinson Agents; Biomarkers; Disease Progression; Female; Humans; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Selegiline; tau Proteins | 2013 |
Malignant melanoma in early-treated Parkinson's disease: the NET-PD trial.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Double-Blind Method; Female; Humans; Incidence; Male; Melanoma; Middle Aged; National Institutes of Health (U.S.); Neuroprotective Agents; Parkinson Disease; Selegiline; Skin Neoplasms; United States; Young Adult | 2014 |
Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; alpha-Tocopherol; Antiparkinson Agents; Cognition Disorders; Cohort Studies; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Selegiline | 2014 |
CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease.
Topics: Adult; Aged; Amyloid beta-Peptides; Antioxidants; Apolipoproteins E; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Female; Humans; Linear Models; Male; Middle Aged; Monoamine Oxidase Inhibitors; Neuropsychological Tests; Parkinson Disease; Peptide Fragments; Predictive Value of Tests; Selegiline; Severity of Illness Index; tau Proteins; Time Factors; Vitamin E | 2015 |
Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Medical Futility; Middle Aged; Neuroprotective Agents; Parkinson Disease; Pioglitazone; Selegiline; Thiazolidinediones; Treatment Outcome | 2015 |
Fourteen-year final report of the randomized PDRG-UK trial comparing three initial treatments in PD.
Topics: Antiparkinson Agents; Bromocriptine; Disability Evaluation; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Motor Skills; Parkinson Disease; Quality of Life; Selegiline | 2008 |
A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.
Topics: Aged; Antioxidants; Cohort Studies; Disability Evaluation; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Retrospective Studies; Selegiline; Tocopherols | 2009 |
Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.
Topics: Adult; Aged; Algorithms; Contraindications; Diet; Dose-Response Relationship, Drug; Double-Blind Method; Drug Labeling; Female; Humans; Hypertension; Indans; Isoenzymes; Male; Methoxyhydroxyphenylglycol; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Tyramine; United States | 2010 |
The relationship between depression and regional cerebral blood flow in Parkinson's disease and the effect of selegiline treatment.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Blood Circulation Time; Brain; Cerebrovascular Circulation; Depressive Disorder; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Psychiatric Status Rating Scales; Radionuclide Imaging; Selegiline; Treatment Outcome | 2011 |
Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson's disease.
Topics: Administration, Oral; Administration, Sublingual; Aged; Chemistry, Pharmaceutical; Drug Substitution; Female; Follow-Up Studies; Humans; Male; Parkinson Disease; Selegiline; Treatment Outcome | 2011 |
The effect of deprenyl washout in patients with long-standing Parkinson's disease.
Topics: Activities of Daily Living; Adult; Antiparkinson Agents; Double-Blind Method; Drug Administration Schedule; Humans; Levodopa; Middle Aged; Monoamine Oxidase Inhibitors; Motor Activity; Parkinson Disease; Psychiatric Status Rating Scales; Selegiline; Time Factors; Treatment Outcome | 2002 |
Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial.
Topics: Aged; Antioxidants; Antiparkinson Agents; Chi-Square Distribution; Confidence Intervals; Double-Blind Method; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Tocopherols; Treatment Outcome | 2002 |
Selegiline in the treatment of Parkinson's disease: its impact on orthostatic hypotension.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Autonomic Nervous System; Blood Pressure; Carbidopa; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypotension, Orthostatic; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Supine Position | 2003 |
Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication.
Topics: Aged; Aged, 80 and over; Amphetamine; Amphetamines; Antiparkinson Agents; Drug Administration Schedule; Female; Hair; Hair Color; Humans; Male; Melanins; Methamphetamine; Middle Aged; Parkinson Disease; Patient Compliance; Selegiline; Spectrophotometry | 2003 |
Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD.
Topics: Adenosine A2 Receptor Antagonists; Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Chronic Disease; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Humans; Levodopa; Male; Nausea; Parkinson Disease; Purines; Safety; Selegiline; Treatment Outcome | 2003 |
L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.
Topics: Aged; Antiparkinson Agents; Disorders of Excessive Somnolence; Double-Blind Method; Female; Humans; Levodopa; Parkinson Disease; Pergolide; Polysomnography; Reaction Time; Selegiline | 2003 |
A new low-dose formulation of selegiline: clinical efficacy, patient preference and selectivity for MAO-B inhibition.
Topics: Administration, Oral; Adult; Aged; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Patient Satisfaction; Reference Values; Selegiline; Treatment Outcome; Tyramine | 2003 |
Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: a 3-month, randomized, placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Double-Blind Method; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; Movement Disorders; Parkinson Disease; Selegiline; Severity of Illness Index | 2004 |
Effects of dopaminergic treatment on bladder function in Parkinson's disease.
Topics: Adult; Antiparkinson Agents; Disease Progression; Dopamine Agents; Dopamine Agonists; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Sex Characteristics; Surveys and Questionnaires; Urinary Bladder Diseases; Urination Disorders; Urodynamics; Urologic Diseases | 2004 |
The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Norepinephrine; Parkinson Disease; Pulse; Rest; Selegiline; Supine Position | 2005 |
Efficacy and safety of high-dose cabergoline in Parkinson's disease.
Topics: Adolescent; Adult; Aged; Amantadine; Antiparkinson Agents; Cabergoline; Catechols; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Dystonia; Ergolines; Humans; Levodopa; Middle Aged; Nitriles; Parkinson Disease; Piperidines; Prospective Studies; Quality of Life; Selegiline; Severity of Illness Index; Treatment Outcome | 2006 |
Selegiline slows the progression of the symptoms of Parkinson disease.
Topics: Activities of Daily Living; Aged; Antiparkinson Agents; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Time Factors | 2006 |
Quality of life in Parkinson's disease--Indian scenario.
Topics: Aged; Antiparkinson Agents; Cholinergic Antagonists; Dopamine Agonists; Female; Humans; India; Levodopa; Male; Middle Aged; Parkinson Disease; Quality of Life; Selegiline; Sickness Impact Profile; Surveys and Questionnaires; Treatment Outcome | 2006 |
Selegiline and blood pressure in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Autonomic Nervous System; Blood Pressure; Female; Heart Rate; Humans; Male; Middle Aged; Parkinson Disease; Posture; Selegiline | 2007 |
Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of 'off' episodes in patients with Parkinson's disease.
Topics: Administration, Oral; Aged; Antiparkinson Agents; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Female; Humans; Hypokinesia; Levodopa; Male; Middle Aged; Parkinson Disease; Placebos; Polypharmacy; Selegiline; Tablets; Time Factors; Treatment Outcome | 2007 |
Deprenyl in Parkinson disease.
Topics: Adult; Aged; Carbidopa; Dopamine; Double-Blind Method; Drug Combinations; Epinephrine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Methoxyhydroxyphenylglycol; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1981 |
Clinical and pharmacological aspects of (-)-deprenyl treatment in Parkinson's disease.
Topics: Amphetamine; Clinical Trials as Topic; Double-Blind Method; Humans; Hydrogen-Ion Concentration; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
[Evaluation of the effectiveness of combined (L-dopa + Jumex) therapy based on a multicentric double blind study].
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Deprenyl (selegiline) combined with levodopa and a decarboxylase inhibitor in the treatment of Parkinson's disease.
Topics: Aged; Carboxy-Lyases; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Parkinson Disease; Phenethylamines; Selegiline; Time Factors | 1983 |
Deprenyl in the management of response fluctuations in patients with Parkinson's disease on levodopa.
Topics: Aged; Biotransformation; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1980 |
The effect of deprenyl and levodopa on the progression of Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Bromocriptine; Carbidopa; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Humans; Least-Squares Analysis; Levodopa; Male; Parkinson Disease; Prospective Studies; Selegiline; Statistics, Nonparametric; Treatment Outcome | 1995 |
Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline.
Topics: Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Nitrophenols; Parkinson Disease; Selegiline; Tolcapone | 1995 |
Factors predictive of the need for levodopa therapy in early, untreated Parkinson's disease. The Parkinson Study Group.
Topics: Adult; Age Factors; Aged; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Prospective Studies; Risk Factors; Selegiline; Sex Factors; Vitamin E | 1995 |
Early selegiline therapy reduces levodopa dose requirement in Parkinson's disease.
Topics: Aged; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Placebos; Random Allocation; Selegiline; Treatment Outcome | 1995 |
Comparative study of selegiline plus L-dopa-carbidopa versus L-dopa-carbidopa alone in the treatment of Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Drug Combinations; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Parkinson Disease; Selegiline; Treatment Outcome | 1995 |
Slow recovery of human brain MAO B after L-deprenyl (Selegeline) withdrawal.
Topics: Aged; Brain; Female; Humans; Kinetics; Male; Middle Aged; Models, Biological; Monoamine Oxidase; Parkinson Disease; Selegiline; Substance Withdrawal Syndrome; Tomography, Emission-Computed | 1994 |
Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early parkinsonism.
Topics: Adult; Aged; Analysis of Variance; Blood Platelets; Carbidopa; Citrate (si)-Synthase; Electron Transport; Electron Transport Complex II; Electron Transport Complex III; Female; Humans; Levodopa; Male; Middle Aged; Mitochondria; Multienzyme Complexes; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases; Parkinson Disease; Plateletpheresis; Selegiline; Succinate Dehydrogenase | 1995 |
Cerebrospinal fluid homovanillic acid in the DATATOP study on Parkinson's disease. Parkinson Study Group.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Male; Middle Aged; Parkinson Disease; Placebos; Selegiline; Vitamin E | 1995 |
The effect of deprenyl and tocopherol on cognitive performance in early untreated Parkinson's disease. Parkinson Study Group.
Topics: Aged; Cognition Disorders; Female; Humans; Male; Middle Aged; Parkinson Disease; Selegiline; Vitamin E | 1994 |
Selegiline (L-deprenyl) and L-dopa treatment of Parkinson's disease: a double-blind trial.
Topics: Aged; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1994 |
Fluoxetine and selegiline--lack of significant interaction.
Topics: Adult; Aged; Aged, 80 and over; Depressive Disorder; Drug Interactions; Female; Fluoxetine; Humans; Male; Middle Aged; Parkinson Disease; Selegiline | 1994 |
[A long-term clinical effect of selegiline hydrochloride on Parkinson's disease].
Topics: Aged; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1994 |
Visual control of arm movement in Parkinson's disease.
Topics: Adult; Aged; Attention; Benserazide; Bromocriptine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Motor Skills; Orientation; Parkinson Disease; Psychomotor Performance; Reaction Time; Selegiline | 1994 |
Die Pathoklise [Parkinson's disease].
Topics: Animals; Brain; Cells, Cultured; Disease Models, Animal; Fetus; Humans; Levodopa; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra | 1993 |
Selegiline in de novo parkinsonian patients: the Finnish study.
Topics: Activities of Daily Living; Aged; Double-Blind Method; Drug Therapy, Combination; Female; Finland; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline | 1993 |
Symptomatic effect of selegiline in de novo Parkinsonian patients. The French Selegiline Multicenter Trial.
Topics: Activities of Daily Living; Aged; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; France; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline; Treatment Outcome | 1993 |
Effect of selegiline (deprenyl) on the progression of disability in early Parkinson's disease. Parkinson Study Group.
Topics: Aged; Disability Evaluation; Female; Humans; Long-Term Care; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline | 1993 |
Comparisons of therapeutic effects of levodopa, levodopa and selegiline, and bromocriptine in patients with early, mild Parkinson's disease: three year interim report. Parkinson's Disease Research Group in the United Kingdom.
Topics: Adult; Aged; Aged, 80 and over; Bromocriptine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Prospective Studies; Selegiline; Treatment Outcome | 1993 |
Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease.
Topics: Activities of Daily Living; Arrhythmias, Cardiac; Follow-Up Studies; Humans; Parkinson Disease; Psychiatric Status Rating Scales; Psychomotor Performance; Regression Analysis; Selegiline; Vitamin E | 1993 |
Effects of selegiline dosing on motor fluctuations in Parkinson's disease.
Topics: Aged; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Movement; Parkinson Disease; Selegiline | 1993 |
Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease. Parkinson's Disease Research Group of the United Kingdom.
Topics: Antiparkinson Agents; Benserazide; Bromocriptine; Cause of Death; Disability Evaluation; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Proportional Hazards Models; Prospective Studies; Selegiline; Time Factors; Treatment Failure | 1995 |
L-deprenyl as an adjunct to low-dose bromocriptine in early Parkinson's disease: a short-term, double-blind, and prospective follow-up study.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Chemotherapy, Adjuvant; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Parkinson Disease; Placebos; Prospective Studies; Selegiline | 1995 |
Single vs multiple daily dosing of aminoglycosides.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline; Treatment Outcome | 1996 |
Treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Acute effects of COMT inhibition on L-DOPA pharmacokinetics in patients treated with carbidopa and selegiline.
Topics: Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Dose-Response Relationship, Drug; Humans; Levodopa; Movement Disorders; Nitrophenols; Parkinson Disease; Selegiline; Tolcapone | 1995 |
Effects of selegiline (deprenyl) on cognition in early Parkinson's disease.
Topics: Aged; Cognition; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Selegiline; Time Factors | 1995 |
[A long-term clinical effect of selegiline hydrochloride on Parkinson's disease].
Topics: Aged; Antiparkinson Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1996 |
Time course of physical and psychological responses to selegiline monotherapy in newly diagnosed, idiopathic parkinsonism.
Topics: Aged; Antiparkinson Agents; Arousal; Double-Blind Method; Female; Gait; Humans; Hypokinesia; Male; Muscle Rigidity; Parkinson Disease; Posture; Psychomotor Performance; Research Design; Selegiline; Treatment Outcome; Tremor | 1996 |
Lack of pharmacokinetic interaction between the selective dopamine agonist cabergoline and the MAO-B inhibitor selegiline.
Topics: Aged; Amphetamine; Amphetamines; Antiparkinson Agents; Cabergoline; Dopamine Agonists; Drug Interactions; Ergolines; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1995 |
Pharmacokinetics and relative bioavailability of selegiline in healthy volunteers.
Topics: Adult; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Parkinson Disease; Selegiline; Time Factors | 1995 |
DATATOP-study: significance of its results in the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Double-Blind Method; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Placebos; Selegiline | 1995 |
An add-on study of selegiline to Madopar in the treatment of parkinsonian patients with dose-related fluctuations: comparison between Jumexal and Parkryl.
Topics: Aged; Antiparkinson Agents; Benserazide; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Humans; Levodopa; Middle Aged; Monoamine Oxidase Inhibitors; Movement; Parkinson Disease; Selegiline; Single-Blind Method | 1996 |
Selegiline diminishes cardiovascular autonomic responses in Parkinson's disease.
Topics: Analysis of Variance; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular Diseases; Electrocardiography; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Prospective Studies; Reflex; Selegiline; Tilt-Table Test | 1997 |
The effects of early selegiline therapy on long-term levodopa treatment and parkinsonian disability: an interim analysis of a Norwegian--Danish 5-year study. Norwegian-Danish Study Group.
Topics: Adult; Aged; Antiparkinson Agents; Denmark; Disability Evaluation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Long-Term Care; Male; Middle Aged; Neurologic Examination; Norway; Parkinson Disease; Selegiline | 1997 |
The need for levodopa as an end point of Parkinson's disease progression in a clinical trial of selegiline and alpha-tocopherol. Parkinson Study Group.
Topics: Activities of Daily Living; Adult; Aged; Antioxidants; Antiparkinson Agents; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline; Treatment Outcome; Vitamin E | 1997 |
Cerebrospinal fluid carnitine levels in patients with Parkinson's disease.
Topics: Acylation; Aged; Antiparkinson Agents; Carnitine; Female; Humans; Levodopa; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Reference Standards; Selegiline | 1997 |
Selegiline as the primary treatment of Parkinson's disease--a long-term double-blind study.
Topics: Antiparkinson Agents; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Placebos; Prospective Studies; Regression Analysis; Selegiline; Time Factors | 1997 |
A dose-ranging study of selegiline in patients with Parkinson's disease: effect of platelet monoamine oxidase activity.
Topics: Adult; Aged; Antiparkinson Agents; Blood Platelets; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Selegiline | 1997 |
Mortality associated with selegiline in Parkinson's disease. What do the available data mean?
Topics: Antiparkinson Agents; Cohort Studies; Drug Therapy, Combination; Follow-Up Studies; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Patient Selection; Prospective Studies; Research Design; Selegiline; United Kingdom | 1997 |
Simultaneous MAO-B and COMT inhibition in L-Dopa-treated patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Benserazide; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Over Studies; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Motor Activity; Nitriles; Parkinson Disease; Selegiline | 1997 |
Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Cardiovascular Diseases; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Monoamine Oxidase Inhibitors; Movement Disorders; Parkinson Disease; Selegiline | 1997 |
Moclobemide and selegeline in the treatment of depression in Parkinson's disease.
Topics: Antidepressive Agents; Benzamides; Depressive Disorder; Humans; Moclobemide; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1997 |
Sertraline for the treatment of depression in Parkinson's disease.
Topics: 1-Naphthylamine; Aged; Antidepressive Agents, Second-Generation; Antiparkinson Agents; Depression; Drug Interactions; Drug Therapy, Combination; Humans; Parkinson Disease; Pilot Projects; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Selegiline; Sertraline; Severity of Illness Index; Treatment Outcome | 1997 |
Effect of chronic oral domperidone therapy on gastrointestinal symptoms and gastric emptying in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Carbidopa; Domperidone; Dopamine Antagonists; Drug Therapy, Combination; Female; Follow-Up Studies; Gastric Emptying; Gastrointestinal Diseases; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Severity of Illness Index | 1997 |
Ropinirole versus bromocriptine in the treatment of early Parkinson's disease: a 6-month interim report of a 3-year study. 053 Study Group.
Topics: Adult; Aged; Antiparkinson Agents; Bromocriptine; Confidence Intervals; Disease Progression; Dopamine Agonists; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indoles; Longitudinal Studies; Male; Middle Aged; Odds Ratio; Parkinson Disease; Regression Analysis; Selegiline; Severity of Illness Index; Treatment Outcome | 1998 |
Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Parkinson Study Group.
Topics: Aged; Antiparkinson Agents; Cause of Death; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Parkinson Disease; Selegiline; Vitamin E | 1998 |
Experience with tranylcypromine in early Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Depression; Erectile Dysfunction; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Sleep Initiation and Maintenance Disorders; Time Factors; Tranylcypromine; Tyramine | 1998 |
Deprenyl monotherapy improves visuo-motor control in early parkinsonism.
Topics: Antiparkinson Agents; Female; Humans; Male; Motor Activity; Parkinson Disease; Psychomotor Performance; Selegiline; Severity of Illness Index | 1998 |
Investigation by Parkinson's Disease Research Group of United Kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Parkinson's disease: further results of randomised trial and confidential inquiry
Topics: Antiparkinson Agents; Bromocriptine; Cause of Death; Disabled Persons; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Parkinson Disease; Proportional Hazards Models; Selegiline; Survival Rate; Treatment Failure | 1998 |
Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group.
Topics: Antioxidants; Antiparkinson Agents; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Parkinson Disease; Selegiline; Vitamin E | 1998 |
Mortality in people taking selegiline: observational study.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Antiparkinson Agents; Cohort Studies; Follow-Up Studies; Humans; Middle Aged; Parkinson Disease; Risk Factors; Selegiline; Survival Rate; United Kingdom | 1998 |
A pilot evaluation of the tolerability, safety, and efficacy of tolcapone alone and in combination with oral selegiline in untreated Parkinson's disease patients. Tolcapone De Novo Study Group.
Topics: Administration, Oral; Aged; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neurologic Examination; Nitrophenols; Parkinson Disease; Pilot Projects; Selegiline; Tolcapone; Treatment Outcome | 1998 |
Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Disabled Persons; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neuroprotective Agents; Parkinson Disease; Probability; Selegiline; Time Factors | 1998 |
DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism.
Topics: Antioxidants; Antiparkinson Agents; Clinical Trials as Topic; Disease Progression; Humans; Neuroprotective Agents; Parkinson Disease; Selegiline; Vitamin E | 1998 |
SELEDO: a 5-year long-term trial on the effect of selegiline in early Parkinsonian patients treated with levodopa.
Topics: Adult; Aged; Antiparkinson Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Levodopa; Longitudinal Studies; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Time Factors | 1999 |
Selegiline-induced postural hypotension in Parkinson's disease: a longitudinal study on the effects of drug withdrawal.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Blood Pressure; Dizziness; Drug Therapy, Combination; Epinephrine; Female; Head; Heart Rate; Humans; Hypotension, Orthostatic; Male; Middle Aged; Norepinephrine; Parkinson Disease; Posture; Prospective Studies; Selegiline; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors | 1999 |
Effect of treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporter SPECT imaging with [123I]beta-CIT.
Topics: Aged; Antiparkinson Agents; Biological Transport; Carbidopa; Cocaine; Corpus Striatum; Dopamine; Drug Therapy, Combination; Female; Humans; Iodine Radioisotopes; Levodopa; Male; Monoamine Oxidase; Occipital Lobe; Parkinson Disease; Selegiline; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 1999 |
Combined and selective monoamine oxidase inhibition in the treatment of depression in Parkinson's disease.
Topics: Adult; Aged; Benzamides; Cognition; Depression; Drug Combinations; Female; Humans; Male; Medical Records; Middle Aged; Moclobemide; Monoamine Oxidase Inhibitors; Movement; Parkinson Disease; Selegiline | 1999 |
Does selegiline modify the progression of early Parkinson's disease? Results from a five-year study. The Norwegian-Danish Study Group.
Topics: Adult; Aged; Antiparkinson Agents; Denmark; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Norway; Parkinson Disease; Sample Size; Selegiline | 1999 |
Effect of selegiline on cognitive functions in Parkinson's disease.
Topics: Adult; Antiparkinson Agents; Female; Follow-Up Studies; Humans; Intelligence; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Parkinson Disease; Selegiline | 1999 |
Time course of loss of clinical benefit following withdrawal of levodopa/carbidopa and bromocriptine in early Parkinson' s disease.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Carbidopa; Disability Evaluation; Disease Progression; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Prospective Studies; Selegiline; Substance Withdrawal Syndrome | 2000 |
Levodopa, bromocriptine and selegiline modify cardiovascular responses in Parkinson's disease.
Topics: Aged; Blood Pressure; Bromocriptine; Cardiovascular System; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 2000 |
Long-term persistence of symptomatic effect of selegiline in Parkinson's disease. A two-months placebo-controlled withdrawal study.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Female; Humans; Male; Middle Aged; Motor Activity; Parkinson Disease; Selegiline; Severity of Illness Index; Single-Blind Method; Substance Withdrawal Syndrome | 2001 |
Suppressed sympathetic skin response in Parkinson disease.
Topics: Acoustic Stimulation; Aged; Antiparkinson Agents; Bromocriptine; Carbidopa; Electric Stimulation; Evoked Potentials; Evoked Potentials, Auditory; Female; Foot; Hand; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Reaction Time; Reference Values; Selegiline; Skin; Sympathetic Nervous System | 2000 |
Freezing of gait in PD: prospective assessment in the DATATOP cohort.
Topics: Aged; Double-Blind Method; Female; Gait; Humans; Male; Middle Aged; Parkinson Disease; Prospective Studies; Selegiline; Vitamin E | 2001 |
Ten-year follow-up of three different initial treatments in de-novo PD: a randomized trial.
Topics: Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Bromocriptine; Disability Evaluation; Dyskinesia, Drug-Induced; Female; Follow-Up Studies; Humans; Incidence; Levodopa; Male; Parkinson Disease; Selegiline; Treatment Outcome | 2001 |
Zonisamide has beneficial effects on Parkinson's disease patients.
Topics: Aged; Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Dopamine; Dopamine Agonists; Drug Therapy, Combination; Female; Humans; Isoxazoles; Levodopa; Male; Middle Aged; Motor Activity; Parkinson Disease; Rats; Selegiline; Treatment Outcome; Zonisamide | 2001 |
Placebo-associated improvements in motor function: comparison of subjective and objective sections of the UPDRS in early Parkinson's disease.
Topics: Activities of Daily Living; Aged; Antiparkinson Agents; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Motor Skills; Neurologic Examination; Parkinson Disease; Placebo Effect; Selegiline; Tocopherols | 2002 |
Experiences with L-deprenyl in Parkinsonism.
Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline | 1978 |
A multicenter Italian randomised study on early treatment of Parkinson disease: comparison of L-dopa, l-deprenyl and dopaminoagonists. Study design and short term results. The Italian Parkinson Study Group.
Topics: Dopamine Agents; Female; Humans; Italy; Levodopa; Male; Middle Aged; Parkinson Disease; Prognosis; Research Design; Selegiline; Severity of Illness Index | 1992 |
An interim report of the effect of selegiline (L-deprenyl) on the progression of disability in early Parkinson's disease. The Parkinson Study Group.
Topics: Activities of Daily Living; Adult; Aged; Disability Evaluation; Double-Blind Method; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline; Vitamin E | 1992 |
Deprenyl effects on levodopa pharmacodynamics, mood, and free radical scavenging.
Topics: Affect; Aged; Catalase; Free Radicals; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Levodopa; Middle Aged; Parkinson Disease; Selegiline; Superoxide Dismutase | 1992 |
Antioxidative therapeutic strategies for Parkinson's disease.
Topics: Antioxidants; Double-Blind Method; Free Radical Scavengers; Humans; Parkinson Disease; Selegiline; Vitamin E | 1992 |
Selegiline as initial treatment in de novo parkinsonian patients.
Topics: Aged; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middle Aged; Parkinson Disease; Selegiline | 1992 |
Selegiline in the treatment of Parkinson's disease.
Topics: Humans; Parkinson Disease; Selegiline | 1991 |
Selegiline and cognitive function in Parkinson's disease.
Topics: Adult; Aged; Attention; Double-Blind Method; Female; Humans; Male; Mental Recall; Middle Aged; Neurologic Examination; Neuropsychological Tests; Parkinson Disease; Psychomotor Performance; Selegiline | 1991 |
Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease.
Topics: Adult; Aged; Animals; Drug Interactions; Humans; Middle Aged; Parkinson Disease; Selegiline | 1991 |
Optoelectronic movement analysis in Parkinson's disease: effect of selegiline on the disability in de novo parkinsonian patients--a pilot study.
Topics: Aged; Disability Evaluation; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Pilot Projects; Selegiline; Video Recording | 1991 |
Selegiline as a primary treatment of Parkinson's disease.
Topics: Activities of Daily Living; Double-Blind Method; Humans; Neurologic Examination; Parkinson Disease; Prospective Studies; Selegiline | 1991 |
Selegiline in de novo parkinsonian patients: the French selegiline multicenter trial (FSMT).
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Female; France; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline | 1991 |
Deprenyl's effect at slowing progression of parkinsonian disability: the DATATOP study. The Parkinson Study Group.
Topics: Adult; Aged; Brain; Disability Evaluation; Drug Therapy, Combination; Humans; Middle Aged; Monoamine Oxidase; Neurologic Examination; Parkinson Disease; Selegiline; Vitamin E | 1991 |
Selegiline: initial or adjunctive therapy of Parkinson's disease?
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Parkinson Disease; Selegiline | 1991 |
DATATOP and clinical neuromythology IX.
Topics: Humans; Parkinson Disease; Selegiline; Time Factors | 1991 |
L-deprenyl (selegiline) added to Sinemet CR in the management of Parkinson's disease patients with motor response fluctuations.
Topics: Aged; Antiparkinson Agents; Carbidopa; Drug Combinations; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Movement; Parkinson Disease; Selegiline; Time Factors | 1991 |
Lisuride plus selegiline in the treatment of early Parkinson's disease.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Lisuride; Male; Middle Aged; Motor Skills; Neurologic Examination; Parkinson Disease; Selegiline | 1991 |
Selegiline for Parkinson's disease.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Selegiline | 1990 |
Deprenyl and the progression of Parkinson's disease.
Topics: Clinical Trials as Topic; Humans; Levodopa; Parkinson Disease; Phenethylamines; Selegiline | 1990 |
Selegiline as neuroprotective therapy in Parkinson's disease: concepts and controversies.
Topics: Brain; Free Radicals; Humans; Models, Neurological; Monoamine Oxidase; Neurotoxins; Oxygen; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1990 |
L-deprenyl, a MAO-B inhibitor, as an adjunct to conventional L-dopa therapy in Parkinson's disease: experience in 200 patients.
Topics: Aged; Carbidopa; Follow-Up Studies; Humans; Levodopa; Middle Aged; Neurologic Examination; Parkinson Disease; Prospective Studies; Selegiline | 1990 |
Effects of L-deprenyl on parkinsonian bradyphrenia.
Topics: Adult; Attention; Cognition Disorders; Dementia; Double-Blind Method; Humans; Microcomputers; Middle Aged; Neuropsychological Tests; Parkinson Disease; Psychomotor Performance; Reaction Time; Selegiline | 1990 |
L-deprenyl therapy in Thai patients with Parkinson's disease: before and after, clinical trial of 50 patients.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Parkinson Disease; Selegiline | 1990 |
The effect of dietary protein on the efficacy of L-dopa: a double-blind study.
Topics: Antiparkinson Agents; Bromocriptine; Carbidopa; Clinical Trials as Topic; Dietary Proteins; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Random Allocation; Selegiline | 1989 |
Big first scored with nerve diseases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Designer Drugs; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline; Substantia Nigra | 1989 |
The effect of deprenyl (selegiline) on the natural history of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Random Allocation; Selegiline | 1989 |
Long-term efficacy and safety of deprenyl (selegiline) in advanced Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Clinical Enzyme Tests; Clinical Trials as Topic; Double-Blind Method; Humans; Liver; Liver Function Tests; Middle Aged; Parkinson Disease; Phenethylamines; Safety; Selegiline; Time Factors | 1989 |
Pergolide and selegiline for Parkinson's disease.
Topics: Animals; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Nerve Degeneration; Parkinson Disease; Pergolide; Phenethylamines; Selegiline | 1989 |
DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group.
Topics: Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Parkinson Disease; Phenethylamines; Randomized Controlled Trials as Topic; Selegiline; Vitamin E | 1989 |
Effect of deprenyl on the progression of disability in early Parkinson's disease.
Topics: Activities of Daily Living; Clinical Trials as Topic; Drug Therapy, Combination; Employment; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Multicenter Studies as Topic; Parkinson Disease; Phenethylamines; Random Allocation; Selegiline; Vitamin E | 1989 |
Parkinson's disease update.
Topics: Adrenal Medulla; Clinical Trials as Topic; Humans; Parkinson Disease; Selegiline; Vitamin E | 1989 |
Selegiline use to prevent progression of Parkinson's disease. Experience in 22 de novo patients.
Topics: Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Parkinson Disease; Phenethylamines; Prospective Studies; Selegiline | 1989 |
Selegiline as an adjunct to conventional levodopa therapy in Parkinson's disease. Experience with this type B monoamine oxidase inhibitor in 200 patients.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Prospective Studies; Selegiline | 1989 |
A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease.
Topics: Adjuvants, Pharmaceutic; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Selegiline in the treatment of daily fluctuations in disability of parkinsonian patients with long-term levodopa treatment.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Double-blind, crossover placebo controlled trial of selegiline in Parkinson's disease--an interim analysis.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Randomized Controlled Trials as Topic; Selegiline | 1989 |
Selegiline and levodopa in early or moderately advanced Parkinson's disease: a double-blind controlled short- and long-term study.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Randomized Controlled Trials as Topic; Selegiline | 1989 |
Deprenyl and tocopherol antioxidative therapy of parkinsonism (DATATOP). Parkinson Study Group.
Topics: Adult; Aged; Antioxidants; Canada; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Parkinson Disease; Phenethylamines; Randomized Controlled Trials as Topic; Selegiline; United States; Vitamin E | 1989 |
Selegiline as primary treatment in early phase Parkinson's disease--an interim report.
Topics: Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenethylamines; Randomized Controlled Trials as Topic; Selegiline | 1989 |
Multicenter trial of L-Deprenyl in Parkinson disease.
Topics: Adult; Affect; Aged; Clinical Trials as Topic; Disability Evaluation; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Tremor | 1986 |
Drug trial for Parkinson's.
Topics: Clinical Trials as Topic; Humans; Parkinson Disease; Phenethylamines; Selegiline; Vitamin E | 1987 |
Adrenal-to-brain transplants continue as neurologists test two new drugs.
Topics: Adrenal Glands; Caudate Nucleus; Clinical Trials as Topic; Humans; Parkinson Disease; Phenethylamines; Selegiline; Vitamin E | 1987 |
Selegiline (1-deprenyl) and low-dose levodopa treatment of Parkinson's disease. A double-blind crossover trial.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Placebos; Random Allocation; Selegiline | 1987 |
Double-blind trial of R-(-)-deprenyl for the "on-off" effect complicating Parkinson's disease.
Topics: Adult; Aged; Carbidopa; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Self Concept | 1987 |
Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism.
Topics: Aged; Clinical Trials as Topic; Depression; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Thioxanthenes | 1987 |
Current controversies in the use of selegiline hydrochloride.
Topics: Antidepressive Agents; Biomechanical Phenomena; Clinical Trials as Topic; Humans; Parkinson Disease; Phenethylamines; Selegiline; Time Factors | 1987 |
R-(-)-deprenyl in the treatment of end-of-dose akinesia.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Disability Evaluation; Female; Humans; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline | 1987 |
R-(-)-deprenyl as a possible protective agent in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Models, Theoretical; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline | 1987 |
The effect of R-(-)-deprenyl in de novo Parkinson patients on combination therapy with levodopa and decarboxylase inhibitor.
Topics: Benserazide; Clinical Trials as Topic; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Movement; Parkinson Disease; Phenethylamines; Selegiline | 1987 |
Deprenyl versus placebo in Parkinson disease: a double-blind study.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1987 |
Deprenyl in the treatment of symptom fluctuations in advanced Parkinson's disease.
Topics: Adult; Aged; Carbidopa; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Random Allocation; Selegiline | 1988 |
Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in parkinsonian patients: a double-blind cross-over placebo-controlled trial.
Topics: Aged; Animals; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Placebos; Selegiline | 1988 |
The effect of L-Deprenyl on on-off phenomena in Parkinson's disease.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1985 |
Clinical trial for Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Levodopa; Models, Neurological; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Pyridines; Pyridinium Compounds; Selegiline | 1985 |
371 other study(ies) available for selegiline and Idiopathic Parkinson Disease
Article | Year |
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Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells.
Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Death; Monoamine Oxidase; Morphinans; Parkinson Disease; PC12 Cells; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines | 2009 |
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.
Topics: Coumarins; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Isoforms | 2009 |
New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
Topics: Amines; Animals; Antiparkinson Agents; Cells, Cultured; Humans; Memantine; Molecular Structure; Neurons; Parkinson Disease; Rats; Receptors, N-Methyl-D-Aspartate; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis | 2010 |
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.
Topics: Binding Sites; Humans; Hydrazones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Conformation; Structure-Activity Relationship; Tandem Mass Spectrometry; Thiazoles | 2012 |
Selected chromone derivatives as inhibitors of monoamine oxidase.
Topics: Benzopyrans; Chromones; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Parkinson Disease; Protein Isoforms; Recombinant Proteins; Structure-Activity Relationship | 2012 |
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Topics: Binding Sites; Catalytic Domain; Dopamine; Humans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Parkinson Disease; Pyridines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2013 |
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Small Molecule Libraries; Thermodynamics | 2015 |
New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Female; Male; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Quinoxalines; Rats, Sprague-Dawley; Structure-Activity Relationship | 2016 |
Benzyloxynitrostyrene analogues - A novel class of selective and highly potent inhibitors of monoamine oxidase B.
Topics: Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship; Styrenes | 2017 |
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.
Topics: Acetylcholinesterase; Animals; Antioxidants; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Humans; Hydrazones; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship | 2018 |
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzene Derivatives; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship | 2018 |
Synthesis and evaluation of 2-substituted 4(3H)-quinazolinone thioether derivatives as monoamine oxidase inhibitors.
Topics: Chemistry Techniques, Synthetic; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Quinazolinones; Structure-Activity Relationship | 2018 |
Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.
Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Drug Discovery; Humans; Inflammation; Male; Mannich Bases; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.
Topics: Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Propylamines; Selegiline; Tetrahydronaphthalenes; Tyramine | 2022 |
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.
Topics: Humans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship | 2022 |
The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson's Disease - An Update.
Topics: Antiparkinson Agents; Dopamine; Dopamine Agents; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Parkinson Disease; Selegiline | 2023 |
Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study.
Topics: Disorders of Excessive Somnolence; Humans; Parkinson Disease; Selegiline; Severity of Illness Index | 2022 |
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biflavonoids; Catechin; Oxidative Stress; Parkinson Disease; Proanthocyanidins; Rats; Selegiline; Zebrafish | 2022 |
Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation.
Topics: Blood Platelet Disorders; Deep Brain Stimulation; Hemostatics; Humans; Parkinson Disease; Selegiline; Treatment Outcome | 2022 |
Effects of monotherapy with a monoamine oxidase B inhibitor on motor symptoms in Parkinson's disease are dependent on frontal function.
Topics: Antiparkinson Agents; Dopamine; Dopamine Agents; Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2023 |
Differences in CSF Biomarkers Profile of Patients with Parkinson's Disease Treated with MAO-B Inhibitors in Add-On.
Topics: Biomarkers; Humans; Lactates; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2022 |
Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
Topics: Acetylcysteine; Aldehyde Dehydrogenase; Animals; Dopamine; Monoamine Oxidase Inhibitors; Parkinson Disease; Rats; Rotenone; Selegiline | 2023 |
Safety comparisons among monoamine oxidase inhibitors against Parkinson's disease using FDA adverse event reporting system.
Topics: Amphetamines; Dopamine Agents; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Retrospective Studies; Selegiline | 2023 |
Selegiline reduces daytime sleepiness in patients with Parkinson's disease.
Topics: Disorders of Excessive Somnolence; Dopamine Agonists; Female; Humans; Male; Parkinson Disease; Retrospective Studies; Selegiline | 2021 |
Efficacy of rasagiline and selegiline in Parkinson's disease: a head-to-head 3-year retrospective case-control study.
Topics: Aged; Antiparkinson Agents; Case-Control Studies; Female; Follow-Up Studies; Humans; Indans; Italy; Male; Middle Aged; Parkinson Disease; Retrospective Studies; Selegiline; Severity of Illness Index | 2017 |
Inhibition of Cyclooxygenase-2 (COX-2) Initiates Autophagy and Potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Autophagy; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Lipopolysaccharides; Nerve Tissue Proteins; Neuroblastoma; Parkinson Disease; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Selegiline; Sulfonamides | 2018 |
Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease.
Topics: Administration, Intranasal; Animals; Antiparkinson Agents; Brain; Catalase; Catalepsy; Chitosan; Chlorpromazine; Female; Glutathione; Male; Nanoparticles; Nitrites; Parkinson Disease; Rats, Wistar; Selegiline; Thiobarbituric Acid Reactive Substances | 2019 |
Selegiline Nanoformulation in Attenuation of Oxidative Stress and Upregulation of Dopamine in the Brain for the Treatment of Parkinson's Disease.
Topics: Animals; Antioxidants; Antiparkinson Agents; Brain; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Compounding; Haloperidol; Male; Nanoparticles; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Selegiline; Up-Regulation | 2018 |
Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson's disease.
Topics: Administration, Intranasal; Animals; Antiparkinson Agents; Behavior, Animal; Biological Availability; Brain; Chitosan; Disease Models, Animal; Drug Carriers; Drug Liberation; Male; Nanoparticles; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline; Tissue Distribution | 2018 |
Development and Characterization of Nasal Delivery of Selegiline Hydrochloride Loaded Nanolipid Carriers for the Management of Parkinson's Disease.
Topics: Administration, Intranasal; Animals; Disease Management; Drug Carriers; Drug Delivery Systems; Drug Development; Lipids; Male; Nanostructures; Nasal Mucosa; Parkinson Disease; Rats; Rats, Wistar; Selegiline | 2019 |
Influence of DRD1 and DRD3 Polymorphisms in the Occurrence of Motor Effects in Patients with Sporadic Parkinson's Disease.
Topics: Antiparkinson Agents; Catechols; Cross-Sectional Studies; Dopamine; Dopamine Agonists; Genotype; Humans; Indans; Levodopa; Motor Activity; Nitriles; Parkinson Disease; Polymorphism, Single Nucleotide; Receptors, Dopamine D1; Receptors, Dopamine D3; Selegiline | 2019 |
Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy.
Topics: Adult; Amantadine; Antiparkinson Agents; Benzothiazoles; Carbidopa; Catechols; Disruptive, Impulse Control, and Conduct Disorders; Drug Combinations; Female; Humans; Indans; Indoles; Levodopa; Male; Middle Aged; Neuroprotective Agents; Parkinson Disease; Pramipexole; Selegiline | 2013 |
The pharmacokinetic evaluation of selegiline ODT for the treatment of Parkinson's disease.
Topics: Administration, Oral; Amphetamine; Biological Availability; Drug Evaluation; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Tablets | 2013 |
[Primary prevention with enhancer substances for a longer and healthier life].
Topics: Aging; Antiparkinson Agents; Chronic Disease; Disease Progression; Education, Medical; Feeding Behavior; Humans; Hungary; Life Expectancy; Life Style; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Primary Prevention; Secondary Prevention; Selegiline; Tertiary Prevention | 2013 |
Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; bcl-2-Associated X Protein; Disease Models, Animal; Dopaminergic Neurons; Gait; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Parkinson Disease; Real-Time Polymerase Chain Reaction; RNA, Messenger; Selegiline | 2013 |
Zoophilia and Parkinson's disease.
Topics: Antiparkinson Agents; Benserazide; Drug Combinations; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Sexual Dysfunctions, Psychological | 2013 |
A Bayesian approach to joint analysis of multivariate longitudinal data and parametric accelerated failure time.
Topics: Bayes Theorem; Computer Simulation; Disease Progression; Drug Therapy, Combination; Humans; Longitudinal Studies; Markov Chains; Models, Statistical; Monte Carlo Method; Multivariate Analysis; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline; Tocopherols | 2014 |
C-type natriuretic peptide in Parkinson's disease: reduced secretion and response to deprenyl.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Cognition Disorders; Female; Humans; Male; Middle Aged; Natriuretic Peptide, C-Type; Parkinson Disease; Retrospective Studies; Selegiline; Severity of Illness Index; Time Factors | 2014 |
Subclinical elevation of plasma C-reactive protein and illusions/hallucinations in subjects with Parkinson's disease: case-control study.
Topics: Amantadine; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Delusions; Dopamine Agents; Hallucinations; Humans; Illusions; Levodopa; Logistic Models; Multivariate Analysis; Parkinson Disease; Psychotic Disorders; Risk Factors; Selegiline; Surveys and Questionnaires | 2014 |
Development and evaluation of buccoadhesive tablet for selegiline hydrochloride based on thiolated polycarbophil.
Topics: Acrylic Resins; Administration, Buccal; Animals; Antiparkinson Agents; Cell Line; Chemistry, Pharmaceutical; Cysteine; Delayed-Action Preparations; Humans; Mice; Monoamine Oxidase Inhibitors; Oral Mucosal Absorption; Parkinson Disease; Selegiline; Tablets; Tensile Strength | 2014 |
Essential difference between the pharmacological spectrum of (-)-deprenyl and rasagiline.
Topics: Animals; Indans; Learning Disabilities; Levodopa; Male; Neurons; Parkinson Disease; Rats; Rats, Wistar; Selegiline; Tetrabenazine | 2014 |
Deuterium-substituted L-DOPA displays increased behavioral potency and dopamine output in an animal model of Parkinson's disease: comparison with the effects produced by L-DOPA and an MAO-B inhibitor.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Brain; Deuterium; Disease Models, Animal; Dopamine; Forelimb; Levodopa; Male; Microdialysis; Monoamine Oxidase Inhibitors; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Selegiline; Tyrosine 3-Monooxygenase | 2015 |
Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease.
Topics: Bayes Theorem; Clinical Trials as Topic; Computer Simulation; Humans; Longitudinal Studies; Models, Statistical; Multicenter Studies as Topic; Multivariate Analysis; Parkinson Disease; Selegiline; Survival Analysis; Tocopherols | 2014 |
Comparative efficacy of selegiline versus rasagiline in the treatment of early Parkinson's disease.
Topics: Antiparkinson Agents; Humans; Indans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2014 |
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.
Topics: alpha-Synuclein; Antiparkinson Agents; Humans; Indoles; Parkinson Disease; Protein Aggregation, Pathological; Protein Folding; Protein Stability; Protein Structure, Secondary; Selegiline; Synaptic Vesicles | 2014 |
[Neurological common diseases in the super-elder society. Topics: IV. Parkinson's disease; 2. Current and new drugs for initial treatment of Parkinson's disease].
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 2014 |
[Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report].
Topics: Aged; Benzothiazoles; Delayed-Action Preparations; Drug Substitution; Drug Therapy, Combination; Female; Fever; Humans; Levodopa; Movement Disorders; Parkinson Disease; Pramipexole; Selegiline | 2015 |
Autophagy-related protein expression in the substantia nigra and eldepryl intervention in rat models of Parkinson's disease.
Topics: Animals; Apoptosis Regulatory Proteins; Beclin-1; Disease Models, Animal; Insecticides; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Selegiline; Substantia Nigra; Time Factors | 2015 |
Prescribing pattern and resource utilization of monoamine oxidase-B inhibitors in Parkinson treatment: comparison between rasagiline and selegiline.
Topics: Aged; Antiparkinson Agents; Female; Health Care Costs; Hospitalization; Humans; Indans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Treatment Outcome | 2016 |
Robust Bayesian hierarchical model using normal/independent distributions.
Topics: Bayes Theorem; Biometry; Disease Progression; Humans; Longitudinal Studies; Models, Statistical; Normal Distribution; Parkinson Disease; Selegiline | 2016 |
Rotigotine in Combination with the MAO-B Inhibitor Selegiline in Early Parkinson's Disease: A Post Hoc Analysis.
Topics: Administration, Cutaneous; Adult; Aged; Antiparkinson Agents; Dopamine Agonists; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome | 2016 |
Treatment of Mild Camptocormia with Selegiline in Patients with Parkinson's Disease.
Topics: Aged; Antiparkinson Agents; Female; Humans; Male; Middle Aged; Muscular Atrophy, Spinal; Parkinson Disease; Selegiline; Spinal Curvatures; Treatment Outcome | 2016 |
Bradykinesia in early and advanced Parkinson's disease.
Topics: Aged; Biomechanical Phenomena; Case-Control Studies; Female; Humans; Hypokinesia; Male; Middle Aged; Neuroprotective Agents; Parkinson Disease; Selegiline; Severity of Illness Index | 2016 |
Design Expert(®) supported optimization and predictive analysis of selegiline nanoemulsion via the olfactory region with enhanced behavioural performance in Parkinson's disease.
Topics: Animals; Behavior, Animal; Emulsions; Nanostructures; Olfactory Bulb; Parkinson Disease; Rats; Rats, Wistar; Selegiline; Solubility | 2016 |
Effects of eldepryl on glial cell proliferation and activation in the substantia nigra and striatum in a rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; CD11b Antigen; Cell Proliferation; Corpus Striatum; Disease Models, Animal; Glial Fibrillary Acidic Protein; Male; Neuroglia; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra; Time Factors | 2017 |
Simultaneous determination of MAO-A and -B activity following first time intake of an irreversible MAO-B inhibitor in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Female; Humans; Indans; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Time Factors; Treatment Outcome | 2017 |
1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis Regulatory Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Herbicides; Humans; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phosphorylation; Proteins; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; Selegiline; Serine; Signal Transduction | 2008 |
Detection of levorotatory methamphetamine and levorotatory amphetamine in urine after ingestion of an overdose of selegiline.
Topics: Adult; Amphetamine; Biomarkers; Drug Overdose; Gas Chromatography-Mass Spectrometry; Humans; Male; Methamphetamine; Parkinson Disease; Selegiline; Suicide, Attempted | 2008 |
[Rasagiline in daily clinical use. Results of a treatment study of Parkinson patients with a combination treatment].
Topics: Adult; Aged; Aged, 80 and over; Catechol O-Methyltransferase; Drug Therapy, Combination; Female; Humans; Indans; Levodopa; Male; Middle Aged; Neuroprotective Agents; Parkinson Disease; Quality of Life; Selegiline; Treatment Outcome | 2008 |
Orally disintegrating selegiline for the treatment of Parkinson's disease.
Topics: Drug Tolerance; Humans; Integrative Medicine; Parkinson Disease; Selegiline; Treatment Outcome | 2008 |
Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.
Topics: Animals; Antiparkinson Agents; Biomarkers; Cell Survival; Female; Genomics; Indans; Nerve Growth Factors; Nerve Tissue Proteins; Neurogenesis; Neuroprotective Agents; Parkinson Disease; Proteomics; Rats; Rats, Wistar; Selegiline; Signal Transduction; Substantia Nigra | 2009 |
Selegiline shortage: Causes and costs of a generic drug shortage.
Topics: Antiparkinson Agents; Drug and Narcotic Control; Drug Costs; Drug Industry; Drugs, Generic; Health Services Accessibility; Humans; Parkinson Disease; Prescriptions; Selegiline | 2009 |
Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Corpus Striatum; Cytoprotection; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Pyrimidines; Receptor, Adenosine A2A; Selegiline; Triazoles; Up-Regulation | 2010 |
Incidence of and risk factors for cognitive impairment in an early Parkinson disease clinical trial cohort.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Antiparkinson Agents; Clinical Trials as Topic; Cognition Disorders; Female; Gastrointestinal Tract; Humans; Incidence; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Parkinson Disease; Risk Assessment; Risk Factors; Selection Bias; Selegiline; Tocopherols; United States; Urogenital System | 2009 |
[General anaesthesia for neurological diseases].
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Autonomic Nervous System; Brain; Bromocriptine; Dopamine Agonists; Humans; Intubation; Levodopa; Monoamine Oxidase Inhibitors; Muscle Relaxants, Central; Nervous System Diseases; Neurodegenerative Diseases; Neurosurgery; Parkinson Disease; Piperidines; Premedication; Preoperative Care; Propofol; Remifentanil; Selegiline; Stereotaxic Techniques; Syndrome | 2010 |
Clozapine for medication-related pathological gambling in Parkinson disease.
Topics: Adult; Antiparkinson Agents; Benzothiazoles; Cabergoline; Clozapine; Ergolines; Female; Gambling; Humans; Male; Middle Aged; Parkinson Disease; Pramipexole; Selegiline; Serotonin Antagonists | 2010 |
Slowing the decline.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Creatine; Humans; Indans; Parkinson Disease; Selegiline; Ubiquinone | 2010 |
Ring opening of pymisyl-protected aziridines with organocuprates.
Topics: Aziridines; Combinatorial Chemistry Techniques; Copper; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organometallic Compounds; Parkinson Disease; Selegiline; Stereoisomerism; Sulfhydryl Compounds; Sulfonamides | 2010 |
The fabulous neuroprotection of selegiline: memoir and prospectus.
Topics: Antiparkinson Agents; Forecasting; History, 20th Century; History, 21st Century; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2010 |
Selegiline use is associated with a slower progression in early Parkinson's disease as evaluated by Hoehn and Yahr Stage transition times.
Topics: Aged; Disability Evaluation; Disease Progression; Female; Humans; Longitudinal Studies; Male; Middle Aged; Neuroprotective Agents; Parkinson Disease; Proportional Hazards Models; Psychiatric Status Rating Scales; Selegiline | 2011 |
Orthostatic hypotension: a non-motor complication assessment in 82 patients with idiopathic Parkinson's disease in Phramongkutklao Hospital.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Blood Pressure; Cross-Sectional Studies; Female; Hospitals, Teaching; Humans; Hypotension, Orthostatic; Male; Middle Aged; Multivariate Analysis; Parkinson Disease; Polypharmacy; Posture; Risk Factors; Selegiline; Severity of Illness Index; Time Factors | 2010 |
MAO inhibitors.
Topics: Depression; Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2011 |
CSF xanthine, homovanillic acid, and their ratio as biomarkers of Parkinson's disease.
Topics: Adult; Age of Onset; Antiparkinson Agents; Biomarkers; Chromatography, High Pressure Liquid; Female; Homovanillic Acid; Humans; Male; Middle Aged; Parkinson Disease; Purines; Selegiline; Xanthine; Young Adult | 2011 |
Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.
Topics: Antioxidants; Cholesterol; Disease Progression; Endpoint Determination; Female; Humans; Male; Middle Aged; Parkinson Disease; Proportional Hazards Models; Randomized Controlled Trials as Topic; Selegiline; Tocopherols | 2011 |
Progression of motor and nonmotor features of Parkinson's disease and their response to treatment.
Topics: Antiparkinson Agents; Cognition Disorders; Depression; Disability Evaluation; Disease Progression; Drug Substitution; Drug Therapy, Combination; Gait Disorders, Neurologic; Humans; Hypokinesia; Linear Models; Motor Activity; Nonlinear Dynamics; Parkinson Disease; Patient Dropouts; Postural Balance; Predictive Value of Tests; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Retrospective Studies; Selegiline; Sensation Disorders; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Tocopherols; Treatment Outcome; Tremor | 2012 |
8-Substituted 3-arylcoumarins as potent and selective MAO-B inhibitors: synthesis, pharmacological evaluation, and docking studies.
Topics: Alzheimer Disease; Coumarins; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Binding; Protein Isoforms; Selegiline; Solutions | 2012 |
Disease progress and response to treatment as predictors of survival, disability, cognitive impairment and depression in Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Chi-Square Distribution; Cognition; Cognition Disorders; Depression; Disability Evaluation; Disease Progression; Humans; Kaplan-Meier Estimate; Middle Aged; Parkinson Disease; Patient Dropouts; Predictive Value of Tests; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Risk Factors; Selegiline; Severity of Illness Index; Time Factors; Tocopherols; Treatment Outcome | 2012 |
Cerebral blood flow and freezing of gait in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Cerebrovascular Circulation; Disability Evaluation; Drug Therapy, Combination; Female; Gait Disorders, Neurologic; Humans; Iofetamine; Levodopa; Male; Mental Status Schedule; Middle Aged; Parkinson Disease; Radiopharmaceuticals; Selegiline; Tomography, Emission-Computed, Single-Photon | 2012 |
Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease.
Topics: Adult; Aged; Antiparkinson Agents; Deep Brain Stimulation; Female; Humans; Levodopa; Male; Middle Aged; Movement; Parkinson Disease; Precision Medicine; Selegiline; Subthalamic Nucleus; Treatment Outcome | 2012 |
Pramipexole-related chronic lower limb oedema in a patient with Parkinson's disease.
Topics: Ankle; Antiparkinson Agents; Benserazide; Benzothiazoles; Drug Therapy, Combination; Edema; Humans; Levodopa; Lower Extremity; Male; Middle Aged; Parkinson Disease; Pramipexole; Selegiline | 2012 |
Retention rate of selegiline in early Parkinson's disease: a retrospective survey.
Topics: Antiparkinson Agents; Humans; Medication Adherence; Middle Aged; Parkinson Disease; Retrospective Studies; Selegiline | 2012 |
Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease.
Topics: Aged; Amphetamine; Antiparkinson Agents; Drug Substitution; Female; Humans; Indans; Male; Methamphetamine; Middle Aged; Motor Activity; Neuroprotective Agents; Parkinson Disease; Selegiline; Severity of Illness Index; Time Factors | 2013 |
Selegiline: a second look. Six years later: too risky in Parkinson's disease.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Therapy, Combination; France; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Randomized Controlled Trials as Topic; Retrospective Studies; Selegiline; Treatment Outcome | 2002 |
The multiple actions of selegiline.
Topics: Animals; Antiparkinson Agents; Cells, Cultured; Dopamine; Female; Glutamic Acid; Mesencephalon; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Selegiline | 2002 |
[Long-term treatment of Parkinson's disease patients with selegiline hydrochloride (FPF 1100): outcome of 5-year treatment].
Topics: Aged; Female; Humans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Treatment Outcome | 2002 |
Neuroprotection for Parkinson's disease: prospects and promises.
Topics: Amphetamines; Clinical Trials as Topic; Glial Cell Line-Derived Neurotrophic Factor; Humans; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2003 |
A pharmacological analysis elucidating why, in contrast to (-)-deprenyl (selegiline), alpha-tocopherol was ineffective in the DATATOP study.
Topics: alpha-Tocopherol; Animals; Benzofurans; Brain; Dopamine; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Parkinson Disease; Rats; Rats, Wistar; Selegiline; Treatment Failure | 2003 |
Monoamine oxidase inhibitors--is it time to up the TEMPO?
Topics: Antiparkinson Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Indans; Levodopa; Monoamine Oxidase Inhibitors; Neurologic Examination; Parkinson Disease; Selegiline; Treatment Outcome | 2003 |
[Therapy for patients with early-stage Parkinson's disease].
Topics: Amantadine; Animals; Antiparkinson Agents; Bromocriptine; Dopamine Agonists; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Practice Guidelines as Topic; Selegiline; Trihexyphenidyl | 2003 |
Sublingual selegiline: new formulation. New formulation: new risk of oral adverse effects.
Topics: Administration, Sublingual; Antiparkinson Agents; Clinical Trials as Topic; Humans; Oral Ulcer; Parkinson Disease; Selegiline | 2003 |
Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus.
Topics: Animals; Disease Models, Animal; Dopamine; Encephalitis Virus, Japanese; Hypokinesia; Isatin; Mice; Monoamine Oxidase Inhibitors; Parkinson Disease; Rats; Selegiline | 2004 |
Therapeutic factors causing hallucination in Parkinson's disease patients, especially those given selegiline.
Topics: Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Female; Hallucinations; Humans; Male; Middle Aged; Parkinson Disease; Retrospective Studies; Selegiline; Statistics, Nonparametric | 2004 |
Subthalamic deep brain stimulation masking possible malignant syndrome in Parkinson disease.
Topics: Analgesics, Non-Narcotic; Anti-Infective Agents; Antiparkinson Agents; Combined Modality Therapy; Consciousness Disorders; Dantrolene; Deep Brain Stimulation; Diagnosis, Differential; Diagnostic Errors; Dystonic Disorders; Encephalitis; Female; Fluid Therapy; Foot; Humans; Levodopa; Malignant Hyperthermia; Middle Aged; Muscle Relaxants, Central; Parkinson Disease; Selegiline; Substance Withdrawal Syndrome; Tachycardia | 2004 |
Levodopa-responsive parkinsonism in hereditary spastic paraplegia with thin corpus callosum.
Topics: Adolescent; Antiparkinson Agents; Benztropine; Cognition Disorders; Corpus Callosum; Electroencephalography; Female; Gait Disorders, Neurologic; Humans; Levodopa; Magnetic Resonance Imaging; Male; Muscle Weakness; Neuropsychological Tests; Parkinson Disease; Selegiline; Spastic Paraplegia, Hereditary; Tremor | 2004 |
Indolalkylamines derivatives as antioxidant and neuroprotective agents in an experimental model of Parkinson's disease.
Topics: Animals; Antioxidants; Antiparkinson Agents; Brain; Brain Chemistry; Cell Line, Tumor; Dopamine; Dose-Response Relationship, Drug; Humans; Indoles; Melanins; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Selegiline; Tryptamines | 2004 |
Survival in Parkinson disease: thirteen-year follow-up of the DATATOP cohort.
Topics: Cohort Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Levodopa; Likelihood Functions; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Parkinson Disease; Predictive Value of Tests; Proportional Hazards Models; Randomized Controlled Trials as Topic; Selegiline; Survival Analysis; Time; Tocopherols | 2005 |
"Levodopa phobia": a new iatrogenic cause of disability in Parkinson disease.
Topics: Aged; Amantadine; Benzothiazoles; Catechols; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Humans; Iatrogenic Disease; Indoles; Levodopa; Male; Middle Aged; Neurology; Neuropharmacology; Neurotoxicity Syndromes; Nitriles; Parkinson Disease; Pramipexole; Selegiline; Thiazoles; Treatment Outcome | 2005 |
Administration of selegiline is not associated with visual hallucinations in advanced Parkinson's disease patients.
Topics: Antiparkinson Agents; Hallucinations; Humans; Parkinson Disease; Selegiline | 2005 |
Reexamination of the TEMPO Study.
Topics: Antioxidants; Antiparkinson Agents; Artifacts; Drug Interactions; Humans; Indans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Patient Selection; Randomized Controlled Trials as Topic; Research Design; Selegiline; Treatment Outcome | 2005 |
Rasagiline.
Topics: Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Industry; Humans; Indans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Treatment Outcome | 2005 |
Neuroprotection by pharmacologic blockade of the GAPDH death cascade.
Topics: Animals; Antiparkinson Agents; Apoptosis; Cell Line; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; In Vitro Techniques; Male; Mice; MPTP Poisoning; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide; Nuclear Proteins; Oxepins; Parkinson Disease; Selegiline; Ubiquitin-Protein Ligases | 2006 |
Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments.
Topics: Algorithms; Antiparkinson Agents; Bayes Theorem; Bromocriptine; Disease Progression; Dopamine Agonists; Drug Therapy, Combination; Humans; Levodopa; Models, Biological; Parkinson Disease; Pergolide; Randomized Controlled Trials as Topic; Selegiline; Treatment Outcome | 2006 |
Initial pharmacotherapy in a population of veterans with Parkinson disease.
Topics: Age Factors; Aged; Aged, 80 and over; Amantadine; Antiparkinson Agents; Cholinergic Antagonists; Databases, Factual; Dementia; Dopamine Agonists; Drug Prescriptions; Drug Utilization; Geriatrics; Humans; Levodopa; Male; Medicine; Middle Aged; Neurology; Northwestern United States; Parkinson Disease; Practice Patterns, Physicians'; Primary Health Care; Psychiatry; Psychology; Retrospective Studies; Selegiline; Specialization; United States; United States Department of Veterans Affairs; Veterans | 2006 |
Rationale for considering that propargylamines might be neuroprotective in Parkinson's disease.
Topics: Clinical Trials as Topic; Evidence-Based Medicine; Humans; Indans; Neuroprotective Agents; Pargyline; Parkinson Disease; Practice Guidelines as Topic; Practice Patterns, Physicians'; Propylamines; Selegiline; Treatment Outcome | 2006 |
Hypersexuality and paraphilia induced by selegiline in Parkinson's disease: report of 2 cases.
Topics: Antiparkinson Agents; Compulsive Behavior; Erotica; Humans; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Personality Disorders; Psychiatric Status Rating Scales; Selegiline; Sexual Dysfunctions, Psychological | 2006 |
Transdermal selegiline (Emsam).
Topics: Administration, Cutaneous; Antiparkinson Agents; Clinical Trials as Topic; Depressive Disorder, Major; Double-Blind Method; Drug Interactions; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2006 |
High-performance liquid chromatographic-mass spectrometric determination of methamphetamine and amphetamine enantiomers, desmethylselegiline and selegiline, in hair samples of long-term methamphetamine abusers or selegiline users.
Topics: Amphetamine; Amphetamines; Antiparkinson Agents; Chromatography, High Pressure Liquid; Hair; Humans; Methamphetamine; Parkinson Disease; Selegiline; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2006 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antiparkinson Agents; Antiviral Agents; Anxiety; Carbidopa; Ceftriaxone; Cervical Vertebrae; Depression; Dexamethasone; Diazepam; Doxepin; Electroconvulsive Therapy; Humans; Levodopa; Male; Middle Aged; Neuroleptic Malignant Syndrome; Oxycodone; Pain; Parkinson Disease; Selegiline; Spinal Injuries | 2006 |
Low plasma uric acid level in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Body Mass Index; Energy Intake; Female; Ferritins; Humans; Levodopa; Male; Mass Screening; Middle Aged; Parkinson Disease; Plasma; Risk Factors; Selegiline; Spouses; Uric Acid | 2007 |
Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs.
Topics: Acid-Base Equilibrium; Acids; Alzheimer Disease; Amantadine; Animals; Brain; Brain Chemistry; Brain Diseases; Cell Line, Tumor; Clorgyline; Endocytosis; Exocytosis; Hydrogen-Ion Concentration; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organelles; Pargyline; Parkinson Disease; Protons; Selegiline; Signal Transduction; Transport Vesicles | 2009 |
Rasagiline as a therapy for Parkinson's disease (PD).
Topics: Drug Interactions; Humans; Indans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2007 |
Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.
Topics: Alkynes; Cell Death; Cell Line, Tumor; Energy Metabolism; Genetic Markers; Glial Cell Line-Derived Neurotrophic Factor; Humans; Indans; Membrane Potentials; Mitochondria; Neuroblastoma; Neuroprotective Agents; NF-kappa B; Oligonucleotide Array Sequence Analysis; Pargyline; Parkinson Disease; Propylamines; Proto-Oncogene Proteins c-bcl-2; Selegiline | 2007 |
Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial.
Topics: Activities of Daily Living; Aged; Canada; Cognition Disorders; Cohort Studies; Depressive Disorder; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Parkinson Disease; Predictive Value of Tests; Psychological Tests; Quality of Life; Randomized Controlled Trials as Topic; Retrospective Studies; Selegiline; Tocopherols; United States | 2008 |
Multiple medication use presenting as Parkinson's dementia complex: a message from Titanic.
Topics: Aged; Anti-Infective Agents; Antiparkinson Agents; Antipsychotic Agents; Bacteriuria; Ciprofloxacin; Dementia; Drug Interactions; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Fluoxetine; Haloperidol; Hospitalization; Humans; Hypnotics and Sedatives; Lorazepam; Parkinson Disease; Psychomotor Agitation; Selegiline; Trihexyphenidyl | 2008 |
[The use of Stalevo in Hungary for patients with Parkinson disease and its effect on the quality of life].
Topics: Adult; Aged; Amantadine; Antiparkinson Agents; Carbidopa; Catechols; Cholinergic Antagonists; Dopamine Agonists; Drug Combinations; Female; Humans; Hungary; Levodopa; Male; Middle Aged; Parkinson Disease; Quality of Life; Selegiline; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2008 |
Deprenyl in Parkinson's disease.
Topics: Carboxy-Lyases; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Phenethylamines; Selegiline | 1982 |
Treatment of Parkinson's disease with agents other than levodopa and dopamine agonists: controversies and new approaches.
Topics: Adrenergic beta-Antagonists; Amantadine; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Dopamine; Dopamine Antagonists; Humans; Lithium; Neurology; Parasympatholytics; Parasympathomimetics; Parkinson Disease; Selegiline; Serotonin; Sympathomimetics | 1984 |
Neurochemical insights into monoamine oxidase inhibitors, with special reference to deprenyl (selegiline).
Topics: Aged; Aging; Alzheimer Disease; Brain; Central Nervous System; Female; Humans; Huntington Disease; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Agents; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence.
Topics: Animals; Brain; Catalase; Catecholamines; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Levodopa; Monoamine Oxidase; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Selegiline; Superoxide Dismutase; Superoxides | 1983 |
Combination treatment with selective monoamine oxidase inhibitors and dopaminergic agonists in Parkinson's disease: biochemical and clinical observations.
Topics: Bromocriptine; Dopamine; Drug Therapy, Combination; Humans; Lisuride; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Tranylcypromine | 1983 |
(-)-Deprenyl leads to prolongation of L-dopa efficacy in Parkinson's disease.
Topics: Aged; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
[The use of L-deprenyl in Parkinson's disease].
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Deprenyl prolongs the therapeutic efficacy of combined L-DOPA in Parkinson's disease.
Topics: Animals; Brain Chemistry; Dextroamphetamine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Parkinson Disease; Phenethylamines; Selegiline; Stereotyped Behavior | 1984 |
Adjuvant drugs in the treatment of on-off phenomena in Parkinson's disease.
Topics: Benzamides; Bromocriptine; Carboxy-Lyases; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Phenethylamines; Selegiline; Tiapamil Hydrochloride | 1984 |
Long-term effects of L-deprenyl in chronic levodopa treated parkinsonian patients.
Topics: Aged; Disability Evaluation; Drug Therapy, Combination; Humans; Levodopa; Long-Term Care; Middle Aged; Motor Skills; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
L-deprenyl in the treatment of Parkinson's disease.
Topics: Aged; Benserazide; Disability Evaluation; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Motor Skills; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Deprenyl in the treatment of Parkinson's disease. A specific type B monoamine oxidase inhibitor.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1984 |
Why another anti-Parkinson drug?
Topics: Aged; Antiparkinson Agents; Humans; Parkinson Disease; Phenethylamines; Selegiline | 1984 |
A new approach to the treatment of Parkinson's disease. Symposium, Turku, Finland, May 27, 1983.
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Deprenyl (selegiline) in the treatment of Parkinson's disease.
Topics: Dopamine; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Outcome and Process Assessment, Health Care; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Deprenyl (selegiline) in the treatment of Parkinson's disease.
Topics: Aged; Drug Evaluation; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Time Factors | 1983 |
Clinical and pharmacological problems of deprenyl (selegiline) treatment in Parkinson's disease.
Topics: Amphetamine; Humans; Hydrogen-Ion Concentration; Methamphetamine; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Clinical evaluation of deprenyl (selegiline) in the treatment of Parkinson's disease.
Topics: Aged; Benserazide; Disability Evaluation; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Deprenyl (selegiline) in combination treatment of Parkinson's disease.
Topics: Aged; Benserazide; Carbidopa; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
The effect of deprenyl (selegiline) on cognition and emotion in parkinsonian patients undergoing long-term levodopa treatment.
Topics: Aged; Arousal; Behavior; Cognition; Drug Therapy, Combination; Emotions; Female; Humans; Levodopa; Male; Memory; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Time Factors | 1983 |
Monoamine oxidase inhibitors and their pharmacological significance.
Topics: Animals; Antidepressive Agents; Brain; Clorgyline; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Rats; Selegiline; Tyramine | 1983 |
Deprenyl (selegiline): the history of its development and pharmacological action.
Topics: Aging; Animals; Brain; Depression; Dopamine; Drug Evaluation; History, 20th Century; Humans; Male; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Sexual Behavior | 1983 |
Dose regimen of deprenyl (selegiline) and platelet MAO activities.
Topics: Blood Platelets; Dose-Response Relationship, Drug; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Selegiline | 1983 |
Treatment of Parkinson's disease in early and late phases. Use of pharmacological agents with special reference to deprenyl (selegiline).
Topics: Drug Therapy, Combination; Humans; Levodopa; Outcome and Process Assessment, Health Care; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Selegiline; Time Factors | 1983 |
Deprenyl is a selective inhibitor of brain MAO-B in the long-term treatment of Parkinsons's disease.
Topics: Aged; Brain Chemistry; Dopamine; Humans; Levodopa; Male; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Parkinson Disease; Phenethylamines; Selegiline; Serotonin | 1980 |
Presynaptic neuron and postsynaptic dopamine receptor function in long term treatment of Parkinson's disease: a neuroendocrine study.
Topics: Aged; Apomorphine; Benserazide; Bromocriptine; Carbidopa; Female; Humans; Levodopa; Male; Middle Aged; Nomifensine; Parkinson Disease; Prolactin; Receptors, Dopamine; Selegiline; Tremor | 1980 |
Biochemical characterization of the active site of brain monoamine oxidase.
Topics: Antidepressive Agents; Binding Sites; Brain; Clorgyline; Humans; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Binding; Selegiline; Substrate Specificity; Tissue Distribution | 1980 |
Deprenyl does not cause insomnia in parkinsonian patients.
Topics: Aged; Electroencephalography; Humans; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Sleep; Sleep Initiation and Maintenance Disorders | 1980 |
Deprenyl in Parkinson disease.
Topics: False Negative Reactions; Humans; Parkinson Disease; Phenethylamines; Selegiline | 1981 |
Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: a biochemical assessment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Amphetamines; Biogenic Amines; Carbidopa; Depression; Drug Combinations; Female; Humans; Levodopa; Male; Methamphetamine; Middle Aged; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Tyramine | 1982 |
The contribution of amphetamine metabolites of (-)-deprenyl to its antiparkinsonian properties.
Topics: Amphetamine; Double-Blind Method; Drug Therapy, Combination; Humans; Hydrogen-Ion Concentration; Levodopa; Methamphetamine; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1982 |
(-)Deprenyl in the treatment of Parkinson's disease.
Topics: 5-Hydroxytryptophan; Brain; Dopamine; Drug Synergism; Drug Therapy, Combination; Humans; Levodopa; Long-Term Care; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Serotonin | 1982 |
[Initiation of treatment in Parkinson disease].
Topics: Adult; Age Factors; Aged; Amantadine; Antiparkinson Agents; Dopamine Agonists; Humans; Levodopa; Middle Aged; Parkinson Disease; Selegiline | 1995 |
Treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Bromocriptine; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Pergolide; Prognosis; Selegiline | 1995 |
Clinical and [18F] dopa PET findings in early Parkinson's disease.
Topics: Antiparkinson Agents; Case-Control Studies; Dihydroxyphenylalanine; Discriminant Analysis; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Parkinson Disease; Predictive Value of Tests; Putamen; Selegiline; Severity of Illness Index; Time Factors; Tomography, Emission-Computed | 1995 |
Influence of selective inhibition of monoamine oxidase A or B on striatal metabolism of L-DOPA in hemiparkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Indans; Levodopa; Male; Monoamine Oxidase Inhibitors; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra | 1995 |
Selegiline, fluoxetine, and depression in Parkinson's disease.
Topics: Aged; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluoxetine; Humans; Parkinson Disease; Selegiline | 1995 |
Effect of disease and drug treatment on blood serotonin and monoamine oxidase B activity in Parkinson's disease.
Topics: Adult; Aged; Amantadine; Blood Platelets; Bromocriptine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Selegiline; Serotonin; Treatment Outcome | 1995 |
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats.
Topics: Amantadine; Animals; Bromocriptine; Dopamine; Drug Synergism; Levodopa; Male; Memantine; Motor Activity; N-Methylaspartate; Parkinson Disease; Rats; Rats, Wistar; Selegiline | 1994 |
[Pseudopheochromocytoma in a parkinsonian patient treated with selegiline].
Topics: Aged; Diagnosis, Differential; Female; Humans; Parkinson Disease; Pheochromocytoma; Selegiline | 1995 |
Parkinson's disease.
Topics: Apomorphine; Brain; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 1995 |
Role of selegiline as initial monotherapy in early Parkinson's disease.
Topics: Activities of Daily Living; Drug Tolerance; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Motor Activity; Parkinson Disease; Safety; Selegiline; Time Factors; Tremor | 1994 |
1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol inhibits tyrosine hydroxylase activity in rat striatal synaptosomes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dopamine; Isoquinolines; Monoamine Oxidase; NAD; Nerve Tissue Proteins; Nomifensine; Parkinson Disease; Rats; Selegiline; Sulpiride; Synaptosomes; Tyrosine 3-Monooxygenase | 1994 |
Parkinson's disease: reorganization of the reach to grasp movement in response to perturbation of the distal motor patterning.
Topics: Aged; Antiparkinson Agents; Attention; Carbidopa; Drug Combinations; Female; Hand Strength; Humans; Kinesthesis; Levodopa; Male; Middle Aged; Motor Skills; Neurologic Examination; Orientation; Parkinson Disease; Psychomotor Performance; Reaction Time; Selegiline; Size Perception | 1994 |
Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline.
Topics: Bronchial Spasm; Bronchitis; Depressive Disorder; Diagnosis, Differential; Drug Interactions; Ephedrine; Epinephrine; Humans; Hypertension; Male; Maprotiline; Middle Aged; Norepinephrine; Parkinson Disease; Pheochromocytoma; Selegiline | 1995 |
[Bromocriptine-induced pleuropneumopathy].
Topics: Benserazide; Biperiden; Bromocriptine; Humans; Levodopa; Lung Diseases; Male; Middle Aged; Parkinson Disease; Pleural Effusion; Pulmonary Atelectasis; Pulmonary Fibrosis; Radiography; Selegiline; Time Factors | 1994 |
Pseudophaeochromocytoma in parkinsonian patient treated with fluoxetine plus selegiline.
Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Diagnosis, Differential; Drug Interactions; Female; Fluoxetine; Humans; Hypertension; Parkinson Disease; Pheochromocytoma; Selegiline | 1993 |
Drugs for Parkinson's disease.
Topics: Carbidopa; Dopamine Agents; Drug Combinations; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Selegiline | 1993 |
Neuropsychological correlates of L-deprenyl therapy in idiopathic parkinsonism.
Topics: Aged; Attention; Female; Frontal Lobe; Humans; Language; Learning; Levodopa; Male; Memory; Middle Aged; Neuropsychological Tests; Parkinson Disease; Selegiline; Space Perception; Verbal Learning | 1994 |
Does selegiline delay progression of Parkinson's disease? A critical re-evaluation of the DATATOP study.
Topics: Humans; Parkinson Disease; Research Design; Selegiline; Time Factors; Treatment Outcome | 1994 |
Hypoglycemia caused by selegiline, an antiparkinsonian drug: can such side effects be predicted?
Topics: Aged; Computer Simulation; DNA; Glucose; Humans; Hypoglycemia; Insulin; Male; Monoamine Oxidase Inhibitors; Nucleic Acid Conformation; Parkinson Disease; Selegiline | 1994 |
Deprenyl and the issue of neuroprotection.
Topics: Antioxidants; Cell Survival; Clinical Trials as Topic; Disability Evaluation; Drug Administration Schedule; Humans; Levodopa; Neurons; Parkinson Disease; Selegiline; Substantia Nigra; Vitamin E | 1994 |
Is it safe to combine a selective serotonin reuptake inhibitor with selegiline?
Topics: 1-Naphthylamine; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Parkinson Disease; Paroxetine; Selective Serotonin Reuptake Inhibitors; Selegiline; Sertraline | 1994 |
Antiparkinson efficacy of deprenyl. DATATOP Steering Committee of Parkinson Study Group.
Topics: Humans; Parkinson Disease; Placebos; Proportional Hazards Models; Selegiline; Survival Analysis | 1993 |
Disturbance of colour perception in Parkinson's disease.
Topics: Adult; Aged; Color Perception; Color Perception Tests; Computers; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1993 |
Selegiline.
Topics: Humans; Parkinson Disease; Selegiline | 1993 |
[Parkinson disease: unusual treatments and perspectives].
Topics: Fetal Tissue Transplantation; Humans; Neurons; Parkinson Disease; Selegiline | 1993 |
Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line.
Topics: Ascorbic Acid; Brain; Brain Neoplasms; Catecholamines; Cell Line; Drug Interactions; Female; Humans; Levodopa; Male; Neuroblastoma; Parkinson Disease; Quinones; Selegiline | 1993 |
Treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Costs and Cost Analysis; Dementia; Humans; Parkinson Disease; Physical Therapy Modalities; Selegiline | 1993 |
New mechanisms of action of irreversible monoamine oxidase type B inhibitors.
Topics: Brain; Central Nervous System Diseases; Dopamine; Female; Gene Expression; Humans; Levodopa; Male; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1993 |
Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327.
Topics: Aged; Antiparkinson Agents; Brain; Carbon Radioisotopes; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Picolinic Acids; Reference Values; Selegiline; Tomography, Emission-Computed | 1993 |
End-of-dose dystonia in Parkinson's disease.
Topics: Adult; Carbidopa; Dystonia; Humans; Infusions, Intravenous; Levodopa; Middle Aged; Parkinson Disease; Selegiline; Substance Withdrawal Syndrome | 1993 |
Protective effect of selegiline in the early and late phases of Parkinson's disease.
Topics: Age Factors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Levodopa; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline | 1993 |
Short-term beneficial effect of deprenyl monotherapy in early Parkinson's disease: a quantitative assessment.
Topics: Aged; Female; Humans; Male; Middle Aged; Muscle Contraction; Parkinson Disease; Reaction Time; Selegiline; Time Factors | 1993 |
When selegiline is prescribed, Stelazine may be mistakenly dispensed.
Topics: Drug Prescriptions; Humans; Medication Errors; Parkinson Disease; Selegiline; Trifluoperazine | 1993 |
Slowing of information processing in Parkinson's disease.
Topics: Aged; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Levodopa; Lisuride; Male; Mental Processes; Middle Aged; Neuropsychological Tests; Parkinson Disease; Problem Solving; Reaction Time; Selegiline; Thinking | 1993 |
Effect of selegiline on speech performance in Parkinson's disease.
Topics: Aged; Articulation Disorders; Humans; Male; Middle Aged; Parkinson Disease; Phonation; Pulmonary Ventilation; Selegiline; Speech Disorders; Speech Intelligibility; Speech Production Measurement | 1993 |
Protective effect or symptomatic effect of deprenyl?
Topics: Free Radicals; Humans; Lipid Peroxidation; Parkinson Disease; Selegiline | 1993 |
Speech dysfunction in early Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Articulation Disorders; Dysarthria; Humans; Middle Aged; Parkinson Disease; Selegiline; Severity of Illness Index; Voice Disorders | 1995 |
No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antiparkinson Agents; Brain; Cabergoline; Carbidopa; Diabetes Mellitus; Ergolines; Female; Free Radicals; Humans; Levodopa; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Parkinson Disease; Selegiline; Vitamin E | 1995 |
Selegiline in Parkinson's disease.
Topics: Antiparkinson Agents; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline; Treatment Failure; United Kingdom | 1995 |
Failure of dopamine metabolism: borderlines of parkinsonism and dementia.
Topics: Antiparkinson Agents; Brain; Chronic Disease; Dementia; Dopamine; Humans; Neuropsychological Tests; Organotechnetium Compounds; Oximes; Parkinson Disease; Selegiline; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1995 |
Novel sites of action for deprenyl in MPTP-parkinsonism: metabolite-mediated protection against striatal neurotoxicity and suppression of MPTP-induced increase of dopamine turnover in C57BL mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease; Parkinson Disease, Secondary; Selegiline; Time Factors | 1995 |
A 61-year-old man with Parkinson's disease.
Topics: 1-Naphthylamine; Antiparkinson Agents; Carbidopa; Depression; Dopamine Agents; Drug Interactions; Drug Therapy, Combination; Family Practice; Humans; Levodopa; Male; Middle Aged; Neurology; Neuroprotective Agents; Parkinson Disease; Selegiline; Sertraline; Vitamin E | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Other studies have not shown increased mortality.
Topics: Antiparkinson Agents; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Meta-Analysis as Topic; Parkinson Disease; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Stopping selegeline may lead to problems for patients.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Patients taking selegeline may have received more levodopa than necessary.
Topics: Antiparkinson Agents; Double-Blind Method; Levodopa; Parkinson Disease; Prospective Studies; Randomized Controlled Trials as Topic; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Parkinson's disease is rarely a primary cause of death.
Topics: Antiparkinson Agents; Cause of Death; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Selegeline is effective and safe in early stages.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Selegeline may be toxic in presence of increased dopamine concentrations.
Topics: Antiparkinson Agents; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. "On treatment" rather than intention to treat analysis should have been used.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Research Design; Selegiline | 1996 |
Effect of adding selegeline to levodopa in early, mild Parkinson's disease. Causes of death need confirmation.
Topics: Antiparkinson Agents; Cardiovascular Diseases; Cause of Death; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Selegiline and lymphocyte superoxide dismutase activities in Parkinson's disease.
Topics: Antiparkinson Agents; Brain; Cytosol; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lymphocytes; Male; Middle Aged; Mitochondria; Parkinson Disease; Proteins; Selegiline; Superoxide Dismutase | 1996 |
Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Cells, Cultured; Cerebrospinal Fluid; Culture Media; Dopamine; Female; Humans; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Selegiline | 1995 |
Levodopa and deprenyl treatment effects on peripheral indices of oxidant stress in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Aged, 80 and over; Cysteinyldopa; Humans; Levodopa; Malondialdehyde; Methoxyhydroxyphenylglycol; Middle Aged; Oxidative Stress; Parkinson Disease; Selegiline | 1996 |
Parkinson's disease: consider pallidotomy as a therapeutic option.
Topics: Globus Pallidus; Humans; Parkinson Disease; Selegiline; Stereotaxic Techniques; Treatment Outcome | 1996 |
A 61-year-old man with Parkinson's disease.
Topics: 1-Naphthylamine; Antidepressive Agents; Antiparkinson Agents; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Parkinson Disease; Selective Serotonin Reuptake Inhibitors; Selegiline; Sertraline | 1996 |
[Daily defined doses of parkinsonian drugs in Alcoi].
Topics: Antiparkinson Agents; Dose-Response Relationship, Drug; Drug Utilization; Humans; Levodopa; Parkinson Disease; Selegiline; Spain | 1996 |
Delayed development of symptomatic improvement by (--)-deprenyl in Parkinson's disease.
Topics: Aged; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Time Factors | 1995 |
Plasma levels of the beta-carbolines harman and norharman in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Carbolines; Female; Humans; Levodopa; Male; Middle Aged; Mitochondria; Parkinson Disease; Selegiline | 1995 |
[Levodopa+selegiline combination and increase of risk of mortality in the treatment of Parkinson disease].
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Risk Factors; Selegiline | 1996 |
Deprenyl's neuroprotective action remains unresolved.
Topics: Antiparkinson Agents; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
Deprenyl and levodopa and Parkinson's disease progression.
Topics: Antiparkinson Agents; Humans; Levodopa; Monoamine Oxidase; Parkinson Disease; Selegiline | 1996 |
Deprenyl in Parkinson's disease.
Topics: Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1996 |
[The efficacy of the Umex treatment of parkinsonism patients in the initial stage of the disease].
Topics: Adult; Aged; Antiparkinson Agents; Chronic Disease; Dihydroxyphenylalanine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Parkinson Disease; Selegiline | 1995 |
Sensitive high-performance liquid chromatographic method for the determination of 2-phenylethylamine in human urine.
Topics: Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Circadian Rhythm; Female; Humans; Indicators and Reagents; Linear Models; Male; Middle Aged; Monoamine Oxidase Inhibitors; o-Phthalaldehyde; Parkinson Disease; Phenethylamines; Psychotropic Drugs; Reproducibility of Results; Selegiline; Sensitivity and Specificity; Spectrometry, Fluorescence | 1996 |
Multi-centre trials: U-turns by bandwagons and the patient left by the wayside.
Topics: Antiparkinson Agents; Humans; Multicenter Studies as Topic; Parkinson Disease; Selegiline | 1996 |
Pallidotomy in Parkinson's disease.
Topics: Antiparkinson Agents; Basal Ganglia; Dopamine Agonists; Globus Pallidus; Humans; Levodopa; Motor Skills; Neurons; Parkinson Disease; Patient Selection; Selegiline | 1996 |
Study design problems of DATATOP study analysis.
Topics: Clinical Trials as Topic; Humans; Levodopa; Parkinson Disease; Placebos; Randomized Controlled Trials as Topic; Selegiline; Vitamin E | 1996 |
[Somatosensory evoked potentials and symptomatic response to dopaminergic drugs in Parkinson's disease].
Topics: Adult; Aged; Apomorphine; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Frontal Lobe; Humans; Levodopa; Male; Median Nerve; Middle Aged; Motor Skills; Parietal Lobe; Parkinson Disease; Reaction Time; Selegiline; Walking | 1996 |
Selegiline and mortality in Parkinson's disease: another view.
Topics: Humans; Parkinson Disease; Selegiline | 1997 |
Current therapy of Parkinson's disease.
Topics: Amantadine; Antiparkinson Agents; Cholinergic Antagonists; Humans; Levodopa; Parkinson Disease; Patient Selection; Selegiline | 1997 |
Deprenyl--past and future. Proceedings of a symposium. Lake Starnberg, Bavaria, 1995.
Topics: Antiparkinson Agents; Humans; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Selegiline | 1996 |
Gallium-transferrin binding in treated and untreated Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antiparkinson Agents; Drug Therapy, Combination; Gallium; Humans; Levodopa; Middle Aged; Parkinson Disease; Protein Binding; Selegiline; Transferrin | 1997 |
Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson's disease. Parkinson Study Group.
Topics: Aged; Antidepressive Agents; Antiparkinson Agents; Central Nervous System Diseases; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Serotonin; Syndrome | 1997 |
Treatment of Parkinson's disease: disagreements.
Topics: Disease Progression; Humans; Levodopa; Parkinson Disease; Selegiline | 1997 |
Deprenyl, excess mortality, and epidemiological traps.
Topics: Age Factors; Aged; Aged, 80 and over; Antiparkinson Agents; Humans; Male; Middle Aged; Parkinson Disease; Selegiline | 1997 |
An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Carcinogens; Catalase; Cycloheximide; DNA Damage; Dopamine; Free Radicals; Humans; Microscopy, Fluorescence; Neuroblastoma; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Protein Synthesis Inhibitors; Salsoline Alkaloids; Selegiline; Semicarbazides; Stereoisomerism; Tetrahydroisoquinolines; Tumor Cells, Cultured | 1997 |
Monoamine oxidase inhibitors and cardiac anesthesia revisited.
Topics: Aged; Anesthetics, General; Antiparkinson Agents; Coronary Artery Bypass; Drug Interactions; Hemodynamics; Humans; Male; Monoamine Oxidase Inhibitors; Narcotics; Parkinson Disease; Selegiline | 1997 |
Unexpected findings of study of selegiline have not been treated with caution its authors advised.
Topics: Antiparkinson Agents; Carboxy-Lyases; Humans; Levodopa; Parkinson Disease; Selegiline | 1997 |
Selegiline and excess mortality.
Topics: Antiparkinson Agents; Drug Combinations; Humans; Levodopa; Parkinson Disease; Selegiline | 1997 |
Selegiline, pregnancy, and Parkinson's disease.
Topics: Adult; Antiparkinson Agents; Female; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Selegiline | 1998 |
Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl.
Topics: Animals; Antiparkinson Agents; Apoptosis; Biosensing Techniques; Brain; Cell Line; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Microscopy, Fluorescence; Molecular Structure; Muscles; Neuroblastoma; Neuroprotective Agents; Oligonucleotides, Antisense; Oxepins; Parkinson Disease; Photoaffinity Labels; Propylamines; Protein Binding; Rabbits; Rats; Selegiline | 1998 |
[Clinical pharmacology and therapeutic aspects in certain degenerative neurological diseases].
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antiparkinson Agents; Cholinesterase Inhibitors; Humans; Neuroprotective Agents; Parkinson Disease; Riluzole; Selegiline; Tacrine | 1996 |
Parkinson's disease.
Topics: Antiparkinson Agents; Cholinergic Antagonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1998 |
Cortisol is higher in parkinsonism and associated with gait deficit.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Antiparkinson Agents; Constipation; Female; Gait; Humans; Hydrocortisone; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Risk Factors; Selegiline; Smoking | 1998 |
Selegiline, or the problem of early termination of clinical trials. The clinical questions are not well answered, and probably never will be.
Topics: Aged; Antiparkinson Agents; Clinical Trials as Topic; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 1998 |
Monitoring randomised controlled trials. Parkinson's disease trial illustrates the dangers of stopping early.
Topics: Antiparkinson Agents; Bromocriptine; Decision Making; Humans; Levodopa; Parkinson Disease; Randomized Controlled Trials as Topic; Selegiline | 1998 |
Cerebrospinal fluid cyclic guanosine 3'5' monophosphate levels in Parkinson's disease.
Topics: Aged; Cyclic GMP; Dopamine Agonists; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1998 |
A frequency and correlation analysis of motor deficits in Parkinson patients.
Topics: Adult; Aged; Aged, 80 and over; Amantadine; Antiparkinson Agents; Drug Therapy, Combination; Female; Humans; Incidence; Levodopa; Male; Middle Aged; Movement; Parkinson Disease; Prognosis; Psychomotor Disorders; Psychomotor Performance; Selegiline; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires; Time Factors | 1998 |
In vivo comparison of the effects of inhibition of MAO-A versus MAO-B on striatal L-DOPA and dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline | 1995 |
Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular System; Drug Therapy, Combination; Female; Heart Rate; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Valsalva Maneuver | 1998 |
Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular System; Drug Therapy, Combination; Female; Heart Rate; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; Valsalva Maneuver | 1998 |
Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease.
Topics: Age of Onset; Aged; Antiparkinson Agents; Blood Proteins; Copper; Dopamine Agonists; Female; Humans; Iron; Levodopa; Male; Manganese; Metals, Heavy; Middle Aged; Nutritional Status; Parkinson Disease; Reference Values; Selegiline; Spectrophotometry, Atomic; Trace Elements; Vitamin A; Zinc | 1998 |
Is 10 milligrams selegiline essential as an adjunct therapy for the symptomatic treatment of Parkinson's disease?
Topics: Blood Platelets; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1998 |
Mortality cancer risk in parkinsonian patients: a population-based study.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Antiparkinson Agents; Female; Humans; Levodopa; Male; Middle Aged; Neoplasms; Parkinson Disease; Poisson Distribution; Retrospective Studies; Rome; Selegiline | 1999 |
I2-imidazoline receptors in platelets of patients with Parkinson's disease and Alzheimer's type dementia.
Topics: Alzheimer Disease; Antiparkinson Agents; Blood Platelets; Cell Membrane; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Parkinson Disease; Receptors, Drug; Reference Values; Selegiline | 1999 |
Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Reference Values; Selegiline; Thiamine; Thiamine Monophosphate; Thiamine Pyrophosphate | 1999 |
Parkinson's disease: therapeutic choices and timing decisions in patient management. Interview by Wayne Kuznar.
Topics: Age Factors; Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Disease Progression; Drug Administration Schedule; Electric Stimulation Therapy; Humans; Levodopa; Middle Aged; Nitrophenols; Parkinson Disease; Patient Selection; Selegiline; Time Factors; Tolcapone | 1999 |
Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate.
Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Antioxidants; Butylamines; Corpus Striatum; Dopamine; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Injections, Intraperitoneal; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neurotoxins; Parabens; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline | 1999 |
Deterioration of parkinsonian symptoms following treatment of dopaminergic hallucinosis with olanzapine.
Topics: Aged; Antiparkinson Agents; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Drug Therapy, Combination; Hallucinations; Humans; Levodopa; Male; Olanzapine; Paranoid Disorders; Parkinson Disease; Piperidines; Pirenzepine; Selegiline; Severity of Illness Index | 1999 |
Neuroprotection by (-)-deprenyl and related compounds.
Topics: Aging; Amphetamines; Animals; Antioxidants; Apoptosis; Cattle; DNA Damage; DNA, Neoplasm; Indans; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Nitrates; Oxidants; Parkinson Disease; Selegiline; Tumor Cells, Cultured | 1999 |
Altered redox state of platelet coenzyme Q10 in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antioxidants; Antiparkinson Agents; Biomarkers; Blood Platelets; Coenzymes; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase; Oxidation-Reduction; Parkinson Disease; Selegiline; Ubiquinone | 2000 |
A hypertensive reaction induced by concurrent use of selegiline and dopamine.
Topics: Aged; Blood Pressure; Dopamine; Heart Rate; Humans; Hypertension; Male; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2000 |
Anti-apoptotic function of L-(-)deprenyl (Selegiline) and related compounds.
Topics: Antioxidants; Antiparkinson Agents; Apoptosis; DNA Damage; DNA Fragmentation; Humans; Neurotoxins; Parkinson Disease; Salsoline Alkaloids; Selegiline; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Cells, Cultured | 2000 |
R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition.
Topics: Alzheimer Disease; DNA Primers; Gene Expression Regulation, Enzymologic; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Monocytes; Nerve Degeneration; Neuroblastoma; Neurons; Neurotoxins; Parkinson Disease; RNA, Messenger; Selegiline; Tumor Cells, Cultured | 2000 |
Possible serotonin syndrome arising from an interaction between nortriptyline and selegiline in a lady with parkinsonism.
Topics: Antidepressive Agents, Tricyclic; Antiparkinson Agents; Depressive Disorder; Drug Interactions; Female; Humans; Middle Aged; Nortriptyline; Parkinson Disease; Selegiline; Serotonin Syndrome | 2000 |
Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dopamine; Enzyme Activation; Female; Humans; Male; Neuroprotective Agents; Oligopeptides; Parkinson Disease; Salsoline Alkaloids; Selegiline; Tetrahydroisoquinolines; Tumor Cells, Cultured | 2000 |
Selegiline and Parkinson's disease: it's déjà vu-again.
Topics: Humans; Parkinson Disease; Selegiline | 2000 |
Selegiline and mortality in subjects with Parkinson's disease: a longitudinal community study.
Topics: Aged; Aged, 80 and over; Cause of Death; Female; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Selegiline | 2000 |
The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurones in culture.
Topics: Animals; Cell Survival; Cells, Cultured; Female; Fetus; Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra | 2000 |
[Dopaminergic agonists in the treatment of Parkinson's disease].
Topics: Aged; Antiparkinson Agents; Apomorphine; Benzothiazoles; Biological Availability; Bromocriptine; Catechols; Dopamine Agonists; Drug Combinations; Drug Hypersensitivity; Humans; Hypotension, Orthostatic; Indoles; Levodopa; Metabolic Clearance Rate; Nitriles; Parkinson Disease; Pergolide; Pramipexole; Selegiline; Thiazoles | 2000 |
The economic consequences of a drug-drug interaction.
Topics: Aged; Antipsychotic Agents; Benzodiazepines; Depression; Drug Interactions; Female; Fluoxetine; Haloperidol; Health Care Costs; Humans; Olanzapine; Parkinson Disease; Pirenzepine; Selegiline; Trihexyphenidyl | 2001 |
Neurorescuing effects of the GAPDH ligand CGP 3466B.
Topics: Animals; Animals, Newborn; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Glyceraldehyde-3-Phosphate Dehydrogenases; Ligands; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oxepins; Parkinson Disease; Rats; Rats, Wistar; Selegiline | 2000 |
Normal cerebrospinal fluid levels of insulin in patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Biomarkers; Case-Control Studies; Dopamine Agonists; Female; Humans; Insulin; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 2000 |
Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites.
Topics: Adrenergic Agents; Apoptosis; Caspase 3; Caspases; Cell Survival; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Melanoma; Methamphetamine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Proadifen; Selegiline; Tumor Cells, Cultured | 2001 |
Freezing of gait in patients with advanced Parkinson's disease.
Topics: Adult; Age of Onset; Amantadine; Antiparkinson Agents; Disease Progression; Dopamine Agonists; Female; Freezing; Gait Disorders, Neurologic; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Prevalence; Regression Analysis; Retrospective Studies; Selegiline | 2001 |
L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Carbolines; Cell Hypoxia; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Herbicides; Lactic Acid; Male; Microdialysis; Mitochondria; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxins; Pargyline; Parkinson Disease; Rats; Rats, Wistar; Selegiline | 2001 |
Advances in managing Parkinson's disease.
Topics: Activities of Daily Living; Algorithms; Antiparkinson Agents; Dopamine Agonists; Humans; Levodopa; Parkinson Disease; Selegiline | 2001 |
[Parkinson patients. Normal life expectancy with selegiline?].
Topics: Antiparkinson Agents; Follow-Up Studies; Humans; Life Expectancy; Parkinson Disease; Selegiline; Survival Rate | 2001 |
Current advances in Parkinson's disease.
Topics: Antidepressive Agents; Antiparkinson Agents; Benzothiazoles; Brain Stem; Catechols; Depression; Dopamine Agonists; Humans; Levodopa; Nitriles; Parkinson Disease; Pramipexole; Selegiline; Thiazoles | 2001 |
Selegiline and mortality in subjects with Parkinson's disease: a longitudinal community study.
Topics: Antiparkinson Agents; Humans; Longitudinal Studies; Parkinson Disease; Selegiline | 2001 |
Selegiline and mortality in subjects with Parkinson's disease: a longitudinal community study.
Topics: Antiparkinson Agents; Humans; Longitudinal Studies; Parkinson Disease; Selegiline | 2001 |
Future of neuroprotection in Parkinson's disease.
Topics: Apoptosis; Humans; Molsidomine; Neuroprotective Agents; Neurotoxins; Nitric Oxide Donors; Oxidopamine; Parkinson Disease; Propylamines; Salsoline Alkaloids; Selegiline; Tetrahydroisoquinolines; Tumor Cells, Cultured | 2001 |
Paroxysmal hypertensive crises induced by selegiline in a patient with Parkinson's disease.
Topics: Acute Disease; Humans; Hypertension; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 2001 |
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.
Topics: Antiparkinson Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Parkinson Disease; Recombinant Proteins; Saccharomyces cerevisiae; Selegiline | 2001 |
Oscillations in performance in levodopa-treated parkinsonians: treatment with bromocriptine and L-deprenyl.
Topics: Bromocriptine; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline | 1979 |
2-Phenylethylamine and amphetamine in human brain: effects of L-deprenyl in Parkinson's disease [proceedings].
Topics: Amphetamine; Brain; Humans; Parkinson Disease; Phenethylamines; Selegiline; Tissue Distribution | 1979 |
Monoamine oxidase activity during (--)-deprenil therapy: human brain post-mortem studies.
Topics: Brain; Dopamine; Humans; In Vitro Techniques; Male; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Serotonin | 1978 |
The possible mechanisms of action of (-)deprenyl in Parkinson's disease.
Topics: Acetylcholine; Animals; Biogenic Amines; Biological Transport; Cats; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase; Muscle Contraction; Muscle, Smooth; Parkinson Disease; Phenethylamines; Rabbits; Rats; Selegiline | 1978 |
Overview of present day treatment of Parkinson's disease.
Topics: Adult; Aged; Bromocriptine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Receptors, Dopamine; Selegiline | 1978 |
Absence of "cheese effect" during deprenyl therapy: some recent studies.
Topics: Amphetamines; Animals; Blood Pressure; Humans; Intestines; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Substrate Specificity; Swine; Tyramine | 1978 |
Long term treatment with L-deprenyl.
Topics: Benserazide; Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Phenethylamines; Selegiline; Time Factors | 1978 |
Recent observations on the clinical pharmacology of (-)deprenyl.
Topics: Adult; Aged; Blood Pressure; Drug Therapy, Combination; Heart Rate; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Time Factors; Tyramine | 1978 |
L-deprenyl treatment of on-off phenomena in Parkinson's disease.
Topics: Aged; Benserazide; Dopamine; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline; Vanilmandelic Acid | 1978 |
Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration.
Topics: Amphetamines; Brain; Humans; Parkinson Disease; Phenethylamines; Selegiline | 1978 |
Dopamine agonists used as monotherapy in de novo PD patients: comparisons with selegiline.
Topics: Bromocriptine; Clinical Trials as Topic; Dopamine Agents; Humans; Levodopa; Middle Aged; Parkinson Disease; Selegiline | 1992 |
Therapy of Parkinson's disease: are we at the end of the road?
Topics: Antiparkinson Agents; Dopamine Agents; Humans; India; Levodopa; Neurologic Examination; Parkinson Disease; Selegiline; Vitamin E | 1992 |
Peripheral blood cell activities of monoamine oxidase B and superoxide dismutase in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Female; Humans; Lymphocytes; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Selegiline; Superoxide Dismutase | 1992 |
[Selegine in Parkinson's disease--current status in research and therapy. 2nd Internation Congress of Movement Disorders. Munich, 23 June 1992].
Topics: Humans; Parkinson Disease; Selegiline | 1992 |
Potential fluoxetine-selegiline interaction.
Topics: Aged; Ataxia; Depression; Drug Interactions; Female; Fluoxetine; Humans; Parkinson Disease; Selegiline | 1992 |
Selegiline and manic behavior in Parkinson's disease.
Topics: Adult; Bipolar Disorder; Female; Humans; Male; Middle Aged; Parkinson Disease; Selegiline | 1992 |
Combination therapy of parkinsonism with deprenyl.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; India; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Pilot Projects; Selegiline | 1992 |
The antiparkinson efficacy of deprenyl derives from transient improvement that is likely to be symptomatic.
Topics: Humans; Models, Statistical; Parkinson Disease; Selegiline; Survival Analysis | 1992 |
Drug information discrepancy.
Topics: Advertising; Canada; Humans; Parkinson Disease; Selegiline | 1992 |
Some new aspects of the effect of (-)deprenyl in Parkinson's disease--a retrospective study.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Retrospective Studies; Selegiline; Severity of Illness Index | 1992 |
Long-term experience with selegiline and levodopa in Parkinson's disease.
Topics: Aged; Humans; Levodopa; Longitudinal Studies; Middle Aged; Parkinson Disease; Selegiline | 1992 |
Emerging perspectives in Parkinson's disease.
Topics: Animals; Humans; Levodopa; MPTP Poisoning; Neurology; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1992 |
Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease.
Topics: Age Factors; Blood Glucose; Blood Platelets; Carbidopa; Drug Therapy, Combination; Energy Metabolism; Female; Humans; Lactates; Lactic Acid; Levodopa; Lisuride; Male; Middle Aged; Mitochondria; Oxygen Consumption; Parkinson Disease; Receptors, Dopamine; Selegiline | 1992 |
Selegiline and nigral neurons.
Topics: Humans; Neurons; Parkinson Disease; Selegiline; Substantia Nigra | 1992 |
Severe adverse interaction between pethidine and selegiline.
Topics: Drug Administration Schedule; Drug Interactions; Humans; Male; Meperidine; Middle Aged; Parkinson Disease; Selegiline | 1991 |
The effect of R-(-)-deprenyl in de novo parkinsonian patients pretreated with levodopa and decarboxylase inhibitor correlated to depression and MHPS, HIAA, and HVA levels of cerebrospinal fluid.
Topics: Carboxy-Lyases; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Middle Aged; Motor Skills; Neurologic Examination; Parkinson Disease; Selegiline | 1990 |
Can we differentiate symptomatic and neuroprotective effects in parkinsonism? The dopamine agonist lisuride delays the need for levodopa therapy to a similar extent as reported for deprenyl.
Topics: Humans; Levodopa; Lisuride; Nervous System; Parkinson Disease; Selegiline; Survival Analysis | 1991 |
Parkinson's disease: an epidemiologic method for distinguishing between symptomatic and neuroprotective treatments.
Topics: Aged; Epidemiologic Methods; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline; United States | 1991 |
Experience with selegiline and levodopa in advanced Parkinson's disease.
Topics: Aged; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline | 1991 |
Chemically induced Parkinson's disease. III: A study of a possible role of singlet molecular oxygen in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Free Radicals; Lasers; Monoamine Oxidase; Oxygen; Pargyline; Parkinson Disease; Radiation-Sensitizing Agents; Selegiline | 1991 |
Early combination of selegiline and low-dose levodopa as initial symptomatic therapy in Parkinson's disease. Experience in 26 patients receiving combined therapy for 26 months.
Topics: Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Selegiline | 1991 |
Selegiline (deprenyl) treatment and death of nigral neurons in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Cell Survival; Humans; Neurons; Parkinson Disease; Selegiline; Substantia Nigra | 1991 |
Treating the progressive stages of Parkinson's disease.
Topics: Amantadine; Antiparkinson Agents; Bromocriptine; Carbidopa; Drug Combinations; Electroconvulsive Therapy; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Pergolide; Selegiline | 1991 |
Selegiline (Eldepryl) for Parkinson's disease.
Topics: Drug Therapy, Combination; Humans; Levodopa; Parkinson Disease; Selegiline | 1991 |
[The effect of chronic treatment of deprenyl in animal models of Parkinson's disease].
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Administration Schedule; Levodopa; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotation; Selegiline | 1991 |
Early therapy for Parkinson's disease.
Topics: Humans; Levodopa; Parkinson Disease; Selegiline | 1991 |
Psychiatric effects of selegiline.
Topics: Adult; Female; Humans; Mental Disorders; Middle Aged; Parkinson Disease; Selegiline | 1991 |
(-)-Deprenyl treatment of patients with Parkinson's disease does not affect erythrocyte catechol-O-methyl transferase activity.
Topics: Aged; Benserazide; Catechol O-Methyltransferase; Erythrocytes; Female; Humans; Kinetics; Levodopa; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Selegiline | 1991 |
[Monoamine oxidase inhibitors].
Topics: Antidepressive Agents; Dementia; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1991 |
[Changes in lipid metabolism in patients with Parkinson disease after combined treatment with L-deprenil (iumex) and antiparkinson drugs].
Topics: Adult; Aged; Antiparkinson Agents; Drug Therapy, Combination; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Middle Aged; Parkinson Disease; Phospholipids; Selegiline | 1990 |
New concepts in the treatment of Parkinson's disease.
Topics: Antiparkinson Agents; Carbidopa; Diet; Dopamine Agents; Drug Administration Schedule; Dyskinesia, Drug-Induced; Humans; Intestinal Absorption; Levodopa; Parkinson Disease; Selegiline | 1990 |
Inhibition of human benzylamine oxidase (BzAO) by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benzylamine Oxidase; Carbidopa; Dopamine Agents; Humans; Kinetics; Parkinson Disease; Selegiline | 1990 |
From the National Institutes of Health.
Topics: Aged; Astrocytoma; Autoimmune Diseases; Danazol; HIV-1; Humans; Middle Aged; Parkinson Disease; Phenethylamines; Pregnadienes; Selegiline; Thrombocytopenia; Virus Replication | 1990 |
L-deprenyl, levodopa pharmacokinetics, and response fluctuations in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Humans; Levodopa; Middle Aged; Parkinson Disease; Phenethylamines; Psychomotor Performance; Selegiline | 1990 |
Chromatographic studies on the binding, action and metabolism of (-)-deprenyl.
Topics: Animals; Chromatography; Female; Male; Parkinson Disease; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Deprenyl for the treatment of early Parkinson's disease.
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1990 |
Parkinson's disease: can we influence progression?
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1990 |
Many researchers, few clinicians, using drug that may slow, even prevent, Parkinson's.
Topics: Humans; Parkinson Disease; Selegiline; Vitamin E | 1990 |
Clinical neuromythology IX. Pyramid sale in the bucket shop: DATATOP bottoms out.
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline; Vitamin E | 1990 |
'New studies on Parkinson's disease drug'.
Topics: Humans; Parkinson Disease; Selegiline | 1990 |
Possible interactions between deprenyl and prozac.
Topics: Drug Interactions; Female; Fluoxetine; Humans; Middle Aged; Parkinson Disease; Selegiline | 1990 |
Early combination with deprenyl: a retrospective analysis.
Topics: Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Neurologic Examination; Parkinson Disease; Retrospective Studies; Selegiline | 1990 |
"Stelazine" versus "selegiline"--a hazard in prescription writing.
Topics: Aged; Drug Prescriptions; Female; Humans; Male; Medication Errors; Parkinson Disease; Selegiline; Trifluoperazine | 1990 |
Deprenyl and Parkinson's disease: new use for an old drug.
Topics: Humans; Parkinson Disease; Selegiline | 1990 |
Progression of Parkinson's disease.
Topics: Humans; Neurotoxins; Parkinson Disease; Prognosis; Selegiline; Time Factors | 1990 |
Monoamine oxidase and the bioactivation of MPTP and related neurotoxins: relevance to DATATOP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Humans; In Vitro Techniques; Male; Mice; Monoamine Oxidase; Nervous System; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Inbred Strains; Selegiline; Vitamin E | 1990 |
New drugs for Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Quality of Life; Selegiline | 1990 |
Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l-deprenyl.
Topics: Aged; Amines; Brain; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Indans; Kynuramine; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Selegiline; Serotonin; Tissue Distribution; Tranylcypromine | 1986 |
The effect of R-(-)-deprenyl in de novo parkinsonian patients pretreated with levodopa and decarboxylase inhibitor correlated to depression and MHPG, HIAA and HVA levels in the cerebrospinal fluid.
Topics: Benserazide; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Glycols; Homovanillic Acid; Humans; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Middle Aged; Motor Activity; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Platelet monoamine oxidase in Parkinson patients: effect of L-deprenyl therapy.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Dose-Response Relationship, Drug; Humans; Middle Aged; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Sex Factors | 1989 |
FDA approves marketing of two drugs previously available under treatment IND regulations.
Topics: Acquired Immunodeficiency Syndrome; Drugs, Investigational; Ganciclovir; Humans; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
From the Food and Drug Administration.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Clinical Protocols; Didanosine; Drug Evaluation; Humans; Parkinson Disease; Phenethylamines; Selegiline; United States; United States Food and Drug Administration | 1989 |
[A new drug for Parkinson's disease: selegiline (Eldeprine). Copenhagen, January 26-27, 1989].
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
New strategies in the treatment of Parkinson's disease. Symposium. Copenhagen, Denmark, January 26-27, 1989. Proceedings.
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Combination of selegiline and controlled release levodopa in the treatment of fluctuations of clinical disability in parkinsonian patients.
Topics: Adult; Aged; Benserazide; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
New approaches in the use of selegiline for the treatment of Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Selegiline in the treatment of Parkinson's disease--long term experience.
Topics: Antiparkinson Agents; Carbidopa; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Combination of a dopamine agonist, MAO-B inhibitor and levodopa--a new strategy in the treatment of early Parkinson's disease.
Topics: Drug Therapy, Combination; Ergolines; Female; Humans; Levodopa; Lisuride; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Pharmacokinetics and metabolism of selegiline.
Topics: Aged; Alzheimer Disease; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1989 |
Hypersexuality with antiparkinsonian therapy.
Topics: Adult; Age Factors; Aged; Amantadine; Dopamine Agents; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline; Sex Factors; Sexual Behavior | 1989 |
Localization of MAO-A and MAO-B in human brain: a step in understanding the therapeutic action of L-deprenyl.
Topics: Animals; Brain; Dopamine; Fluorescent Antibody Technique; Humans; Isoenzymes; Macaca fascicularis; Monoamine Oxidase; Neuroglia; Neurons; Norepinephrine; Parkinson Disease; Phenethylamines; Selegiline; Serotonin; Synaptic Transmission | 1987 |
MPTP: clinical implications.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Basal Ganglia; Benserazide; Drug Combinations; Drug Therapy, Combination; Humans; Hydrazines; Levodopa; Parkinson Disease; Phenethylamines; Pyridines; Selegiline | 1986 |
[Deprenyl as a co-adjuvant in the treatment of Parkinson disease].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Selegiline | 1986 |
(-)Deprenyl in perspective: prophylaxis for Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Arylsulfotransferase; Blood Platelets; Humans; Monoamine Oxidase; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline; Sulfurtransferases; Tomography, Emission-Computed | 1986 |
Effect of (-)deprenyl in long-term treatment of Parkinson's disease. A 10-years experience.
Topics: Benserazide; Drug Combinations; Drug Therapy, Combination; Humans; Hydrazines; Levodopa; Parkinson Disease; Phenethylamines; Retrospective Studies; Selegiline; Time Factors | 1986 |
The role of MAO-b inhibitors in the treatment of Parkinson's disease.
Topics: Adult; Aged; Depression; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline | 1986 |
(-)Deprenyl in the treatment of decompensated Parkinson's disease.
Topics: Benserazide; Drug Combinations; Humans; Hydrazines; Levodopa; Movement Disorders; Parkinson Disease; Phenethylamines; Selegiline | 1986 |
(-)Deprenyl in Parkinson's disease: a two-year study in the different evolutive stages.
Topics: Adult; Aged; Carboxy-Lyases; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1986 |
[Therapeutic strategies and tactics in parkinsonism].
Topics: Amantadine; Antidepressive Agents; Antiparkinson Agents; Benserazide; Carbidopa; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Humans; Levodopa; Lisuride; Motor Skills; Parkinson Disease; Selegiline; Sleep Initiation and Maintenance Disorders | 1986 |
[Medicamentous strategy for improving the quality of life in the senescence].
Topics: Aged; Catecholamines; Caudate Nucleus; Corpus Striatum; Depressive Disorder; Dopamine; Humans; Monoamine Oxidase; Neural Pathways; Neurons; Parkinson Disease; Phenethylamines; Quality of Life; Receptors, Dopamine; Selegiline; Sexual Behavior; Substantia Nigra | 1986 |
Critical role of MAO inhibition in Parkinson's disease.
Topics: Acetylcholine; Animals; Dopamine; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline; Structure-Activity Relationship | 1987 |
MAO type B inhibitors as adjunct to L-dopa therapy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkynes; Animals; Brain; Drug Therapy, Combination; Humans; Indans; Isoenzymes; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Receptors, Dopamine; Selegiline; Structure-Activity Relationship; Tyramine | 1987 |
Current and future approaches to therapy.
Topics: Antiparkinson Agents; Benserazide; Bromocriptine; Carbidopa; Drug Therapy, Combination; Humans; Levodopa; Lisuride; Parkinson Disease; Selegiline | 1987 |
Parkinson's disease: current view.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Selegiline; Substantia Nigra; Tomography, Emission-Computed | 1987 |
Parkinson's disease in the elderly: current management strategies.
Topics: Aged; Amantadine; Antiparkinson Agents; Bromocriptine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Selegiline | 1987 |
[Use of iumeks in the combined therapy of parkinsonism patients ].
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Brain; Drug Evaluation; Drug Therapy, Combination; Higher Nervous Activity; Humans; Middle Aged; Monoamine Oxidase Inhibitors; Muscles; Parkinson Disease; Phenethylamines; Selegiline | 1987 |
MAO-B-Inhibitor selegiline (R-(-)-deprenyl). A new therapeutic concept in the treatment of Parkinson's disease. Proceedings of the international symposium. Berlin, January 23-25, 1987.
Topics: Humans; Parkinson Disease; Phenethylamines; Selegiline | 1987 |
Milestones in the development of modern Parkinson therapy.
Topics: 2,3-Diketogulonic Acid; Alloxan; Behavior; Bromocriptine; Drug Combinations; Drug Therapy, Combination; Ferric Compounds; Humans; Levodopa; Neurology; Parkinson Disease; Selegiline; Tryptophan | 1987 |
Selegiline in the early and late phases of Parkinson's disease.
Topics: Dihydroxyphenylalanine; Disability Evaluation; Humans; Parkinson Disease; Phenethylamines; Selegiline; Time Factors | 1987 |
Experience with selegiline in the treatment of Parkinson's disease.
Topics: Disability Evaluation; Humans; Parkinson Disease; Phenethylamines; Retrospective Studies; Selegiline; Time Factors | 1987 |
R-(-)-deprenyl as an adjuvant to levodopa in the treatment of Parkinson's disease.
Topics: Adjuvants, Pharmaceutic; Disability Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Levodopa; Longitudinal Studies; Parkinson Disease; Phenethylamines; Selegiline | 1987 |
Selegiline and the prophylaxis of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chemical Phenomena; Chemistry; Humans; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Tissue Distribution | 1987 |
Parkinson's disease and PET tracer studies.
Topics: Animals; Carbon Radioisotopes; Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Energy Metabolism; Fluorine Radioisotopes; Humans; Ligands; Nomifensine; Parkinson Disease; Receptors, Dopamine; Selegiline; Spiperone; Tomography, Emission-Computed | 1988 |
L-deprenyl in prevention of MPTP induced depletion of striatal enkephalins in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1988 |
Drugs for parkinsonism.
Topics: Amantadine; Bromocriptine; Carbidopa; Drug Combinations; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Selegiline | 1988 |
Hypomania in a patient receiving deprenyl (selegiline) after adrenal-striatal implantation for Parkinson's disease.
Topics: Adrenal Medulla; Adult; Caudate Nucleus; Combined Modality Therapy; Female; Humans; Parkinson Disease; Phenethylamines; Selegiline; Transplantation, Autologous | 1988 |
[Experience using selective monoamine oxidase inhibitors in treating parkinsonism patients].
Topics: Adult; Antiparkinson Agents; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1988 |
Deprenyl in Parkinson disease: personal experience.
Topics: Adult; Aged; Benserazide; Carbidopa; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1985 |
Practical therapeutics: advances in the management of Parkinson's disease.
Topics: Ergolines; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Phenethylamines; Selegiline | 1985 |
Clinical evaluation of selegiline (L-deprenyl) in the long-term L-dopa treatment syndrome.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline | 1985 |