Page last updated: 2024-08-23

selegiline and Aging

selegiline has been researched along with Aging in 108 studies

Research

Studies (108)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (15.74)	18.7374
1990's	57 (52.78)	18.2507
2000's	24 (22.22)	29.6817
2010's	8 (7.41)	24.3611
2020's	2 (1.85)	2.80

Authors

Authors	Studies
Ferdinandy, P; Fürst, S; Gyires, K; Miklya, I; Muraoka, S; Yoneda, F	1
Farkas, J; Gáborján, A; Humli, V; Köles, L; Miklya, I; Polony, G; Szepesy, J; Szirmai, Á; Tábi, T; Tamás, L; Tímár, J; Vizi, ES; Zelles, T	1
Miklya, I	3
Knoll, J; Miklya, I	1
Malavolta, M; Mocchegiani, E	1
Cohen, S; Dror, V; Eliash, S; Rehavi, M	1
Bagriyanik, HA; Ergur, BU; Kiray, M; Pekcetin, C; Topcu, A	1
Campbell, S; Kozan, B; Trettien, A	1
Henn, FA; Mirrione, MM; Schulz, D	1
James, TJ; Subramanian, MV	2
Mishra, M; Sharma, D; Singh, R; Singh, S	1
Bellinger, DL; Boehm, GW; Felten, DL; Madden, KS; Stevens, SY; Thyagarajan, S	1
Kaur, J; Sharma, D; Singh, R; Singh, S	1
Hatakeyama, Y; Nakano, N; Yoshida, T	1
Currer, JM; Flurkey, K	1
Landsberg, G	1
Bagriyanik, HA; Buldan, Z; Ergur, BU; Kiray, M; Ozyurt, D; Pekcetin, C; Uysal, N	1
Bromberg, E; Caldana, F; de Lima, MN; Laranja, DC; Roesler, R; Schröder, N	1
Kitani, K	1
Alper, G; Caglayan, O; Duman, E; Irer, S; Yilmaz, C	1
Ames, D; Ritchie, C	1
Alper, GE; Duman, E; Irer, SV; Saatcioglu, F; Sezer, ED; Yilmaz, C	1
Aksu, I; Bagriyanik, A; Buldan, Z; Ergur, BU; Kiray, M; Pekcetin, C	1
Chen, JJ; Fernandez, HH	1
Fung, SC; Kong, YC; Lam, DM	1
Jellinger, K; Riederer, P	1
Benedetti, MS; Fowler, CJ	1
Dallo, J; Knoll, J; Yen, TT	2
Knoll, J	12
Fowler, CJ; Marcusson, J; Oreland, L; Winblad, B	1
Lai, JC; Leung, TK; Lim, L	1
Lillrank, S; Oja, SS; Saransaari, P; Suhonen, J	1
Amenta, F; Bongrani, S; Bronzetti, E; Cadel, S; Ricci, A; Valsecchi, B; Zeng, YC	2
Gupta, M; Wiener, HL	1
Delanney, LE; Finnegan, KT; Irwin, I; Langston, JW	1
Amenta, F; Bongrani, S; Cadel, S; Ferrante, F; Valsecchi, B; Zeng, YC	1
Berry, MD; Juorio, AV; Paterson, IA	1
Meites, J; Quadri, SK; Thyagarajan, S	1
Correa, RM; Oxenkrug, GF; Requintina, PJ; Yuwiler, A	1
Hafner, U; Müller, WE; Pohl, O; Stoll, S	1
Amenta, F; Bongrani, S; Cadel, S; Ricci, A; Valsecchi, B; Zeng, YC	1
Head, E; Ivy, GO; Milgram, NW; Murphy, MP; Reid, C; Rick, JT	1
Antognini, A; Basso, A; Piantanelli, L; Rossolini, G; Testa, R; Viticchi, C; Zaia, A	1
Amenta, F; Bograni, S; Cadel, S; Ferrante, F; Valsecchi, B; Vega, JA	1
Heinonen, E; Riekkinen, P; Sirviö, J; Yavich, L	1
Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Miyasaka, K; Sato, Y	3
Clow, A; Glover, V; Sandler, M	1
Barber, AJ; Boulton, AA; Yu, PH	1
Ansari, KS; Kruck, TP; Tatton, WG; Yu, PH	1
Singer, TP; Tipton, KF	1
Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Nokubo, M; Sato, Y	1
Ali, SF; Freyaldenhoven, TE; Hart, RW	1
Bruyette, DS; Cotman, CW; Cummings, BJ; DePaoli, A; Head, E; Milgram, NW; Ruehl, WW	1
Ivy, GO; Milgram, NW; Murphy, MP; Rick, JT	1
Nagy, IZ	1
Cano, J; de la Cruz, CP; Machado, A; Revilla, E; Rodríguez-Gómez, JA; Steffen, V	1
Haapalinna, A; Heinonen, E; Hervonen, A; Salonen, T; Suhonen, J	1
Hartley, J; Head, E; Ivy, GO; Kameka, AM; Mehta, R; Milgram, NW; Ruehl, WW	1
Haapalinna, A; Heinonen, E; Koivisto, E; Puumala, T; Riekkinen, PJ; Sirviö, J; Yavich, L	1
Amenta, F; Barili, P; Battisti, A; Ferrante, F; Valsecchi, B	1
Archer, JR; Harrison, DE	1
Bruyette, DS; Darling, L; Entriken, T; Griffin, D; Ruehl, WW	1
Cano, J; Machado, A; Rodríguez-Gómez, JA; Romero-Ramos, M; Venero, JL	1
Cano, J; De la Cruz, CP; Machado, A; Revilla, E; Rodríguez-Gómez, JA; Vizuete, ML	1
Mahmood, I	1
Fowler, JS; Logan, J; MacGregor, RR; Pappas, N; Shea, C; Volkow, ND; Wang, GJ	1
Bruyette, DS; Cummings, BJ; Hart, B; Head, E; Neilson, J; Ruehl, WW	1
Felten, DL; Felten, SY; ThyagaRajan, S	1
Felten, DL; Madden, KS; Thyagarajan, S	1
Dimitrova, SS; Felten, DL; Felten, SY; Kalvass, JC; Madden, KS; ThyagaRajan, S	1
Berry, MD; Boulton, AA; Gillott, C; Jordens, RG	1
Ersoz, B; Girgin, FK; Mentes, G; Ozgonul, M; Sozmen, EY	1
Maruyama, W; Naoi, M	1
Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K	1
Felten, DL; Madden, KS; Stevens, SY; ThyagaRajan, S	1
Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Maruyama, W; Minami, C; Yamamoto, T	1
Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T	1
Felten, DL; ThyagaRajan, S	1
Carrillo, MC; Isobe, K; Ivy, GO; Kanai, S; Kitani, K; Maehara, K; Minami, C	1
Callingham, BA; Lyles, GA	1
Head, E; Milgram, NW	1
Knoll, J; Kummert, M; Sugár, J; Tóth, V	1
Wagner, GC; Walsh, SL	1
Aquilonius, SM; d'Argy, R; Gillberg, PG; Halldin, C; Jossan, SS; Långström, B; Oreland, L	1
Dluzen, DE; McDermott, JL	1
Borelli, G; Brandeis, R; Cadel, S; Kapon, Y; Sapir, M; Valsecchi, B	1
Ivy, GO; Mendonca, A; Milgram, NW; Nellis, P; Racine, RJ	1
Cohen, RM; Mellow, AM; Mueller, EA; Murphy, DL; Newhouse, PA; Sunderland, T; Tariot, PN	1
Amenta, F; Bonifati, V; Collier, WL; Meco, M; Ramacci, MT	1
Harik, SI; Kalaria, RN	1

Reviews

29 review(s) available for selegiline and Aging

Article	Year
The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015). Molecular psychiatry, 2016, Volume: 21, Issue:11 Topics: Aging; Alzheimer Disease; Animals; Brain; Catecholamines; Depressive Disorder, Major; Dopamine; History, 20th Century; Humans; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Rats; Selegiline	2016
Possible new antiaging strategies related to neuroendocrine-immune interactions. Neuroimmunomodulation, 2008, Volume: 15, Issue:4-6 Topics: Adult; Aged; Aging; Animals; Anticarcinogenic Agents; Antioxidants; Carnosine; Child, Preschool; Dogs; Female; Ghrelin; Humans; Leptin; Longevity; Male; Neuroimmunomodulation; Nitric Oxide Donors; Selegiline; Young Adult; Zinc	2008
[Slowing the age-induced decline of brain function with prophylactic use of (-)-deprenyl (Selegiline, Jumex). Current international view and conclusions 25 years after the Knoll's proposal]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2009, Volume: 11, Issue:4 Topics: Aging; Apoptosis; Brain; Cell Culture Techniques; Humans; Mental Disorders; Neurodegenerative Diseases; Neuroprotective Agents; Selegiline	2009
[Mild cognitive impairment]. Ryoikibetsu shokogun shirizu, 2003, Issue:40 Topics: Aging; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Diagnosis, Differential; Disease Progression; Humans; Psychiatric Status Rating Scales; Selegiline; Severity of Illness Index; Vitamin E	2003
Pitfalls of animal model systems in ageing research. Best practice & research. Clinical endocrinology & metabolism, 2004, Volume: 18, Issue:3 Topics: Aging; Animals; Biomarkers; Dehydroepiandrosterone; Humans; Models, Animal; Research; Resveratrol; Selegiline; Stilbenes	2004
Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:3 Topics: Aging; Animals; Behavior, Animal; Cognition Disorders; Complementary Therapies; Diet Therapy; Dogs; Environment; Humans; Neuroprotective Agents; Neuropsychological Tests; Selegiline	2005
Community and long-term care management of Parkinson's disease in the elderly: focus on monoamine oxidase type B inhibitors. Drugs & aging, 2007, Volume: 24, Issue:8 Topics: Aged; Aging; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase Inhibitors; Dopamine Agonists; Homes for the Aged; Humans; Indans; Levodopa; Monoamine Oxidase Inhibitors; Nursing Homes; Parkinson Disease; Selegiline	2007
Rationale for (-)deprenyl (selegiline) medication in Parkinson's disease and in prevention of age-related nigral changes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1995, Volume: 49, Issue:4 Topics: Aging; Alzheimer Disease; Animals; Antiparkinson Agents; Drug Administration Schedule; Humans; Parkinson Disease; Selegiline; Substantia Nigra	1995
Possible mechanisms of action of (-)deprenyl and other MAO-B inhibitors in some neurologic and psychiatric disorders. Progress in neurobiology, 1994, Volume: 44, Issue:2 Topics: Aging; Alzheimer Disease; Animals; Cognition Disorders; Depressive Disorder; Humans; Longevity; Mental Disorders; Monoamine Oxidase Inhibitors; Nervous System Diseases; Parkinson Disease; Schizophrenia; Selegiline	1994
Age-related memory decline and longevity under treatment with selegiline. Life sciences, 1994, Volume: 55, Issue:25-26 Topics: Aging; Animals; Avoidance Learning; Cricetinae; Female; Longevity; Maze Learning; Memory Disorders; Mesocricetus; Mice; Mice, Inbred Strains; Selegiline	1994
Effects of L-deprenyl on manifestations of aging in the rat and dog. Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717 Topics: Aging; Animals; Body Weight; Dogs; Female; Learning; Life Expectancy; Male; Memory; Rats; Rats, Inbred F344; Selegiline	1994
Effects of dopaminergic drugs on superoxide dismutase: implications for senescence. Journal of neural transmission. Supplementum, 1993, Volume: 40 Topics: Aging; Animals; Corpus Striatum; Enzyme Induction; Free Radicals; Humans; Isatin; Life Expectancy; Nerve Degeneration; Parkinson Disease; Pergolide; Rats; Selegiline; Substantia Nigra; Superoxide Dismutase	1993
The pharmacological basis of the beneficial effects of (-)deprenyl (selegiline) in Parkinson's and Alzheimer's diseases. Journal of neural transmission. Supplementum, 1993, Volume: 40 Topics: Aging; Alzheimer Disease; Animals; Avoidance Learning; Catalase; Corpus Striatum; Drug Therapy, Combination; Learning; Levodopa; Male; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra; Superoxide Dismutase	1993
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. Journal of neurochemistry, 1993, Volume: 61, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aging; Animals; Biological Transport; Humans; Mitochondria; Nervous System; Oxidation-Reduction; Parkinson Disease; Selegiline; Species Specificity	1993
Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Progress in brain research, 1995, Volume: 106 Topics: Aging; Alzheimer Disease; Animals; Cognition Disorders; Dementia; Disease Models, Animal; Dogs; Humans; Selegiline	1995
On the possible role of nootropica in geriatric prevention and therapy. Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786 Topics: Aging; Free Radical Scavengers; Humans; Nootropic Agents; Piracetam; Proline; Selegiline	1996
Management of canine pituitary-dependent hyperadrenocorticism with l-deprenyl (Anipryl). The Veterinary clinics of North America. Small animal practice, 1997, Volume: 27, Issue:2 Topics: Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Aging; Animals; Dog Diseases; Dogs; Dopamine; Dose-Response Relationship, Drug; Monoamine Oxidase Inhibitors; Pituitary Gland; Selegiline	1997
Clinical pharmacokinetics and pharmacodynamics of selegiline. An update. Clinical pharmacokinetics, 1997, Volume: 33, Issue:2 Topics: Administration, Cutaneous; Aging; Area Under Curve; Cohort Studies; Drug Interactions; Female; Food-Drug Interactions; Humans; Intestinal Absorption; Male; Monoamine Oxidase Inhibitors; Selegiline; Sex Factors; Structure-Activity Relationship; Tissue Distribution	1997
Alterations in sympathetic noradrenergic innervation in lymphoid organs with age. Annals of the New York Academy of Sciences, 1998, May-01, Volume: 840 Topics: Aging; Animals; Humans; Lymphatic System; Monoamine Oxidase Inhibitors; Norepinephrine; Selegiline; Spleen; Sympathetic Nervous System; Thymus Gland	1998
(-)Deprenyl (Selegiline): past, present and future. Neurobiology (Budapest, Hungary), 2000, Volume: 8, Issue:2 Topics: Aging; Alzheimer Disease; Animals; Brain Chemistry; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline	2000
Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain. CNS drug reviews, 2001,Fall, Volume: 7, Issue:3 Topics: Aging; Alzheimer Disease; Animals; Benzofurans; Brain; Catecholamines; Depression; Humans; Neuroprotective Agents; Parkinson Disease; Propylamines; Selegiline; Serotonin	2001
Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy. Annals of the New York Academy of Sciences, 2001, Volume: 928 Topics: Aging; Alkynes; Animals; Antioxidants; Brain; Brain Chemistry; Catalase; Corpus Striatum; Cricetinae; Dogs; Dopamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Induction; Female; Free Radicals; Heart; Humans; Indans; Kidney; Longevity; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Neuroprotective Agents; Organ Specificity; Rats; Rats, Inbred F344; Selegiline; Superoxide Dismutase	2001
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. Annals of the New York Academy of Sciences, 2002, Volume: 959 Topics: Aging; Animals; Catalase; Free Radical Scavengers; Humans; Life Expectancy; Neuroprotective Agents; Pargyline; Propylamines; Selegiline; Superoxide Dismutase	2002
Modulation of neuroendocrine--immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mechanisms of ageing and development, 2002, Apr-30, Volume: 123, Issue:8 Topics: Aging; Amphetamines; Animals; Cardiovascular System; Humans; Immune System; Lymphoid Tissue; Mammary Neoplasms, Animal; Neuroimmunomodulation; Neuroprotective Agents; Neurosecretory Systems; Selegiline; Signal Transduction	2002
Why (--)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects. Mechanisms of ageing and development, 2002, Apr-30, Volume: 123, Issue:8 Topics: Aging; Animals; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; Catalase; Cytokines; Dose-Response Relationship, Drug; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neuroprotective Agents; Selegiline; Superoxide Dismutase	2002
Pharmacological basis of the therapeutic effect of (-)deprenyl in age-related neurological diseases. Medicinal research reviews, 1992, Volume: 12, Issue:5 Topics: Aging; Animals; Drug Administration Schedule; Humans; Nervous System Diseases; Selegiline; Structure-Activity Relationship	1992
(-)Deprenyl-medication: a strategy to modulate the age-related decline of the striatal dopaminergic system. Journal of the American Geriatrics Society, 1992, Volume: 40, Issue:8 Topics: Aging; Alzheimer Disease; Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Parkinson Disease; Rats; Receptors, Dopamine; Selegiline; Substantia Nigra	1992
R-(-)-deprenyl (Selegiline, Movergan) facilitates the activity of the nigrostriatal dopaminergic neuron. Journal of neural transmission. Supplementum, 1987, Volume: 25 Topics: Aging; Animals; Biogenic Amines; Brain; Catecholamines; Corpus Striatum; Dopamine; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Phenethylamines; Receptors, Cell Surface; Receptors, Dopamine; Selegiline; Substantia Nigra; Synapses	1987
The facilitation of dopaminergic activity in the aged brain by (-)deprenyl. A proposal for a strategy to improve the quality of life in senescence. Mechanisms of ageing and development, 1985, May-13, Volume: 30, Issue:2 Topics: Aged; Aging; Animals; Brain; Depression; Dopamine; Geriatrics; Humans; Male; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Quality of Life; Rats; Selegiline; Sexual Behavior	1985

Trials

1 trial(s) available for selegiline and Aging

Article	Year
A noncomparative open-label study evaluating the effect of selegiline hydrochloride in a clinical setting. Veterinary therapeutics : research in applied veterinary medicine, 2001,Winter, Volume: 2, Issue:1 Topics: Aging; Animals; Cognition Disorders; Dog Diseases; Dogs; Female; Male; Neuroprotective Agents; Selegiline	2001

Other Studies

78 other study(ies) available for selegiline and Aging

Article	Year
Geroprotection in the future. In memoriam of Joseph Knoll: The selegiline story continues. European journal of pharmacology, 2020, Feb-05, Volume: 868 Topics: Aging; Brain; Drug Development; Geriatrics; History, 20th Century; Humans; Life Expectancy; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Selegiline	2020
Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice. International journal of molecular sciences, 2021, Mar-11, Volume: 22, Issue:6 Topics: Administration, Oral; Aging; Animals; Antiparkinson Agents; Auditory Threshold; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Sensorineural; Humans; Male; Mice, Inbred BALB C; Mice, Inbred DBA; Protective Agents; Selegiline; Synaptic Transmission	2021
[Primary prevention with enhancer substances for a longer and healthier life]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2013, Volume: 15, Issue:2 Topics: Aging; Antiparkinson Agents; Chronic Disease; Disease Progression; Education, Medical; Feeding Behavior; Humans; Hungary; Life Expectancy; Life Style; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Primary Prevention; Secondary Prevention; Selegiline; Tertiary Prevention	2013
Longevity study with low doses of selegiline/(-)-deprenyl and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP). Life sciences, 2016, Dec-15, Volume: 167 Topics: Aging; Animals; Learning; Longevity; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Wistar; Selegiline	2016
Neuroprotection by rasagiline in thiamine deficient rats. Brain research, 2009, Feb-23, Volume: 1256 Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Brain; Disease Models, Animal; Indans; Kaplan-Meier Estimate; Male; Maze Learning; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Degeneration; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Selegiline; Thiamine Deficiency	2009
Antioxidant and antiapoptotic activities of deprenyl and estradiol co-administration in aged rat kidney. Acta biologica Hungarica, 2009, Volume: 60, Issue:1 Topics: Aging; Animals; Apoptosis; Drug Therapy, Combination; Estradiol; Estrogens; Female; Kidney; Lipid Peroxidation; Monoamine Oxidase Inhibitors; Oxidative Stress; Rats; Rats, Wistar; Selegiline	2009
Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl. Neurobiology of learning and memory, 2010, Volume: 93, Issue:2 Topics: Aging; Animals; Anxiety; Cognition; Electroshock; Exploratory Behavior; Habituation, Psychophysiologic; Helplessness, Learned; Male; Monoamine Oxidase Inhibitors; Motor Activity; Neuropsychological Tests; Rats; Rats, Inbred Strains; Selegiline; Species Specificity; Time Factors	2010
Supplementation of deprenyl attenuates age associated alterations in rat cerebellum. Molecular biology reports, 2010, Volume: 37, Issue:8 Topics: Aging; Animals; Cerebellum; Dietary Supplements; Hexosamines; Hexoses; Male; Organ Size; Purkinje Cells; Rats; Rats, Wistar; Selegiline	2010
Age-related protective effect of deprenyl on changes in the levels of diagnostic marker enzymes and antioxidant defense enzymes activities in cerebellar tissue in Wistar rats. Cell stress & chaperones, 2010, Volume: 15, Issue:5 Topics: Aging; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Catalase; Cerebellum; Creatine Kinase; Glutathione Peroxidase; Glutathione Transferase; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Rats; Rats, Wistar; Selegiline; Superoxide Dismutase	2010
Effect of L-deprenyl treatment on electrical activity, Na+, K+ ATPase, and protein kinase C activities in hippocampal subfields (CA1 and CA3) of aged rat brain. Indian journal of experimental biology, 2012, Volume: 50, Issue:2 Topics: Action Potentials; Aging; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Electroencephalography; Electrophysiological Phenomena; Learning; Male; Protein Kinase C; Rats; Rats, Wistar; Reaction Time; Regression Analysis; Selegiline; Sodium-Potassium-Exchanging ATPase	2012
L-Deprenyl reverses age-associated decline in splenic norepinephrine, interleukin-2 and interferon-γ production in old female F344 rats. Neuroimmunomodulation, 2013, Volume: 20, Issue:2 Topics: Aging; Animals; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Immunity, Cellular; Interferon-gamma; Interleukin-2; Neuroprotective Agents; Norepinephrine; Rats; Rats, Inbred F344; Selegiline; Spleen; Sympathetic Nervous System	2013
Neurostimulatory and antioxidative effects of L-deprenyl in aged rat brain regions. Biogerontology, 2003, Volume: 4, Issue:2 Topics: Action Potentials; Aging; Animals; Antioxidants; Brain; Electrophysiology; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Lipofuscin; Male; Neuroprotective Agents; Rats; Rats, Wistar; Selegiline; Sodium-Potassium-Exchanging ATPase	2003
Deprenyl and the relationship between its effects on spatial memory, oxidant stress and hippocampal neurons in aged male rats. Physiological research, 2006, Volume: 55, Issue:2 Topics: Aging; Animals; Glutathione Peroxidase; Hippocampus; Lipid Peroxidation; Male; Memory; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Oxidative Stress; Prefrontal Cortex; Rats; Rats, Wistar; Selegiline; Spatial Behavior; Superoxide Dismutase	2006
Reversal of age-related deficits in object recognition memory in rats with l-deprenyl. Experimental gerontology, 2005, Volume: 40, Issue:6 Topics: Aging; Animals; Antiparkinson Agents; Behavior, Animal; Injections; Male; Memory; Memory Disorders; Memory, Short-Term; Rats; Rats, Wistar; Recognition, Psychology; Selegiline	2005
"My involvement in aging research was just a series of coincidences" An interview with Kenichi Kitani. Interview by Sataro Goto. Biogerontology, 2005, Volume: 6, Issue:3 Topics: Aging; Brain; Caloric Restriction; Geriatrics; Life Style; Liver; Longevity; Reactive Oxygen Species; Selegiline	2005
Effect of I-deprenyl and gliclazide on oxidant stress/antioxidant status and dna damage in a diabetic rat model. Endocrine research, 2005, Volume: 31, Issue:3 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Antioxidants; Blood Glucose; Body Weight; Deoxyguanosine; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Damage; Gliclazide; Hypoglycemic Agents; Lipid Peroxidation; Liver; Male; Malondialdehyde; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidants; Oxidative Stress; Rats; Rats, Inbred Strains; Selegiline; Superoxide Dismutase; Vitamin A; Vitamin E	2005
Antioxidants and Alzheimer's disease: time to stop feeding vitamin E to dementia patients? International psychogeriatrics, 2007, Volume: 19, Issue:1 Topics: Aging; Alzheimer Disease; Antioxidants; Cognition Disorders; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidative Stress; Selegiline; Vitamin E	2007
The effect of l-deprenyl on tissue mRNA expressions of NOS isoforms and NO levels in an experimental diabetes mellitus model. Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:6 Topics: Aging; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Heart; Isoenzymes; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; RNA, Messenger; Selegiline; Treatment Outcome	2007
Suppression of apoptosis and oxidative stress by deprenyl and estradiol in aged rat liver. Acta histochemica, 2007, Volume: 109, Issue:6 Topics: Aging; Animals; Apoptosis; Estradiol; Female; In Situ Nick-End Labeling; Lipid Peroxidation; Liver; Ovariectomy; Oxidative Stress; Rats; Rats, Wistar; Selegiline; Thiobarbituric Acid Reactive Substances	2007
Postnatal development of dopaminergic neurons in the rabbit retina. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1981, Volume: 1, Issue:10 Topics: Aging; Animals; Animals, Newborn; Benzylamines; Clorgyline; Dopamine; Kinetics; Monoamine Oxidase; Neurons; Potassium; Rabbits; Retina; Selegiline; Tyrosine 3-Monooxygenase	1981
Neurochemical insights into monoamine oxidase inhibitors, with special reference to deprenyl (selegiline). Acta neurologica Scandinavica. Supplementum, 1983, Volume: 95 Topics: Aged; Aging; Alzheimer Disease; Brain; Central Nervous System; Female; Humans; Huntington Disease; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Agents; Parkinson Disease; Phenethylamines; Selegiline	1983
The metabolism of dopamine by both forms of monoamine oxidase in the rat brain and its inhibition by cimoxatone. Journal of neurochemistry, 1983, Volume: 40, Issue:6 Topics: Aging; Animals; Brain; Clorgyline; Dopamine; Isoenzymes; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Inbred Strains; Selegiline; Species Specificity	1983
Long-lasting, true aphrodisiac effect of (-)-deprenyl in sexually sluggish old male rats. Modern problems of pharmacopsychiatry, 1983, Volume: 19 Topics: Aging; Amphetamine; Animals; Aphrodisiacs; Castration; Clorgyline; Copulation; Male; Phenethylamines; Rats; Selegiline; Sexual Behavior, Animal; Time Factors	1983
Deprenyl (selegiline): the history of its development and pharmacological action. Acta neurologica Scandinavica. Supplementum, 1983, Volume: 95 Topics: Aging; Animals; Brain; Depression; Dopamine; Drug Evaluation; History, 20th Century; Humans; Male; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Sexual Behavior	1983
Titration of human brain monoamine oxidase -A and -B by clorgyline and L-deprenil. Naunyn-Schmiedeberg's archives of pharmacology, 1980, Volume: 311, Issue:3 Topics: Adult; Aged; Aging; Benzylamines; Brain; Cerebral Cortex; Child, Preschool; Clorgyline; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Monoamine Oxidase; Nerve Tissue Proteins; Phenethylamines; Propylamines; Selegiline; Serotonin	1980
The regional distribution of monoamine oxidase activities towards different substrates: effects in rat brain of chronic administration of manganese chloride and of ageing. Journal of neurochemistry, 1981, Volume: 36, Issue:6 Topics: Aging; Animals; Benzylamines; Brain; Chlorides; Clorgyline; Dopamine; Female; Male; Manganese; Manganese Compounds; Monoamine Oxidase; Rats; Selegiline; Serotonin; Tissue Distribution	1981
Effects of long-term treatment with a monoamine oxidase B inhibitor, selegeline (L-deprenyl), on amino acid transmitter systems in the ageing rat brain. Proceedings of the Western Pharmacology Society, 1995, Volume: 38 Topics: Aging; Animals; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; In Vitro Techniques; Male; Membranes; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Selegiline	1995
Influence of long-term treatment with L-deprenyl on the age-dependent changes in rat brain microanatomy. Mechanisms of ageing and development, 1994, Volume: 73, Issue:2 Topics: Aging; Animals; Body Weight; Cerebellar Cortex; Cognition; Frontal Lobe; Hippocampus; Lipofuscin; Male; Organ Size; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Selegiline; Silver Staining; Staining and Labeling; Time Factors	1994
Effects of deprenyl on monoamine oxidase and neurotransmitters in the brains of MPTP-treated aging mice. Neurochemical research, 1995, Volume: 20, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Corpus Striatum; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Neurotransmitter Agents; Olfactory Pathways; Selegiline	1995
Effect of long-term treatment with L-deprenyl on the age-dependent microanatomical changes in the rat hippocampus. Mechanisms of ageing and development, 1995, Apr-14, Volume: 79, Issue:2-3 Topics: Aging; Animals; Evaluation Studies as Topic; Hippocampus; Male; Monoamine Oxidase; Rats; Rats, Sprague-Dawley; Selegiline; Time Factors	1995
Age-dependent effects of the 2'-methyl analog of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine: prevention by inhibitors of monoamine oxidase B. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Clorgyline; Corpus Striatum; Dopamine; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Selegiline	1995
Influence of treatment with L-deprenyl on the structure of the cerebellar cortex of aged rats. Mechanisms of ageing and development, 1994, Volume: 75, Issue:2 Topics: Aging; Animals; Body Weight; Cerebellar Cortex; Male; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley; Selegiline	1994
Deprenyl reinitiates estrous cycles, reduces serum prolactin, and decreases the incidence of mammary and pituitary tumors in old acyclic rats. Endocrinology, 1995, Volume: 136, Issue:3 Topics: Aging; Animals; Body Weight; Estrus; Female; Mammary Neoplasms, Experimental; Menopause; Organ Size; Pituitary Neoplasms; Prolactin; Rats; Rats, Sprague-Dawley; Selegiline	1995
The effect of 6-months l-deprenyl administration on pineal MAO-A and MAO-B activity and on the content of melatonin and related indoles in aged female Fisher 344N rats. Journal of neural transmission. Supplementum, 1994, Volume: 41 Topics: Aging; Animals; Female; Indoles; Melatonin; Monoamine Oxidase; Pineal Gland; Rats; Rats, Inbred F344; Reference Values; Selegiline; Time Factors	1994
Neuroanatomy of aging brain. Influence of treatment with L-deprenyl. Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717 Topics: Aging; Animals; Astrocytes; Cell Count; Frontal Lobe; Hippocampus; Histocytochemistry; Male; Monoamine Oxidase; Neurons; Rats; Rats, Sprague-Dawley; Selegiline	1994
Influence of L-deprenyl treatment on mouse survival kinetics. Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717 Topics: Aging; Animals; Crosses, Genetic; Life Expectancy; Mice; Mice, Inbred BALB C; Mice, Nude; Selegiline; Survival Analysis	1994
Microanatomical changes in the frontal cortex of aged rats: effect of L-deprenyl treatment. Brain research bulletin, 1994, Volume: 34, Issue:2 Topics: Aging; Animals; Cell Count; Frontal Lobe; Male; Rats; Rats, Sprague-Dawley; Reference Values; Selegiline	1994
The interaction of L-deprenyl and scopolamine on spatial learning/memory in rats. Journal of neural transmission. Parkinson's disease and dementia section, 1993, Volume: 6, Issue:3 Topics: Aging; Animals; Learning; Memory; Rats; Rats, Inbred Strains; Scopolamine; Selegiline; Space Perception	1993
(-)deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male mice. Life sciences, 1994, Volume: 54, Issue:14 Topics: Aging; Animals; Brain; Catalase; Cerebral Cortex; Corpus Striatum; Male; Mice; Mice, Inbred C57BL; Random Allocation; Selegiline; Substantia Nigra; Superoxide Dismutase	1994
The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats. Biochemical pharmacology, 1994, Apr-20, Volume: 47, Issue:8 Topics: Aging; Animals; Body Weight; Brain; Catalase; Dose-Response Relationship, Drug; Female; Rats; Rats, Inbred F344; Selegiline; Superoxide Dismutase; Time Factors	1994
Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice. Life sciences, 1993, Volume: 53, Issue:9 Topics: Aging; Animals; Behavior, Animal; Body Weight; Brain; Drinking; Isoenzymes; Locomotion; Male; Memory; Mice; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Time Factors	1993
Rescue of axotomized immature rat facial motoneurons by R(-)-deprenyl: stereospecificity and independence from monoamine oxidase inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:9 Topics: Aging; Animals; Axons; Brain Stem; Cell Survival; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Facial Nerve; Functional Laterality; Monoamine Oxidase; Motor Neurons; Rats; Rats, Sprague-Dawley; Selegiline; Stereoisomerism; Time Factors	1993
The optimal dosage of (-)deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats. Life sciences, 1993, Volume: 52, Issue:24 Topics: Aging; Analysis of Variance; Animals; Brain; Catalase; Dose-Response Relationship, Drug; Female; Isoenzymes; Male; Organ Specificity; Rats; Rats, Inbred F344; Selegiline; Sex Factors; Superoxide Dismutase	1993
MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice. Brain research, 1995, Aug-07, Volume: 688, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Aging; Analysis of Variance; Animals; Body Temperature Regulation; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Selegiline; Species Specificity	1995
Short intertrial intervals impair water maze performance in old Fischer 344 rats. The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:4 Topics: Aging; Animals; Disease Susceptibility; Escape Reaction; Fatigue; Female; Male; Maze Learning; Monoamine Oxidase Inhibitors; Psychomotor Performance; Rats; Rats, Inbred F344; Reaction Time; Selegiline; Stress, Physiological; Swimming; Temperature; Time Factors; Water	1996
Protection of the aged substantia nigra of the rat against oxidative damage by (-)-deprenyl. British journal of pharmacology, 1996, Volume: 117, Issue:8 Topics: Aging; Animals; Dopamine; Male; Monoamine Oxidase Inhibitors; Oxidative Stress; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Tyrosine	1996
Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity. Acta neuropathologica, 1996, Volume: 91, Issue:5 Topics: Aging; Animals; Immunohistochemistry; Male; Microscopy, Fluorescence; Monoamine Oxidase Inhibitors; Oxidopamine; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Selegiline; Superior Cervical Ganglion; Tyrosine 3-Monooxygenase	1996
The effects of L-deprenyl on spatial short term memory in young and aged dogs. Progress in neuro-psychopharmacology & biological psychiatry, 1996, Volume: 20, Issue:3 Topics: Aging; Animals; Dogs; Female; Male; Memory, Short-Term; Selegiline; Time Factors	1996
Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain. Life sciences, 1996, Volume: 59, Issue:13 Topics: Aging; Animals; Brain; Catalase; Male; Mice; Mice, Inbred C57BL; Selegiline; Superoxide Dismutase	1996
The systemic administration of tacrine or selegiline facilitate spatial learning in aged fisher 344 rats. Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:5 Topics: Aging; Animals; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Escape Reaction; Male; Maze Learning; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred F344; Reaction Time; Selegiline; Tacrine	1996
Effect of treatment with L-deprenyl on age-dependent microanatomical changes in the rat kidney. Mechanisms of ageing and development, 1996, Jul-31, Volume: 89, Issue:1 Topics: Aging; Analysis of Variance; Animals; Evaluation Studies as Topic; Image Processing, Computer-Assisted; Kidney; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline	1996
L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:6 Topics: Aging; Animals; Eating; Female; Fertility; Male; Mice; Selegiline; Superoxide Dismutase	1996
Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra. Free radical biology & medicine, 1997, Volume: 23, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Blotting, Western; Dopamine; Dopamine Uptake Inhibitors; Free Radicals; Male; Nomifensine; Oxidative Stress; Proteins; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase	1997
(-)-Deprenyl treatment restores serum insulin-like growth factor-I (IGF-I) levels in aged rats to young rat level. European journal of pharmacology, 1997, May-30, Volume: 327, Issue:2-3 Topics: Age Factors; Aging; Animals; Biomarkers; Insulin-Like Growth Factor I; Male; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Wistar; Selegiline; Tyrosine 3-Monooxygenase	1997
Visualization of monoamine oxidase in human brain. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Monoamine Oxidase; Organ Specificity; Radionuclide Imaging; Reference Values; Regression Analysis; Selegiline	1998
Therapeutic actions of L-deprenyl in dogs: a model of human brain aging. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: Aging; Animals; Brain; Cognition Disorders; Dementia; Dogs; Humans; Models, Biological; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline	1998
Restoration of sympathetic noradrenergic nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized and old Fischer 344 rats. Journal of neuroimmunology, 1998, Volume: 81, Issue:1-2 Topics: Adrenergic Fibers; Aging; Animals; Immunity, Cellular; Male; Monoamine Oxidase Inhibitors; Nerve Regeneration; Nerve Tissue Proteins; Neuropeptide Y; Norepinephrine; Oxidopamine; Rats; Rats, Inbred F344; Selegiline; Spleen; Sympathectomy, Chemical; Tyrosine 3-Monooxygenase	1998
L-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of noradrenergic nerve fibers in the spleens of old F344 rats. Journal of neuroimmunology, 1998, Dec-01, Volume: 92, Issue:1-2 Topics: Aging; Animals; B-Lymphocytes; Immunoglobulin M; Interleukin-2; Killer Cells, Natural; Lymphocyte Count; Male; Nerve Fibers; Nerve Regeneration; Neuropeptide Y; Neuroprotective Agents; Norepinephrine; Rats; Rats, Inbred F344; Selegiline; Spleen	1998
Prolongation of life in an experimental model of aging in Drosophila melanogaster. Neurochemical research, 1999, Volume: 24, Issue:2 Topics: Aging; Animals; Drosophila melanogaster; Free Radical Scavengers; Galactose; Longevity; Mutation; Reactive Oxygen Species; Selegiline; Sucrose; Superoxide Dismutase	1999
Link between catecholamine and nitric oxide metabolism. Nitric oxide : biology and chemistry, 1999, Volume: 3, Issue:6 Topics: Aging; Animals; Catecholamines; Monoamine Oxidase; Nitrates; Nitric Oxide; Nitrites; Rats; Selegiline	1999
Neuroprotection by (-)-deprenyl and related compounds. Mechanisms of ageing and development, 1999, Volume: 111, Issue:2-3 Topics: Aging; Amphetamines; Animals; Antioxidants; Apoptosis; Cattle; DNA Damage; DNA, Neoplasm; Indans; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Nitrates; Oxidants; Parkinson Disease; Selegiline; Tumor Cells, Cultured	1999
Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. Mechanisms of ageing and development, 1999, Volume: 111, Issue:2-3 Topics: Aging; Animals; Antioxidants; Catalase; Cats; Cricetinae; Dogs; Female; Glutathione Peroxidase; Glutathione Transferase; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nitrobenzenes; Oxidoreductases; Rats; Rats, Inbred F344; Selegiline; Superoxide Dismutase; Triterpenes; Up-Regulation; Ursodeoxycholic Acid; Ursolic Acid	1999
Restoration of splenic noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-deprenyl and L-desmethyldeprenyl. International journal of immunopharmacology, 2000, Volume: 22, Issue:7 Topics: Adrenergic Fibers; Aging; Amphetamines; Animals; Male; Nerve Regeneration; Norepinephrine; Rats; Rats, Inbred F344; Selegiline; Spleen	2000
Selective influences of age and thyroid hormones on type A monoamine oxidase of the rat heart. The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:11 Topics: Aging; Animals; Clorgyline; Heart; In Vitro Techniques; Monoamine Oxidase; Myocardium; Organ Size; Rats; Selegiline; Substrate Specificity; Thyroid Hormones	1979
Changes in spontaneous behavior in the dog following oral administration of L-deprenyl. Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:3 Topics: Aging; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Female; Grooming; Male; Motor Activity; Selegiline; Sex Characteristics; Stereotyped Behavior; Urination; Vocalization, Animal	1992
(-)deprenyl and (-)parafluorodeprenyl-treatment prevents age-related pigment changes in the substantia nigra. A TV-image analysis of neuromelanin. Mechanisms of ageing and development, 1992, Volume: 63, Issue:2 Topics: Aging; Animals; Male; Melanins; Neurons; Pigmentation; Rats; Selegiline; Substantia Nigra	1992
Evaluation of the effects of inhibition of monoamine oxidase and senescence on methamphetamine-induced neuronal damage. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1991, Volume: 9, Issue:2 Topics: Aging; Animals; Clorgyline; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nervous System Diseases; Neurons; Selegiline	1991
Quantitative localization of human brain monoamine oxidase B by large section autoradiography using L-[3H]deprenyl. Brain research, 1991, Apr-26, Volume: 547, Issue:1 Topics: Adult; Aged; Aging; Autoradiography; Brain; Caudate Nucleus; Female; Humans; Male; Monoamine Oxidase; Selegiline; Tomography, Emission-Computed	1991
The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats. Journal of neural transmission. General section, 1991, Volume: 85, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amphetamine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Levodopa; Male; Rats; Selegiline	1991
Improvement of cognitive function by MAO-B inhibitor L-deprenyl in aged rats. Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:2 Topics: Aggression; Aging; Animals; Cognition; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Memory; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Selegiline; Space Perception; Swimming	1991
Maintenance on L-deprenyl prolongs life in aged male rats. Life sciences, 1990, Volume: 47, Issue:5 Topics: Aging; Animals; Blood; Body Weight; Longevity; Male; Phenethylamines; Rats; Rats, Inbred F344; Selegiline	1990
Dose-dependent effects of deprenyl on CSF monoamine metabolites in patients with Alzheimer's disease. Psychopharmacology, 1987, Volume: 91, Issue:3 Topics: Aging; Alzheimer Disease; Biogenic Amines; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Middle Aged; Phenethylamines; Selegiline	1987
Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl. Life sciences, 1989, Volume: 45, Issue:6 Topics: Aging; Animals; Corpus Striatum; Dopamine; Female; Longevity; Male; Ovariectomy; Phenethylamines; Rats; Rats, Inbred Strains; Reference Values; Selegiline; Sexual Behavior, Animal	1989
The pharmacology of (-)deprenyl. Journal of neural transmission. Supplementum, 1986, Volume: 22 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Aging; Animals; Catecholamines; Corpus Striatum; Dopamine; Humans; Hydroxydopamines; In Vitro Techniques; Monoamine Oxidase; Oxidopamine; Phenethylamines; Pyridines; Selegiline	1986
Enzyme histochemistry of monoamine oxidase in the heart of aged rats. Mechanisms of ageing and development, 1987, Volume: 38, Issue:2 Topics: Aging; Animals; Clorgyline; Heart; Histocytochemistry; Male; Monoamine Oxidase; Myocardium; Rats; Rats, Inbred Strains; Selegiline	1987
Differential postnatal development of monoamine oxidases A and B in the blood-brain barrier of the rat. Journal of neurochemistry, 1987, Volume: 49, Issue:5 Topics: Aging; Animals; Benzylamines; Blood-Brain Barrier; Brain; Cerebral Cortex; Clorgyline; Microcirculation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Inbred Strains; Selegiline; Substrate Specificity; Tryptamines	1987
Extension of life span of rats by long-term (-)deprenyl treatment. The Mount Sinai journal of medicine, New York, 1988, Volume: 55, Issue:1 Topics: Aging; Animals; Life Expectancy; Male; Nerve Degeneration; Phenethylamines; Rats; Selegiline; Time Factors	1988
The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl. Mechanisms of ageing and development, 1988, Volume: 46, Issue:1-3 Topics: Aging; Animals; Corpus Striatum; Dopamine; Female; Life Expectancy; Male; Phenethylamines; Rats; Selegiline; Sexual Behavior, Animal	1988