securinine has been researched along with Parkinson-Disease* in 1 studies
1 other study(ies) available for securinine and Parkinson-Disease
| Article | Year |
|---|---|
Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.
Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson's disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target to alleviate neurodegeneration. Securinine, a major natural alkaloid product from the root of the plant Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Azepines; Blotting, Western; Cell Survival; Heterocyclic Compounds, Bridged-Ring; Interferon-Stimulated Gene Factor 3; Lactones; Lipopolysaccharides; Mice; Microglia; Mitogen-Activated Protein Kinases; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Parkinson Disease; Phosphorylation; Piperidines; Polymerase Chain Reaction | 2017 |