secinh3 has been researched along with Prostatic-Neoplasms* in 1 studies
1 other study(ies) available for secinh3 and Prostatic-Neoplasms
| Article | Year |
|---|---|
Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate.
Prostate smooth muscle contraction is critical for etiology and treatment of male lower urinary tract symptoms (LUTS) and is promoted by small monomeric GTPases (RhoA and Rac). GTPases may be activated by guanosine nucleotide exchange factors (GEFs). GEFs of the cytohesin family may indirectly activate Rac, or ADP ribosylation factor (ARF) GTPases directly. Here we investigated the expression of cytohesin family GEFs and effects of the cytohesin inhibitor Sec7 inhibitor H3 (secinH3) on smooth muscle contraction and GTPase activities in human prostate tissues. Of all four cytohesin isoforms, cytohesin-1 and -2 showed the highest expression in real-time PCR. Western blot and fluorescence staining suggested that cytohesin-2 may be the predominant isoform in prostate smooth muscle cells. Contractions induced by norepinephrine, the α Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Humans; Male; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Prostate; Prostatic Neoplasms; Triazoles | 2018 |