secalonic-acid and Lung-Neoplasms

secalonic-acid has been researched along with Lung-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for secalonic-acid and Lung-Neoplasms

Article	Year
4,4'‑Bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma. Molecular medicine reports, 2020, Volume: 21, Issue:6 The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD), a compound isolated from the marine‑derived fungus Penicillium oxalicum, inhibited the growth of side population (SP) cells isolated from human liver cancer cell lines PLC/PRF/5 and HuH‑7 by attenuating the expression of ATP‑binding cassette superfamily G member 2. Furthermore, the results of wound healing, Transwell, western blotting and reverse transcription‑quantitative PCR assays demonstrated that 4,4'‑SAD suppressed the invasion and migration of SP cells by downregulating matrix metallopeptidase 9 (MMP‑9) and upregulating the antagonist tissue inhibitor of metalloproteinases 1 in vitro. Moreover, in vivo study results found that 4,4'‑SAD had anti‑lung metastasis efficacy via the decrease of MMP‑9 expression in the H22 HCC model of Kunming mice. Therefore, the present study identified the potential of 4,4'‑SAD as a promising candidate for the treatment of advanced liver cancer. Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Penicillium; Side-Population Cells; Tissue Inhibitor of Metalloproteinase-1; Transplantation, Heterologous; Xanthones	2020
Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. Journal of natural products, 2001, Volume: 64, Issue:8 Bioassay-guided fractionation of the organic extract from a culture of Phomopsis longicolla, an endophytic fungus of the endangered mint Dicerandra frutescens, led to the isolation of dicerandrols A, B, and C. Extensive NMR and HRFABMS experiments were used to identify these new yellow antibiotic and cytotoxic compounds as 2,2'-dimeric tetrahydroxanthones. Topics: Antibiotics, Antineoplastic; Ascomycota; Bacillus subtilis; Colonic Neoplasms; Florida; Geotrichum; Humans; Lamiaceae; Lung Neoplasms; Magnetic Resonance Spectroscopy; Molecular Structure; Saccharomyces cerevisiae; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Staphylococcus aureus; Stereoisomerism; Tumor Cells, Cultured; Xanthenes; Xanthones	2001

Article

Year

4,4'‑Bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma.

Molecular medicine reports, 2020, Volume: 21, Issue:6

The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD), a compound isolated from the marine‑derived fungus Penicillium oxalicum, inhibited the growth of side population (SP) cells isolated from human liver cancer cell lines PLC/PRF/5 and HuH‑7 by attenuating the expression of ATP‑binding cassette superfamily G member 2. Furthermore, the results of wound healing, Transwell, western blotting and reverse transcription‑quantitative PCR assays demonstrated that 4,4'‑SAD suppressed the invasion and migration of SP cells by downregulating matrix metallopeptidase 9 (MMP‑9) and upregulating the antagonist tissue inhibitor of metalloproteinases 1 in vitro. Moreover, in vivo study results found that 4,4'‑SAD had anti‑lung metastasis efficacy via the decrease of MMP‑9 expression in the H22 HCC model of Kunming mice. Therefore, the present study identified the potential of 4,4'‑SAD as a promising candidate for the treatment of advanced liver cancer.

Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Penicillium; Side-Population Cells; Tissue Inhibitor of Metalloproteinase-1; Transplantation, Heterologous; Xanthones

2020

Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint.

Journal of natural products, 2001, Volume: 64, Issue:8

Bioassay-guided fractionation of the organic extract from a culture of Phomopsis longicolla, an endophytic fungus of the endangered mint Dicerandra frutescens, led to the isolation of dicerandrols A, B, and C. Extensive NMR and HRFABMS experiments were used to identify these new yellow antibiotic and cytotoxic compounds as 2,2'-dimeric tetrahydroxanthones.

Topics: Antibiotics, Antineoplastic; Ascomycota; Bacillus subtilis; Colonic Neoplasms; Florida; Geotrichum; Humans; Lamiaceae; Lung Neoplasms; Magnetic Resonance Spectroscopy; Molecular Structure; Saccharomyces cerevisiae; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Staphylococcus aureus; Stereoisomerism; Tumor Cells, Cultured; Xanthenes; Xanthones

2001