scyx-7158 and Leishmaniasis--Visceral

Visceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. Current therapies are unsuitable, and there is an urgent need for safe, short-course, and low-cost oral treatments to combat this neglected disease. The benzoxaborole chemotype has previously delivered clinical candidates for the treatment of other parasitic diseases. Here, we describe the development and optimization of this series, leading to the identification of compounds with potent

Topics: Animals; Antiprotozoal Agents; Benzoxazoles; Boron Compounds; Cricetinae; Disease Models, Animal; Dogs; Humans; Leishmaniasis, Visceral; Mice; Pyridines; Structure-Activity Relationship