scp-1 has been researched along with Fever* in 1 studies
1 other study(ies) available for scp-1 and Fever
| Article | Year |
|---|---|
Synthesis, hepatotoxic evaluation and antipyretic activity of nitrate ester analogs of the acetaminophen derivative SCP-1.
A series of nitrate ester analogues of the acetaminophen derivative SCP-1 were prepared by triflic acid catalyzed O-acylation of SCP-1 with chloroalkanoyl chlorides followed by nitration with silver nitrate. The chloroesters and corresponding nitrate esters were obtained in high yields. Preliminary hepatotoxicity studies revealed nitrate esters 5b (MD-38) and 5c (MD-39) to be well tolerated by human hepatocytes and had little effect on the three cytochrome P450 enzymes tested (CYP3A4, CYP2E1 and CYP2D6). In addition, the nitrate ester 5c (MD-39) exhibited antipyretic activity similar to acetaminophen. Topics: Acetaminophen; Animals; Antipyretics; Chemical and Drug Induced Liver Injury; Crystallography, X-Ray; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Esterification; Fever; Hepatocytes; Humans; Models, Molecular; Nitrates; Rats; Saccharin | 2018 |