scopolin and Inflammation

Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.

Topics: Animals; Anti-Inflammatory Agents; Calcimycin; Carrageenan; Chromatography, Thin Layer; Coumarins; Dinoprostone; Inflammation; Ionophores; Leukotrienes; Macrophages, Peritoneal; Magnetic Resonance Spectroscopy; Mice; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Spain; Spectrophotometry, Ultraviolet