sciadopitysin has been researched along with Alzheimer-Disease* in 2 studies
2 other study(ies) available for sciadopitysin and Alzheimer-Disease
| Article | Year |
|---|---|
Naturally occurring biflavonoids with amyloid β aggregation inhibitory activity for development of anti-Alzheimer agents.
Amyloid β (Aβ) aggregation plays an essential role in promoting the progression of Alzheimer's disease (AD). Therefore, the inhibition of Aβ aggregation is a potential therapeutic approach for AD. Herein, twenty-seven biflavonoids with different inter-flavonyl linkages and methoxy substitution patterns were isolated from several plants, and their Aβ Topics: Alzheimer Disease; Amyloid beta-Peptides; Biflavonoids; Humans | 2019 |
Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.
Five taxane diterpenoids derived from the 95% ethanol extract of Taxus chinensis were tested for the inhibitory activities on amyloid-beta (Aβ) peptide aggregation. Using thioflavin-T fluorescence assay, sciadopitysin was found to exhibit the most potency against Aβ aggregation and the formation of fibrils. Further cellular assay indicated that sciadopitysin increased the cell viability of SH-SY5Y cell and demonstrated neuroprotection against Aβ protein-induced insult in primary cortical neurons. According to the authors' best knowledge, this is the first report that sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons. Topics: Alzheimer Disease; Amyloid beta-Peptides; Biflavonoids; Cell Line; Drug Evaluation, Preclinical; Humans; Neurons; Neuroprotective Agents; Taxus; Toxicity Tests | 2013 |