schweinfurthin-a and Lung-Neoplasms

schweinfurthin-a has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for schweinfurthin-a and Lung-Neoplasms

ArticleYear
Synthesis and biological activity of a fluorescent schweinfurthin analogue.
    Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13

    Most of the natural schweinfurthins are potent and selective inhibitors of cell growth as measured by the National Cancer Institute's 60-cell line screen. Due to the limited supply of these natural products, we have initiated a program aimed at their synthesis. To date, this effort has led to the preparation of three natural schweinfurthins and more than 40 analogues, and assays on these compounds have afforded some understanding of structure-activity relationships in this family. Further development of schweinfurthins as chemotherapeutic agents would benefit from characterization of their mechanism(s) of action. This perspective led to development of a fluorescent schweinfurthin analogue that retains the differential activity of the natural products, and yet has properties that facilitate its visualization within cells.

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Euphorbiaceae; Fluorescent Dyes; Humans; Lung Neoplasms; Molecular Structure; Structure-Activity Relationship; Xanthenes

2009