Compounds > schizandrol b
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schizandrol b and Chemical and Drug Induced Liver Injury

schizandrol b has been researched along with Chemical and Drug Induced Liver Injury in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's2 (13.33)18.2507
2000's0 (0.00)29.6817
2010's5 (33.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Bi, HC; Chen, PP; Chen, YX; Fan, SC; Gao, Y; Huang, M; Jiang, YM; Jiao, TY; Tian, JN; Yang, X; Yao, XP; Zhao, YY; Zhou, YY1
Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Bi, HC; Chen, P; Fan, XM; Huang, M; Jiang, YM; Tan, HS; Wang, Y; Yu, T; Zeng, H1
Aburada, M; Shimada, T; Teraoka, R1
Choi, YH; Hong, JT; Hwang, DY; Hwang, IS; Kang, BC; Kim, JE; Kwak, MH; Lee, YJ1
Kawasaki, H; Murawaki, Y; Yamada, S1
Aburada, M; Hosoya, E; Mizoguchi, Y; Morisawa, S; Ohkura, Y; Takeda, S1
Liu, GT1
Liu, GT; Wei, HL1
Higashimori, T; Kobayashi, K; Miyajima, K; Mizoguchi, Y; Morisawa, S; Okura, Y; Sakagami, Y; Tsutsui, H; Yamamoto, S1
Aburada, M; Arai, I; Hasegawa, M; Hosoya, E; Kase, Y; Ohkura, Y; Sekiguchi, Y; Sudo, K; Takeda, S1
Aburada, M; Arai, I; Fujii, Y; Funo, S; Hosoya, E; Kase, Y; Maemura, S; Ohkura, Y; Sudo, K; Takeda, S1
Aburada, M; Harada, M; Maeda, S; Miyamoto, Y; Takeda, S1
Hikino, H; Ikeya, Y; Kiso, Y; Taguchi, H; Tohkin, M1

Other Studies

15 other study(ies) available for schizandrol b and Chemical and Drug Induced Liver Injury

ArticleYear
Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 84

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Hepatomegaly; Humans; Lignans; Liver; Male; Mice, Inbred C57BL; Organ Size; Pregnane X Receptor; Schisandra; Signal Transduction; Transcription Factors; YAP-Signaling Proteins

2021
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis Regulatory Proteins; Benzoquinones; Binding Sites; Biomarkers; Catalytic Domain; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytoprotection; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Imines; Lignans; Liver; Liver Regeneration; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria, Liver; Molecular Docking Simulation; Protein Binding; Protein Conformation; Signal Transduction

2015
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
    Chemico-biological interactions, 2015, Apr-25, Volume: 231

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dioxoles; Lignans; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Polycyclic Compounds; Protective Agents; Schisandra

2015
Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidant Response Elements; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Gene Expression Regulation; Hep G2 Cells; Humans; Lignans; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Protective Agents; RNA, Messenger; Schisandra; Signal Transduction

2016
The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:2

    Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Interleukin-1beta; Lignans; Lipid Peroxidation; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha

2012
Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.
    International journal of molecular medicine, 2013, Volume: 31, Issue:4

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Kidney; Lignans; Liver; MAP Kinase Signaling System; Organ Size; Phosphorylation; Protective Agents; Rats; Rats, Sprague-Dawley; Schisandra

2013
Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats.
    Biochemical pharmacology, 1993, Sep-14, Volume: 46, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione; Lignans; Lipid Peroxides; Liver; Liver Diseases; Male; Organ Size; Rats; Rats, Wistar; Time Factors

1993
Effect of gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:2

    Topics: Animals; Arachidonic Acids; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Exudates and Transudates; Leukotriene B4; Lignans; Lipoxygenase; Macrophages; Male; Phospholipases A; Phospholipases A2; Polycyclic Compounds; Rats; Rats, Inbred Strains

1990
Pharmacological actions and clinical use of fructus schizandrae.
    Chinese medical journal, 1989, Volume: 102, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Drugs, Chinese Herbal; Hepatitis B; Humans; Lignans; Lipid Peroxidation; Mice; Microsomes, Liver; Polycyclic Compounds; Rats

1989
[Protection by fructus Schizandrae against acetaminophen hepatotoxicity in mice].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1987, Volume: 22, Issue:9

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione; Lignans; Liver; Male; Mice; Microsomes, Liver; Polycyclic Compounds

1987
[The protective effect of gomisin A on experimentally induced acute hepatic injury].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987, Volume: 84, Issue:3

    Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Guinea Pigs; Lignans; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Rats

1987
[Pharmacological studies on antihepatotoxic action of (+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy++ + -6,7-dimethyl-10,11-methylenedioxy-6-dibenzo[a,c] cyclooctenol (TJN-101), a lignan component of Schisandra fruits. Influences of resolven
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1987, Volume: 107, Issue:7

    Topics: Animals; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Lignans; Liver; Male; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Polysorbates; Rats; Rats, Inbred Strains; Solvents; Transaminases

1987
[Effects of gomisin A, a lignan component of Schizandra fruits, on experimental liver injuries and liver microsomal drug-metabolizing enzymes].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 87, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Ethionine; Galactosamine; Lignans; Liver Diseases; Male; Microsomes, Liver; Mixed Function Oxygenases; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sleep

1986
Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.
    Japanese journal of pharmacology, 1985, Volume: 38, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Galactosamine; Indocyanine Green; Lignans; Liver; Liver Function Tests; Male; Orotic Acid; Polycyclic Compounds; Rats; Rats, Inbred Strains

1985
Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A.
    Planta medica, 1985, Issue:4

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Inbred Strains

1985