schisanhenol and Chemical-and-Drug-Induced-Liver-Injury

Twenty-one new schisanhenol derivatives were synthesized, and their hepatoprotective effects against liver injury induced by concanavalin A (Con A) were evaluated in vitro using an MTT assay. The data indicated that most derivatives exhibited equivalent or better protective activity than the positive control (dimethyl dicarboxylate biphenyl, DDB) under the same conditions. Among them, compound 1b showed the most potent hepatoprotective activity against Con A-induced immunological injury. Mechanistic studies in vitro revealed that 1b inhibited cell apoptosis and inflammatory responses caused by Con A treatment via IL-6/JAK2/STAT3 signaling pathway. Consistently, it also exhibited significant hepatoprotective activity in mice with Con A-induced immunological liver injury. These results clearly indicated that 1b might be a highly potent hepatoprotective agent targeting IL-6/STAT3 signaling pathway.

Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Concanavalin A; Cyclooctanes; Dose-Response Relationship, Drug; Female; Humans; Interleukin-6; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Polycyclic Compounds; Protective Agents; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship