sch 42495 has been researched along with Hypertension in 11 studies
*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ardeleani, G; Casati, C; Monopoli, A; Morganti, A; Ongini, E; Sala, C; Zanchetti, A | 1 |
| Masuo, K; Mikami, H; Nagano, M; Ogihara, T; Rakugi, H; Yu, H | 1 |
| Crozier, IG; Espiner, EA; Nicholls, MG; Richards, AM; Yandle, TG | 1 |
| Crozier, IG; Espiner, EA; Frampton, C; Ikram, H; Kosoglou, T; Nicholls, MG; Rallings, M; Richards, AM; Yandle, TG | 1 |
| Banfield, CR; Batra, V; Fettner, SH; Kosoglou, T; Pai, S; Zhu, GR | 1 |
| Allen, TJ; Burrell, LM; Cooper, ME; Johnston, CI; Rockell, MD; Tikkanen, I; Tikkanen, T | 1 |
| Burrell, LM; Farina, NK; Johnston, CI | 1 |
| Alton, KB; Alvarez, N; Hernandez, A; Patrick, JE | 1 |
| Forlani, A; Monopoli, A; Ongini, E | 1 |
| Chiu, PJ; Sybertz, EJ; Vemulapalli, S; Watkins, RW | 1 |
4 trial(s) available for sch 42495 and Hypertension
| Article | Year |
|---|---|
Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension.
Topics: Aged; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Female; Heart Rate; Humans; Hypertension; Male; Methionine; Middle Aged; Neprilysin | 1994 |
Plasma brain natriuretic peptide and endopeptidase 24.11 inhibition in hypertension.
Topics: Adult; Aged; Angiotensin II; Atrial Natriuretic Factor; Double-Blind Method; Humans; Hypertension; Indans; Male; Methionine; Middle Aged; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Posture; Propionates; Time Factors | 1993 |
Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension.
Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Guanosine Monophosphate; Heart Rate; Humans; Hypertension; Male; Methionine; Middle Aged; Natriuresis; Neprilysin; Norepinephrine; Renin-Angiotensin System; Sodium; Sympathetic Nervous System; Time Factors | 1993 |
Pharmacokinetic-pharmacodynamic (PK-PD) modeling for a new antihypertensive agent (neutral metalloendopeptidase inhibitor SCH 42354) in patients with mild to moderate hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Humans; Hypertension; Male; Methionine; Middle Aged; Placebos; Prodrugs; Protease Inhibitors | 1995 |
7 other study(ies) available for sch 42495 and Hypertension
| Article | Year |
|---|---|
Hemodynamic and humoral effects of chronic treatment with the neutral endopeptidase inhibitor SCH 42495 in spontaneously hypertensive rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cyclic GMP; Diuresis; Enalapril; Hemodynamics; Hypertension; Male; Methionine; Natriuresis; Neprilysin; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 1994 |
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Glucose; Blood Pressure; Body Weight; Captopril; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hypertension; Male; Methionine; Neprilysin; Propionates; Rats; Rats, Inbred SHR; Renal Circulation; Renin; Sulfhydryl Compounds | 1998 |
SCH 42495.
Topics: Drugs, Investigational; Endopeptidases; Heart Failure; Humans; Hypertension; Methionine; Prodrugs; Protease Inhibitors | 1999 |
Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cardiomegaly; Enzyme Inhibitors; Fibrosis; Hypertension; Kidney; Male; Methionine; Myocardium; Neprilysin; Organ Size; Propionates; Protease Inhibitors; Rats; Rats, Inbred SHR; Renin; Sulfhydryl Compounds | 2000 |
High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric de
Topics: Chromatography, High Pressure Liquid; Gold; Humans; Hypertension; Mercury; Methionine; Neprilysin; Sulfhydryl Compounds | 1992 |
Chronic inhibition of neutral endopeptidase reduces left ventricular hypertrophy without changing blood pressure in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Dioxolanes; Dipeptides; Enalapril; Hypertension; Methionine; Myocardium; Neprilysin; Rats; Rats, Inbred SHR | 1991 |
Neutral metalloendopeptidase inhibition: a novel means of circulatory modulation.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Bradykinin; Desoxycorticosterone; Dioxolanes; Dipeptides; Hypertension; Male; Methionine; Neprilysin; Rats; Rats, Inbred Strains; Sodium, Dietary | 1990 |