sch-23390 and Acute-Disease

sch-23390 has been researched along with Acute-Disease* in 1 studies

Other Studies

1 other study(ies) available for sch-23390 and Acute-Disease

ArticleYear
Blockade of dopamine D1-like receptor signalling protects mice against OVA-induced acute asthma by inhibiting B-cell activating transcription factor signalling and Th17 function.
    The FEBS journal, 2013, Volume: 280, Issue:23

    Previous studies have consistently demonstrated that dopamine D1-like receptor (D1-like-R) signalling is implicated in the pathogenesis of experimental autoimmune encephalomyelitis and type I diabetes. Given that allergic asthma shares certain disease aetiology similarities with autoimmune diseases, we conducted studies in OVA-induced mice aiming to address the impact of D1-like-R signalling on the pathogenesis of allergic asthma. It was noted that blockade of D1-like-R signalling provided protection for mice against OVA-induced acute asthma. Particularly, treatment of OVA-induced mice with SCH23390, a D1-like-R antagonist, significantly attenuated inflammatory infiltration in the airways along with repressed goblet cell hyperplasia and mucus production, as well as airway resistance. By contrast, administration of SKF83959, a D1-like-R agonist, displayed the opposite effect. Blockade of D1-like-R signalling impaired Th17 function, as manifested by a significant reduction of Th17 cells in the spleen and bronchoalveolar lavage fluid. Mechanistic studies revealed that D1-like-R signalling enhances B-cell activating transcription factor activity, which then transcribes the expression of RORĪ³t, a Th17 transcription factor; accordingly, D1-like-R signalling regulates Th17 differentiation to promote the development of allergic asthma. Taken together, the data obtained in the present suggest that blockade of D1-like-R signalling could be an effective therapeutic strategy for the prevention and treatment of allergic asthma in clinical practice.

    Topics: Acute Disease; Animals; Asthma; B-Lymphocytes; Basic-Leucine Zipper Transcription Factors; Benzazepines; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cell Proliferation; Dopamine; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunoenzyme Techniques; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, Dopamine D1; RNA, Small Interfering; Th17 Cells

2013