sch-22219 and Skin-Diseases

This is a randomized single blind parallel comparison of alclometasone dipropionate cream 0.1% vs hydrocortisone butyrrate in 39 geriatric patients (greater than 60 years old) with steroid sensible skin diseases. The regimen consisted of dosing patients with two applications of the two drugs every day for 4 weeks. Follow-up evaluations have been done weekly, and subjective and objective clinical symptoms, adherence to the study protocol, evolution of the disease, onset of adverse reactions including atrophy have been recorded. Furthermore possible side-effects on hypophysis-adrenal axis have been monitored in baseline conditions, after 7 days and at the end of therapy. In most patients bioptic skin patterns for histomorphometric examination have been drawn before and after therapy to be evaluated by a blind examinator. Alclometasone has reduced initial skin lesions by 82.2%, the extent as hydrocortisone butyrrate. In five patients the complete clearance of the disease has been obtained. Study drugs have been tolerated well by all patients, nor clinical signs of atrophy have been observed. Fluctuations of blood cortisol levels ranged between the normal values. In patients treated with alclometasone histomorphometry revealed a better skin trophism than in patients treated with hydrocortisone butyrrate.

Topics: Aged; Aged, 80 and over; Dermatologic Agents; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Single-Blind Method; Skin Diseases

Topics: Administration, Topical; Clinical Trials as Topic; Dermatitis, Seborrheic; Eczema; Humans; Methylprednisolone; Skin Diseases

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Middle Aged; Random Allocation; Skin Diseases

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Clinical Trials as Topic; Double-Blind Method; Eczema; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Middle Aged; Ointments; Random Allocation; Skin Diseases

Topics: Administration, Topical; Adolescent; Adult; Aged; Female; Humans; Male; Methylprednisolone; Middle Aged; Multicenter Studies as Topic; Ointments; Skin Diseases

Topics: Administration, Topical; Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Methylprednisolone; Middle Aged; Ointments; Random Allocation; Skin Diseases

Isolated, hyperpigmented lesions arising on the skin of the head and neck in the elderly rarely prompt consideration of connective tissue diseases. Histologic evaluation, however, may reveal changes compatible with chronic cutaneous lupus erythematosus (CCLE). A retrospective review of cutaneous biopsies compatible with CCLE evaluated by the Vanderbilt University Division of Dermatopathology over a five-year period (1998-2002) was undertaken. Cases with isolated lesions arising on the head and neck in patients 40 years or older were selected and the histopathology was confirmed. Patients were interviewed by phone and their charts were reviewed. A total of 11 cases were found, including nine women and two men. These patients averaged 68 years of age and presented with single, hyperpigmented macular lesions. Photosensitivity was rare and no associated stigmata of lupus erythematosus were noted. Response to topical application of corticosteroid preparations was excellent.

Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Aged; Biopsy; Child; Child, Preschool; Chronic Disease; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Interviews as Topic; Lupus Erythematosus, Discoid; Male; Methylprednisolone; Pigments, Biological; Retrospective Studies; Skin Diseases; Time Factors; Treatment Outcome; White People

Topics: Administration, Topical; Costs and Cost Analysis; Humans; Methylprednisolone; Skin Diseases