sch-22219 and Psoriasis

This was a double-blind, randomized, parallel-groups comparison of alclometasone dipropionate and desonide ointments (0.05%) applied twice daily without occlusion for 3 weeks by patients with moderate to severe psoriasis. Data from thirty-three patients in each group showed that both treatments produced rapid amelioration of erythema, induration, and, especially, scaling; substantial improvement was evident after 1 week and continued thereafter. Differences between the groups were not statistically significant, but trends consistently favoured alclometasone. No adverse drug reaction occurred.

Topics: Administration, Topical; Adolescent; Adult; Aged; Clinical Trials as Topic; Desonide; Double-Blind Method; Female; Humans; Male; Methylprednisolone; Middle Aged; Ointments; Pregnadienetriols; Psoriasis

In a parallel group design, and using a 'blind evaluator' technique, alclometasone cream 0.05% and clobetasone butyrate cream 0.5% applied twice a day for 21 days were compared in thirty-one patients presenting with psoriasis. Erythema, induration and scaling were assessed at the start of treatment. Seven, 14 and 21 days later, effects of the two treatments were assessed and recorded together with the physician's global evaluation of overall improvement. Both drugs had similar beneficial effects on the clinical signs. No adverse experience was reported and the overall results indicate that alclometasone and clobetasone have comparable efficacy and safety.

Topics: Adult; Anti-Inflammatory Agents; Betamethasone; Clobetasol; Drug Evaluation; Humans; Methylprednisolone; Psoriasis