sb-590885 and Stroke

sb-590885 has been researched along with Stroke* in 1 studies

Other Studies

1 other study(ies) available for sb-590885 and Stroke

Article	Year
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorganic & medicinal chemistry letters, 2008, Aug-01, Volume: 18, Issue:15 Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke. Topics: Animals; Central Nervous System; Furans; Imidazoles; Indans; Molecular Structure; Proto-Oncogene Proteins B-raf; Pyridines; Rats; Stroke; Structure-Activity Relationship	2008

Article

Year

The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.

Bioorganic & medicinal chemistry letters, 2008, Aug-01, Volume: 18, Issue:15

Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.

Topics: Animals; Central Nervous System; Furans; Imidazoles; Indans; Molecular Structure; Proto-Oncogene Proteins B-raf; Pyridines; Rats; Stroke; Structure-Activity Relationship

2008