sb-265610 and Inflammation

sb-265610 has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for sb-265610 and Inflammation

Article	Year
Nicotinamide N-oxides as CXCR2 antagonists. Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14 A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders. Topics: Autoimmune Diseases; Binding Sites; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Chemotaxis; Growth Substances; Humans; Hypersensitivity; Inflammation; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Interleukin-8; Neutrophils; Niacinamide; Protein Binding; Receptors, Interleukin-8B; Structure-Activity Relationship	2001

Article

Year

Nicotinamide N-oxides as CXCR2 antagonists.

Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14

A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.

Topics: Autoimmune Diseases; Binding Sites; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Chemotaxis; Growth Substances; Humans; Hypersensitivity; Inflammation; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Interleukin-8; Neutrophils; Niacinamide; Protein Binding; Receptors, Interleukin-8B; Structure-Activity Relationship

2001