sb-258585 has been researched along with Neuralgia* in 1 studies
1 other study(ies) available for sb-258585 and Neuralgia
| Article | Year |
|---|---|
Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment.
A novel series of 3-arylsulfonylamino-5,6-dihydro-6-substituted-1H-pyrazolo[3,4-c]pyridine-7-ones was designed and synthesized as 5-HT6 ligands. Among the derivatives synthesized, the lead compound, 12b, having piperidine functionality at the 6-position and (1-naphthyl)sulfonamino at the 3-position of the core structure showed the most potent 5-HT6 inhibitory activity in vitro, good stability without CYP liability, and good neuropathic pain alleviation activity in a rat animal model. Topics: Animals; Disease Models, Animal; Drug Stability; Enzyme Inhibitors; Inhibitory Concentration 50; Molecular Structure; Neuralgia; Protein Binding; Pyrazoles; Pyridones; Rats; Receptors, Serotonin | 2013 |