sb 239063 has been researched along with Stroke in 4 studies
SB 239063: structure in first source
SB-239063 : A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Numerous pathological mediators of cardiac hypertrophy (eg, neurohormones, cytokines, and stretch) have been shown to activate p38 MAPK." | 1.31 | Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction. ( Adams, JL; Angermann, CE; Behr, TM; Brooks, DP; Chandra, S; Coatney, RW; Kumar, S; Lee, JC; Nelson, AH; Nerurkar, SS; Ohlstein, EH; Sackner-Bernstein, JD; Sisko, J; Sulpizio, A; Willette, RN; Woods, TN, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wallace, BK | 1 |
| Jelks, KA | 1 |
| O'Donnell, ME | 1 |
| Lenhard, SC | 1 |
| Nerurkar, SS | 2 |
| Schaeffer, TR | 1 |
| Mirabile, RC | 1 |
| Boyce, RW | 1 |
| Adams, DF | 1 |
| Jucker, BM | 1 |
| Willette, RN | 2 |
| Barone, FC | 1 |
| Parsons, AA | 1 |
| Behr, TM | 1 |
| Nelson, AH | 1 |
| Coatney, RW | 1 |
| Woods, TN | 1 |
| Sulpizio, A | 1 |
| Chandra, S | 1 |
| Brooks, DP | 1 |
| Kumar, S | 1 |
| Lee, JC | 1 |
| Ohlstein, EH | 1 |
| Angermann, CE | 1 |
| Adams, JL | 1 |
| Sisko, J | 1 |
| Sackner-Bernstein, JD | 1 |
1 review available for sb 239063 and Stroke
| Article | Year |
|---|---|
Therapeutic potential of anti-inflammatory drugs in focal stroke.
Topics: Animals; Anti-Inflammatory Agents; Brain Injuries; Cell Adhesion Molecules; Cytokines; Gene Expressi | 2000 |
3 other studies available for sb 239063 and Stroke
| Article | Year |
|---|---|
Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases.
Topics: Animals; Anthracenes; Blood-Brain Barrier; Brain; Brain Ischemia; Bumetanide; Cattle; Cell Hypoxia; | 2012 |
p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging.
Topics: Albuminuria; Animals; Contrast Media; Creatinine; Dietary Fats; Endothelium, Vascular; Enzyme Inhibi | 2003 |
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; E | 2001 |