Page last updated: 2024-11-04

sb 239063 and Stroke

sb 239063 has been researched along with Stroke in 4 studies

SB 239063: structure in first source
SB-239063 : A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"Numerous pathological mediators of cardiac hypertrophy (eg, neurohormones, cytokines, and stretch) have been shown to activate p38 MAPK."1.31Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction. ( Adams, JL; Angermann, CE; Behr, TM; Brooks, DP; Chandra, S; Coatney, RW; Kumar, S; Lee, JC; Nelson, AH; Nerurkar, SS; Ohlstein, EH; Sackner-Bernstein, JD; Sisko, J; Sulpizio, A; Willette, RN; Woods, TN, 2001)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wallace, BK1
Jelks, KA1
O'Donnell, ME1
Lenhard, SC1
Nerurkar, SS2
Schaeffer, TR1
Mirabile, RC1
Boyce, RW1
Adams, DF1
Jucker, BM1
Willette, RN2
Barone, FC1
Parsons, AA1
Behr, TM1
Nelson, AH1
Coatney, RW1
Woods, TN1
Sulpizio, A1
Chandra, S1
Brooks, DP1
Kumar, S1
Lee, JC1
Ohlstein, EH1
Angermann, CE1
Adams, JL1
Sisko, J1
Sackner-Bernstein, JD1

Reviews

1 review available for sb 239063 and Stroke

ArticleYear
Therapeutic potential of anti-inflammatory drugs in focal stroke.
    Expert opinion on investigational drugs, 2000, Volume: 9, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Brain Injuries; Cell Adhesion Molecules; Cytokines; Gene Expressi

2000

Other Studies

3 other studies available for sb 239063 and Stroke

ArticleYear
Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases.
    American journal of physiology. Cell physiology, 2012, Feb-01, Volume: 302, Issue:3

    Topics: Animals; Anthracenes; Blood-Brain Barrier; Brain; Brain Ischemia; Bumetanide; Cattle; Cell Hypoxia;

2012
p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Albuminuria; Animals; Contrast Media; Creatinine; Dietary Fats; Endothelium, Vascular; Enzyme Inhibi

2003
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction.
    Circulation, 2001, Sep-11, Volume: 104, Issue:11

    Topics: Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; E

2001