sb 239063 has been researched along with Pulmonary Fibrosis in 1 studies
SB 239063: structure in first source
SB-239063 : A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a bleomycin-induced pulmonary fibrosis model in rats, treatment with SB 239063 (2." | 1.31 | SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. ( Adams, JL; Bochnowicz, S; Griswold, DE; Hay, DW; Lee, JC; Osborn, RR; Rieman, DJ; Romanic, AM; Underwood, DC; Webb, EF, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Underwood, DC | 1 |
| Osborn, RR | 1 |
| Bochnowicz, S | 1 |
| Webb, EF | 1 |
| Rieman, DJ | 1 |
| Lee, JC | 1 |
| Romanic, AM | 1 |
| Adams, JL | 1 |
| Hay, DW | 1 |
| Griswold, DE | 1 |
1 other study available for sb 239063 and Pulmonary Fibrosis
| Article | Year |
|---|---|
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.
Topics: Animals; Bleomycin; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Guinea Pi | 2000 |