sb 239063 has been researched along with Hypertension in 2 studies
SB 239063: structure in first source
SB-239063 : A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Numerous pathological mediators of cardiac hypertrophy (eg, neurohormones, cytokines, and stretch) have been shown to activate p38 MAPK." | 1.31 | Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction. ( Adams, JL; Angermann, CE; Behr, TM; Brooks, DP; Chandra, S; Coatney, RW; Kumar, S; Lee, JC; Nelson, AH; Nerurkar, SS; Ohlstein, EH; Sackner-Bernstein, JD; Sisko, J; Sulpizio, A; Willette, RN; Woods, TN, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lenhard, SC | 1 |
| Nerurkar, SS | 2 |
| Schaeffer, TR | 1 |
| Mirabile, RC | 1 |
| Boyce, RW | 1 |
| Adams, DF | 1 |
| Jucker, BM | 1 |
| Willette, RN | 2 |
| Behr, TM | 1 |
| Nelson, AH | 1 |
| Coatney, RW | 1 |
| Woods, TN | 1 |
| Sulpizio, A | 1 |
| Chandra, S | 1 |
| Brooks, DP | 1 |
| Kumar, S | 1 |
| Lee, JC | 1 |
| Ohlstein, EH | 1 |
| Angermann, CE | 1 |
| Adams, JL | 1 |
| Sisko, J | 1 |
| Sackner-Bernstein, JD | 1 |
2 other studies available for sb 239063 and Hypertension
| Article | Year |
|---|---|
p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging.
Topics: Albuminuria; Animals; Contrast Media; Creatinine; Dietary Fats; Endothelium, Vascular; Enzyme Inhibi | 2003 |
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; E | 2001 |