sb 239063 has been researched along with Disease Models, Animal in 19 studies
SB 239063: structure in first source
SB-239063 : A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ozone exposure worsens the development of allergen-induced asthma." | 7.79 | Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma. ( Bao, A; Chung, KF; Li, F; Liang, L; Zhang, M; Zhou, X, 2013) |
| "Ozone exposure worsens the development of allergen-induced asthma." | 3.79 | Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma. ( Bao, A; Chung, KF; Li, F; Liang, L; Zhang, M; Zhou, X, 2013) |
| "Adult male rats were subjected to 30 min ischemia and 4 (apoptosis assay) or 24 h (myocardial infarction determination) of reperfusion and treated with vehicle, SB 239063, insulin or insulin plus wortmannin." | 3.72 | Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion. ( Christopher, TA; Gao, E; Gao, F; Liu, HR; Lopez, BL; Ma, XL; Tao, L; Yan, W, 2004) |
| "Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear." | 2.52 | PET and MR imaging of neuroinflammation in hepatic encephalopathy. ( Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ, 2015) |
| "Bronchial asthma is a chronic inflammatory disorder of the airway accompanied by increased vascular permeability." | 1.38 | Inhibition of p38 MAPK reduces expression of vascular endothelial growth factor in allergic airway disease. ( Jeon, MS; Kim, SR; Lee, KS; Lee, YC; Park, SJ, 2012) |
| "In a bleomycin-induced pulmonary fibrosis model in rats, treatment with SB 239063 (2." | 1.31 | SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. ( Adams, JL; Bochnowicz, S; Griswold, DE; Hay, DW; Lee, JC; Osborn, RR; Rieman, DJ; Romanic, AM; Underwood, DC; Webb, EF, 2000) |
| "Numerous pathological mediators of cardiac hypertrophy (eg, neurohormones, cytokines, and stretch) have been shown to activate p38 MAPK." | 1.31 | Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction. ( Adams, JL; Angermann, CE; Behr, TM; Brooks, DP; Chandra, S; Coatney, RW; Kumar, S; Lee, JC; Nelson, AH; Nerurkar, SS; Ohlstein, EH; Sackner-Bernstein, JD; Sisko, J; Sulpizio, A; Willette, RN; Woods, TN, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 2 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Gibbs, KL | 1 |
| Kalmar, B | 1 |
| Rhymes, ER | 1 |
| Fellows, AD | 1 |
| Ahmed, M | 1 |
| Whiting, P | 1 |
| Davies, CH | 1 |
| Greensmith, L | 1 |
| Schiavo, G | 1 |
| Liang, L | 1 |
| Li, F | 1 |
| Bao, A | 1 |
| Zhang, M | 1 |
| Chung, KF | 1 |
| Zhou, X | 1 |
| Agusti, A | 2 |
| Dziedzic, JL | 1 |
| Hernandez-Rabaza, V | 2 |
| Guilarte, TR | 1 |
| Felipo, V | 2 |
| Su, YY | 1 |
| Yang, GF | 1 |
| Lu, GM | 1 |
| Wu, S | 1 |
| Zhang, LJ | 1 |
| Grassmé, H | 1 |
| Jernigan, PL | 1 |
| Hoehn, RS | 1 |
| Wilker, B | 1 |
| Soddemann, M | 1 |
| Edwards, MJ | 1 |
| Müller, CP | 1 |
| Kornhuber, J | 1 |
| Gulbins, E | 1 |
| Xiong, LL | 1 |
| Tan, Y | 1 |
| Ma, HY | 1 |
| Dai, P | 1 |
| Qin, YX | 1 |
| Yang, RA | 1 |
| Xu, YY | 1 |
| Deng, Z | 1 |
| Zhao, W | 1 |
| Xia, QJ | 1 |
| Wang, TH | 1 |
| Zhang, YH | 1 |
| Karunakaran, S | 1 |
| Saeed, U | 1 |
| Mishra, M | 1 |
| Valli, RK | 1 |
| Joshi, SD | 1 |
| Meka, DP | 1 |
| Seth, P | 1 |
| Ravindranath, V | 1 |
| Chen, M | 1 |
| Chen, Q | 1 |
| Cheng, XW | 1 |
| Lu, TJ | 1 |
| Liu, HX | 1 |
| Jia, JM | 1 |
| Zhang, C | 1 |
| Xu, L | 1 |
| Xiong, ZQ | 1 |
| Kim, SR | 2 |
| Lee, KS | 2 |
| Park, SJ | 2 |
| Min, KH | 1 |
| Lee, KA | 1 |
| Bartov, O | 1 |
| Atlas, D | 1 |
| Lee, YC | 2 |
| Cauli, O | 1 |
| Rodrigo, R | 1 |
| Llansola, M | 1 |
| Levit, RD | 1 |
| Taylor, WR | 1 |
| Jeon, MS | 1 |
| Agthong, S | 1 |
| Tomlinson, DR | 1 |
| Gao, F | 1 |
| Tao, L | 1 |
| Yan, W | 1 |
| Gao, E | 1 |
| Liu, HR | 1 |
| Lopez, BL | 1 |
| Christopher, TA | 1 |
| Ma, XL | 1 |
| de Boer, RA | 1 |
| Pokharel, S | 1 |
| Flesch, M | 1 |
| van Kampen, DA | 1 |
| Suurmeijer, AJ | 1 |
| Boomsma, F | 1 |
| van Gilst, WH | 1 |
| van Veldhuisen, DJ | 1 |
| Pinto, YM | 1 |
| Jia, YT | 1 |
| Wei, W | 1 |
| Ma, B | 1 |
| Xu, Y | 1 |
| Liu, WJ | 1 |
| Wang, Y | 1 |
| Lv, KY | 1 |
| Tang, HT | 1 |
| Wei, D | 1 |
| Xia, ZF | 1 |
| Underwood, DC | 1 |
| Osborn, RR | 1 |
| Bochnowicz, S | 1 |
| Webb, EF | 1 |
| Rieman, DJ | 1 |
| Lee, JC | 2 |
| Romanic, AM | 1 |
| Adams, JL | 2 |
| Hay, DW | 1 |
| Griswold, DE | 1 |
| Behr, TM | 1 |
| Nerurkar, SS | 1 |
| Nelson, AH | 1 |
| Coatney, RW | 1 |
| Woods, TN | 1 |
| Sulpizio, A | 1 |
| Chandra, S | 1 |
| Brooks, DP | 1 |
| Kumar, S | 1 |
| Ohlstein, EH | 1 |
| Angermann, CE | 1 |
| Sisko, J | 1 |
| Sackner-Bernstein, JD | 1 |
| Willette, RN | 1 |
1 review available for sb 239063 and Disease Models, Animal
| Article | Year |
|---|---|
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disea | 2015 |
18 other studies available for sb 239063 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS.
Topics: Acetylcarnitine; Amyotrophic Lateral Sclerosis; Animals; Axonal Transport; Disease Models, Animal; E | 2018 |
Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma.
Topics: Adrenal Cortex Hormones; Animals; Asthma; Disease Models, Animal; Drug Therapy, Combination; Dual Sp | 2013 |
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition.
Topics: Animals; Biomarkers; Brain; Carrier Proteins; Disease Models, Animal; Hepatic Encephalopathy; Imidaz | 2014 |
Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression.
Topics: Adaptation, Ocular; Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Disease Models, A | 2015 |
Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation.
Topics: Acute Lung Injury; Animals; Aquaporin 4; Disease Models, Animal; Humans; Imidazoles; Intestines; Lun | 2016 |
Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Benzothiazoles; Brain; | 2008 |
Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus.
Topics: Actins; Animals; CA1 Region, Hippocampal; Cells, Cultured; Chelating Agents; Coumarins; Disease Mode | 2009 |
A novel dithiol amide CB3 attenuates allergic airway disease through negative regulation of p38 mitogen-activated protein kinase.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dis | 2011 |
p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts.
Topics: Ammonia; Animals; Blotting, Western; Cerebellum; Cerebral Cortex; Cognition; Disease Models, Animal; | 2011 |
A clinical commentary on the article "N-acetylglucosamine conjugated to nanoparticles enhances myocyte uptake and improves delivery of a small molecule p38 inhibitor for post-infarct healing" : N-acetylglucosamine conjugated nanoparticles: translational o
Topics: Acetylglucosamine; Animals; Cardiovascular Agents; Chemistry, Pharmaceutical; Disease Models, Animal | 2011 |
Inhibition of p38 MAPK reduces expression of vascular endothelial growth factor in allergic airway disease.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Dise | 2012 |
Inhibition of p38 MAP kinase corrects biochemical and neurological deficits in experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhi | 2002 |
Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion.
Topics: Androstadienes; Animals; Apoptosis; Disease Models, Animal; Imidazoles; Insulin; Male; Myocardial In | 2004 |
Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Atr | 2004 |
Activation of p38 MAPK by reactive oxygen species is essential in a rat model of stress-induced gastric mucosal injury.
Topics: Acetylcysteine; Animals; Apoptosis; Cold Temperature; Cyclic N-Oxides; Cytokines; Disease Models, An | 2007 |
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.
Topics: Animals; Bleomycin; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Guinea Pi | 2000 |
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; E | 2001 |