sb 216763 and Disease Models, Animal

Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Adenosine; Adenosine A2 Receptor Agonists; Adult; Aged; Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Glycogen Synthase Kinases; Hippocampus; Humans; Indoles; Isoquinolines; Male; Maleimides; Mice; Mice, Knockout; Middle Aged; Neurons; Phenethylamines; Phosphorylation; Protein Kinase Inhibitors; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; tau Proteins; Triazines; Triazoles

Topics: Acute Kidney Injury; Alcoholism; Analysis of Variance; Animals; beta-Arrestin 2; Blood Alcohol Content; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Fibrosis; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Kidney; Male; Maleimides; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Reperfusion Injury

Topics: Animals; Animals, Genetically Modified; Arrhythmogenic Right Ventricular Dysplasia; Desmoplakins; Disease Models, Animal; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Indoles; Maleimides; Morphogenesis; Myocardium; Oligonucleotides, Antisense; Wnt Signaling Pathway; Zebrafish; Zebrafish Proteins

Topics: Adolescent; Animals; Child; Disease Models, Animal; Female; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Liver; Liver Cirrhosis; Male; Maleimides; Mice; Mice, Inbred C57BL; Osteopontin; Signal Transduction; Transcription Factor AP-1; Up-Regulation

Topics: Animals; beta Catenin; Cognitive Dysfunction; Corticosterone; Depressive Disorder; Disease Models, Animal; Gene Transfer Techniques; Glycogen Synthase Kinase 3 beta; Hippocampus; Indoles; Intercellular Signaling Peptides and Proteins; Learning Disabilities; Male; Maleimides; Maze Learning; Memory Disorders; Nootropic Agents; Rats, Sprague-Dawley; Signal Transduction; Stress, Psychological; Uncertainty

Topics: Animals; Biomarkers; Cells, Cultured; Cerebellum; Dendritic Spines; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Inflammation; Longevity; Maleimides; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B p50 Subunit; Phenotype; Protein Kinase Inhibitors; Rett Syndrome; Signal Transduction; Survival Analysis; Synapses; Up-Regulation

Topics: Animals; beta Catenin; Brain Infarction; Bromodeoxyuridine; Disease Models, Animal; Doublecortin Domain Proteins; Enzyme Inhibitors; Gene Expression Regulation; In Situ Nick-End Labeling; Indoles; Infarction, Middle Cerebral Artery; Male; Maleimides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Protein Phosphatase 2C; Severity of Illness Index; Statistics, Nonparametric; Wnt Signaling Pathway

Topics: Animals; Ankyrins; Arrhythmogenic Right Ventricular Dysplasia; beta Catenin; Disease Models, Animal; Female; Humans; Indoles; Male; Maleimides; Mice; Mice, Knockout; Myocardium; Wnt Signaling Pathway

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Glycogen Synthase Kinase 3; Indoles; Male; Maleimides; Mice; Mice, Transgenic; Molecular Targeted Therapy; N-Methylaspartate; Neuronal Plasticity; Neurons; rab5 GTP-Binding Proteins; Rats; Receptors, N-Methyl-D-Aspartate

Topics: Animals; beta Catenin; Collagen; Disease Models, Animal; Enzyme Inhibitors; Fibronectins; Glycogen Synthase Kinase 3; Guinea Pigs; Indoles; Lipopolysaccharides; Lung; Male; Maleimides; Muscle, Smooth; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Smad Proteins

Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Glucocorticoids; Glycogen Synthase Kinase 3; Guinea Pigs; Indoles; Lipopolysaccharides; Male; Maleimides; Muscle Development; Muscle, Skeletal; Muscular Atrophy; Pulmonary Disease, Chronic Obstructive; Tumor Necrosis Factor-alpha

Topics: Animals; Cell Line, Transformed; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Extracellular Matrix Proteins; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Indoles; Intercellular Signaling Peptides and Proteins; Maleimides; Pituitary Neoplasms; Prolactin; Prolactinoma; Rats; Rats, Inbred F344; Time Factors

Topics: Acute Kidney Injury; Androstadienes; Animals; Apoptosis; Chromones; Contrast Media; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Iohexol; Ischemic Preconditioning; Kidney Tubules; Male; Maleimides; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Nephrectomy; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Wortmannin

Topics: Animals; Apoptosis Regulatory Proteins; Beclin-1; Chromones; Disease Models, Animal; Echocardiography; Emulsions; Fatty Acids, Omega-3; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Male; Maleimides; Mice; Mice, Inbred C57BL; Morpholines; Myocardial Reperfusion Injury; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction

Topics: Animals; Apoptosis; Cell Survival; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Indoles; Learning Disabilities; Male; Maleimides; Maze Learning; Mice, Knockout; Neural Stem Cells; Neurogenesis; Neurons; Neuroprotective Agents; Nootropic Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Spatial Memory

Topics: Animals; Animals, Newborn; Brain; Brain Infarction; Caspase 3; Cerebrovascular Circulation; Disease Models, Animal; Doublecortin Domain Proteins; Drug Administration Schedule; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Hypoxia-Ischemia, Brain; Indoles; Maleimides; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neuropeptides; STAT3 Transcription Factor; Stem Cells; Subcellular Fractions

Topics: Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Gene Silencing; Glycogen Synthase Kinase 3 beta; Indoles; Lithium Chloride; Male; Maleimides; Neurons; NF-E2-Related Factor 2; Rats; Signal Transduction

Topics: Animals; Disease Models, Animal; Indoles; Ischemia; Maleimides; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Potassium Channels, Voltage-Gated

Topics: Adjuvants, Immunologic; Animals; beta-Arrestins; Cyclic AMP; Disease Models, Animal; Dopamine Agonists; Endocytosis; Enzyme Inhibitors; Fenoldopam; Glycogen Synthase Kinase 3 beta; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indoles; Lithium Chloride; Maleimides; Prefrontal Cortex; Protein Transport; Rats; Receptors, Dopamine D1; Schizophrenia

Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antimanic Agents; Brain; Citrates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fragile X Mental Retardation Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3; Indoles; Lithium Chloride; Male; Maleimides; Mice; Mice, Knockout; Pyridines; Seizures; Serine; Thiazoles; Urea

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Cells, Cultured; Disease Models, Animal; DNA Fragmentation; Enzyme Inhibitors; Gliosis; Glycogen; Glycogen Synthase Kinase 3; Hippocampus; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Maze Learning; Nerve Degeneration; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; tau Proteins

Topics: Analysis of Variance; Animals; Blotting, Western; Cell Fractionation; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Glycogen Synthase Kinase 3; Huntingtin Protein; Huntington Disease; Indoles; Maleimides; Membrane Microdomains; Mice; Mice, Transgenic; Microscopy, Confocal; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nuclear Proteins

Topics: Acoustic Stimulation; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Evoked Potentials, Auditory, Brain Stem; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hair Cells, Auditory; Hearing Loss; Indoles; Injections, Intraperitoneal; Interleukin-1beta; Interleukin-6; Lithium Chloride; Maleimides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Organ Culture Techniques; Organ of Corti; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha

Topics: Animals; Calcium; Cardiotonic Agents; Disease Models, Animal; Down-Regulation; Glucose; Glycogen; Glycogen Synthase Kinase 3; Glycolysis; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Male; Maleimides; Myocardial Reperfusion Injury; Myocardium; Palmitic Acid; Perfusion; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Recovery of Function; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Time Factors; Up-Regulation; Ventricular Function, Left

Topics: Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Blood-Brain Barrier; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Mutant Strains; Molecular Targeted Therapy; Motor Activity; Reproducibility of Results; Thiadiazoles; Thiazoles; Urea

Topics: Animals; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; DNA-Binding Proteins; DNA, Mitochondrial; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glucose; Glycogen Synthase Kinase 3; High Mobility Group Proteins; Hypoxia; Indoles; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Maleimides; Mice; Mitochondria; Mutation; Neurons; Nuclear Respiratory Factor 1; Organelle Biogenesis; Reactive Oxygen Species; RNA, Messenger; Transfection

Topics: Animals; Bleomycin; Cells, Cultured; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibroblasts; Fibrosis; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred DBA; RNA, Small Interfering; Scleroderma, Systemic; Skin; Wnt Signaling Pathway

Topics: Animals; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Indoles; Learning; Male; Maleimides; Mice; Mice, Knockout; Nerve Net; Neurogenesis; Neurons; Phosphorylation; Protein Kinase Inhibitors

Topics: Alanine Transaminase; Animals; Apoptosis; Axin Protein; beta Catenin; Blotting, Western; Cell Proliferation; Cyclin D1; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Indoles; Inhibitor of Apoptosis Proteins; Liver; Liver Regeneration; Male; Maleimides; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Repressor Proteins; Signal Transduction; Survivin; Time Factors

Topics: Animals; Apoptosis; Caspase 12; Disease Models, Animal; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Inhibitors; Galactosamine; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Maleimides; Mice; Mitogen-Activated Protein Kinase Kinases; Signal Transduction; Toll-Like Receptor 4; Transaminases; Transcription Factor CHOP

Topics: Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Hindlimb Suspension; Humans; Indoles; Ketamine; Male; Maleimides; Mice; Motor Activity; Stress, Physiological; Sucrose

Topics: Analgesics, Opioid; Androstadienes; Animals; Benzamides; Benzopyrans; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanidines; Heart Rate; Imidazoles; Indoles; Ion Channel Gating; Male; Maleimides; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Sarcolemma; Signal Transduction; Time Factors; Wortmannin

Topics: Animals; Cardiotonic Agents; Cyclosporine; Diazoxide; Disease Models, Animal; Glyburide; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypertension; In Vitro Techniques; Indoles; Lithium Chloride; Male; Maleimides; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Ventricular Function, Left; Ventricular Pressure

Topics: Animals; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Ischemic Preconditioning, Myocardial; Maleimides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Phosphorylation; Phosphorylation