sb-215505 has been researched along with Obsessive-Compulsive-Disorder* in 1 studies
1 other study(ies) available for sb-215505 and Obsessive-Compulsive-Disorder
Article | Year |
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5-HT2c receptor activation induces grooming behaviour in rats: possible correlations with obsessive-compulsive disorder.
Excessive self-grooming in animal models of obsessive-compulsive disorder (OCD) is regarded as an equivalent of compulsive behaviour in OCD patients. Previous studies have suggested a key modulatory role of certain serotonin2 receptor subtypes both in grooming behaviour and OCD. Certain 5-HT2 receptor agonists were reported to exacerbate symptoms in OCD patients. Here we report that activation of the serotonin2c (5-HT2c) receptor induces self-grooming in rats, which result supports the hypothesis that selective stimulation of central 5-HT2c receptors exacerbates symptoms also in OCD. The present findings may help to understand serotonergic mechanisms underlying psychiatric disorders of the obsessive-compulsive spectrum and may progress the development of novel anxiolytic and anti-OCD medications. Topics: Aminopyridines; Animals; Grooming; Indoles; Male; Obsessive-Compulsive Disorder; Piperazines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2006 |