Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and Inflammation

sb 203580 has been researched along with Inflammation in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's45 (40.91)29.6817
2010's58 (52.73)24.3611
2020's7 (6.36)2.80

Authors

AuthorsStudies
Albrecht, W; Bauer, SM; Laufer, SA; Unger, A1
Anderson, WF; Arancio, O; Chico, LW; Minasov, G; Pelletier, JC; Roy, SM; Van Eldik, LJ; Watterson, DM1
Chai, J; Jiang, S; Liu, Z; Zheng, R; Zhong, Z1
Chen-Yu Hsu, A; Guan, X; Guo, Y; Pang, Z; Ran, N; Wang, F; Wang, G; Wang, Z; Yuan, Y; Zheng, R1
Feijóo, CG; García-López, JP; Vilos, C1
Chen, W; Fan, HN; Fan, LN; Wu, JT; Zhang, J; Zhu, JS1
Chai, ZT; Ding, JD; Duan, KY; Liu, XW; Zhang, HW; Zhang, ZS; Zhao, SS; Zhao, WF; Zhu, BQ1
Duan, J; Li, T; Ma, JY; Wang, H; Wu, YN; Zhai, SS1
Cao, H; Zhang, Y1
Ding, Z; Duan, H; Ge, W; Hu, J; Jiang, Y; Lv, J; Xiao, L; Zhang, Y; Zhao, X1
Bai, C; Chai, L; Deng, P; Jia, Y; Li, J; Liu, C; Sun, Q; Zhao, X; Zheng, C1
Collazo, J; Friedman, T; Hikim, AS; Jimenez, T; Pervin, S; Singh, R; Singh, V; Sinha, S; Tucker, A; Vadgama, J1
Chen, J; Chen, W; Ma, D; Miao, C; Shi, Q; Sun, Z; Wang, H; Weng, M; Xu, Y; Zhong, J1
Dastidar, SG; Diwan, M; Najmi, AK; Singh, RK1
Chi, C; Cui, L; Hou, F; Li, C; Liu, R; Liu, X; Wang, Y; Wen, Y; Yin, C; Yu, X1
Dixon, CL; Menon, R; Richardson, L; Saade, G; Sheller-Miller, S1
Du, K; Li, Q; Liu, XZ; Zhou, M1
Han, M; Hu, R; Huang, G; Li, H; Liu, H; Liu, X; Liu, Y; Otsu, K; Xiao, S; Zhao, W; Zheng, T1
Chen, Y; Geng, S; Jiang, Y; Li, X; Li, Y; Meng, Y; Wang, S; Wang, X; Wu, J; Xie, C; Yang, X; Zhong, C; Zhu, J; Zhu, W1
Li, M; Mei, F; Wang, W; Xia, H; You, Y; Zhao, K; Zhao, L; Zhou, Y1
Jiang, Z; Li, D; Ren, W; Zhu, L1
Bae, JS; Gee, MS; Inn, KS; Jin, HK; Kim, N; Kim, NJ; Kim, SW; Lee, JK; Lee, SJ; Oh, MS1
Guang, Y; Hu, SH; Wang, WX1
Bian, ZZ; Pan, XT; Wan, YD; Zhu, RX1
Cho, JY; Jeong, D; Kim, KW; Lee, J; Yang, Y; Yi, YS1
Akhtari, Z; Eidi, A; Ruhani, AH; Tekieh, E; Zaringhalam, J1
Gaestel, M1
Barbi, J; Bu, S; Chen, C; Chen, Z; Dang, E; Fu, J; Gao, Y; Gao, Z; Greene, MI; Jinasena, D; Li, B; Li, L; Li, X; Li, Y; Li, Z; Lin, F; Loser, K; Luo, W; Nie, J; Pan, F; Pan, Z; Pardoll, DM; Park, BV; Semenza, GL; Shan, Z; Tian, H; Tsun, A; Wang, H; Yang, HY; Yao, Z; Yu, N; Zhang, J; Zheng, SG; Zheng, Y1
Bai, X; Li, HY; Li, XN; Liu, F; Su, J; Sun, LK; Wang, W; Xiang, JB; Zhao, L; Zhong, JT1
Ali, S; Amir, M; Somakala, K1
Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY1
Beaulieu, LM; Benjamin, EJ; Freedman, JE; Genco, CA; Koupenova, M; Kramer, CD; Larson, MG; Lin, E; Mick, E; Tanriverdi, K; Weinberg, EO1
Fu, J; He, M; Jin, W; Li, J; Liu, W; Shao, C; Xiao, L; Xie, Y1
Antushevich, H; Bochenek, J; Herman, A; Herman, AP; Krawczyńska, A; Tomaszewska-Zaremba, D1
Batel, T; Behnen, M; Klinger, M; Laskay, T; Leschczyk, C; Möller, S; Solbach, W1
Asim, M; Barry, DP; Bravo, LE; Chaturvedi, R; Correa, P; de Sablet, T; Delgado, AG; Gobert, AP; Peek, RM; Piazuelo, MB; Verriere, T; Wilson, KT1
Blasco, F; Fu, Y; Hervé, M; Seah, PG; Shi, PY; Yip, A1
Belosevic, M; Xie, J1
D'Silva, NJ; Hyer, JM; Kirkwood, KL; Yu, H; Zhang, X1
Ferguson, SJ; Hausmann, O; Klasen, J; Konno, S; Krupkova, O; Sekiguchi, M; Wuertz-Kozak, K1
Ahmad, S; Bhatia, K; Elsherbini, AM; Elsherbiny, NM; Fulzele, S; Liou, GI1
Al-Jahdali, H; Al-Kufaidy, R; Al-Muhsen, S; Alnassar, SA; BaHammam, AS; Halwani, R; Hamid, Q; Pureza, MA; Vazquez-Tello, A1
Gu, B; Liu, N; Nie, J; Zhang, B1
Dhamija, S; Gaestel, M; Kotlyarov, A; Menon, MB1
He, F; Li, J; Pei, M; Pizzute, T; Zhang, Y1
Dezawa, K; Honda, K; Inoue, T; Iwata, K; Kamakura, S; Katagiri, A; Kiyomoto, M; Nakaya, Y; Shinoda, M1
Chan, SC; Cui, LY; Ip, MS; Lau, WK; Mak, JC1
Chen, X; Liu, H; Liu, W; Liu, Y; Xie, Y; Xu, X; Zhang, W1
Chang, M; Li, Y; Liu, D; Tang, H; Zhang, H; Zhang, L1
Choi, DY; Han, SB; Hong, JT; Hwang, CJ; Hwang, DY; Jeong, HS; Kim, SY; Kim, TH; Kim, YM; Lee, HJ; Lee, HP; Lee, TH; Moon, DB; Oh, KW; Park, SS1
Cancedda, FD; Cancedda, R; Ulivi, V1
Boyle, DL; Edgar, M; Firestein, GS; Levine, YA; Pavlov, VA; Sorkin, LS; Tracey, K; Waldburger, JM1
Eckert, RE; Jones, SL; Sharief, Y1
Bhakdi, S; Dersch, K; Dragneva, Y; Fenske, D; Han, SR; Husmann, M; Lux, C; Suriyaphol, P; Zipse, L1
Brack, A; Hackel, D; Mousa, SA; Rittner, HL; Schäfer, M; Stein, C; Yamdeu, RS1
Alunni-Fabbroni, M; Baekelandt, V; Görner, K; Kahle, PJ; Pham, TT; Reumers, V; Schell, H; Vogt-Weisenhorn, D; Waak, J; Waldenmaier, A; Weber, SS; Wurst, W1
Goi, Y; Hirasawa, N; Ishihara, K; Ohtsu, H; Ohuchi, K; Tanaka, R1
Botez, GM; Sima, AV; Simionescu, M; Stancu, CS; Toma, L1
Chen, QH; Chen, QX; Zhou, WD1
Chen, J; Liu, JW; Su, ZX; Zeng, HL; Zeng, YY1
Andreucci, M; Bertucci, B; Faga, T; Fuiano, G; Lucisano, G; Michael, A; Pisani, A; Sabbatini, M; Salzano, S; Tamburrini, O; Vitale, M1
Chen, Y; Hedger, MP; Loveland, KL; Makanji, Y; Phillips, DJ; Smith, JA; Winnall, WR; Wu, H1
Chang, WC; Liao, WL; Tseng, JT; Wang, WC1
He, SZ; Jian, CX; Li, CJ; Liu, XC; Liu, XF1
Dong, S; Wang, J1
Dapeng, L; Hualin, C; Qingfeng, P; Wenli, X; Xijing, L; Xiuhua, P1
Ammit, AJ; Che, W; Chen, Y; Manetsch, M; Seidel, P1
de Bold, AJ; Ogawa, T1
Chen, D; Guo, Y; Mao, X; Zhang, X1
Siegl, S; Uhlig, S1
Harris, T; Mackay, GA; Stewart, AG; Xia, YC1
Lyons, D; Ma, F; Westlund, KN; Zhang, L1
Ji, SH; Jiang, JX; Wang, ZG; Zhang, Y; Zhu, P1
Gerl, RE; Guo, X; Schrader, JW1
Farnell, MB; He, H; Kogut, MH1
Berger, S; Denkert, C; Hauptmann, S; Köbel, M; Koch, I; Siegert, A1
Cho, KN; Chung, KC; Kang, CD; Kim, CH; Koo, JS; Lee, WJ; Seong, JK; Song, KS; Yoon, JH1
Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL1
Brown, JW; Dinarello, CA; March, KL; Meldrum, DR; Meldrum, KK; Sankula, R; Tsai, BM; Turrentine, M; Wang, M1
Cohen, RA; Hou, X; Jiang, B; Pimentel, DR; Xu, S1
de Bold, AJ; Ma, KK; Ogawa, T1
Cerezo, CS; Gruppuso, PA; Kulpa-Oliver, V; Morin, MJ1
Hammerschmidt, S; Hippenstiel, S; Hocke, AC; Hoffmann, E; Huber, S; Kracht, M; Moog, K; Opitz, B; Rosseau, S; Schmeck, B; Suttorp, N; van Laak, V; Zahlten, J; Zerrahn, J1
Chen, JW; Chen, YH; Chen, YL; Hung, YY; Ku, HH; Lin, SJ; Shyue, SK; Tam, KB1
Hollenbach, E; Malfertheiner, P; Naumann, M; Neumann, M; Roessner, A; Vieth, M1
Ferreri, K; Kandeel, F; Kuroda, Y; Matsuda, T; Mullen, Y; Omori, K; Pascual, M; Smith, CV; Todorov, I; Valiente, L; Vuong, T1
Kim, H; Kokkotou, E; LaMont, JT; Moyer, MP; Na, X; Pothoulakis, C; Rhee, SH; Savidge, T1
Chang, WC; Tseng, JT; Wang, JM1
Bertelsen, M; Sanfridson, A1
Blaut, M; Haller, D; Hoffmann, M; Ruiz, PA; Szcesny, S1
Li, T; Li, Y; Zhang, G1
Arcand, M; du Souich, P; Fradette, C; Kourylko, O1
Choi, AM; Kim, HP; Song, R; Wang, XM1
Bondada, S; Chelvarajan, RL; Getchell, ML; Getchell, TV; Liu, Y; Popa, D; Stromberg, AJ1
Cheung, PF; Ip, WK; Lam, CW; Wong, CK1
Davis, T; Kipling, D1
Bücker-Gärtner, C; Linderer, A; Pauschinger, M; Riad, A; Rutschow, S; Schultheiss, HP; Sobirey, M; Tschöpe, C; Van Linthout, S; Westermann, D1
Chen, LF; Ishinaga, H; Jono, H; Koga, T; Kweon, SM; Li, JD; Lim, JH; Rixter, D; Wang, B; Xu, H1
Clarkin, CE; Coates, AR; Henderson, B; Lawrence, RA; Lewthwaite, JC; Pitsillides, AA; Poole, S; Singh, M; Wheeler-Jones, CP1
Jung, SH; Kim, HS; Park, JS; Seo, H1
Billgren, J; Bulger, E; Cuschieri, J; Garcia, I; Jelacic, S; Knoll, M; Maier, R; Schaeffer, V1
Chen, J; Cui, XY; Dai, Y; Kobayashi, K; Noguchi, K; Obata, K; Wang, SL; Yamanaka, H1
Gerthoffer, WT; Hedges, JC; Singer, CA1
Bosmann, M; Chang, JH; Hellmuth, M; Huwiler, A; Mühl, H; Ninic, R; Nold, M; Paulukat, J; Pfeilschifter, J1
Lee, J; Mira-Arbibe, L; Ulevitch, RJ1
Hasegawa, T; Hato, F; Hino, M; Kitagawa, S; Sakamoto, C; Suzuki, K; Tatsumi, N; Zhou, YM1
Adams, JL; Badger, AM; Barone, FC; Erhardt, JA; Hunter, AJ; Irving, EA; Kassis, S; Kumar, S; Lee, JC; Legos, JJ; McVey, MJ; Nelson, AH; Ohlstein, EH; Parsons, AA; Ray, AM; Smith, BR; Ward, K; White, RF1
Almeida, IC; Closel, M; Cohen, P; Ferguson, MA; Gazzinelli, RT; Ropert, C; Travassos, LR1
Davis, A; Fox, A; Ganju, P; Núñez, X; Patel, S1
Dackiw, AP; Marshall, JC; McGilvray, ID; Rotstein, OD; Tsai, V1

Reviews

3 review(s) available for sb 203580 and Inflammation

ArticleYear
A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.
    Journal of medicinal chemistry, 2019, 06-13, Volume: 62, Issue:11

    Topics: Animals; Brain; Cognitive Dysfunction; Humans; Inflammation; Nervous System Diseases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors

2019
What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition.
    Biological chemistry, 2013, Volume: 394, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gene Expression Regulation; Humans; Imidazoles; Immunity, Innate; Inflammation; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Pyridines

2013
[The action of p38 MAP kinase and its inhibitors on endometriosis].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endometriosis; Enzyme Inhibitors; Female; Humans; Imidazoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha

2010

Other Studies

107 other study(ies) available for sb 203580 and Inflammation

ArticleYear
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
    Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Discovery; Humans; Imidazoles; Inflammation; Mitogen-Activated Protein Kinase 14; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha

2017
miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling Pathways to Enhance Inflammation in the Amnion Leading to Labor.
    International journal of molecular sciences, 2022, Feb-07, Volume: 23, Issue:3

    Topics: Amnion; Animals; Anthracenes; Cyclooxygenase 2; Dual-Specificity Phosphatases; Epithelial Cells; Female; Imidazoles; Inflammation; Labor, Obstetric; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Pregnancy; Pyridines

2022
Combined treatment with SB203580 and dexamethasone suppresses non-typeable Haemophilus influenzae-induced Th17 inflammation response in murine allergic asthma.
    European journal of pharmacology, 2019, Nov-05, Volume: 862

    Topics: Animals; Asthma; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Female; Haemophilus influenzae; Humans; Imidazoles; Inflammation; Lung; Mice; Mucin 5AC; Mucin-5B; Neutrophils; Ovalbumin; p38 Mitogen-Activated Protein Kinases; Pyridines; Respiratory Mucosa; Signal Transduction; Symptom Flare Up; Th17 Cells

2019
Zebrafish, a model to develop nanotherapeutics that control neutrophils response during inflammation.
    Journal of controlled release : official journal of the Controlled Release Society, 2019, 11-10, Volume: 313

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Materials; Cell Line; Drug Compounding; Drug Liberation; Fluorescent Dyes; Green Fluorescent Proteins; Imidazoles; Inflammation; Larva; Models, Animal; Nanocapsules; Neutrophils; Optical Imaging; p38 Mitogen-Activated Protein Kinases; Phosphatidylethanolamines; Polyesters; Polyethylene Glycols; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Theranostic Nanomedicine; Zebrafish

2019
Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy.
    International immunopharmacology, 2019, Volume: 77

    Topics: Acute Disease; Animals; Autophagy; Caspase 1; Cytokines; Disease Models, Animal; Imidazoles; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Pyridines; Signal Transduction

2019
Critical Role of p38 in Spinal Cord Injury by Regulating Inflammation and Apoptosis in a Rat Model.
    Spine, 2020, Apr-01, Volume: 45, Issue:7

    Topics: Animals; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Inflammation; Inflammation Mediators; Locomotion; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries

2020
Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway.
    Molecular immunology, 2020, Volume: 120

    Topics: Acute Lung Injury; Animals; Autophagy; Death-Associated Protein Kinases; Imidazoles; Inflammation; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrrolidines; Signal Transduction; Thiocarbamates

2020
Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells.
    Bosnian journal of basic medical sciences, 2020, Nov-02, Volume: 20, Issue:4

    Topics: Antigens, CD; Apoptosis; Atherosclerosis; C-Reactive Protein; Cell Adhesion; Cell Adhesion Molecules; Cell Proliferation; Cells, Cultured; Coronary Vessels; Cyclooxygenase 2; Endothelial Cells; Humans; Imidazoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Time Factors; Vascular Endothelial Growth Factor A

2020
17β-estradiol protects sheep oviduct epithelial cells against lipopolysaccharide-induced inflammation in vitro.
    Molecular immunology, 2020, Volume: 127

    Topics: Animals; Aromatase; Cytokines; Epithelial Cells; Estradiol; Female; Fulvestrant; Gene Expression Regulation; Imidazoles; Inflammation; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NF-kappa B; Oviducts; Phosphatidylinositol 3-Kinases; Phosphorylation; Protective Agents; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; Sheep; Signal Transduction

2020
Lipoxin A4-Mediated p38 MAPK Signaling Pathway Protects Mice Against Collagen-Induced Arthritis.
    Biochemical genetics, 2021, Volume: 59, Issue:1

    Topics: Animals; Anisomycin; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Collagen; Female; Imidazoles; Inflammation; Lipoxins; MAP Kinase Signaling System; Mice; Mice, Inbred DBA; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Synovial Membrane

2021
Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth.
    Mediators of inflammation, 2020, Volume: 2020

    Topics: Animal Feed; Animals; Anti-Inflammatory Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diet, High-Fat; Female; Humans; Imidazoles; Inflammasomes; Inflammation; Mammary Neoplasms, Animal; Mecamylamine; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Nicotine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Up-Regulation

2020
Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways.
    Cell death & disease, 2017, 05-04, Volume: 8, Issue:5

    Topics: Animals; Cell Cycle Proteins; Cell Polarity; DNA-Binding Proteins; HEK293 Cells; Humans; Imidazoles; Inflammation; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopeptides; Macrophages; Mice; Nitric Oxide Synthase Type II; Oncogene Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; Ubiquitination

2017
Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro.
    Human & experimental toxicology, 2018, Volume: 37, Issue:5

    Topics: Anti-Inflammatory Agents; Biomarkers; Cell Survival; Cells, Cultured; Cytokines; Hep G2 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inflammation; Intracellular Signaling Peptides and Proteins; Leukocytes, Mononuclear; Lipopolysaccharides; MAP Kinase Kinase 4; Naphthalenes; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyridazines; Pyridines; Pyrimidines; THP-1 Cells; U937 Cells

2018
Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase/nuclear factor-κB pathway.
    International journal of molecular medicine, 2018, Volume: 41, Issue:1

    Topics: Acinar Cells; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Humans; Imidazoles; Inflammation; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pancreas; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptors, G-Protein-Coupled; Signal Transduction

2018
A distinct mechanism of senescence activation in amnion epithelial cells by infection, inflammation, and oxidative stress.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2018, Volume: 79, Issue:3

    Topics: Amnion; Cells, Cultured; Cellular Senescence; Epithelial Cells; Extraembryonic Membranes; Female; Humans; Imidazoles; Infections; Inflammation; Interleukin-6; Lipopolysaccharides; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pregnancy; Premature Birth; Primary Cell Culture; Pyridines; Tumor Necrosis Factor-alpha

2018
Chlamydia trachomatis inhibits the production of pro-inflammatory cytokines in human PBMCs through induction of IL-10.
    Journal of medical microbiology, 2018, Volume: 67, Issue:2

    Topics: Butadienes; Chlamydia trachomatis; Cytokines; Enzyme Inhibitors; Humans; Imidazoles; Inflammation; Interleukin-10; Interleukin-6; Interleukin-8; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinase 1; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Pyrimidines; Real-Time Polymerase Chain Reaction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Up-Regulation

2018
p38α signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation.
    Science signaling, 2018, 03-13, Volume: 11, Issue:521

    Topics: Animals; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Imidazoles; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Interleukin-6; Langerhans Cells; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 14; Psoriasis; Pyridines; Signal Transduction; Skin; T-Lymphocytes; Th17 Cells

2018
Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Anthracenes; Benzhydryl Compounds; Cell Line; Curcumin; Enzyme Activation; Humans; Imidazoles; Inflammation; Insulin Resistance; MAP Kinase Signaling System; NF-kappa B; Oxidative Stress; Phenols; Pyridines; Pyrrolidines; Thiocarbamates

2018
SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy.
    Inflammopharmacology, 2019, Volume: 27, Issue:1

    Topics: Acute Disease; Acute Lung Injury; Animals; Female; Imidazoles; Inflammation; Interleukin-1beta; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreatitis; Phosphorylation; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha

2019
Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury.
    Molecular medicine reports, 2018, Volume: 18, Issue:5

    Topics: Acute Lung Injury; Animals; Caspases; Disease Models, Animal; Humans; Imidazoles; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; Lung; Macrophages; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyroptosis; Respiratory Distress Syndrome; Signal Transduction

2018
A Novel and Selective p38 Mitogen-Activated Protein Kinase Inhibitor Attenuates LPS-Induced Neuroinflammation in BV2 Microglia and a Mouse Model.
    Neurochemical research, 2018, Volume: 43, Issue:12

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Inflammation Mediators; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines

2018
Protective Effects of Calcitonin Gene-Related Peptide-Mediated p38 Mitogen-Activated Protein Kinase Pathway on Severe Acute Pancreatitis in Rats.
    Digestive diseases and sciences, 2019, Volume: 64, Issue:2

    Topics: Acute Disease; Amylases; Animals; Calcitonin Gene-Related Peptide; Cytokines; Disease Progression; Enzyme Inhibitors; Imidazoles; Inflammation; Interleukin-1beta; Interleukin-6; Interleukin-8; Lipase; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Peptide Fragments; Peroxidase; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Signal Transduction; Tumor Necrosis Factor-alpha

2019
Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, 06-21, Volume: 25

    Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Microbiome; Imidazoles; Inflammation; Interleukin-1beta; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pancreatitis; Pyridines; Rats; Rats, Sprague-Dawley; Taurocholic Acid; Tumor Necrosis Factor-alpha

2019
p38/AP-1 pathway in lipopolysaccharide-induced inflammatory responses is negatively modulated by electrical stimulation.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Animals; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Electric Stimulation; Humans; Imidazoles; Inflammation; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2013
Relationship between serum IL10 level and p38MAPK enzyme activity on behavioral and cellular aspects of variation of hyperalgesia during different stages of arthritis in rats.
    Inflammopharmacology, 2014, Volume: 22, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis, Experimental; Hyperalgesia; Imidazoles; Inflammation; Interleukin-10; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptors, Opioid, mu

2014
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.
    Immunity, 2013, Aug-22, Volume: 39, Issue:2

    Topics: Animals; Autoimmune Diseases; Cells, Cultured; Cytokines; Enzyme Inhibitors; Forkhead Transcription Factors; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Imidazoles; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phenotype; Pyridines; RNA Interference; RNA, Small Interfering; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Ubiquitin-Protein Ligases; Ubiquitination

2013
The p38 MAPK inhibitor JLU1124 inhibits the inflammatory response induced by lipopolysaccharide through the MAPK-NF-κB pathway in RAW264.7 macrophages.
    International immunopharmacology, 2013, Volume: 17, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Imidazoles; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sulfones; Thiazepines; Tumor Necrosis Factor-alpha

2013
p38 MAP kinase inhibitors as anti inflammatory agents.
    Mini reviews in medicinal chemistry, 2013, Volume: 13, Issue:14

    Topics: Amides; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Humans; Imidazoles; Indoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Structure-Activity Relationship; Urea

2013
Blockade of peripheral P2Y1 receptors prevents the induction of thermal hyperalgesia via modulation of TRPV1 expression in carrageenan-induced inflammatory pain rats: involvement of p38 MAPK phosphorylation in DRGs.
    Neuropharmacology, 2014, Volume: 79

    Topics: Adenosine Diphosphate; Animals; Carrageenan; Deoxyadenine Nucleotides; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Imidazoles; Inflammation; Male; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Pain; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Touch; TRPV Cation Channels

2014
Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.
    Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:3

    Topics: Animals; Atherosclerosis; Bacteroidaceae Infections; Cell Line; Collagen; Dietary Fats; Disease Models, Animal; Gene Expression Profiling; Humans; Imidazoles; Inflammation; Interleukin-1beta; MAP Kinase Signaling System; Megakaryocytes; Mice; Mice, Knockout; NF-kappa B; Obesity; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Platelet Adhesiveness; Porphyromonas gingivalis; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Interleukin-1 Type I; Thrombin; Transcription, Genetic

2014
Irradiated U937 cells trigger inflammatory bystander responses in human umbilical vein endothelial cells through the p38 pathway.
    Radiation research, 2014, Volume: 182, Issue:1

    Topics: Atherosclerosis; Benzoates; Bystander Effect; Coculture Techniques; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Isothiuronium; Macrophages; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; U937 Cells

2014
Peripheral injection of SB203580 inhibits the inflammatory-dependent synthesis of proinflammatory cytokines in the hypothalamus.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Gene Expression Regulation; Humans; Hypothalamus; Imidazoles; Inflammation; Injections; Interleukin-1; Interleukin-6; Lipopolysaccharides; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Sheep; Tumor Necrosis Factor-alpha

2014
Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Aug-15, Volume: 193, Issue:4

    Topics: Aminopyrine; Antigen-Antibody Complex; Antioxidants; Ascorbic Acid; Autoimmune Diseases; Butadienes; CD11a Antigen; CD18 Antigens; Cell Degranulation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; GPI-Linked Proteins; Humans; Imidazoles; Inflammation; Intracellular Signaling Peptides and Proteins; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mesalamine; Neutrophil Activation; Neutrophils; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Reactive Oxygen Species; Receptors, IgG; src-Family Kinases; Syk Kinase

2014
Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Sep-15, Volume: 193, Issue:6

    Topics: Animals; Antigens, Bacterial; Bacterial Proteins; Cell Line; Enzyme Inhibitors; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Heme Oxygenase-1; Humans; Imidazoles; Inflammation; Interleukin-10; Macrophages; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Phosphorylation; Pyridines; Signal Transduction; Stomach; Th1 Cells; Th17 Cells

2014
Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580.
    Antiviral research, 2014, Volume: 110

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Line; Chemokine CCL5; Cricetinae; Culicidae; Dengue; Dengue Virus; Enzyme Inhibitors; Hematocrit; Humans; Imidazoles; Inflammation; Interleukin-8; Lymphopenia; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha

2014
Functional characterization of receptor-interacting serine/threonine kinase 2 (RIP2) of the goldfish (Carassius auratus L.).
    Developmental and comparative immunology, 2015, Volume: 48, Issue:1

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Aeromonas salmonicida; Animals; Antibodies; Goldfish; Imidazoles; Inflammasomes; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophages; Monocytes; Mycobacterium marinum; Neutrophils; NF-kappa B; Nod1 Signaling Adaptor Protein; Nod2 Signaling Adaptor Protein; p38 Mitogen-Activated Protein Kinases; Peptidoglycan; Poly I-C; Pyridines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Recombinant Proteins; Spleen; Tumor Necrosis Factor-alpha

2015
DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma.
    Cancer research, 2014, Dec-15, Volume: 74, Issue:24

    Topics: Animals; Carcinoma, Squamous Cell; Dual Specificity Phosphatase 1; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Imidazoles; Inflammation; Interleukin-1beta; Macrophages; MAP Kinase Signaling System; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger

2014
Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats.
    European cells & materials, 2014, Nov-25, Volume: 28

    Topics: Adult; Animals; Catechin; Cells, Cultured; Female; Humans; Imidazoles; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-1beta; Intervertebral Disc; Intervertebral Disc Degeneration; Male; MAP Kinase Kinase 4; Matrix Metalloproteinases; Middle Aged; Neuralgia; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Radiculopathy; Rats; Rats, Sprague-Dawley

2014
Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.
    Journal of neuroimmunology, 2014, Dec-15, Volume: 277, Issue:1-2

    Topics: Adenosine; Adenosine Kinase; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Equilibrative Nucleoside Transporter 1; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Morpholines; Neurotoxicity Syndromes; Nitric Oxide Synthase Type I; Optic Nerve Injuries; Oxidative Stress; Pyridines; Pyrimidines; Retina

2014
IL-17 Enhances Chemotaxis of Primary Human B Cells during Asthma.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Adult; Asthma; B-Lymphocytes; Bronchi; Chemokine CXCL13; Chemotaxis; Enzyme Activation; Female; Humans; Imidazoles; Inflammation; Interleukin-17; Interleukin-8; Male; p38 Mitogen-Activated Protein Kinases; Pulmonary Disease, Chronic Obstructive; Pyridines; Receptors, Interleukin; Receptors, Interleukin-17; Th17 Cells

2014
Effects of p38 mitogen-activated protein kinase on osteogenic differentiation of human periodontal ligament stem cells in inflammatory microenvironment.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2015, Volume: 37, Issue:1

    Topics: Alkaline Phosphatase; Anthraquinones; Blotting, Western; Cell Differentiation; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Imidazoles; Inflammation; Interleukin-1beta; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Staining and Labeling; Stem Cells; Tumor Necrosis Factor-alpha

2015
The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.
    Autophagy, 2015, Volume: 11, Issue:8

    Topics: Autophagy; Autophagy-Related Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Membrane Proteins; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Vesicular Transport Proteins

2015
sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment - A feasible approach for autologous stem cell based osteoarthritic cartilage repair.
    Biomaterials, 2015, Volume: 64

    Topics: Adult; Adult Stem Cells; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cells, Cultured; Chondrogenesis; Culture Media; Drug Evaluation, Preclinical; Extracellular Matrix; Female; HLA-DR Antigens; Humans; Imidazoles; In Vitro Techniques; Inflammation; Interleukin-1beta; Male; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Regeneration; Rejuvenation; Synovial Membrane; Transplantation, Autologous

2015
p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats.
    Molecular pain, 2015, Aug-12, Volume: 11

    Topics: Animals; Enzyme Activation; Facial Pain; Freund's Adjuvant; Imidazoles; Inflammation; Injections; Interleukin-1beta; Male; Medulla Oblongata; Microglia; Models, Neurological; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats, Sprague-Dawley; Skin

2015
The presence of serotonin in cigarette smoke - a possible mechanistic link to 5-HT-induced airway inflammation.
    Free radical research, 2016, Volume: 50, Issue:5

    Topics: Alveolar Epithelial Cells; Animals; Antioxidants; Butadienes; Cyclic N-Oxides; Free Radicals; Humans; Imidazoles; Inflammation; MAP Kinase Signaling System; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reactive Oxygen Species; Serotonin; Smoking; Spin Labels; Tandem Mass Spectrometry

2016
Role of Metallothionein in Post-Burn Inflammation.
    Inflammation, 2016, Volume: 39, Issue:2

    Topics: Animals; Burns; Chemokine CCL2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Interleukin-1beta; Interleukin-6; Macrophages; Male; MAP Kinase Signaling System; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

2016
Melatonin prevents secondary intra-abdominal hypertension in rats possibly through inhibition of the p38 MAPK pathway.
    Free radical biology & medicine, 2016, Volume: 97

    Topics: Animals; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Intra-Abdominal Hypertension; Melatonin; Microscopy, Electron, Transmission; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Vena Cava, Inferior

2016
Inhibitory effect of thiacremonone on MPTP-induced dopaminergic neurodegeneration through inhibition of p38 activation.
    Oncotarget, 2016, Jul-26, Volume: 7, Issue:30

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Astrocytes; Behavioral Symptoms; Cell Line; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Imidazoles; Inflammation; Male; Mice; Mice, Inbred ICR; Microglia; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiophenes

2016
15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.
    Journal of cellular physiology, 2008, Volume: 217, Issue:2

    Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Enzyme Induction; Enzyme Repression; Imidazoles; Inflammation; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Lipopolysaccharides; Mice; NF-kappa B; Oncogene Proteins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; PPAR alpha; PPAR gamma; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors; Tyrosine

2008
Spinal p38 MAP kinase regulates peripheral cholinergic outflow.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:9

    Topics: Acetylcholine; Analysis of Variance; Animals; Cholinesterase Inhibitors; Electrocardiography; Enzyme Inhibitors; Galantamine; Heart Rate; Imidazoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Spinal Cord; Vagus Nerve

2008
p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration.
    Veterinary immunology and immunopathology, 2009, Jun-15, Volume: 129, Issue:3-4

    Topics: Animals; CD18 Antigens; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Horses; Imidazoles; Inflammation; Leukotriene B4; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines

2009
Enzymatically hydrolyzed low-density lipoprotein modulates inflammatory responses in endothelial cells.
    Thrombosis and haemostasis, 2008, Volume: 100, Issue:6

    Topics: Cell Line; Endothelial Cells; Fatty Acids, Nonesterified; Humans; Hydrolysis; I-kappa B Proteins; Imidazoles; Inflammation; Interleukin-8; Lipoproteins, LDL; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Pyridines; Sterol Esterase; Time Factors; Transcription Factor AP-1; Transcription Factor RelA; Trypsin; Tumor Necrosis Factor-alpha

2008
Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.
    Brain, behavior, and immunity, 2009, Volume: 23, Issue:4

    Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Apoptosis; beta-Endorphin; Blotting, Western; Cell Count; Drug Administration Schedule; Enkephalin, Methionine; Flow Cytometry; Imidazoles; Immunohistochemistry; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Necrosis; Neutrophils; Opioid Peptides; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Peripheral Nerves; Phosphorylation; Pyridines; Radioimmunoassay; Rats; Rats, Wistar; Saline Solution, Hypertonic

2009
Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:8

    Topics: Animals; Apoptosis; Astrocytes; Base Sequence; Cells, Cultured; Cyclooxygenase 2; DNA, Complementary; Enzyme Inhibitors; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Lipopolysaccharides; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Oncogene Proteins; p38 Mitogen-Activated Protein Kinases; Parkinsonian Disorders; Peroxiredoxins; Protein Deglycase DJ-1; Pyridines; Toll-Like Receptor 4

2009
Involvement of prostaglandins and histamine in nickel wire-induced acute inflammation in mice.
    Journal of biomedical materials research. Part A, 2010, Jun-15, Volume: 93, Issue:4

    Topics: Animals; Cyclooxygenase 2; Histamine; Imidazoles; Inflammation; Male; Mice; Mice, Knockout; Necrosis; Nickel; Permeability; Prostaglandins; Pyridines; Receptors, Histamine H1; Skin; Time Factors

2010
Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose.
    Biochemical and biophysical research communications, 2009, Dec-18, Volume: 390, Issue:3

    Topics: Cell Line; Cell Proliferation; Chemokine CCL2; Endothelium, Vascular; Gene Expression; Glucose; Glycation End Products, Advanced; Humans; Hyperglycemia; Imidazoles; Inflammation; Lipoproteins, LDL; NADPH Oxidase 4; NADPH Oxidases; Nitriles; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Sulfones

2009
[p38 mitogen-activated protein kinase inhibitor suppresses the expression of pro-inflammatory cytokines in liver from brain dead rats].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010, Volume: 18, Issue:9

    Topics: Animals; Brain Death; Imidazoles; Inflammation; Interleukin-1beta; Liver; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha

2010
Differential activation of signaling pathways involved in cell death, survival and inflammation by radiocontrast media in human renal proximal tubular cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 119, Issue:2

    Topics: Cell Death; Cell Line; Cell Survival; Contrast Media; Humans; Imidazoles; Inflammation; Kidney Tubules, Proximal; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Signal Transduction

2011
Tumour necrosis factor-α stimulates human neutrophils to release preformed activin A.
    Immunology and cell biology, 2011, Volume: 89, Issue:8

    Topics: Activins; Apoptosis; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Inflammation; Inflammation Mediators; Leukocytes, Mononuclear; Lipopolysaccharides; MAP Kinase Signaling System; Neutrophils; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

2011
The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells.
    The Journal of biological chemistry, 2011, Oct-14, Volume: 286, Issue:41

    Topics: 3' Untranslated Regions; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyclooxygenase 2; ELAV Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group IV Phospholipases A2; Humans; Imidazoles; Inflammation; Interleukin-1beta; Lung Neoplasms; MAP Kinase Signaling System; Mutation; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA Stability; RNA, Neoplasm

2011
IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells.
    Inflammation, 2012, Volume: 35, Issue:2

    Topics: Amyloid beta-Peptides; Anthracenes; Butadienes; Cell Line; Humans; Imidazoles; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-1beta; Interleukin-33; Interleukin-6; Interleukin-8; Interleukins; JNK Mitogen-Activated Protein Kinases; Macular Degeneration; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; Peptide Fragments; Pyridines; Receptors, Cell Surface; Retinal Pigment Epithelium; Sulfones; Tumor Necrosis Factor-alpha

2012
ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.
    Inflammation, 2012, Volume: 35, Issue:3

    Topics: Cell Line; Cell Survival; Curcumin; Diethylhexyl Phthalate; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-8; MAP Kinase Signaling System; Medicine, Chinese Traditional; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger

2012
The anti-inflammatory mechanism of heme oxygenase-1 induced by hemin in primary rat alveolar macrophages.
    Inflammation, 2012, Volume: 35, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginase; Cells, Cultured; Heme Oxygenase-1; Hemin; Imidazoles; Inflammation; Inflammation Mediators; Interleukin-10; Lipopolysaccharides; Lung; Lung Injury; Macrophages, Alveolar; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Protoporphyrins; Pyridines; Rats

2012
MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.
    Cellular signalling, 2012, Volume: 24, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Diterpenes; Dual Specificity Phosphatase 1; Epoxy Compounds; Feedback, Physiological; Gene Expression Regulation; Histones; Humans; Imidazoles; Inflammation; Interleukin-8; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Primary Cell Culture; Promoter Regions, Genetic; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; RNA Stability; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha

2012
Uncoordinated regulation of atrial natriuretic factor and brain natriuretic peptide in lipopolysaccharide-treated rats.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2012, Volume: 17, Issue:2

    Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Inflammation; Lipopolysaccharides; Myocardium; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction

2012
Inhibition of p38 mitogen-activated protein kinase down-regulates the inflammatory osteolysis response to titanium particles in a murine osteolysis model.
    Inflammation, 2012, Volume: 35, Issue:6

    Topics: Acid Phosphatase; Animals; Bone and Bones; Down-Regulation; Enzyme Inhibitors; Female; Imidazoles; Inflammation; Isoenzymes; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Osteoclasts; Osteolysis; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Tartrate-Resistant Acid Phosphatase; Titanium; Tumor Necrosis Factor-alpha

2012
Using the one-lung method to link p38 to pro-inflammatory gene expression during overventilation in C57BL/6 and BALB/c mice.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Animals; Cytokines; Enzyme Inhibitors; Female; Gene Expression Regulation; Imidazoles; Inflammation; Lung; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Positive-Pressure Respiration; Proto-Oncogene Proteins c-akt; Pyridines; Species Specificity; Ventilator-Induced Lung Injury

2012
Secreted factors from human mast cells trigger inflammatory cytokine production by human airway smooth muscle cells.
    International archives of allergy and immunology, 2013, Volume: 160, Issue:1

    Topics: Asthma; Cell Line; Culture Media, Conditioned; Exosomes; Humans; Imidazoles; Immunoglobulin E; Inflammation; Interleukin-6; Interleukin-8; Mast Cells; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Receptors, Fc; Respiratory System; RNA, Messenger; src-Family Kinases

2013
Orofacial neuropathic pain mouse model induced by Trigeminal Inflammatory Compression (TIC) of the infraorbital nerve.
    Molecular brain, 2012, Dec-28, Volume: 5

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Facial Pain; Hyperalgesia; Imidazoles; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Nerve Compression Syndromes; Neuralgia; Neurons; Orbit; p38 Mitogen-Activated Protein Kinases; Purinergic P2X Receptor Antagonists; Pyridines; Tetrazoles; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Neuralgia; Trigeminal Nucleus, Spinal

2012
Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production.
    Shock (Augusta, Ga.), 2002, Volume: 18, Issue:4

    Topics: Animals; Cytokines; Female; Flavonoids; Imidazoles; Inflammation; Interleukin-10; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sepsis; Tumor Necrosis Factor-alpha

2002
Defining the involvement of p38alpha MAPK in the production of anti- and proinflammatory cytokines using an SB 203580-resistant form of the kinase.
    The Journal of biological chemistry, 2003, Jun-20, Volume: 278, Issue:25

    Topics: Animals; Cell Line; Cytokines; Enzyme Inhibitors; Humans; Imidazoles; Inflammation; Interferon-gamma; Interleukin-10; Kinetics; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Pyridines; T-Lymphocytes

2003
Inflammatory agonist stimulation and signal pathway of oxidative burst in neonatal chicken heterophils.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2003, Volume: 135, Issue:1

    Topics: Animals; Animals, Newborn; Chickens; Enzyme Inhibitors; Flavonoids; Fluoresceins; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Neutrophils; Protein Kinase C; Pyridines; Respiratory Burst; Salmonella enteritidis; Signal Transduction; Staphylococcus aureus; Teichoic Acids; Tetradecanoylphorbol Acetate

2003
Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells.
    Cancer letters, 2003, May-30, Volume: 195, Issue:1

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Cytokines; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Inflammation; Interleukin-1; Laminin; MAP Kinase Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteoglycans; Pyridines; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2003
Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells.
    The Journal of biological chemistry, 2003, Sep-12, Volume: 278, Issue:37

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA Primers; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Interleukin-1; MAP Kinase Signaling System; Mucins; Nasal Mucosa; Polymerase Chain Reaction; Pyridines; Respiratory Mucosa; Ribosomal Protein S6 Kinases, 90-kDa

2003
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
    Journal of neurochemistry, 2003, Volume: 86, Issue:6

    Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P

2003
P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.
    Shock (Augusta, Ga.), 2004, Volume: 21, Issue:2

    Topics: Animals; Blotting, Western; Cytokines; Endotoxins; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Interleukin-1; Interleukin-6; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardial Contraction; Myocardium; p38 Mitogen-Activated Protein Kinases; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Ventricular Function, Left

2004
Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK.
    The Journal of biological chemistry, 2004, May-07, Volume: 279, Issue:19

    Topics: Adenoviridae; Androstadienes; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Inflammation; Interleukin-1; Isoenzymes; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Vascular Cell Adhesion Molecule-1; Wortmannin

2004
Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase.
    Journal of molecular and cellular cardiology, 2004, Volume: 36, Issue:4

    Topics: Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cytokines; Densitometry; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Imidazoles; Inflammation; Interferon-gamma; Interleukin-1; Lymphocytes; Myocardium; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphorylation; Promoter Regions, Genetic; Protein Biosynthesis; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Transplantation; Tumor Necrosis Factor-alpha; Up-Regulation

2004
Regulation of adolescent rat intestinal epithelial inducible nitric oxide synthase expression in endotoxin tolerance: modulation of signal transduction.
    Shock (Augusta, Ga.), 2004, Volume: 21, Issue:5

    Topics: Animals; Blotting, Northern; Blotting, Western; Cell Nucleus; Cytoplasm; Densitometry; Down-Regulation; Endotoxins; Epithelium; Female; Ileum; Imidazoles; Immunohistochemistry; Inflammation; Intestines; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Models, Genetic; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA; Sex Factors; Signal Transduction; Time Factors

2004
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.
    The Journal of biological chemistry, 2004, Dec-17, Volume: 279, Issue:51

    Topics: Animals; Blotting, Western; Bronchi; Cell Nucleus; Cells, Cultured; Chemokines; Chromatin Immunoprecipitation; Cytokines; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation, Enzymologic; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Inflammation; Interleukin-8; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pneumonia; Promoter Regions, Genetic; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA Polymerase II; RNA, Complementary; Serine; Signal Transduction; Streptococcus pneumoniae; Time Factors; Transcription, Genetic; Transfection

2004
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:2

    Topics: Anthracenes; Aorta; Arteriosclerosis; Cell Adhesion; Depression, Chemical; Endothelial Cells; Endothelium, Vascular; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NADPH Oxidases; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Recombinant Fusion Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Transcription Factor AP-1; Transcription, Genetic; Transduction, Genetic; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2005
Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.
    The Journal of biological chemistry, 2005, Apr-15, Volume: 280, Issue:15

    Topics: Animals; Crohn Disease; Cytokines; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Female; Imidazoles; Immunoblotting; Inflammation; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Pyridines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Subcellular Fractions; Trinitrobenzenesulfonic Acid; Up-Regulation

2005
Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Cyclooxygenase 2; Cytokines; Humans; Imidazoles; Inflammation; Interferon-gamma; Interleukin-1; Islets of Langerhans; Islets of Langerhans Transplantation; Lipopolysaccharides; Membrane Proteins; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Tumor Necrosis Factor-alpha

2005
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Animals; Bacterial Toxins; Cell Line; Colon; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Humans; Ileum; Imidazoles; Immunohistochemistry; Inflammation; Intramolecular Oxidoreductases; Luciferases; Membrane Proteins; Mice; Mice, SCID; Models, Biological; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tissue Transplantation; Transfection

2005
Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells.
    Molecular biology of the cell, 2005, Volume: 16, Issue:7

    Topics: Amino Acid Motifs; Androstadienes; Blotting, Western; CCAAT-Enhancer-Binding Protein-delta; Cell Line, Tumor; Cell Nucleus; Chromatin Immunoprecipitation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Epidermal Growth Factor; Genes, Reporter; Humans; Imidazoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Binding; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transfection; Wortmannin

2005
Inflammatory pathway analysis using a high content screening platform.
    Assay and drug development technologies, 2005, Volume: 3, Issue:3

    Topics: Anthracenes; Cell Line, Tumor; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescence; Fluorescent Antibody Technique; HeLa Cells; Humans; Imidazoles; Immunoblotting; Inflammation; Interleukin-1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reproducibility of Results; RNA, Small Interfering; Signal Transduction; Technology, Pharmaceutical; Transcription Factor RelA; Transfection

2005
Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats.
    Immunology, 2005, Volume: 115, Issue:4

    Topics: Animals; Bifidobacterium; Cell Line; Cysteine Endopeptidases; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Imidazoles; Inflammation; Interleukin-6; Intestines; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; NF-kappa B; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Probiotics; Proteins; Pyridines; Rats; Rats, Inbred F344; Receptors, Cell Surface; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptors; Transcription Factor RelA; Tumor Necrosis Factor alpha-Induced Protein 3

2005
[The variations of p38 MAPK activity on lipopolysaccharide-induced inflammation of nasal epithelial cells and its significance in vitro].
    Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 2005, Volume: 19, Issue:13

    Topics: Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Humans; Imidazoles; Inflammation; Lipopolysaccharides; Nasal Mucosa; p38 Mitogen-Activated Protein Kinases; Pyridines

2005
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Imidazoles; Immune Sera; Inflammation; Interleukin-6; Male; Mitogen-Activated Protein Kinase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rabbits; Signal Transduction; Turpentine

2006
Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway.
    American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:4

    Topics: Animals; Caveolin 1; Cells, Cultured; Cytokines; Enzyme Activation; Imidazoles; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages, Alveolar; Macrophages, Peritoneal; MAP Kinase Kinase 3; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Transcription Factor AP-1

2006
Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:6

    Topics: Aging; Animals; Cells, Cultured; Chemokines; Cytokines; Disease Susceptibility; Female; Gene Expression Regulation; Imidazoles; Inflammation; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Chemokine; Receptors, Cytokine; RNA, Messenger; Signal Transduction; Subtraction Technique; Toll-Like Receptors

2006
IL-25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation.
    Allergy, 2006, Volume: 61, Issue:7

    Topics: Apoptosis; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Eosinophilia; Eosinophils; Gene Expression Regulation; Humans; Hypersensitivity; Imidazoles; Inflammation; Interleukin-17; Interleukins; JNK Mitogen-Activated Protein Kinases; Leupeptins; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger

2006
Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?
    Rejuvenation research, 2006,Fall, Volume: 9, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cellular Senescence; DNA Helicases; Exodeoxyribonucleases; Fibroblasts; Humans; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Mutation; p38 Mitogen-Activated Protein Kinases; Pyridines; RecQ Helicases; Signal Transduction; Werner Syndrome; Werner Syndrome Helicase

2006
Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus.
    Diabetologia, 2006, Volume: 49, Issue:10

    Topics: Animals; Body Weight; Cytokines; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Inhibitors; Heart; Imidazoles; Inflammation; Male; Mice; Mice, Inbred C57BL; Organ Size; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Systole; Ventricular Dysfunction, Left; Ventricular Function, Left

2006
Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK.
    Biochemical and biophysical research communications, 2006, Dec-15, Volume: 351, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Casein Kinase II; Cell Nucleus; Cells, Cultured; Haemophilus influenzae; Humans; I-kappa B Kinase; Imidazoles; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pneumococcal Infections; Pyridines; Signal Transduction; Streptococcus pneumoniae; Transcription Factor RelA

2006
Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases.
    International immunopharmacology, 2007, Volume: 7, Issue:2

    Topics: Cells, Cultured; Chaperonin 60; Cytokines; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Inflammation; Lipopolysaccharide Receptors; Monocytes; Mycobacterium tuberculosis; p38 Mitogen-Activated Protein Kinases; Pyridines

2007
SB203580 enhances interleukin-1 receptor antagonist gene expression in IFN-gamma-stimulated BV2 microglial cells through a composite nuclear factor-kappaB/PU.1 binding site.
    Neuroscience letters, 2007, Apr-12, Volume: 416, Issue:2

    Topics: Animals; Blotting, Western; Cell Line; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; Inflammation; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein; Mice; Microglia; Mutagenesis, Site-Directed; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Promoter Regions, Genetic; Proto-Oncogene Proteins; Pyridines; RNA, Messenger; Trans-Activators; Transfection

2007
The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway.
    Shock (Augusta, Ga.), 2007, Volume: 27, Issue:6

    Topics: Cell Separation; Complement C5a; Enzyme Activation; Flow Cytometry; Humans; Imidazoles; Inflammation; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; MAP Kinase Signaling System; Monocytes; p38 Mitogen-Activated Protein Kinases; Peptides; Pyridines; Tumor Necrosis Factor-alpha

2007
Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.
    Molecular pain, 2008, Apr-30, Volume: 4

    Topics: Animals; Bee Venoms; Butadienes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Hypersensitivity; Imidazoles; Immunohistochemistry; Inflammation; Male; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord

2008
Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes.
    American journal of respiratory cell and molecular biology, 2000, Volume: 23, Issue:1

    Topics: Anti-Inflammatory Agents; Bronchi; Cell Line; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger

2000
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways.
    Free radical biology & medicine, 2000, Nov-15, Volume: 29, Issue:10

    Topics: Chemokine CCL4; Chemokines; Cyclic AMP; Dexamethasone; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Inflammation; Interleukin-8; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Triazenes; U937 Cells

2000
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
    Journal of leukocyte biology, 2000, Volume: 68, Issue:6

    Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypertonic Solutions; I-kappa B Kinase; Imidazoles; Inflammation; Insulin-Like Growth Factor I; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandins A; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection; Tumor Cells, Cultured; Wortmannin

2000
Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Jan-15, Volume: 166, Issue:2

    Topics: Adult; Apoptosis; Caspases; Cell Adhesion; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; DNA Fragmentation; Dose-Response Relationship, Immunologic; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Hydrolysis; Imidazoles; Inflammation; Jurkat Cells; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Superoxides; Tumor Necrosis Factor-alpha

2001
SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain; Cerebrovascular Circulation; Enzyme Inhibitors; Hemodynamics; Hippocampus; Imidazoles; Inflammation; Ischemic Attack, Transient; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Rats; Rats, Inbred Lew; Rats, Inbred SHR

2001
Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasiti
    Journal of immunology (Baltimore, Md. : 1950), 2001, Mar-01, Volume: 166, Issue:5

    Topics: Activating Transcription Factor 2; Animals; Cyclic AMP Response Element-Binding Protein; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycosylphosphatidylinositols; I-kappa B Proteins; Imidazoles; Immune Tolerance; Inflammation; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages; MAP Kinase Kinase 4; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mucins; NF-kappa B; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protozoan Proteins; Pyridines; Receptors, Cell Surface; Transcription Factors; Trypanosoma cruzi; Tumor Necrosis Factor-alpha

2001
p38 stress-activated protein kinase inhibitor reverses bradykinin B(1) receptor-mediated component of inflammatory hyperalgesia.
    European journal of pharmacology, 2001, Jun-15, Volume: 421, Issue:3

    Topics: Animals; Cell Line; Cyclooxygenase 2; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hindlimb; Humans; Hyperalgesia; Imidazoles; Inflammation; Interleukin-1; Isoenzymes; Kallidin; Male; Membrane Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptors, Bradykinin; Tumor Necrosis Factor-alpha

2001
Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.
    Shock (Augusta, Ga.), 2002, Volume: 18, Issue:1

    Topics: Antibodies; CD18 Antigens; Cell Adhesion; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Imidazoles; Inflammation; Integrin beta1; Mitogen-Activated Protein Kinases; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Pyridines; Thromboplastin; Tumor Necrosis Factor-alpha

2002